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Transfusional Medicine

We are dedicated to investigate transfusional activity, the alteration of erythrocytes during the conservation period and extracorporeal photoapheresis. We work on the molecular and serological characterization of blood group variants. In non-invasive fetal genotyping strategies due to blood group incompatibilities. We develop iPSC lines and produce in vitro erythrocytes with rare phenotypes.

We deepen in the knowledge of epidemiology and the detection of infectious agents relevant for safety of the products supplied by the Blood and Tissue Bank.

We investigate in clinical immunology and develop our own HLA and KIR typing protocols. We develop and incorporate new therapeutic applications in cell therapy including hematopoietic transplantation, cellular immunology and regenerative medicine.

We investigate the molecular mechanisms and genotype-phenotype correlation of coagulopathies, haemorrhagic diathesis and other associated congenital pathologies. We develop tools based on the new technologies of parallel massive sequencing with application to the molecular study, genetic counselling and prenatal diagnosis.

Team

Martinez Raneque, Fran

Martinez Raneque, Fran

Transfusional Medicine
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Merce Albert Bayo

Merce Albert Bayo

Research technician
Transfusional Medicine
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Nina Borràs Agustí

Nina Borràs Agustí

Postdoctoral researcher
Transfusional Medicine
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Ribas Badia, Maria Esperanza

Ribas Badia, Maria Esperanza

Transfusional Medicine
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Vanesa Pleguezuelos Hernandez

Vanesa Pleguezuelos Hernandez

Predoctoral researcher
Transfusional Medicine
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Angie Rico Blazquez

Angie Rico Blazquez

Research technician
Transfusional Medicine
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Martinez Raneque, Fran

Martinez Raneque, Fran

Transfusional Medicine
Read more
Merce Albert Bayo

Merce Albert Bayo

Research technician
Transfusional Medicine
Read more
Nina Borràs Agustí

Nina Borràs Agustí

Postdoctoral researcher
Transfusional Medicine
Read more
Ribas Badia, Maria Esperanza

Ribas Badia, Maria Esperanza

Transfusional Medicine
Read more
Vanesa Pleguezuelos Hernandez

Vanesa Pleguezuelos Hernandez

Predoctoral researcher
Transfusional Medicine
Read more
Angie Rico Blazquez

Angie Rico Blazquez

Research technician
Transfusional Medicine
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Projects

TRASLACIÓN DE UN PRODUCTO DE INGENIERÍA TISULAR ALOGÉNICO CON MSC DE GELATINA DE WHARTON PARA EL TRATAMIENTO DE LA OSTEONECROSIS EN PACIENTES ONCOLÓGICOS PEDIÁTRICOS.

IP: Joaquim Vives Armengol
Collaborators: Roberto Vélez Villa, Nayana Joshi Jubert, Lluis Martorell Cedres, Maria Cristina Díaz de Heredia Rubio, Màrius Aguirre Canyadell, Irene Portas Torres, Raquel Cabrera Perez
Funding agency: Instituto de Salud Carlos III
Funding: 87120
Reference: PI19/01788
Duration: 01/01/2020 - 30/06/2024

Impact of HLA haplotypes and HDV viremia in developing of clinical events and quality of life of patients with chronic hepatitis delta.

IP: Maria Buti Ferret
Collaborators: Maria Jose Herrero Mata, Ana Barreira Diaz, Maria del Mar Riveiro Barciela, Jordi Llaneras Artigues, Adriana Palom Agusti
Funding agency: Instituto de Salud Carlos III
Funding: 117370
Reference: PI20/01692
Duration: 01/01/2021 - 30/06/2025

TISSUE ENGINEERING FOR THE IMPROVEMENT OF THE FETOSCOPIC REPAIR OF OPEN SPINAL NEURAL TUBE DEFECTS IN OVINE FETUSES (TISSUE-NTD)

IP: Nerea Maiz Elizaran
Collaborators: Ana Lain Fernandez, Margarita Codinach Creus, Silvia Arévalo Martínez, Pablo García Manau, Paula Garcia Aguilar, Susana Manrique Muñoz, Manuel López Paredes, Ester Del Barco Martínez, Erika Bonacina
Funding agency: Instituto de Salud Carlos III
Funding: 135520
Reference: PI20/00421
Duration: 01/01/2021 - 30/06/2025

Publications

HBsAg protein composition and clinical outcomes in chronic hepatitis D and variations across HBeAg-negative chronic HBsAg carriers.

PMID: 37745192
Journal: JHEP Reports
Year: 2023
Reference: JHEP Rep. 2023 Jul 13;5(10):100842. doi: 10.1016/j.jhepr.2023.100842. eCollection 2023 Oct.
Impact factor:
Publication type: Paper in international publication
Authors: Berg, Thomas; Bes, Marta; Buti, Maria; Buti, Maria; Casillas, Rosario; Esteban, Rafael; Esteban, Rafael; Palom, Adriana; Pfefferkorn, Maria; Rando-Segura, Ariadna et al.
DOI: 10.1016/j.jhepr.2023.100842

Clinical performance of a new multiplex assay for the detection of HIV-1, HIV-2, HCV, HBV, and HEV in blood donations in Catalonia (Spain).

PMID: 37767741
Journal: TRANSFUSION
Year: 2023
Reference: Transfusion. 2023 Sep 28. doi: 10.1111/trf.17518.
Impact factor:
Publication type: Paper in international publication
Authors: Bes, Marta; Carrio, Jaume; Coco, Sonia Bakkour; Linnen, Jeffrey M; Ong, Edgar; Piron, Maria; Sauleda, Silvia et al.
DOI: 10.1111/trf.17518

Mitochondrial dysfunction, lipids metabolism, and amino acid biosynthesis are key pathways for COVID-19 recovery.

PMID: 37810253
Journal: iScience
Year: 2023
Reference: iScience. 2023 Sep 19;26(10):107948. doi: 10.1016/j.isci.2023.107948. eCollection 2023 Oct 20.
Impact factor:
Publication type: Paper in international publication
Authors: Almirante, Benito; Buzon, Maria Jose; Chafino, Silvia; Fernandez-Veledo, Sonia; Foguet-Romero, Elisabet; Garcia-Pardo, Graciano; Gomez-Bertomeu, Frederic; Lopez-Dupla, Miguel; Olona, Montserrat; Peraire, Joaquim et al.
DOI: 10.1016/j.isci.2023.107948

Hierarchical Cluster Analysis Based on Clinical and Neuropsychological Symptoms Reveals Distinct Subgroups in Fibromyalgia: A Population-Based Cohort Study.

PMID: 37893239
Journal: Biomedicines
Year: 2023
Reference: Biomedicines. 2023 Oct 23;11(10):2867. doi: 10.3390/biomedicines11102867.
Impact factor:
Publication type: Paper in international publication
Authors: Aban, M; Abraldes, Juan G; Alegre-Martin, Jose; Alessandria, Carlo; Allegretti, Andrew S; Alonso, Sonia; Andrade, R; Angeli, P; Asrani, Sumeet K; Avitabile, E et al.
DOI: 10.3390/biomedicines11102867

Unraveling the Influence of Common von Willebrand factor variants on von Willebrand Disease Phenotype: An Exploratory Study on the Molecular and Clinical Profile of von Willebrand Disease in Spain Cohort.

PMID: 32135566
Journal: THROMBOSIS AND HAEMOSTASIS
Year: 2020
Reference: Thromb Haemost. 2020 Mar;120(3):437-448. doi: 10.1055/s-0040-1702227. Epub 2020 Mar 5.
Impact factor: 4.379
Publication type: Paper in international publication
Authors: Borras, Nina, Garcia-Martinez, Iris, Batlle, Javier, Perez-Rodriguez, Almudena, Parra, Rafael, Altisent, Carme, Lopez-Fernandez, Maria Fernanda, Costa Pinto, Joana, Batlle-Lopez, Fernando, Cid, Ana Rosa et al.
DOI: 10.1055/s-0040-1702227

Distribution of Human Killer Cell Immunoglobulin-Like Receptors and Ligands Among Blood Donors Of Catalonia.

PMID: 31702113
Journal: HLA
Year: 2020
Reference: HLA. 2020 Mar;95(3):179-188. doi: 10.1111/tan.13754. Epub 2019 Nov 25.
Impact factor: 2.955
Publication type: Paper in international publication
Authors: Herrero, Maria J, Closa, Laia, Vidal, Francisco, Caro, Jose L et al.
DOI: 10.1111/tan.13754

Joint status in Spanish haemophilia B patients assessed using the Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) score.

PMID: 30444298
Journal: HAEMOPHILIA
Year: 2019
Reference: Haemophilia. 2019 Jan;25(1):144-153. doi: 10.1111/hae.13628. Epub 2018 Nov 16.
Impact factor: 3.59
Publication type: Paper in international publication
Authors: Martinoli, Carlo, Jimenez-Yuste, Victor, Alvarez-Roman, Maria Teresa, Martin-Salces, Monica, De la Corte-Rodriguez, Hortensia, Altisent, Carmen, Parra, Rafael, Nunez, Ramiro, Perez, Rosario, Garcia-Candel, Faustino et al.
DOI: 10.1111/hae.13628

Recombinant FXIII (rFXIII-A2) Prophylaxis Prevents Bleeding and Allows for Surgery in Patients with Congenital FXIII A-Subunit Deficiency.

PMID: 29448295
Journal: THROMBOSIS AND HAEMOSTASIS
Year: 2018
Reference: Thromb Haemost. 2018 Mar;118(3):451-460. doi: 10.1055/s-0038-1624581. Epub 2018 Feb 15.
Impact factor: 4.952
Publication type: Paper in international publication
Authors: Kessler, Craig, Lassila, Riitta, Nugent, Diane, Oldenburg, Johannes, Garly, May-Lill, Rosholm, Anders, Inbal, Aida, Kerlin, Bryce A, Fukutake, Katsuyuki, Altisent, Carmen et al.
DOI: 10.1055/s-0038-1624581

Practical aspects of factor concentrate use in patients with von Willebrand disease undergoing invasive procedures: a European survey.

PMID: 27292438
Journal: HAEMOPHILIA
Year: 2016
Reference: Haemophilia. 2016 Sep;22(5):739-51. doi: 10.1111/hae.12955. Epub 2016 Jun 13.
Impact factor: 2.673
Publication type: Review in international publication
Authors: Windyga, J, Dolan, G, Altisent, C, Katsarou, O, Lopez Fernandez, M-F, Zulfikar, B et al.
DOI: 10.1111/hae.12955

Molecular and clinical profile of von Willebrand disease in Spain (PCM-EVW-ES): Proposal for a new diagnostic paradigm.

PMID: 26245874
Journal: THROMBOSIS AND HAEMOSTASIS
Year: 2016
Reference: Thromb Haemost. 2016 Jan;115(1):40-50. doi: 10.1160/TH15-04-0282. Epub 2015 Aug 6.
Impact factor: 5.255
Publication type: Paper in international publication
Authors: Arribalzaga, Karmele, Cabrera, Noelia, Moret, Andres, Parra, Rafael, Mingot-Castellano, Maria Eva, Balda, Ignacia, Altisent, Carmen, Perez-Montes, Rocio, Fisac, Rosa Maria, Iruin, Gemma et al.
DOI: 10.1160/TH15-04-0282