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Translational Immunology

The main objectives are to improve the diagnosis of immunodeficiencies and autoimmune diseases, addressing also their heterogeneity and mechanisms in close collaboration with the pediatrics, thyroid and systemic disease groups, being internationally recognized in both areas. The group participates in numerous research projects at the Vall d'Hebron Barcelona Hospital Campus that use immunological tests developed for specific projects led by the kidney transplantation, intensive care medicine, internal medicine, allergy and rheumatology groups. During the COVID pandemic the group made contributions in improving the immunogenetic and immunological risk profiles and in the evaluation of the immune response to vaccination and natural infection, collaborating with national and international networks. The group has also generated a biobank of more than 8.000 samples from patients with COVID-19 that have been incorporated into the VHIR biobank.

The group works as a coordinator of the "Focis" Center of Excellence (Federation of Clinical Immunology Societies) of Barcelona.

Team

Janire Perurena Prieto

Janire Perurena Prieto

Predoctoral researcher
Translational Immunology
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Janire Perurena Prieto

Janire Perurena Prieto

Predoctoral researcher
Translational Immunology
Read more

Projects

Determinació de biomarcadors mitjançant anàlisi transcriptòmica per a la diferenciació en fenotips i endotips de pacients amb angioedema idiopàtic i angioedema hereditari

IP: Ingrid Johana Gil Serrano
Collaborators: -
Funding agency: Stat. Catalana d'Al·lèrgia i Immunologia Clínica
Funding: 9000
Reference: SCAIC/BEQUES/2020/GIL
Duration: 01/06/2020 - 01/01/2025

Caracterización de Neisseria meningitidis tras la introducción de la vacuna frente al serogrupo B e identificación de factores predisponentes para la enfermedad meningocócica invasiva

IP: Juan Jose Gonzalez Lopez
Collaborators: Manuel Hernández González, Jose Angel Rodrigo Pendás, Maria Belén Viñado Perez, Aina Aguiló Cucurull, Alba Mir Cros, Albert Moreno Mingorance, Andrea Martín Nalda, Nuria Serre Delcor, Josep Roca Grande, Laura Batlle Masó
Funding agency: Instituto de Salud Carlos III
Funding: 123420
Reference: PI21/00132
Duration: 01/01/2022 - 30/06/2026

OPTIMIZACIÓN DEL TRATAMIENTO QUIMIOLINFODEPLECTIVO CON FLUDARABINA PREVIO A LA INFUSIÓN DE TERAPIA DE CÉLULAS T CON RECEPTOR DE ANTÍGENO QUIMÉRICO (CAR-T)

IP: OPTIMIZACIÓN DEL TRATAMIENTO QUIMIOLINFODEPLECTIVO CON FLUDARABINA PREVIO A LA INFUSIÓN DE TERAPIA DE CÉLULAS T CON RECEPTOR DE
Collaborators: OPTIMIZACIÓN DEL TRATAMIENTO QUIMIOLINFODEPLECTIVO CON FLUDARABINA PREVIO A LA INFUSIÓN DE TERAPIA DE CÉLULAS T CON RECEPTOR DE , Gloria Inés Iacoboni García-Calvo, Maria Queralt Gorgas Torner, Lucas Rivera Sánchez, Anna Maria Farriols Danes, Pere Barba Suñol, Carla Alonso Martinez, Janire Perurena Prieto, Maria Josep Carreras Soler, Cecilia Carmen Carpio Segura
Funding agency: Instituto de Salud Carlos III
Funding: 111320
Reference: PI21/00197
Duration: 01/01/2022 - 31/12/2024

Blog

News

A Vall d’Hebron team demonstrates, for the first time, the potential of optical genome mapping to detect genetic alterations associated with this rare disease that are not identified using conventional methods.

The study describes the first documented case worldwide of hereditary angioedema transmission through assisted reproduction.

The paper describes the case of a patient in whom, years after a bone marrow transplant, two immune cell lines corrected the original genetic defect.