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Translational Immunology

The main objectives are to improve the diagnosis of immunodeficiencies and autoimmune diseases, addressing also their heterogeneity and mechanisms in close collaboration with the pediatrics, thyroid and systemic disease groups, being internationally recognized in both areas. The group participates in numerous research projects at the Vall d'Hebron Barcelona Hospital Campus that use immunological tests developed for specific projects led by the kidney transplantation, intensive care medicine, internal medicine, allergy and rheumatology groups. During the COVID pandemic the group made contributions in improving the immunogenetic and immunological risk profiles and in the evaluation of the immune response to vaccination and natural infection, collaborating with national and international networks. The group has also generated a biobank of more than 8.000 samples from patients with COVID-19 that have been incorporated into the VHIR biobank.

The group works as a coordinator of the "Focis" Center of Excellence (Federation of Clinical Immunology Societies) of Barcelona.

Publications

Notch signaling in thyrocytes is essential for adult thyroid function and mammalian homeostasis.

PMID: 38123718
Journal: Nature Metabolism
Year: 2023
Reference: Nat Metab. 2023 Dec;5(12):2094-2110. doi: 10.1038/s42255-023-00937-1. Epub 2023 Dec 20.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Sierra, Daniel; Choudhury, Feroza K; Hankeova, Simona; Kamath, Binita M; Lai, Zijuan; Mosteiro, Lluc; Nguyen, Thi Thu Thao; Piskol, Robert; Pujol-Borrell, Ricardo; Reichelt, Mike et al.
DOI: 10.1038/s42255-023-00937-1

LYMPHOCYTIC THYROIDITIS TRANSCRIPTOMIC PROFILES SUPPORT THE ROLE OF CHECKPOINT PATHWAYS AND B CELLS IN PATHOGENESIS.

PMID: 35403441
Journal: THYROID
Year: 2022
Reference: Thyroid. 2022 Jun;32(6):682-693. doi: 10.1089/thy.2021.0694. Epub 2022 May 25.
Impact factor: 6.568
Publication type: Paper in international publication
Authors: Zafon, Carles, Alvarez de la Sierra, Daniel, Marin-Sanchez, Ana, Gomez-Brey, Aroa, Bello, Irene, Caubet, Enric, Moreno-Llorente, Pablo, Petit, Anna, Pujol-Borrell, Ricardo, Gonzalez, Oscar et al.
DOI: 10.1089/thy.2021.0694

Recovery of serum testosterone levels is an accurate predictor of survival from COVID-19 in male patients.

PMID: 35351135
Journal: BMC Medicine
Year: 2022
Reference: BMC Med. 2022 Mar 29;20(1):129. doi: 10.1186/s12916-022-02345-w.
Impact factor: 8.775
Publication type: Paper in international publication
Authors: Gallo, Monica Martinez, Arrese-Munoz, Iria, Gine, Anna, Diaz-Troyano, Noelia, Gabriel-Medina, Pablo, Riveiro-Barciela, Mar, Labrador-Horrillo, Moises, Martinez-Valle, Fernando, Montalva, Adrian Sanchez, Hernandez-Gonzalez, Manuel et al.
DOI: 10.1186/s12916-022-02345-w

Stratification of hospitalized COVID-19 patients into clinical severity progression groups by immuno-phenotyping and machine learning.

PMID: 35177626
Journal: Nature Communications
Year: 2022
Reference: Nat Commun. 2022 Feb 17;13(1):915. doi: 10.1038/s41467-022-28621-0.
Impact factor: 14.919
Publication type: Paper in international publication
Authors: Kraker, Geoffrey, Jaimes, Maria C, Van Bockstael, Sebastiaan, Hernandez-Gonzalez, Manuel, Rokx, Casper, Rijnders, Bart J A, Pujol-Borrell, Ricardo, Katsikis, Peter D, van Wees, Tamara, Laport, Danique A et al.
DOI: 10.1038/s41467-022-28621-0

Cellular and humoral immunogenicity of the mRNA-1273 SARS-CoV-2 vaccine in patients with hematologic malignancies.

PMID: 34844263
Journal: Blood Advances
Year: 2022
Reference: Blood Adv. 2022 Feb 8;6(3):774-784. doi: 10.1182/bloodadvances.2021006101.
Impact factor: 6.799
Publication type: Paper in international publication
Authors: Orfao, Alberto, Jimenez, Moraima, Roldan, Elisa, Fernandez-Naval, Candela, Villacampa, Guillermo, Martinez-Gallo, Monica, Medina-Gil, Daniel, Peralta-Garzon, Soraya, Pujadas, Gemma, Hernandez, Cristina et al.
DOI: 10.1182/bloodadvances.2021006101

Molecular analysis of the novel L243R mutation in STXBP2 reveals impairment of degranulation activity.

PMID: 31865540
Journal: INTERNATIONAL JOURNAL OF HEMATOLOGY
Year: 2020
Reference: Int J Hematol. 2020 Mar;111(3):440-450. doi: 10.1007/s12185-019-02796-7. Epub 2019 Dec 21.
Impact factor: 2.245
Publication type: Paper in international publication
Authors: Rincon, Rafael, Vinas-Gimenez, Laura, Donadeu, Laura, Alsina, Laia, Catala, Albert, Colobran, Roger, de la Cruz, Xavier, Sayos, Joan, Martinez-Gallo, Monica, Esteve-Sole, Ana et al.
DOI: 10.1007/s12185-019-02796-7

Serum IL-10 Levels and Its Relationship with Parasitemia in Chronic Chagas Disease Patients.

PMID: 31701864
Journal: AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Year: 2020
Reference: Am J Trop Med Hyg. 2020 Jan;102(1):159-163. doi: 10.4269/ajtmh.19-0550.
Impact factor: 2.126
Publication type: Paper in international publication
Authors: Molina, Israel, Silgado, Aroa, Moure, Zaira, Bosch-Nicolau, Pau, Salvador, Fernando, Sanchez-Montalva, Adrian, Martinez-Gallo, Monica, Sulleiro, Elena, Franco-Jarava, Clara, Sao Aviles, Augusto et al.
DOI: 10.4269/ajtmh.19-0550

Blog

News

A study from the Vall d’Hebron Campus demonstrates that the Ex Vivo C5b-9 deposition test is useful for monitoring the activity of the complement system (CS) in patients with aHUS or transplant-associated TMA.

The results show that, in some patients with mutations in the X chromosome, the healthy gene is inactivated and the mutated gene manifests itself, which favors the onset of the disease.

Researchers have used an innovative protocol to identify people with this autoimmune disease who have a higher risk of cancer.