About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The main objectives are to improve the diagnosis of immunodeficiencies and autoimmune diseases, addressing also their heterogeneity and mechanisms in close collaboration with the pediatrics, thyroid and systemic disease groups, being internationally recognized in both areas. The group participates in numerous research projects at the Vall d'Hebron Barcelona Hospital Campus that use immunological tests developed for specific projects led by the kidney transplantation, intensive care medicine, internal medicine, allergy and rheumatology groups. During the COVID pandemic the group made contributions in improving the immunogenetic and immunological risk profiles and in the evaluation of the immune response to vaccination and natural infection, collaborating with national and international networks. The group has also generated a biobank of more than 8.000 samples from patients with COVID-19 that have been incorporated into the VHIR biobank.
The group works as a coordinator of the "Focis" Center of Excellence (Federation of Clinical Immunology Societies) of Barcelona.
IP: Pere Soler Palacín Collaborators: Mónica Martínez Gallo Funding agency: EUROPEAN COMMISSION Funding: 62500 Reference: RECOMB_H2020SCI2017 Duration: 01/01/2018 - 31/12/2024
IP: Mar Guilarte Clavero Collaborators: Manuel Hernández González, Moisés Labrador Horrillo, Anna Sala Cunill, Olga Luengo Sanchez, Paula Galvan Blasco, Ingrid Johana Gil Serrano Funding agency: Instituto de Salud Carlos III Funding: 84700 Reference: PI20/01061 Duration: 01/01/2021 - 30/06/2025
IP: Roger Colobran Oriol Collaborators: Aina Aguiló Cucurull, Andrea Martín Nalda, Laura Batlle Masó Funding agency: Instituto de Salud Carlos III Funding: 159720 Reference: PI20/00761 Duration: 01/01/2021 - 30/06/2025
IP: Ingrid Johana Gil Serrano Collaborators: - Funding agency: Stat. Catalana d'Al·lèrgia i Immunologia Clínica Funding: 9000 Reference: SCAIC/BEQUES/2020/GIL Duration: 01/06/2020 - 01/01/2025
PMID: 37597073 Journal: JOURNAL OF CLINICAL IMMUNOLOGY Year: 2023 Reference: J Clin Immunol. 2023 Aug 19. doi: 10.1007/s10875-023-01556-x. Impact factor: Publication type: Paper in international publication Authors: Aguilo-Cucurull, Aina; Batlle-Maso, Laura; Castells, Neus; Colobran, Roger; Franco-Jarava, Clara; Garcia-Prat, Marina; Martin-Nalda, Andrea; Martinez-Gallo, Monica; Parra-Martinez, Alba; Riviere, Jacques G et al. DOI: 10.1007/s10875-023-01556-x
PMID: 37769243 Journal: RHEUMATOLOGY Year: 2023 Reference: Rheumatology (Oxford). 2023 Sep 28:kead520. doi: 10.1093/rheumatology/kead520. Impact factor: Publication type: Paper in international publication Authors: Callejas-Moraga, Eduardo Luis; Callejas-Moraga, Eduardo Luis; Colobran, Roger; Colobran, Roger; Del-Castillo, Alfredo Guillen-; Del-Castillo, Alfredo Guillen-; Perurena-Prieto, Janire; Sanz-Martinez, Maria Teresa; Selva-O'Callaghan, Albert; Selva-O'Callaghan, Albert et al. DOI: 10.1093/rheumatology/kead520
PMID: 37799110 Journal: EUROPEAN JOURNAL OF IMMUNOLOGY Year: 2023 Reference: Eur J Immunol. 2023 Oct 6:e2350633. doi: 10.1002/eji.202350633. Impact factor: Publication type: Paper in international publication Authors: Andres-Leon, Eduardo; Arutyunyan, Anna; Ballestar, Esteban; Barmada, Anis; Calero-Nieto, Fernando J; Carrascosa, Jose Manuel; Carrillo, Jorge; Casafont-Sole, Ivette; Ciudad, Laura; de la Calle-Fabregat, Carlos et al. DOI: 10.1002/eji.202350633
PMID: 37837609 Journal: EUROPEAN JOURNAL OF ENDOCRINOLOGY Year: 2023 Reference: Eur J Endocrinol. 2023 Oct 14:lvad143. doi: 10.1093/ejendo/lvad143. Impact factor: Publication type: Paper in international publication Authors: Adriaansen, Bas P H; Ahmed, S Faisal; Ali, Salma R; Amr, Nermine Hussein; Bachega, Tania A S S; Baronio, Federico; Birkebaek, Niels Holtum; Bonfig, Walter; Bryce, Jillian; Cardona, Victoria et al. DOI: 10.1093/ejendo/lvad143
PMID: 35784294 Journal: Frontiers in Immunology Year: 2022 Reference: Front Immunol. 2022 Jun 17;13:897975. doi: 10.3389/fimmu.2022.897975. eCollection 2022. Impact factor: 7.561 Publication type: Letter or abstract Authors: Valenzuela, Irene; Franco-Jarava, Clara; Colobran, Roger; Batlle-Maso, Laura; Castells, Neus; Dieli-Crimi, Romina; Martinez-Gallo, Monica; Garcia-Prat, Marina; Riviere, Jacques G; Soler-Palacin, Pere et al. DOI: 10.3389/fimmu.2022.897975
PMID: 34515070 Journal: BLOOD PURIFICATION Year: 2022 Reference: Blood Purif. 2022;51(7):630-633. doi: 10.1159/000518229. Epub 2021 Sep 7. Impact factor: 2.614 Publication type: Letter or abstract Authors: Gonzalez, Juan Jose; Larrosa, Nieves; Perez-Carrasco, Marcos; Ruiz-Sanmartin, Adolf; Palmada, Clara; Chiscano-Camon, Luis; Ruiz-Rodriguez, Juan Carlos; Hernandez-Gonzalez, Manuel; Ferrer, Ricard et al. DOI: 10.1159/000518229
PMID: 35727945 Journal: BRAIN Year: 2022 Reference: Brain. 2022 Jun 21. pii: 6612696. doi: 10.1093/brain/awac220. Impact factor: 13.501 Publication type: Paper in international publication Authors: Rodriguez-Acevedo, Breogan, Ruiz-Ortiz, Mariano, Salerno, Annalaura, Tagliani, Paula, Tur, Carmen, Vidal-Jordana, Angela, Zabalza, Ana, Sastre-Garriga, Jaume, Rovira, Alex, Comabella, Manuel et al. DOI: 10.1093/brain/awac220
PMID: 34863919 Journal: CLINICAL MICROBIOLOGY AND INFECTION Year: 2022 Reference: Clin Microbiol Infect. 2022 Jun;28(6):881.e1-881.e5. doi: 10.1016/j.cmi.2021.11.021. Epub 2021 Dec 1. Impact factor: 8.067 Publication type: Paper in international publication Authors: Bosch-Nicolau, P, Salvador, F, Sanchez-Montalva, A, Franco-Jarava, C, Arrese-Munoz, I, Sulleiro, E, Roure, S, Valerio, Ll, Oliveira-Souto, I, Serre-Delcor, N et al. DOI: 10.1016/j.cmi.2021.11.021
PMID: 34021148 Journal: Nature Communications Year: 2021 Reference: Nat Commun. 2021 May 21;12(1):3010. doi: 10.1038/s41467-021-23333-3. Impact factor: 14.919 Publication type: Paper in international publication Authors: Perea, David, Rosado, Joel, Falco, Anna, Kirkegaard, Cristina, Torrella, Ariadna, Planas, Bibiana, Navarro, Jordi, Suanzes, Paula, Alvarez-Sierra, Daniel, Ayora, Alfonso et al. DOI: 10.1038/s41467-021-23333-3
PMID: 34016150 Journal: Immunity & Ageing Year: 2021 Reference: Immun Ageing. 2021 May 20;18(1):24. doi: 10.1186/s12979-021-00237-w. Impact factor: 6.4 Publication type: Paper in international publication Authors: Quirant, Bibiana, Martinez-Caceres, Eva, Boiges, Marc, Alonso, Marta, Esparcia-Pinedo, Laura, Lopez-Sanz, Celia, Munoz-Vico, Javier, Lopez-Palmero, Serafin, Trujillo, Antonio, Alvarez, Paula et al. DOI: 10.1186/s12979-021-00237-w
PMID: 32896249 Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY Year: 2021 Reference: Clin Exp Rheumatol. 2021 May-Jun;39(3):519-524. Epub 2020 Sep 3. Impact factor: 4.473 Publication type: Paper in international publication Authors: Casal-Dominguez, Maria, Pinal-Fernandez, Iago, Pak, Katherine, Sanz-Martinez, Maria Teresa, Baucells, Andres, Hosono, Yuji, Christopher-Stine, Lisa, Mammen, Andrew L, Marin-Sanchez, Ana et al. DOI:
PMID: 34016160 Journal: Biomarker Research Year: 2021 Reference: Biomark Res. 2021 May 20;9(1):37. doi: 10.1186/s40364-021-00290-z. Impact factor: 6.148 Publication type: Paper in international publication Authors: Franco-Jarava, Clara, Jimenez, Isabel, Tazon-Vega, Barbara, Abrisqueta, Pau, Nieto, Juan C, Bobillo, Sabela, Palacio-Garcia, Carles, Carabia, Julia, Valdes-Mas, Rafael, Munuera, Magdalena et al. DOI: 10.1186/s40364-021-00290-z
PMID: 32465574 Journal: JOURNAL OF HEART AND LUNG TRANSPLANTATION Year: 2020 Reference: J Heart Lung Transplant. 2020 Apr;39(4S):S380. doi: 10.1016/j.healun.2020.01.485. Epub 2020 Mar 30. Impact factor: 7.865 Publication type: Paper in international publication Authors: Sandiumenge, A, Bello, I, Coll, E, Franco, C, Perez, M, Crowley, S, Minambres, E, Naranjo, S, Penafiel, S, Sacanell, J et al. DOI: 10.1016/j.healun.2020.01.485
PMID: 32431704 Journal: Frontiers in Immunology Year: 2020 Reference: Front Immunol. 2020 May 5;11:771. doi: 10.3389/fimmu.2020.00771. eCollection 2020. Impact factor: 5.085 Publication type: Paper in international publication Authors: Urcelay, Elena, Espino-Paisan, Laura, Agudo-Jimenez, Teresa, Rosales-Martinez, Isabel, Lopez-Cotarelo, Pilar, Garcia-Martinez, Maria Angel, Dominguez-Mozo, Maria Inmaculada, Perez-Perez, Silvia, Dieli-Crimi, Romina, Comabella, Manuel et al. DOI: 10.3389/fimmu.2020.00771
PMID: 31599728 Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY Year: 2020 Reference: J Investig Allergol Clin Immunol. 2020 Apr 24;30(2):143-145. doi: 10.18176/jiaci.0459. Epub 2019 Oct 10. Impact factor: 3.488 Publication type: Paper in international publication Authors: Labrador Horrillo, M, Cardona, V, Sala Cunill, A, Guilarte, M, Luengo, O, Molina Molina, G J, Carrasco Gonzalez, M D, Vinas Gimenez, L, Sanz Martinez, M, Galvan Blasco, P et al. DOI: 10.18176/jiaci.0459
PMID: 31799703 Journal: CLINICAL AND EXPERIMENTAL IMMUNOLOGY Year: 2020 Reference: Clin Exp Immunol. 2020 Apr;200(1):61-72. doi: 10.1111/cei.13405. Epub 2020 Jan 19. Impact factor: 3.532 Publication type: Paper in international publication Authors: Alonso, Laura, Riviere, Jacques G, Soler-Palacin, Pere, Colobran, Roger, Sayos, Joan, Martinez-Gallo, Monica, Franco-Jarava, Clara, Ossowski, Stephan, Drechsel, Oliver, Magallon-Lorenz, Miriam et al. DOI: 10.1111/cei.13405
PMID: 30334372 Journal: CYTOMETRY PART B-CLINICAL CYTOMETRY Year: 2019 Reference: Cytometry B Clin Cytom. 2019 May;96(3):223-233. doi: 10.1002/cyto.b.21728. Epub 2018 Oct 17. Impact factor: 2.938 Publication type: Paper in international publication Authors: Garcia-Prat, Marina, Alvarez-Sierra, Daniel, Aguilo-Cucurull, Aina, Salgado-Perandres, Sandra, Briongos-Sebastian, Sara, Franco-Jarava, Clara, Montserrat, Isabel, Hernandez-Gonzalez, Manuel, Pujol-Borrell, Ricardo, Soler-Palacin, Pere et al. DOI: 10.1002/cyto.b.21728
PMID: 30767873 Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY Year: 2019 Reference: Clin Exp Rheumatol. 2019 Jul-Aug;37 Suppl 119(4):41-48. Epub 2019 Feb 11. Impact factor: 3.238 Publication type: Paper in international publication Authors: Callejas-Moraga, Eduardo Luis, Guillen-Del-Castillo, Alfredo, Marin-Sanchez, Ana Maria, Roca-Herrera, Maria, Balada, Eva, Tolosa-Vilella, Carles, Fonollosa-Pla, Vicente, Simeon-Aznar, Carmen Pilar et al. DOI:
PMID: 30738005 Journal: ALLERGY Year: 2019 Reference: Allergy. 2019 Jul;74(7):1384-1386. doi: 10.1111/all.13735. Epub 2019 Mar 14. Impact factor: 6.771 Publication type: Letter whit IF Authors: Gil-Serrano, Ingrid Johana, Galvan-Blasco, Paula, Guilarte, Mar, Cardona, Victoria, Labrador-Horrillo, Moises, Sala-Cunill, Anna, Luengo, Olga et al. DOI: 10.1111/all.13735
PMID: 30721140 Journal: CLINICAL CHEMISTRY AND LABORATORY MEDICINE Year: 2019 Reference: Clin Chem Lab Med. 2019 Jul 26;57(8):e179-e182. doi: 10.1515/cclm-2018-1121. Impact factor: 3.638 Publication type: Letter whit IF Authors: Franco-Jarava, Clara, Dieli-Crimi, Romina, Vila-Pijoan, Gemma, Pujol-Borrell, Ricardo, Hernandez-Gonzalez, Manuel, Colobran, Roger et al. DOI: 10.1515/cclm-2018-1121
PMID: 29603375 Journal: JOURNAL OF CLINICAL LABORATORY ANALYSIS Year: 2018 Reference: Journal of Clinical Laboratory Analysis. 2018 Jul;32(6):e22420. doi: 10.1002/jcla.22420. Impact factor: 1.303 Publication type: Paper in international publication Authors: Garcia-Prat, Marina, Vila-Pijoan, Gemma, Martos Gutierrez, Susana, Gala Yerga, Guadalupe, Garcia Guantes, Esther, Martinez-Gallo, Monica, Martin-Nalda, Andrea, Soler-Palacin, Pere, Hernandez-Gonzalez, Manuel et al. DOI: 10.1002/jcla.22420
PMID: 29473763 Journal: Expert Review of Clinical Immunology Year: 2018 Reference: Expert Rev Clin Immunol. 2018 Mar;14(3):215-224. doi: 10.1080/1744666X.2018.1440206. Epub 2018 Feb 23. Impact factor: 3.436 Publication type: Paper in international publication Authors: Grau-Junyent, Josep Maria, Selva-O'Callaghan, Albert, Alvarado-Cardenas, Marcelo, Pinal-Fernandez, Iago, Trallero-Araguas, Ernesto, Milisenda, Jose Cesar, Martinez, Maria Angeles, Marin, Ana, Labrador-Horrillo, Moises, Juarez, Candido et al. DOI: 10.1080/1744666X.2018.1440206
PMID: 28285170 Journal: AUTOIMMUNITY REVIEWS Year: 2017 Reference: Autoimmun Rev. 2017 May;16(5):461-468. doi: 10.1016/j.autrev.2017.03.012. Epub 2017 Mar 8. Impact factor: 8.961 Publication type: Review in national publication Authors: Simeon-Aznar, Carmen Pilar, Fonollosa-Pla, Vicent, Bernal-Bello, David, de Tena, Jaime Garcia, Guillen-Del Castillo, Alfredo, Selva-O'Callaghan, Albert, Callejas-Moraga, Eduardo L, Marin-Sanchez, Ana Maria et al. DOI: 10.1016/j.autrev.2017.03.012
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PMID: 18798799 Journal: PEDIATRIC ALLERGY AND IMMUNOLOGY Year: 2009 Reference: Pediatr Allergy Immunol. 2009 Mar;20(2):113-8. Impact factor: 2.723 Publication type: Paper in international publication Authors: Llobet, M Pilar, Soler-Palacin, Pere, Detkova, Drahomira, Hernandez, Manuel, Caragol, Isabel, Espanol, Teresa et al. DOI: 10.1111/j.1399-3038.2008.00744.x
PMID: 19779048 Journal: BLOOD Year: 2009 Reference: Blood. 2009 Sep 24;114(13):2846-8. Impact factor: 10.432 Publication type: Letter or abstract Authors: Detkova, Drahomira, Arostegui, Juan I, Alvarez, Antonio, Soler-Palacin, Pere, Vidaller, Antonio, Espanol, Teresa, Sampalo, Almudena, de Gracia, Javier, Hernandez, Manuel, Yague, Jordi et al. DOI: 10.1182/blood-2009-05-213025
PMID: 19633526 Journal: PEDIATRIC INFECTIOUS DISEASE JOURNAL Year: 2009 Reference: Pediatr Infect Dis J. 2009 Aug;28(8):753-4. Impact factor: 3.176 Publication type: Paper in international publication Authors: Martin, Andrea, Marques, Laura, Soler-Palacin, Pere, Caragol, Isabel, Hernandez, Manuel, Figueras, Concepcion, Espanol, Teresa et al. DOI: 10.1097/INF.0b013e31819c6f3a
The new technology allows more sensitive detection of scleroderma patients' autoantibodies, which are related to the severity and progression of the disease.
A study from the Vall d’Hebron Campus demonstrates that the Ex Vivo C5b-9 deposition test is useful for monitoring the activity of the complement system (CS) in patients with aHUS or transplant-associated TMA.
The results show that, in some patients with mutations in the X chromosome, the healthy gene is inactivated and the mutated gene manifests itself, which favors the onset of the disease.
