Skip to main content

Translational Molecular Pathology

Our group aims to unravel the molecular mechanisms of cancer progression and metastasis to identify new diagnostic, prognostic and therapeutic targets in cancer. By combining the knowledge and availability of human tumors in the Pathology department with the expertise of the basic molecular cell biology research group, we focus on:

  • Understanding: the molecular mechanisms underlying clonal cooperation and intercellular communication in heterogeneous tumors.
  • The role of MNK kinases in cellular stress resistance.
  • The role of ITGB3 in intercellular communication via extracellular vesicles in cancer metastasis (Santiago Ramon y Cajal).
  • The role of direct cell-cell communication via gap junctions and intercellular protrusions in cancer (Trond Aasen)
  • The malignant transition of Plexiform Neurofibromas (Cleofe Romagosa).

Team

Cleofé Romagosa Pérez-Portabell

Cleofé Romagosa Pérez-Portabell

Main researcher
Translational Molecular Pathology
Read more
Javier Hernandez Losa

Javier Hernandez Losa

Main researcher
Translational Molecular Pathology
Read more
Josep Castellví Vives

Josep Castellví Vives

Translational Molecular Pathology
Read more
Marta Cano Galietero

Marta Cano Galietero

Research technician
Translational Molecular Pathology
Read more
Marta Sese Faustino

Marta Sese Faustino

Postdoctoral researcher
Translational Molecular Pathology
Read more
Mercedes Martinez Mansilla

Mercedes Martinez Mansilla

Research technician
Translational Molecular Pathology
Read more
Cleofé Romagosa Pérez-Portabell

Cleofé Romagosa Pérez-Portabell

Main researcher
Translational Molecular Pathology
Read more
Javier Hernandez Losa

Javier Hernandez Losa

Main researcher
Translational Molecular Pathology
Read more
Josep Castellví Vives

Josep Castellví Vives

Translational Molecular Pathology
Read more
Marta Cano Galietero

Marta Cano Galietero

Research technician
Translational Molecular Pathology
Read more
Marta Sese Faustino

Marta Sese Faustino

Postdoctoral researcher
Translational Molecular Pathology
Read more
Mercedes Martinez Mansilla

Mercedes Martinez Mansilla

Research technician
Translational Molecular Pathology
Read more

Research lines

Study of PTOV1 modulation in tumor proliferation and progression : Interaction with IGF1 pathways. Notch and Wnt expression in TMAs of tumors.

To evaluate the expression (nuclear and cytoplasmatic) of PTOV1 , Notch and Wnt on TMAs in c different histological types of carcinomas with low and high grades of malignancy  . To correlate the inmunoexpression with classical parameters of  tumor behaviour : tumoral size, grade of malignancy, vascular permeation, lymph nodes metastasis in each histological subtype and demonstrated the role of PTOV1 as predictive molecular marker in carcinomas.

(Research Biomedical Unit)


IP: Inés de Torres Ramirez

Projects

Nuevas terapias aplicables a cánceres mamarios de naturaleza agresiva y metastática en base a aniquilar la población de células madre de cáncer.

IP: Matilde Lleonart Pajarin
Collaborators: Irene Braña Garcia, Margarita Alberola Ferranti, Sergio Benavente Norza, Carmela Iglesias i Felip, Josep Castellví Vives, Maria Alsina Maqueda
Funding agency: Instituto de Salud Carlos III
Funding: 195415
Reference: PI15/01262
Duration: 01/01/2016 - 30/11/2020

Nanomedicine and type II diabetes: Pathophysiological and clinical implications.

IP: José Raul Herance Camacho
Collaborators: Roso Marès Pagès
Funding agency: Instituto de Salud Carlos III
Funding: 86313.21
Reference: CP13/00252
Duration: 01/01/2014 - 30/06/2018

Efectos bifásicos y formas truncadas de la Cx43 en cáncer de mama: aplicaciones pronósticas y terapéuticas

IP: Trond Aasen
Collaborators: Jordi Temprana Salvador, Teresa Moline Marimon, Marta Sese Faustino
Funding agency: Instituto de Salud Carlos III
Funding: 92565
Reference: PI16/00772
Duration: 01/01/2017 - 30/06/2021

Study of the Main Molecular Pathways Activating Brachiury in Chordomas (PDGFR, EGFR, FGFR and Wnt)

IP: Cleofé Romagosa Pérez-Portabell
Collaborators: -
Funding agency: GRUPO ESPAÑOL INVESTIGACIÓN SARCOMAS (GEIS)
Funding: 8000
Reference: GEIS/BRACHURY/2016/CLEOFÉ
Duration: 06/06/2016 - 05/06/2019

Blog

News

The grants promote new therapeutic strategies and diagnostic tools in highly complex tumors such as glioblastoma, triple-negative breast cancer, and endometrial cancer.

The Department of Health of the Generalitat de Catalunya grants subsidies for carrying out validation tests on innovative projects in the field of health that are in the early stages of development.

The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.

Rates

Check the current rates for the services offered by the Translational Molecular Pathology research group.

Icona fitxers

Current Rates

PDF 0.25 MB

Icona fitxers

Rates Anatomia Patologica VHIR 2021

PDF 0.22 MB