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Translational Molecular Pathology

Our group aims to unravel the molecular mechanisms of cancer progression and metastasis to identify new diagnostic, prognostic and therapeutic targets in cancer. By combining the knowledge and availability of human tumors in the Pathology department with the expertise of the basic molecular cell biology research group, we focus on:

  • Understanding: the molecular mechanisms underlying clonal cooperation and intercellular communication in heterogeneous tumors.
  • The role of MNK kinases in cellular stress resistance.
  • The role of ITGB3 in intercellular communication via extracellular vesicles in cancer metastasis (Santiago Ramon y Cajal).
  • The role of direct cell-cell communication via gap junctions and intercellular protrusions in cancer (Trond Aasen)
  • The malignant transition of Plexiform Neurofibromas (Cleofe Romagosa).

Team

Milena Marcela Riaño Rodríguez

Milena Marcela Riaño Rodríguez

Research assistant
Translational Molecular Pathology
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Sara Garcia Ortega

Sara Garcia Ortega

Predoctoral researcher
Translational Molecular Pathology
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Sonia Borao Arriazu

Sonia Borao Arriazu

Research technician
Translational Molecular Pathology
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Aldo Di  Vito

Aldo Di Vito

Predoctoral researcher
Translational Molecular Pathology
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Cleofé Romagosa Pérez-Portabell

Cleofé Romagosa Pérez-Portabell

Main researcher
Translational Molecular Pathology
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Javier Hernandez Losa

Javier Hernandez Losa

Main researcher
Translational Molecular Pathology
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Milena Marcela Riaño Rodríguez

Milena Marcela Riaño Rodríguez

Research assistant
Translational Molecular Pathology
Read more
Sara Garcia Ortega

Sara Garcia Ortega

Predoctoral researcher
Translational Molecular Pathology
Read more
Sonia Borao Arriazu

Sonia Borao Arriazu

Research technician
Translational Molecular Pathology
Read more
Aldo Di  Vito

Aldo Di Vito

Predoctoral researcher
Translational Molecular Pathology
Read more
Cleofé Romagosa Pérez-Portabell

Cleofé Romagosa Pérez-Portabell

Main researcher
Translational Molecular Pathology
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Javier Hernandez Losa

Javier Hernandez Losa

Main researcher
Translational Molecular Pathology
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Research lines

Study of PTOV1 modulation in tumor proliferation and progression : Interaction with IGF1 pathways. Notch and Wnt expression in TMAs of tumors.

To evaluate the expression (nuclear and cytoplasmatic) of PTOV1 , Notch and Wnt on TMAs in c different histological types of carcinomas with low and high grades of malignancy  . To correlate the inmunoexpression with classical parameters of  tumor behaviour : tumoral size, grade of malignancy, vascular permeation, lymph nodes metastasis in each histological subtype and demonstrated the role of PTOV1 as predictive molecular marker in carcinomas.

(Research Biomedical Unit)


IP: Inés de Torres Ramirez

Projects

MnkImmunOnco) - Overcoming therapy resistance and immune evasion with a novel MNK inhibibtor

IP: Santiago Ramon y Cajal Agüeras
Collaborators: Inés de Torres Ramirez, Jordi Temprana Salvador, Vicente Peg Camara, Stefan Hummer
Funding agency: Fundació Institut Bioenginyeria de Catalunya
Funding: 0.01
Reference: M6871
Duration: 02/01/2023 - 31/12/2024

Patologia molecular translacional

IP: Santiago Ramon y Cajal Agüeras
Collaborators: Cleofé Romagosa Pérez-Portabell, Maria Rosa Somoza Lopez de Haro, Jordi Temprana Salvador, Teresa Moline Marimon, Jessica Camacho Soriano, Carmela Iglesias i Felip, Josep Castellví Vives, Elena Muro Blanc, Marta Cano Galietero, Elena Antima Martinez Saez, Javier Hernandez Losa, Marta Sese Faustino, Vicente Peg Camara, Irene Sansano Valero, Trond Aasen, Stefan Hummer
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 40000
Reference: 2021 SGR 01138
Duration: 01/01/2022 - 30/06/2025

Estudio de expresión de antígenos en tejido tumoral de pacientes con Esclerosis Sistémica.

IP: Alfredo Guillen Del Castillo
Collaborators: Carmen Pilar Simeón i Aznar, Vicenç Fonollosa Pla, Maria Roca Herrera, Janire Perurena Prieto, Irene Sansano Valero
Funding agency: Instituto de Salud Carlos III
Funding: 75020
Reference: PI22/01804
Duration: 01/01/2023 - 31/12/2025

Enhancing CD8+ Resident Memory T cell function to control and eliminate viral reservoirs

IP: Meritxell Genesca Ferrer
Collaborators: Vicente Descalzo Jorro, Josep Castellví Vives, Laura Mañalich Barrachina
Funding agency: Instituto de Salud Carlos III
Funding: 171820
Reference: PI20/00160
Duration: 01/01/2021 - 30/06/2025

Blog

News

The grants promote new therapeutic strategies and diagnostic tools in highly complex tumors such as glioblastoma, triple-negative breast cancer, and endometrial cancer.

The Department of Health of the Generalitat de Catalunya grants subsidies for carrying out validation tests on innovative projects in the field of health that are in the early stages of development.

The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.

Rates

Check the current rates for the services offered by the Translational Molecular Pathology research group.

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Current Rates

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Rates Anatomia Patologica VHIR 2021

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