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Translational Molecular Pathology

Our group aims to unravel the molecular mechanisms of cancer progression and metastasis to identify new diagnostic, prognostic and therapeutic targets in cancer. By combining the knowledge and availability of human tumors in the Pathology department with the expertise of the basic molecular cell biology research group, we focus on:

  • Understanding: the molecular mechanisms underlying clonal cooperation and intercellular communication in heterogeneous tumors.
  • The role of MNK kinases in cellular stress resistance.
  • The role of ITGB3 in intercellular communication via extracellular vesicles in cancer metastasis (Santiago Ramon y Cajal).
  • The role of direct cell-cell communication via gap junctions and intercellular protrusions in cancer (Trond Aasen)
  • The malignant transition of Plexiform Neurofibromas (Cleofe Romagosa).

Projects

Desarrollo de un test no invasivo para el diagnóstico de cáncer de endometrio basado en la detección de marcadores proteicos en biopsia líquida cervical

IP: Eva Colas Ortega
Collaborators: Vicente Bebia Conesa, Carina Masferrer Ferragutcasas, Fco Javier De la Torre Fdez de Vega, Silvia Cabrera Diaz, Ana Luzarraga Aznar, Lourdes Elena Salazar Huayna
Funding agency: Instituto de Salud Carlos III
Funding: 177500
Reference: PI23/01470
Duration: 01/01/2024 - 31/12/2026

Papel de la proteína MFGE8 como potencial biomarcador y diana terapéutica en la angiopatía amiloide cerebral

IP: Maria Mar Hernandez Guillamon
Collaborators: Berta Paez Montserrat, Jessica Camacho Soriano, Anas Chaachou Charradi, Olalla Pancorbo Rosal
Funding agency: Instituto de Salud Carlos III
Funding: 208750
Reference: PI23/00082
Duration: 01/01/2024 - 30/06/2028

ESTUDIO DEL PAPEL DE LA CENTRALIZACIÓN DEL DIAGNÓSTICO ANATOMOPATOLÓGICO Y LA APLICACIÓN DE ESTRATÉGIAS DE MEDICINA DE PRECISIÓN EN SARCOMAS

IP: Cleofé Romagosa Pérez-Portabell
Collaborators: Xavier Martínez Gómez, Ximena Garcia Torres
Funding agency: Asociación Española Contra el Cáncer
Funding: 270130
Reference: ECAEC222952DEAL
Duration: 01/12/2022 - 30/11/2027

Targeting extracelluar vesicel mediated intercellular communication as a novel approach to combat cancer metastasis.

IP: Santiago Ramon y Cajal Agüeras
Collaborators: Elena Muro Blanc, Elena Muro Blanc, Vicente Peg Camara, Stefan Hummer
Funding agency: Fundación Ramón Areces
Funding: 127486
Reference: CIVP21S13325
Duration: 06/07/2023 - 05/07/2026

Blog

News

The ten groups within the Cancer Area combine basic, translational and clinical research to identify new targets, biomarkers and therapeutic strategies

The grants promote new therapeutic strategies and diagnostic tools in highly complex tumors such as glioblastoma, triple-negative breast cancer, and endometrial cancer.

The Department of Health of the Generalitat de Catalunya grants subsidies for carrying out validation tests on innovative projects in the field of health that are in the early stages of development.

Rates

Check the current rates for the services offered by the Translational Molecular Pathology research group.

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Current Rates

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Rates Anatomia Patologica VHIR 2021

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