Vés al contingut

Manuel Comabella Lopez

El Dr. Manuel Comabella és llicenciat en Medicina i Cirurgia per la Universitat de Barcelona, especialista en Neurologia pel Servei de Neurologia de l’Hospital Universitari Vall d’Hebron (HUVH) i Doctor en Medicina i Cirurgia per la Universitat Autònoma de Barcelona. Des de 2004 és el Cap del laboratori de Neuroimmunologia Clínica de la Fundació Institut de Recerca de l’HUVH. Des de june de 2008 forma part de l’equip del Servei de Neurologia / Neuroinmunologia de l’HUVH de Barcelona - Centre d’Esclerosi Múltiple de Catalunya (Cemcat) on actualment és adjunt.

Institucions de les que formen part

Investigador predoctoral
Neuroimmunologia clínica
Vall Hebron Institut de Recerca
Responsable Laboratori
Centre d'Esclerosi Múltiple de Catalunya
Entre 1996-1999, el Dr. Manuel Comabella va realitzar una estada de recerca en Neuroimmunologia al Center for Neurologic Diseases del Brigham and Women Hospital, a Boston. Al 2010 va rebre el Premi dels Ajuts de Merck Serono d’Investigació en l’àrea d’Investigació Clínica en esclerosi múltiple. Al 2011 va rebre el Premi Biogen Idec de la Sociedad Española de Neurología (SEN) al millor treball publicat sobre malalties desmielinitzants. Al 2013 va rebre el Premi Novartis de la SEN a la millor comunicació oral i al millor treball publicat sobre malalties desmielinitzants. Al 2014 va rebre el Premi de la SEN de Enfermedades Neurológicas, modalitat científica. Al 2016 va rebre el Premi dels Ajuts de Merck Serono d’Investigació en l’àrea d’Investigació Clínica en esclerosi múltiple. Entre 2018-2020, el Dr. Manuel Comabella va ser col·laborador de l'àrea de biomedicina de la Divisió de Coordinació, Avaluació i Seguiment Científic tècnic de l'Agència Estatal d'Investigació, Ministerio de Ciencia, Innovación, y Universidades.

És membre de l’Editorial Board de les revistes Multiple Sclerosis Journal i Journal of Neuroimmunology, membre del Board de la ESNI (European School of Neuroimmunology), i membre del Grup Estratègic del IMSGC (International Multiple Sclerosis Genetics Consortium). És coautor de 297 articles indexats en MedLine (Scopus: 12916 citacions rebudes, amb índex h de 54). El seu focus fonamental de recerca és la identificació de biomarcadors moleculars relacionats amb diferents aspectes de l’esclerosi múltiple, i el desenvolupament de nous tractaments que puguin tenir aplicació en la pràctica clínica del pacient.

Línies de recerca

Susceptibility, diagnostic and prognostic markers in multiple sclerosis

2.1. Search for casual variants of genes associated with MS 

Lead scientist: Manuel Comabella

This line of research seeks to identify causal variants responsible for the MS risk of genes found to be associated with the disease in GWAS by means if deep sequencing.


2.2. To develop dynamic risk scores according to dynamic prognostic models for MS based on clinical, biological and radiological variables

Lead scientist: Mar Tintoré

In particular: 

1. Develop a dynamic risk score based on the evaluation of demographical, clinical, radiological, and biological factors that entail a higher risk of developing a second relapse after a clinically isolated syndrome (CIS), i.e. risk of CDMS, through building models of a dynamic nature.

2. Develop a dynamic risk score based on the evaluation of demographical, clinical, radiological, and biological factors entail a higher risk of progression of disability, as measured by the Expanded Disability Status Scale (EDSS) (Kurtzke Neurology 1983), in people who have suffered a CIS, also through building models of a dynamic nature.


Since 1995, patients presenting with a CIS or first attack suggestive of MS are included in a prospective cohort study. One thousand and one hundred CIS patients with a median follow-up of almost 10 years, have been included up to now. Clinical variables (age, gender, topography of the syndrome), radiological variables (number of lesions, number of Barkhof criteria, topography of the lesions, atrophy measures), as well as biological markers (IgG and IgM oligoclonal bands). In a subgroup of patients additional biomarkers (neurofilaments light and heavy chains, fetuin A, GFAP, anti-neurofascin antibodies, anti-glycan panel, chitinase, S1P, etc.) are studied as predictors of conversion to MS and as predictors of disability progression. Mathematical and marginal structural models with different combinations of the variables listed above are investigated.


2.3. Neuropsychological assessment of neurocognitive deficits in patients with multiple sclerosis

Lead scientist: Mª Jesús Arévalo

Unified neuropsychological assessment is considered necessary to make comparisons between different groups of patients and to draw general conclusions as well as to evolve in the knowledge of cognitive impairment of patients.

There is no consensus on protocols for neuropsychological assessment of people with MS in Catalonia and patient evaluations are performed disparately among different hospitals. Neurologists and neuropsychologists from 13 hospitals and patient foundations from Catalonia have held work meetings every two months since July 2012 to seek common work ground. Consensus has been reached as to a common neuropsychological protocol for the assessment of cognitive impairment in MS. We have set up a common database including clinical and neuropsychological variables recorded from interviews with patients introduced into one application.

Our work group has been incorporated into the Neuropsychology Section of the Official College of Psychology of Catalonia.


2.4. Upper limbs function and psychometric properties of outcome measures

Lead scientist: Núria Filló / Ingrid Galán

Upper limbs impairment impacts on daily activities and social participation of persons with MS. Under-recognition of upper limb dysfunction may result in part from limited availability of performance-based and patient self-report measures that are validated for use in MS and that can be readily incorporated into clinical practice for screening and regularly scheduled assessments This line of research seeks to study the psychometric properties of outcome measures for upper limb function in MS.


2.5 EpidEMcat

Lead scientist: Susana Otero

The Multiple Sclerosis Centre of Catalonia (Cemcat) coordinates a project that aims to characterize the epidemiology of MS in Catalonia. For this purpose, a prospective registry of new cases of MS in Catalonia was set up in 2009 with the participation of 21 hospitals throughout Catalonia. Prevalence and incidence studies based on this population-based registry are being performed. A new research line on co-morbidity and healthcare resource utilization in MS patients is now starting.


2.6 Search of genetic modifiers associated with aggressive and benign disease courses

Lead scientist: Manuel Comabella

We aim to identify genetic variants that influence the course of the disease by means of exome sequencing of MS patients with divergent clinical courses, i.e. aggressive and benign disease courses.


2.7 Search of biomarkers for multiple sclerosis by RNA, microRNA and exome sequencing approaches

Lead scientist: Manuel Comabella

Biomarkers are needed in MS to understand the complex and multifactorial heterogeneity of the disease, particularly disease activity biomarkers that may help to distinguish between different MS clinical courses or activity phases of the disease. Here, we aimed to identify disease activity biomarkers in MS by applying RNA, microRNA, and DNA sequencing approaches.

IP: Manuel Comabella Lopez, Mar Tintore Subirana, Jaume Sastre Garriga, M Jesus Arevalo Navines, Susana Otero Romero

Study of the response to interferon-beta treatment in multiple sclerosis patients

3.1. Clinical, radiological and biological prognostic factors of response to treatment with interferon-beta

Lead scientist: Jordi Río / Manuel Comabella

Cohort study to establish outcome measures for clinical trials with clinical validity and clinical and radiological indicators associated with poor response to interferon-beta treatment.

Study to identify gene signatures that may predict the good or bad response to interferon-beta in patients with MS before initiating treatment or in the first months of treatment and to identify gene expression signatures that may help to predict patients who will develop neutralizing antibodies against interferon-beta.

IP: Manuel Comabella Lopez, Jordi Rio Izquierdo

MRI measures of neurodegeneration in Multiple Sclerosis - Clinical implications

Lead scientist: Jaume Sastre-Garriga / Deborah Pareto

Brain volumetry is about to take a central role in the management of patients with MS. Recent evidence suggests that the neurodegenerative process can be reliably estimated in vivo with the help of MRI and appropriate software tools, and that such measurements are clinically relevant both for prognosis as well as in monitoring of treatment response. In the Clinical Neuroimmunology Group, brain volumetry estimates have been already obtained using well-tested methodologies in selected cohorts and its clinical relevance has been confirmed. New, more sophisticated software tools to obtain in-depth measuring of brain and spinal cord areas are now being tested for clinical relevance. This has been achieved through collaboration with the MRI Unit at the Institut de Diagnòstic per la Imatge.

IP: Manuel Comabella Lopez, Carmen Espejo Ruiz, Jordi Barquinero Mañez, Nicolás Miguel Fissolo

Projectes

Complicacions neurològiques associades a cèl·lules CAR-T (CAR-T: Chimeric Antigen Receptor T-cell)

IP: Manuel Comabella Lopez
Col·laboradors: Andreu Vilaseca Jolonch, Miriam Izquierdo Sans
Entitat finançadora: Fundació Institut de Recerca HUVH
Finançament: 35000
Referència: HUVH/BPFSE_CM/2022/VILASECA
Durada: 01/06/2022 - 31/05/2023

Human induced pluripotent stem cell-based chimeric mice to study astrocyte pathology and neuroprotective strategies in multiple sclerosis patients

IP: Manuel Comabella Lopez
Col·laboradors: Clara Matute Blanch, Andres Miguez Gonzalez, Rucsanda Pinteac
Entitat finançadora: Instituto de Salud Carlos III
Finançament: 286770
Referència: PI21/01611
Durada: 01/01/2022 - 31/12/2024

Search of prognostic factors of conversion to multiple sclerosis in patients with radiologically isolated syndrome_RIS

IP: Manuel Comabella Lopez
Col·laboradors: -
Entitat finançadora: National Multiple Sclerosis Society
Finançament: 300486.36
Referència: RIS_NMSS-PMSC2021
Durada: 01/05/2022 - 30/04/2024

A study to perform a Genome-wide association study (GWAS) that search for single nucleotide polymorphisms (SNPs) associated with the progression of the disease.

IP: Manuel Comabella Lopez
Col·laboradors: -
Entitat finançadora:
Finançament:
Referència: PR(AG)224/2019
Durada: -

Notícies relacionades

La investigació dirigida per Vall d’Hebron és un pas endavant en la cerca de tractaments específics i efectius per a la malaltia.

L’estudi realitzat a Vall d’Hebron indica que tenir nivells alts de les cadenes lleugeres de neurofilaments es tradueix, passats els anys, en un nivell de discapacitat més gran.

La recerca buscarà identificar quins pacients amb síndrome radiològica aïllada són més propensos a desenvolupar la malaltia

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