LegislationLegislation of the Autonomous Community of Catalonia Decree 214/97 of 30 July which regulates the use of animals for research and other scientific purposes.Spanish legislation: RD 53/2013.European legislation: Directive 2010/63/UE, of 22 September 2010 on the protection of animals used for scientific purposes.Sociedad Española de la Ciencia de Animales de Laboratorio (SECAL).Legislation and guides of the UAB.Annual statistics of animal use in Spain (map)Useful linksAlternative methodsFRAME: Frame website, a foundation which aims to promote the replacement of animals experiments. Contains general information as well as numerous links to web pages about alternatives.Invitroderm: Database on in vitro alternatives to skin irritation tests.NORINA: NORINA website (The Norwegian Reference Centre for Laboratory Animal Science & Alternatives). It is one of the most important databases for teaching alternative resources to the use of experimental animals. It contains a large amount of information with a search system and references to each resource.Red Española para el Desarrollo de Métodos Alternativos a la Experimentación Animal (REMA).Johns Hopkins University.The European Centre for the Validation of Alternative Methods (ECVAM).OECD Test Guidelines for Chemicals.Interniche. Interniche website (International Network for Humane Education). It aims to spread alternative methods to animal testing. It offers a loan system of teaching materials.Oficina de investigación responsableSearch for alternative methodsMonitoring protocolsSample sizeAnimal welfareThe Animal Welfare Institut.CCAC guidelines on: choosing an appropriate end point in experiments using animals for research, teaching and testing.SeveritySeverity ScalesNo Recovery.Mild Severity.Moderate Severity.Severe Severity.Resources for interpreting severityAnnex IX del RD 53/2013 d'1 de febrer.http://ec.europa.eu/environment/chemicals/lab_animals/pdf/Endorsed_Severity_Assessment.pdfhttp://ec.europa.eu/environment/chemicals/lab_animals/pdf/guidance/severity/es.pdfhttp://ec.europa.eu/environment/chemicals/lab_animals/interpretation_en.htmhttp://ec.europa.eu/environment/chemicals/lab_animals/pdf/guidance/severity/es.pdfAnaesthesia-AnalgesiaGuidelines for the Use of Anesthetics, Analgesics and Tranquilizers in Laboratory Animals (University of Minnesota).The Virtual Anaesthesia Textbook.CCAC guidelines on: Anesthesia.CCAC guidelines on: Analgesia.TrainingUABAnimalariaCEBUniversidad Miguel Hernández. Oficina de investigación responsable AssociationsSECAL.FELASA.LASA.Scan-LAS.
