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Anna Meseguer Navarro

Institutions of which they are part

Head of group
Kidney Physiopathology
Vall Hebron Institut de Recerca

Research lines

Androgen activity in renal pathophysiology: Identification of androgen-regulated kidney-specific genes and functional characterization of them, in processes of inflammation, oxidative stress and fibrosis underlying chronic kidney disease, hypertension and metabolic syndrome.

Among the genes identified in our laboratory that are kidney-specific and regulated by androgens at the transcriptional level we are particularly focused on the one that codes for the kidney androgen-regulated protein (KAP). Besides characterization of the functional promoter elements that enable KAP expression in proximal tubule epithelial cells, we have generated a transgenic (Tg) mouse model that overexpresses KAP in proximal tubule cells under the presence of androgens, in order to mimick the endogenous KAP expression pattern. KAP Tg mice show altered lipid metabolism, glycosuria, proteinuria and hypertension, as well as focal segmental glomerulosclerosis mediated by increased oxidative stress. We are currently working in this Tg model and also preparing conditional knock-out mice to further caharacterize the role of KAP in renal pathophysiology. Moreover, we are also studying the role of KAP in the metabolic syndrome. Besides KAP, we are studying the role of KAP-interacting immunophilins in inflammation and kidney fibrosis.

IP: Anna Meseguer Navarro

Rare inhirited renal diseases

Our group is focused in research in primary or inherited tubular renal diseases, such as Dent’s Disease, Bartter syndrome, Tubular Acidosis, Familial Hypomagnesemia with Hypercalciuria and Nephrocalcinosis, among others. Currently we are collaborating with other groups in Spain, within a research project named Renaltube the main purpose of which is to build a database while facilitating access to genotyping in order to improve the clinical and molecular knowledge of primary tubulopathies. Renaltube has a web-based approach with multilateral collaboration scheme that enhances the recruitment of data and promotes the understanding of underlying mechanisms of rare inherited diseases, defines more accurate diagnostic and follow-up criteria, develops new molecular techniques and will improve the overall care of the patients. Currently we are offering the analysis of 22 genes corresponding to 23 primary tubulopathies. After two years of activity Renaltube has collected data from 222 patients, the mayority from Spain and Latin America (85.3%). The most common tubulopathies are distal renal tubular acidosis (22.5%), and classical Bartter syndrome (19.3%) followed by familial hypomagesemia with hipercalciuria and nephrocalcinosis (15.7%), and Gitelman syndrome (15%).

IP: Gema Ariceta Iraola, Anna Meseguer Navarro

Role of HAVRC/KIM-1 in the development and progression of the renal clear cell carcinoma (ccRCC) and in the damage/regeneration renal tubular processes

Overexpression of this protein in 60% of the ccRCCs has already been described. HAVR/KIM-1 overexpression in human ccRCC cell lines blocks cell differentiation and promotes cell scattering. We aim to determine the role of HAVR/KIM-1 in the development and progression of ccRCC, and its possible value as a diagnostic and prognostic biomarker. We also focus on KIM-1’s role in ischemia/reperfusion- or nephrotoxic-induced renal tubular injury. Overexpression of this protein in kidney injury has been described. However, whether its involvement is associated with processes enabling to recover tubular epithelium or potentially increasing damage is not known to this date. With the assistance of cultured renal tubular cell models, we are now investigating whether KIM-1 expression shifts are correlated with renal proximal tubule regeneration ability and, as a consequence, investigating its potential therapeutic application.

IP: Anna Meseguer Navarro

Projects

ACTUALIZACIÓN DE EQUIPAMIENTOS DE ALTA TECNOLOGIA PARA LA PLATAFORMA DE IMAGEN PRECLINICA. ADQUISICION DE UN EQUIPO DE ULTRASONIDOS DE INVESTIGACION PRECLINICA

IP: Inmaculada Fuentes Camps
Collaborators: ACTUALIZACIÓN DE EQUIPAMIENTOS DE ALTA TECNOLOGIA PARA LA PLATAFORMA DE IMAGEN PRECLINICA. ADQUISICION DE UN EQUIPO DE ULTRASON, Diego Arango Corro, Anna Meseguer Navarro, ACTUALIZACIÓN DE EQUIPAMIENTOS DE ALTA TECNOLOGIA PARA LA PLATAFORMA DE IMAGEN PRECLINICA. ADQUISICION DE UN EQUIPO DE ULTRASON, Antonio Rodríguez Sinovas, Francesc Bosch Albareda, Victor Franco Puntes, José Raul Herance Camacho, Jordi Giralt López de Sagred, Màrius Aguirre Canyadell, Xavier Serres Créixams, Simon Schwartz Navarro, ACTUALIZACIÓN DE EQUIPAMIENTOS DE ALTA TECNOLOGIA PARA LA PLATAFORMA DE IMAGEN PRECLINICA. ADQUISICION DE UN EQUIPO DE ULTRASON, Joaquim Mateo Valderrama, Mario Marotta Baleriola, Anna Rosell Novel, Joan Genescà Ferrer
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 108390
Reference: EQC2019-006322-P
Duration: 01/01/2019 - 31/12/2020

Ministerio de Ciencia

ACTUALIZACIÓN DE EQUIPAMIENTOS DE ALTA TECNOLOGIA PARA LA PLATAFORMA DE IMAGEN PRECLINICA. ADQUISICION DE UN EQUIPO DE IMAGEN OPTICA

IP: Inmaculada Fuentes Camps
Collaborators: ACTUALIZACIÓN DE EQUIPAMIENTOS DE ALTA TECNOLOGIA PARA LA PLATAFORMA DE IMAGEN PRECLINICA. ADQUISICION DE UN EQUIPO DE IMAGEN OP, Diego Arango Corro, Ibane Abasolo Olaortua, Santiago Ramon y Cajal Agüeras, Miquel Vila Bover, Anna Meseguer Navarro, ACTUALIZACIÓN DE EQUIPAMIENTOS DE ALTA TECNOLOGIA PARA LA PLATAFORMA DE IMAGEN PRECLINICA. ADQUISICION DE UN EQUIPO DE IMAGEN OP, Joan Gavaldà Santapau, Francesc Bosch Albareda, Miguel Segura Ginard, Maria Martell Pérez-Alcalde, Victor Franco Puntes, Mª Jesús Cruz Carmona, Simon Schwartz Navarro, ACTUALIZACIÓN DE EQUIPAMIENTOS DE ALTA TECNOLOGIA PARA LA PLATAFORMA DE IMAGEN PRECLINICA. ADQUISICION DE UN EQUIPO DE IMAGEN OP, Joaquim Mateo Valderrama, Juan Angel Recio Conde , Anna Rosell Novel, Josep Roma Castanyer
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 134516.7
Reference: EQC2019-006306-P
Duration: 01/01/2019 - 31/12/2020

Ministerio de Ciencia

ADQUISICIÓN DE UN MICROSCOPIO CONFOCAL ESPECTRAL DE RASTREO DE ALTA RESOLUCIÓN DESTINADO A LA PLATAFORMA DE MICROSCOPÍA DE LA UNIDAD DE ALTA TECNOLOGÍA (UAT)

IP: Inmaculada Fuentes Camps
Collaborators: Maria Vicario Perez, Miquel Vila Bover, Anna Meseguer Navarro, José García Arumí, Joan Gavaldà Santapau, Joan Xavier Comella Carnicé, Miguel Segura Ginard, Maria Martell Pérez-Alcalde, Victor Franco Puntes, Anna Santamaria Margalef, Carmen Espejo Ruiz, María José Buzón Gómez, Javier Inserte Igual, Anna Rosell Novel, Eduardo Fidel Tizzano , Trond Aasen
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 502000
Reference: EQC2019-006247-P
Duration: 01/01/2019 - 31/12/2020

Ministerio de Ciencia

ADQUISICIÓN DE UN MICROSCOPIO MULTIDIMENSIONAL WIDEFIELD EQUIPADO PARA REALIZAR EXPERIMENTOS IN VIVO, DESTINADO A LA PLATAFORMA DE MICROSCOPÍA DE LA UNIDAD DE ALTA TECNOLOGÍA (UAT)

IP: Inmaculada Fuentes Camps
Collaborators: Maria Vicario Perez, Soledad Gallego Melcón, Fco Javier Santos Vicente, Diego Arango Corro, Gema Ariceta Iraola, Santiago Ramon y Cajal Agüeras, Marta Martínez Vicente, Anna Meseguer Navarro, Manuel Comabella Lopez, Ricardo Pujol Borrell, Joan Sahuquillo Barris, Joan Xavier Comella Carnicé, Miguel Segura Ginard, Simon Schwartz Navarro, Anna Rosell Novel, Meritxell Genesca Ferrer
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 177204.2
Reference: EQC2019-006309-P
Duration: 01/01/2019 - 31/12/2020

Ministerio de Ciencia

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