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Joan Genescà Ferrer

Internal medicine doctor expert in hepatology. Special dedication to advanced liver disease, liver cirrhosis and portal hypertension. Interest in non-invasive methods for the diagnosis and control of liver disease, especially liver elastography. Both clinical and experimental research in animal models of liver disease, including therapeutic studies with nanomedicine.

Institutions of which they are part

Head of group
Liver Diseases
Vall Hebron Institut de Recerca
Hepatologia
General Hospital

Joan Genescà Ferrer

Institutions of which they are part

Head of group
Liver Diseases
Vall Hebron Institut de Recerca
Hepatologia
General Hospital

Internal medicine doctor expert in hepatology. Special dedication to advanced liver disease, liver cirrhosis and portal hypertension. Interest in non-invasive methods for the diagnosis and control of liver disease, especially liver elastography. Both clinical and experimental research in animal models of liver disease, including therapeutic studies with nanomedicine.

Chief Liver Unit.
Clinical director of Digestive Diseases.
Professor of Medicine of the UAB.

Research lines

Malaltia hepàtica crònica avançada

Tractaments combinats per prevenir les lesions o fibrosis hepàtica en malaltia hepàtica crònica/NASH

Tractaments dirigits a cèl·lules sinusoïdals hepàtiques a través de nanopartícules biodegradables

Desenvolupament de models animals experimentals translacionals a la patologia en humans de NASH i malaltia hepàtica per alcohol

Mètodes no invasius per malaltia hepàtica crònica avançada

Hipertensió portal


Serveis o tecnologies rellevants:


Models animals de malaltia hepàtica crònica: PVL; BDL; CCL4; TAA; NAFLD; NASH; MAFLD

Determinació de paràmetres hemodinàmics en models animals: PP; MAP; SMABF; SMAR, PF; IHVR

Aïllament de cèl·lules primàries de fetge: hepatòcits; LSEC; KC; HSC

Tincions histològiques

Cultius cel·lulars

Citometria de flux

Anàlisis de proteïnes: Wb, IIHC, IF, Proteòmica diferencial

Anàlisis d'expressió gènica: RT-qPCR, ISH, Microarrays

Microscòpia confocal i Microscòpia electrònica

Administració de fàrmacs en nanopartícules: Internalizació; direccionament; biodistribució; efectivitat; assaigs MTT y MTD

IP: Maria Nieves Martell Pérez-Alcalde, Joan Genescà Ferrer

Projects

Non-invasive assessment of cACLD and CSPH

IP: Joan Genescà Ferrer
Collaborators: Juan Bañares Sanchez
Funding agency: Hospital Universitari Vall d'Hebron
Funding: 35000
Reference: AULA/2024/BAÑERAS
Duration: 01/06/2024 - 31/05/2025

Plataforma de soporte para la Investigación Clínica

IP: Inmaculada Fuentes Camps
Collaborators: Antonio Moreno Galdó, Rafael Simó Canonge, Tamara Del Rio Higueras, Ariadna Martín Balcells, Mª Eulàlia Molinas Guilera, Laura Cascales Bolaño, Olga Sánchez- Maroto Carrizo, Maria Soraya Badia Ventura, Angelica Valderrama Rodríguez, Amaia Latasa Arrazubi, Joan Genescà Ferrer, Gemma Vona Giralt, Paula Isabel Roldan Caballero
Funding agency: Instituto de Salud Carlos III
Funding: 274920
Reference: PT23/00062
Duration: 01/01/2024 - 31/12/2026

Malalties hepàtiques

IP: Joan Genescà Ferrer
Collaborators: Beatriz Minguez Rosique, Sergi Colomer Castell, Elena Vargas Accarino, Immaculada Raurell Saborit, Lluís Viladomiu Catà, Lluis Castells Fusté, Maria del Mar Riveiro Barciela, Malalties hepàtiques, Maria Buti Ferret, Montserrat Gomez Perez, Malalties hepàtiques, Judit Vico Romero, Josep Quer Sivila, Adriana Palom Agusti, Juan Manuel Pericàs Pulido, Maria Nieves Martell Pérez-Alcalde, Damir Garcia Cehic, Daniel Martinez Vazquez, Laura Puente Ramo, Isabel Campos Varela, María Bermúdez Ramos, Juan Ignacio Esteban Mur, Ester Palacio Gutierrez, Susana Anton Calvo, Monica Higuera Urbano, Meritxell Ventura Cots, Ares Aurora Villagrasa Vilella, Emma Bigas Alsina, Carolina Campos Martinez, Macarena Simon-Talero Horga, Malalties hepàtiques, David Tabernero Caellas, Mònica Pons Delgado, Marcella Salzano, Malalties hepàtiques
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 60000
Reference: 2021 SGR 00462
Duration: 01/01/2022 - 30/06/2025

OPTIMIZACIÓN DE NUEVOS TRATAMIENTOS EN LA ENFERMEDAD HEPÁTICA CRÓNICA-NASH

IP: Joan Genescà Ferrer
Collaborators: Immaculada Raurell Saborit, Maria Nieves Martell Pérez-Alcalde, Mònica Pons Delgado
Funding agency: Instituto de Salud Carlos III
Funding: 268620
Reference: PI21/00691
Duration: 01/01/2022 - 31/12/2024

Related news

Using computed tomography (CT), with or without contrast, it is possible to perform an accurate and safe detection of the disease without the need for biopsies and avoiding the limitations of other non-invasive diagnostic tools.

Preliminary study results confirm that the drug resmetirom reduces the presence of fat, inflammation, cell damage and fibrosis in the liver.

The European project, in which Vall d'Hebron participates, will favor personalized diagnosis and innovative therapeutic strategies in patients with the disease.

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