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Juan Lorente Guerrero

Sóc el cap d'Otorinolaringologia de Vall d'Hebron, on treballo des de l'any 1989. La meva especialitat és el tractament de la patologia oncològica faringoloaríngea i la patologia benigna d'aquesta àrea. La meva activitat científica se centra en la recerca en patologia oncològica i benigna faringolaríngea i patologia inflamatòria de les foses nasals. A més sóc professor titular d'otorinolaringologia a la Universitat Autònooma de Barcelona on imparteixo classes des de l'any 1991.

Institutions of which they are part

Senior researcher
Biomedical Research in Cancer Stem Cells
Vall Hebron Institut de Recerca
Head of Department
Ear, Nose and Throat
General Hospital
Des de l'any 1989 sóc otorinolaringòleg a Vall d'Hebron on vaig fer l'especialitat MIR i on des del 1991 sóc metge adjunt.
des que em vaig incorporar com a adjunt la meva activitat professional està dedicada al diagnòstic i tractament de la patologia oncològica i benigna faringolaríngea, patologia inflamatòria de les foses nasals i patologia infecciosa de l'orella, motiu pel qual he dirigit projectes de recerca com a investigador priincipal d'aquestes patologies.
L'an 1991 vaig presentar la meva tesi doctoral: alteracions cocleovestibulars en malalts urèmics sotmesos a hemodiàlisi i trasplantament renal en què vaig obtenir la qualificació Apto "Cum Laude" por Unanimidad per unanimitat.
Pel que fa a la meva activitat docent i investigadora, he partipat en 16 projectes de recerca, dels quals he dirigit 11, i, també, he dirigit 11 tesines i treballs de recerca i 10 tesis doctorals, en tinc 5 en fase de desenvolupament. He estat codirector de 3 ponències de la Societat Espanyola d'Otorinolaringologia.
A més, he estat ponent en 65 cursos i seminaris i la meva publicació cinetífica es tradueix en 64 capítols en llibres, 65 articles en revistes internacionals, més de 200 participacions, entre comunicacions i pòsters, en congressos nacionals i internacionals.
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Research lines

Research group in obstructive sleep apnea syndrome (osas).

Research group in obstructive sleep apnea syndrome (OSAS), using as animal model the brachiocephalic breed, Boxer (English and French) is constituted by Drs. Juan Lorente Guerrero (UAB Lecturer, Hospital de la Vall d’Hebron), Santiago Lavin González (Professor), Rafaela Cuenca Valera (Lecturer), Josep Pastor Milán (Lecturer), Roser Velarde Nieto (Specialized Technician in Research Support) and Marta Planellas Bachs (Associate Professor at the Hospital Clínico Veterinario de la UAB.). The main objective of this investigation is to define similarities and differences between human patients and animals regarding this particular disease  in order to, if that were the case, use brachiocephalic breed as animal models in the options of treatment for the human disease. The specific objectives of this research line are the following ones: 1. Defining histopathological and immunohistochemical changes regarding myosin fiber distribution of type I and II,  that produce soft palate in brachiocephalic dogs affected by upper airway obstruction syndrome,  regarding dogs without this pathology which have been euthanize for different reasons. 2. Establishing existing similarities and differences between soft palates in brachiocephalic dogs affected by upper airway obstruction syndrome and uvula of human patients with OSAS. 3. Determining correlation between degree of injuries observed at histopathological and immunohistochemical level and the clinics presented in each patient, firstly in each specie alone and afterwards comparing them. 4. Determining levels of canine acute-phase proteins (C-reactive protein, haptoglobin), as inflation indicators, and levels of cardiac troponin I, as myocardial damage indicator, in animals affected by upper airway obstruction syndrome to compare them afterwards with those that present dogs that are not affected by this pathology. 5. Evaluating surgical treatment efficacy as therapeutic alternative, in dogs affected by upper airway obstruction syndromes, through a clinical monitoring, supported by complementary diagnostic tests.

IP: Juan Lorente Guerrero

Gastroesophageal reflux prevalence in patients with obstructive sleep apnea syndrome.

Different studies suggest the association between gastroesophageal reflux disease (GERD) and OSAS, but GERD prevalence in OSAS and the severity influence of OSAS upon  GERD are not known yet. OBJECTIVES: The main objective of this study is to determine the prevalence of GERD in patients with obstructive sleep apnea syndrome using conventional polygraphic sleep. Wiht this study we also want to assess the efficacy of a symptom questionnaire in the diagnosis of gastroesophageal reflux in these patients. PURPOSE: Identifying patients with gastroesophageal reflux among patients affected by obstructive sleep apnea, in order to establish therapeutic measures to prevent GERD complications.

IP: Juan Lorente Guerrero, Juan Luis Quesada Martínez, Mª Jose Jurado Luque, Ana María Accarino Garaventa

Projects

Desenvolupament de noves nanopartícules funcionals dirigides al nòdul limfàtic per a l'eliminació del reservori latent de VIH

IP: María José Buzón Gómez
Collaborators: Ibane Abasolo Olaortua, Félix Pumarola Segura, Juan Lorente Guerrero, Laura García Latorre, Jordi Temprana Salvador, Joaquin Seras Franzoso, Marc Pellicer Sarasa, David Perea Pérez, Simon Schwartz Navarro, Francesc Martínez Trucharte, Jordi Navarro Mercadé, Sandra Mancilla Zamora, Zamira Vanessa Diaz Riascos, Meritxell Genesca Ferrer, Fernanda Raquel Da Silva Andrade, Diana Fernandes de Rafael
Funding agency: Fundació La Marató de TV3
Funding: 199998.75
Reference: 20180510
Duration: 10/05/2019 - 31/12/2022

Cesión de muestras para Proyecto "Estudio de resistencia en Carcinoma escamoso de cabeza y cuello"

IP: Juan Lorente Guerrero
Collaborators: -
Funding agency:
Funding:
Reference: PR(CS)86/2017
Duration: -

La expresión de Catelicidina LL-37 en mucosa afecta de carcinoma epidermoide faringolaríngeo

IP: Juan Lorente Guerrero
Collaborators: -
Funding agency:
Funding:
Reference: PR(AG)22/2017
Duration: -

GC16173720CARR Definición de mecanismos clave de la multiresistencia de tumores de cabeza y cuello a los tratamientos quimio- y radioterapéuticos. Identificación de nuevos antitumorales individualizados.

IP: Matilde Lleonart Pajarin
Collaborators: Yoelsis Garcia Mayea, Juan Lorente Guerrero, GC16173720CARR Definición de mecanismos clave de la multiresistencia de tumores de cabeza y cuello a los tratamientos quimio- y , Josep Castellví Vives, Cristina Mir Perez, Vicente Peg Camara, Almudena Sanchez Garcia
Funding agency: Asociación Española Contra el Cáncer
Funding: 380000
Reference: AECC/GCE/2016/LLEONART
Duration: 01/10/2016 - 30/09/2022

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