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Basic, Translational and Clinical Pharmacy Research

The work of our group is mainly focused on personalized medicine, including chemical-functional stability studies of drugs in individualized preparations to be administered both orally and parenterally, as well as parenteral nutrition;  research focused on the evaluation and/or design of population pharmacokinetic/pharmacodynamic (PK/PD) models and the characterization of the pharmacokinetics of certain drugs of therapeutic interest in the general population or in certain population groups; and research focused on pharmacogenetics and pharmacogenomics. Our research is also focused on advanced interventions: drug evaluation studies (effectiveness, safety and economic studies); and mobile health and telepharmacy.

Team

Carla Alonso Martinez

Carla Alonso Martinez

Basic, Translational and Clinical Pharmacy Research
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Juan Carlos Juarez Giménez

Juan Carlos Juarez Giménez

Basic, Translational and Clinical Pharmacy Research
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Maria José Cabañas Poy

Maria José Cabañas Poy

Senior researcher
Basic, Translational and Clinical Pharmacy Research
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Susana Clemente Bautista

Susana Clemente Bautista

Basic, Translational and Clinical Pharmacy Research
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Carlos javier Parramon Teixido

Carlos javier Parramon Teixido

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Inés Jimenez Lozano

Inés Jimenez Lozano

Research technician
Basic, Translational and Clinical Pharmacy Research
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Carla Alonso Martinez

Carla Alonso Martinez

Basic, Translational and Clinical Pharmacy Research
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Juan Carlos Juarez Giménez

Juan Carlos Juarez Giménez

Basic, Translational and Clinical Pharmacy Research
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Maria José Cabañas Poy

Maria José Cabañas Poy

Senior researcher
Basic, Translational and Clinical Pharmacy Research
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Susana Clemente Bautista

Susana Clemente Bautista

Basic, Translational and Clinical Pharmacy Research
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Carlos javier Parramon Teixido

Carlos javier Parramon Teixido

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Inés Jimenez Lozano

Inés Jimenez Lozano

Research technician
Basic, Translational and Clinical Pharmacy Research
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Research lines

Investigació clínica observacional i experimental: Centrada en farmacogenètica o farmacogenòmica.

IP: Marta Miarons Font

Investigació clínica observacional i experimental: Centrada en l'avaluació de models PK/PD y caracterització PK de fàrmacs d'elevat interès terapèutic en la població o en determinats grups de pacients.

IP: Marta Miarons Font

Investigació clínica observacional: Centrada en l'avaluació de l'efectivitat, seguretat i costos de fàrmacs innovadors o d'elevat cost en determinades indicacions o en poblacions concretes de pacients CV.

IP: J. Bruno Montoro Ronsano

Investigació tècnica: Centrada en l'avaluació de l'estabilitat química-funcional de fàrmacs en preparacions individualitzades, tant per administració oral com a parenteral.

IP: David Berlana Martín

Projects

OPTIMIZACIÓN DEL TRATAMIENTO QUIMIOLINFODEPLECTIVO CON FLUDARABINA PREVIO A LA INFUSIÓN DE TERAPIA DE CÉLULAS T CON RECEPTOR DE ANTÍGENO QUIMÉRICO (CAR-T)

IP: Marta Miarons Font
Collaborators: Javier Varela Gonzalez-aller, Gloria Inés Iacoboni García-Calvo, Maria Queralt Gorgas Torner, Carolina Valdivia Vadell, Lucas Rivera Sánchez, Anna Maria Farriols Danes, Pere Barba Suñol, Carla Alonso Martinez, Janire Perurena Prieto, Maria Josep Carreras Soler
Funding agency: Instituto de Salud Carlos III
Funding: 111320
Reference: PI21/00197
Duration: 01/01/2022 - 31/12/2024

Calidad y seguridad en la utilización de factores estimulantes de la eritropoyesis en pacientes con cáncer sólido. Estudio observacional retrospectivo multicéntrico.

IP: Maria Josep Carreras Soler
Collaborators: Maria Rosa Gómez Domingo, Anna Maria Farriols Danes
Funding agency: Ministerio Sanidad, Servicios Socials e Igualdad
Funding: 40000
Reference: EC10-334
Duration: 01/01/2011 - 31/05/2012

Calidad y seguridad en la utilización de factores estimulantes de la eritropoyesis en pacientes con cáncer sólido. Estudio observacional retrospectivo multicéntrico.

IP: Maria Josep Carreras Soler
Collaborators: Maria Rosa Gómez Domingo, Anna Maria Farriols Danes
Funding agency: Ministerio Sanidad, Servicios Socials e Igualdad
Funding: 40000
Reference: EC10-334
Duration: 01/01/2011 - 31/05/2012

Publications

Early outcomes in adults hospitalized with severe SARS-CoV-2 infection receiving tocilizumab.

PMID: 35755602
Journal: MEDICINA CLINICA
Year: 2022
Reference: Med Clin. 2022 Jun 10;158(11):509-518. doi: 10.1016/j.medcle.2021.06.023. Epub 2022 Jun 18.
Impact factor: 1.725
Publication type: Paper in international publication
Authors: Sellares-Nadal, Julia; Almirante, Benito; Guillen-Del-Castillo, Alfredo; Sampol, Julia; Augustin, Salvador; Bosch-Nicolau, Pau; Monforte-Pallares, Arnau; Sempere-Gonzalez, Abiu; Eremiev-Eremiev, Simeon; Miarons, Marta et al.
DOI: 10.1016/j.medcle.2021.06.023

Simulated Y-site compatibility of atosiban acetate with selected intravenous drugs.

PMID: 35779331
Journal: European Journal of Obstetrics & Gynecology and Re
Year: 2022
Reference: Eur J Obstet Gynecol Reprod Biol. 2022 Aug;275:106-109. doi: 10.1016/j.ejogrb.2022.06.006. Epub 2022 Jun 20.
Impact factor: 2.435
Publication type: Paper in international publication
Authors: Poy, Maria Josep Cabanas; Bautista, Susana Clemente; Boix-Montanes, Antoni; Larrosa-Garcia, Maria; Jimenez-Lozano, Ines et al.
DOI: 10.1016/j.ejogrb.2022.06.006

Early outcomes in adults hospitalized with severe SARS-CoV-2 infection receiving tocilizumab.

PMID: 34544604
Journal: MEDICINA CLINICA
Year: 2022
Reference: Med Clin (Barc). 2022 Jun 10;158(11):509-518. doi: 10.1016/j.medcli.2021.06.012. Epub 2021 Jun 18.
Impact factor: 1.725
Publication type: Paper in national publication
Authors: Espinosa-Pereiro, Juan, Fernandez-Hidalgo, Nuria, Perez-Hoyos, Santiago, Salvador, Fernando, Dura, Xavier, Miarons, Marta, Anton, Andres, Eremiev-Eremiev, Simeon, Sempere-Gonzalez, Abiu, Monforte-Pallares, Arnau et al.
DOI: 10.1016/j.medcli.2021.06.012

Carglumic acid in methylmalonic acidemia: Use of breast milk as an alternative vehicle to water.

PMID: 35633061
Journal: JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
Year: 2022
Reference: J Clin Pharm Ther. 2022 May 27. doi: 10.1111/jcpt.13704.
Impact factor: 2.512
Publication type: Letter or abstract
Authors: Garcia-Diaz, Hector C, Parramon-Teixido, Carlos J, Clemente-Batista, Susana, Jimenez-Lozano, Ines, Montaner-Ramon, Alicia, Del Toro, Mireia et al.
DOI: 10.1111/jcpt.13704

Pharmaceutical interventions in the emergency department: cost-effectiveness and cost-benefit analysis.

PMID: 35049519
Journal: European Journal of Hospital Pharmacy
Year: 2021
Reference: Eur J Hosp Pharm. 2021 May;28(3):133-138. doi: 10.1136/ejhpharm-2019-002067. Epub 2020 Feb 25.
Impact factor: 1.652
Publication type: Paper in international publication
Authors: Miarons, Marta, Marin, Sergio, Amenos, Imma, Campins, Lluis, Rovira, Montse, Daza, Manuel et al.
DOI: 10.1136/ejhpharm-2019-002067

COVID-19 Clinical Profile in Latin American Migrants Living in Spain: Does the Geographical Origin Matter?

PMID: 34830495
Journal: Journal of Clinical Medicine
Year: 2021
Reference: J Clin Med. 2021 Nov 9;10(22). pii: jcm10225213. doi: 10.3390/jcm10225213.
Impact factor: 4.242
Publication type: Paper in international publication
Authors: Sempere, Abiu, Salvador, Fernando, Monforte, Arnau, Sampol, Julia, Espinosa-Pereiro, Juan, Miarons, Marta, Bosch-Nicolau, Pau, Guillen-Del-Castillo, Alfredo, Aznar, Maria Luisa, Campos-Varela, Isabel et al.
DOI: 10.3390/jcm10225213

Organization of a reference haemophilia unit and its change of activity during the COVID-19 pandemic.

PMID: 32997851
Journal: HAEMOPHILIA
Year: 2021
Reference: Haemophilia. 2021 Jul;27(4):e473-e475. doi: 10.1111/hae.14160. Epub 2020 Sep 30.
Impact factor: 4.287
Publication type: Letter or abstract
Authors: Gironella Mesa, Mercedes, Martinez Garcia, Maria Fernanda, Benitez Hidalgo, Olga, Alvarez Martinez, Eva, Juarez Gimenez, Juan-Carlos, Fernandez Sarmiento, Carmen, Suito Alcantara, Milagros, Soto Bonet, Nuria, Cardona Lopez, Raquel, Iacoboni Garcia-Calvo, Gloria et al.
DOI: 10.1111/hae.14160

Long-term Effects of COVID-19 in Solid Organ Transplantation Recipients.

PMID: 34174006
Journal: Transplant Infectious Disease
Year: 2021
Reference: Transpl Infect Dis. 2021 Aug;23(4):e13677. doi: 10.1111/tid.13677. Epub 2021 Jul 12.
Impact factor: 2.228
Publication type: Letter or abstract
Authors: Garcia-Garcia, Sonia, Los-Arcos, Ibai, Moreso, Francesc, Berastegui, Cristina, Castells, Lluis, Gorgas Torner, Maria Q, Miarons, Marta, Larrosa-Garcia, Maria et al.
DOI: 10.1111/tid.13677

Información biomédica en tiempos de pandemia

PMID: NOPMID0077
Journal: El Farmacéutico. Hospitales
Year: 2020
Reference: El Farmacéutico Hospitales. 2020; 219: 27-34
Impact factor: 0
Publication type: Paper in national publication
Authors: Juarez Giménez, Juan Carlos, Puyal González, Cristina et al.
DOI:

An electronic alert system increases screening for hepatitis B and C and improves management of patients with haematological disorders.

PMID: 32080253
Journal: Scientific Reports
Year: 2020
Reference: Sci Rep. 2020 Feb 20;10(1):3038. doi: 10.1038/s41598-020-59476-4.
Impact factor: 3.998
Publication type: Paper in international publication
Authors: Riveiro-Barciela, Mar, Gubern, Paula, Roade, Luisa, Abrisqueta, Pau, Carreras, Maria Jose, Farriols, Anna, Bosch, Francesc, Esteban, Rafael, Buti, Maria et al.
DOI: 10.1038/s41598-020-59476-4

Hospital pharmacist's roles and responsibilities with CAR-T medicines.

PMID: 31901059
Journal: Farmacia hospitalaria
Year: 2020
Reference: Farm Hosp. 2020 Jan 1;44(1):26-31. doi: 10.7399/fh.11333.
Impact factor: 0
Publication type: Paper in international publication
Authors: Moreno-Martinez, Maria Estela, Vinent-Genestar, Joan, Munoz-Sanchez, Carmen, Carreras-Soler, Maria Josep et al.
DOI: 10.7399/fh.11333

Survey of oncohematological pharmaceutical care situation in Spain.

PMID: 31705643
Journal: Farmacia hospitalaria : organo oficial de expresio
Year: 2019
Reference: Farm Hosp. 2019 Nov 1;43(6):194-201. doi: 10.7399/fh.11239.
Impact factor: 0
Publication type: Paper in international publication
Authors: Martinez-Bautista, Maria Jose, Mangues-Bafalluy, Irene, Cajaraville-Ordonana, Gerardo, Carreras-Soler, Maria Josep, Clopes-Estela, Ana, Moreno-Martinez, Estela et al.
DOI: 10.7399/fh.11239

Trastuzumab-related cardiotoxicity in the elderly: a role for cardiovascular risk factors.

PMID: 30624599
Journal: ANNALS OF ONCOLOGY
Year: 2019
Reference: Ann Oncol. 2019 Jul 1;30(7):1178. doi: 10.1093/annonc/mdy534.
Impact factor: 14.196
Publication type: Letter or abstract
Authors: Baselga, J, Serrano, C, Cortes, J, De Mattos-Arruda, L, Bellet, M, Gomez, P, Saura, C, Perez, J, Vidal, M, Munoz-Couselo, E et al.
DOI: 10.1093/annonc/mdy534

Evaluation of the efficiency under current use of human fibrinogen concentrate in trauma patients with life-threatening hemorrhagic disorders.

PMID: 27254440
Journal: BLOOD COAGULATION & FIBRINOLYSIS
Year: 2017
Reference: Blood Coagul Fibrinolysis. 2017 Jan;28(1):66-71. doi: 10.1097/MBC.0000000000000543.
Impact factor: 1.367
Publication type: Paper in international publication
Authors: Juarez-Gimenez, Juan C, Gonzalez-Guerrero, Celia, Lozano-Andreu, Toni, Roch-Santed, Maria, Rivera-Sanchez, Lucas, Brandariz-Nunez, David, Pasto-Cardona, Lourdes, Montoro-Ronsano, Jose B et al.
DOI: 10.1097/MBC.0000000000000543

Pancreatic cancer heterogeneity and response to Mek inhibition.

PMID: 28581516
Journal: ONCOGENE
Year: 2017
Reference: Oncogene. 2017 Oct 5;36(40):5639-5647. doi: 10.1038/onc.2017.174. Epub 2017 Jun 5.
Impact factor: 7.519
Publication type: Paper in international publication
Authors: Pedersen, K, Bilal, F, Bernado Morales, C, Salcedo, M T, Macarulla, T, Masso-Valles, D, Mohan, V, Vivancos, A, Carreras, M-J, Serres, X et al.
DOI: 10.1038/onc.2017.174

[Pharmacological interactions: a professional challenge].

PMID: 24951899
Journal: Farmacia hospitalaria : organo oficial de expresio
Year: 2014
Reference: Farm Hosp. 2014 May 1;38(3):151-3. doi: 10.7399/fh.2014.38.3.7494.
Impact factor: 0
Publication type: Editorial in national publication
Authors: Lalueza Broto, P, Girona Brumos, L, Juarez Gimenez, J C et al.
DOI: 10.7399/fh.2014.38.3.7494

[Recommendations for the use of social networks by hospital pharmacists (12 advises that one should consider before jumping into the network)].

PMID: 24669891
Journal: Farmacia hospitalaria : organo oficial de expresio
Year: 2014
Reference: Farm Hosp. 2014 Jan 1;38(2):86-8.
Impact factor: 0
Publication type: Editorial in national publication
Authors: Juarez Gimenez, J C, Fernandez Lison, L C, Monte Boquet, E et al.
DOI:

[Review of evidence of thalidomide and lenalidomide in different hematological diseases: chronic lymphocytic leukemia, primary amyloidosis, myelofibrosis and syndrome myelodysplastic].

PMID: 24010694
Journal: Farmacia hospitalaria : organo oficial de expresio
Year: 2013
Reference: Farm Hosp. 2013 Jul-Aug;37(4):322-34. doi: 10.7399/FH.2013.37.4.677.
Impact factor: 0
Publication type: Review in national publication
Authors: Jimenez Lozano, I, Juarez Jimenez, J C et al.
DOI: 10.7399/FH.2013.37.4.677

A phase I pharmacokinetic study of PM00104 (Zalypsis) administered as a 24-h intravenous infusion every 3 weeks in patients with advanced solid tumors.

PMID: 23455428
Journal: CANCER CHEMOTHERAPY AND PHARMACOLOGY
Year: 2013
Reference: Cancer Chemother Pharmacol. 2013 May;71(5):1247-54. doi: 10.1007/s00280-013-2119-8. Epub 2013 Mar 2.
Impact factor: 2.795
Publication type: Paper in international publication
Authors: Capdevila, J, Clive, S, Casado, E, Michie, C, Piera, A, Sicart, E, Carreras, M J, Coronado, C, Kahatt, C, Soto Matos-Pita, A et al.
DOI: 10.1007/s00280-013-2119-8

Trastuzumab-related cardiotoxicity in the elderly: a role for cardiovascular risk factors.

PMID: 21828361
Journal: ANNALS OF ONCOLOGY
Year: 2012
Reference: Ann Oncol. 2012 Apr;23(4):897-902. Epub 2011 Aug 9.
Impact factor: 6.425
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1093/annonc/mdr348

Application of the Technology Web 2.0 in a drug information centre.

PMID: 22035600
Journal: Farmacia hospitalaria : organo oficial de expresio
Year: 2011
Reference: Farm Hosp. 2011 Nov-Dec;35(6):315.e1-5. doi: 10.1016/j.farma.2011.07.001. Epub 2011 Oct 27.
Impact factor: 0
Publication type: Letter whit IF
Authors: Juarez Gimenez, J C, Puyal Gonzalez, C, Valdivia Vadell, C, Palacio Lacambra, M E, Vidal Otero, J, Cerqueira Dapena, M J et al.
DOI: 10.1016/j.farma.2011.07.001

Aprataxin tumor levels predict response of colorectal cancer patients to irinotecan-based treatment.

PMID: 20371676
Journal: CLINICAL CANCER RESEARCH
Year: 2010
Reference: Clin Cancer Res. 2010 Apr 15;16(8):2375-82. Epub 2010 Apr 6.
Impact factor: 6.747
Publication type: Paper in international publication
Authors: Dopeso, Higinio, Mateo-Lozano, Silvia, Elez, Elena, Landolfi, Stefania, Ramos Pascual, Francisco Javier, Hernandez-Losa, Javier, Mazzolini, Rocco, Rodrigues, Paulo, Bazzocco, Sarah, Carreras, Maria Josep et al.
DOI: 10.1158/1078-0432.CCR-09-3275

[Optimisation of the prescription of medication for patients undergoing elective surgery].

PMID: 19401096
Journal: Farmacia hospitalaria : organo oficial de expresio
Year: 2009
Reference: Farm Hosp. 2009 Jan-Feb;33(1):37-42.
Impact factor: 0
Publication type: Paper in national publication
Authors: Girona Brumos, L, Lalueza Broto, M P, Juarez Gimenez, J C, Candela Custardoy, A et al.
DOI: https://doi.org/10.1016/S2173-5085(09)70067-X

Thesis

Influencia del tipo de lípidos de la nutrición parenteral sobre la retinopatía de la prematuridad

PhD student: Maria José Cabañas Poy
Director/s: J. Bruno Montoro Ronsano, Félix Castillo Salinas
University: Universitat de Barcelona
Year: 2022

Anàlisi de la despesa farmacèutica en el tractament de tumors sòlids a l’Hospital Universitari Vall d’Hebron i la seva contribució a la sostenibilitat del sistema sanitari

PhD student: Maria Josep Carreras Soler
Director/s: Josep Tabernero Caturla
University: Universitat Autònoma de Barcelona
Year: 2020