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Basic, Translational and Clinical Pharmacy Research

The work of our group is mainly focused on personalized medicine, including chemical-functional stability studies of drugs in individualized preparations to be administered both orally and parenterally, as well as parenteral nutrition;  research focused on the evaluation and/or design of population pharmacokinetic/pharmacodynamic (PK/PD) models and the characterization of the pharmacokinetics of certain drugs of therapeutic interest in the general population or in certain population groups; and research focused on pharmacogenetics and pharmacogenomics. Our research is also focused on advanced interventions: drug evaluation studies (effectiveness, safety and economic studies); and mobile health and telepharmacy.

Team

Maria José Cabañas Poy

Maria José Cabañas Poy

Main researcher
Basic, Translational and Clinical Pharmacy Research
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Susana Clemente Bautista

Susana Clemente Bautista

Main researcher
Basic, Translational and Clinical Pharmacy Research
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Juan Carlos Juarez Giménez

Juan Carlos Juarez Giménez

Basic, Translational and Clinical Pharmacy Research
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Alba Pau Parra

Alba Pau Parra

Main researcher
Basic, Translational and Clinical Pharmacy Research
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Carla Alonso Martinez

Carla Alonso Martinez

Basic, Translational and Clinical Pharmacy Research
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Carlos javier Parramon Teixido

Carlos javier Parramon Teixido

Predoctoral researcher
Basic, Translational and Clinical Pharmacy Research
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Maria José Cabañas Poy

Maria José Cabañas Poy

Main researcher
Basic, Translational and Clinical Pharmacy Research
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Susana Clemente Bautista

Susana Clemente Bautista

Main researcher
Basic, Translational and Clinical Pharmacy Research
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Juan Carlos Juarez Giménez

Juan Carlos Juarez Giménez

Basic, Translational and Clinical Pharmacy Research
Read more
Alba Pau Parra

Alba Pau Parra

Main researcher
Basic, Translational and Clinical Pharmacy Research
Read more
Carla Alonso Martinez

Carla Alonso Martinez

Basic, Translational and Clinical Pharmacy Research
Read more
Carlos javier Parramon Teixido

Carlos javier Parramon Teixido

Predoctoral researcher
Basic, Translational and Clinical Pharmacy Research
Read more

Research lines

Investigació clínica observacional i experimental: Centrada en farmacogenètica o farmacogenòmica.

IP: Investigació clínica observacional i experimental: Centrada en farmacogenètica o farmacogenòmica.

Investigació clínica observacional i experimental: Centrada en l'avaluació de models PK/PD y caracterització PK de fàrmacs d'elevat interès terapèutic en la població o en determinats grups de pacients.

IP: Investigació clínica observacional i experimental: Centrada en l'avaluació de models PK/PD y caracterització PK de fàrmacs d'ele

Investigació clínica observacional: Centrada en l'avaluació de l'efectivitat, seguretat i costos de fàrmacs innovadors o d'elevat cost en determinades indicacions o en poblacions concretes de pacients CV.

IP: J. Bruno Montoro Ronsano

Investigació tècnica: Centrada en l'avaluació de l'estabilitat química-funcional de fàrmacs en preparacions individualitzades, tant per administració oral com a parenteral.

IP: David Berlana Martín

Projects

OPVIH (Optimización del proceso VIH): Definición del mapa del recorrido de la persona VIH y oportunidades para su optimización mediante salud digital.

IP: Adria Curran Fàbregas
Collaborators: Anna Sala Cunill, Vicenç Falcó Ferrer, Yolima Cossio Gil, Ignasi Cardona Pascual, Paula Suanzes Diez, Jordi Navarro Mercadé, Joaquin Burgos Cibrian, Núria Castany Viñas, Maria Belén Gutiérrez Iglesias, Silvina Andrea Magnani
Funding agency: Laboratorio ViiV Healthcare
Funding: 55000
Reference: VIIV/BECAS/2023/CURRAN
Duration: 15/01/2024 - 14/01/2026

Herramienta de soporte a la decisión para la estratificación de pacientes con COVID-19 según características sociodemográficas, clínicas y de tratamiento habitual mediante inteligencia artificial.

IP: -
Collaborators: -
Funding agency: Sociedad Española de Farmacia Hospitalaria
Funding: 4420
Reference: 2021/SEFH/FARMACIA/MIARONS
Duration: 06/09/2022 - 05/09/2024

Aplicación clínica de la impresión 3D para el tratamiento personalizado en pediatría.

IP: Maria José Cabañas Poy
Collaborators: -
Funding agency: Sociedad Española de Farmacia Hospitalaria
Funding: 14700
Reference: 2021/SEFH/FARMACIA/CABAÑAS
Duration: 06/09/2022 - 05/09/2024

Desarrollo de dos modelos farmacocinéticos poblacionales, uno de infliximab y otro de adalimumab, en pacientes pediátricos con enfermedad inflamatoria intestinal incluyendo variantes farmacogenéticas.

IP: Susana Clemente Bautista
Collaborators: Maria José Cabañas Poy, Oscar Segarra Canton, Marina Álvarez Beltrán, Sonia García García
Funding agency: Sociedad Española de Farmacia Hospitalaria
Funding: 6240
Reference: 2021/SEFH/FARMACIA/CLEMENTE
Duration: 06/09/2022 - 05/09/2024

Publications

Allelic Frequency of DPYD Genetic Variants in Patients With Cancer in Spain: The PhotoDPYD Study.

PMID: 37014829
Journal: ONCOLOGIST
Year: 2023
Reference: Oncologist. 2023 May 8;28(5):e304-e308. doi: 10.1093/oncolo/oyad077.
Impact factor:
Publication type: Paper in international publication
Authors: Abdel-Kader Martin, Laila; Agustin, Maria Jose; Alcacera Lopez, M feminine Aranzazu; Alonso Castane, Maria Dolores; Alvarez Martin, Tamara; Beloqui, Juan Jose; Bernal Noguera, Sara; Burgos San Jose, Amparo; Cachafeiro Pin, Ana Isabel; Castellote Belles, Laura et al.
DOI: 10.1093/oncolo/oyad077

Population pharmacokinetic modelling of fibrinogen in patients with congenital or acquired-chronic or acute-hypofibrinogenaemia.

PMID: 37041125
Journal: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
Year: 2023
Reference: Br J Clin Pharmacol. 2023 Sep;89(9):2703-2713. doi: 10.1111/bcp.15741. Epub 2023 May 2.
Impact factor:
Publication type: Paper in international publication
Authors: Arevalo, Angel Guillermo; Blasi, Annabel; Cendros, Josep Maria; Colom, Helena; Montoro, Bruno; Sabate, Antoni et al.
DOI: 10.1111/bcp.15741

VHrare study: Prevalence, clinical features and management of severe rare bleeding disorders in a large cohort.

PMID: 37206292
Journal: EJHaem
Year: 2023
Reference: EJHaem. 2023 Mar 9;4(2):476-482. doi: 10.1002/jha2.664. eCollection 2023 May.
Impact factor:
Publication type: Review in international publication
Authors: Benitez Hidalgo, Olga; Comes Fernandez, Natalia; Corrrales Insa, Irene; Cortina Giner, Vicente; Fernandez-Caballero, Mariana; Juarez Gimenez, Juan Carlos; Martinez Garcia, Maria Fernanda; Ramirez Orihuela, Lorena et al.
DOI: 10.1002/jha2.664

A PET-CT score for discriminating malignant from benign pleural effusions.

PMID: 37487808
Journal: MEDICINA CLINICA
Year: 2023
Reference: Med Clin (Barc). 2023 Jul 22:S0025-7753(23)00368-8. doi: 10.1016/j.medcli.2023.06.011.
Impact factor:
Publication type: Paper in national publication
Authors: Aleman, Carmen; Montoro, Bruno; Persiva, Oscar; Sanchez, Leire; Sansano, Irene; Simo, Marc; Vazquez, Ana et al.
DOI: 10.1016/j.medcli.2023.06.011

Rapid and accurate method for quantifying busulfan in plasma samples by isocratic liquid chromatography-tandem mass spectrometry (LC-MS/MS)

PMID: NOPMID0100
Journal: Advances in Laboratory Medicine
Year: 2022
Reference: Adv Lab Med / Av en Med Lab. 2022;3(3):263-271. doi:10.1515/almed-2022-0016
Impact factor:
Publication type: Paper in national publication
Authors: Barquin Del Pino , Raquel ; Benitez Carabante, Maria Isabel ; Casis Saenz, Ernesto; Castellote Bellés, Laura; Ferrer Costa, Roser; López Hellin, Joan; Martinez Sánchez, Luisa; Miarons Font , Marta; Paciucci Barzanti, Rosanna; Rodríguez Frias, Francisco et al.
DOI: 10.1515/almed-2022-0016

Effect of tocilizumab versus standard of care in adults hospitalized with moderate-severe COVID-19 pneumonia.

PMID: 35531306
Journal: Medicina clinica (English ed.)
Year: 2022
Reference: Med Clin (Engl Ed). 2022 Apr 8;158(7):301-307. doi: 10.1016/j.medcle.2021.03.036. Epub 2022 May 3.
Impact factor:
Publication type: Paper in international publication
Authors: Berlana, David; Campany-Herrero, David; Cardona-Pascual, Ignacio; Martinez-Valle, Ferran; Montoro-Ronsano, Jose Bruno et al.
DOI: 10.1016/j.medcle.2021.03.036

Early outcomes in adults hospitalized with severe SARS-CoV-2 infection receiving tocilizumab.

PMID: 35755602
Journal: MEDICINA CLINICA
Year: 2022
Reference: Med Clin. 2022 Jun 10;158(11):509-518. doi: 10.1016/j.medcle.2021.06.023. Epub 2022 Jun 18.
Impact factor: 1.725
Publication type: Paper in international publication
Authors: Sellares-Nadal, Julia; Almirante, Benito; Guillen-Del-Castillo, Alfredo; Sampol, Julia; Augustin, Salvador; Bosch-Nicolau, Pau; Monforte-Pallares, Arnau; Sempere-Gonzalez, Abiu; Eremiev-Eremiev, Simeon; Miarons, Marta et al.
DOI: 10.1016/j.medcle.2021.06.023

Simulated Y-site compatibility of atosiban acetate with selected intravenous drugs.

PMID: 35779331
Journal: European Journal of Obstetrics & Gynecology and Re
Year: 2022
Reference: Eur J Obstet Gynecol Reprod Biol. 2022 Aug;275:106-109. doi: 10.1016/j.ejogrb.2022.06.006. Epub 2022 Jun 20.
Impact factor: 2.435
Publication type: Paper in international publication
Authors: Poy, Maria Josep Cabanas; Bautista, Susana Clemente; Boix-Montanes, Antoni; Larrosa-Garcia, Maria; Jimenez-Lozano, Ines et al.
DOI: 10.1016/j.ejogrb.2022.06.006

Pharmaceutical interventions in the emergency department: cost-effectiveness and cost-benefit analysis.

PMID: 35049519
Journal: European Journal of Hospital Pharmacy
Year: 2021
Reference: Eur J Hosp Pharm. 2021 May;28(3):133-138. doi: 10.1136/ejhpharm-2019-002067. Epub 2020 Feb 25.
Impact factor: 1.652
Publication type: Paper in international publication
Authors: Miarons, Marta, Marin, Sergio, Amenos, Imma, Campins, Lluis, Rovira, Montse, Daza, Manuel et al.
DOI: 10.1136/ejhpharm-2019-002067

COVID-19 Clinical Profile in Latin American Migrants Living in Spain: Does the Geographical Origin Matter?

PMID: 34830495
Journal: Journal of Clinical Medicine
Year: 2021
Reference: J Clin Med. 2021 Nov 9;10(22). pii: jcm10225213. doi: 10.3390/jcm10225213.
Impact factor: 4.242
Publication type: Paper in international publication
Authors: Sempere, Abiu, Salvador, Fernando, Monforte, Arnau, Sampol, Julia, Espinosa-Pereiro, Juan, Miarons, Marta, Bosch-Nicolau, Pau, Guillen-Del-Castillo, Alfredo, Aznar, Maria Luisa, Campos-Varela, Isabel et al.
DOI: 10.3390/jcm10225213

Organization of a reference haemophilia unit and its change of activity during the COVID-19 pandemic.

PMID: 32997851
Journal: HAEMOPHILIA
Year: 2021
Reference: Haemophilia. 2021 Jul;27(4):e473-e475. doi: 10.1111/hae.14160. Epub 2020 Sep 30.
Impact factor: 4.287
Publication type: Letter or abstract
Authors: Gironella Mesa, Mercedes, Martinez Garcia, Maria Fernanda, Benitez Hidalgo, Olga, Alvarez Martinez, Eva, Juarez Gimenez, Juan-Carlos, Fernandez Sarmiento, Carmen, Suito Alcantara, Milagros, Soto Bonet, Nuria, Cardona Lopez, Raquel, Iacoboni Garcia-Calvo, Gloria et al.
DOI: 10.1111/hae.14160

Long-term Effects of COVID-19 in Solid Organ Transplantation Recipients.

PMID: 34174006
Journal: Transplant Infectious Disease
Year: 2021
Reference: Transpl Infect Dis. 2021 Aug;23(4):e13677. doi: 10.1111/tid.13677. Epub 2021 Jul 12.
Impact factor: 2.228
Publication type: Letter or abstract
Authors: Garcia-Garcia, Sonia, Los-Arcos, Ibai, Moreso, Francesc, Berastegui, Cristina, Castells, Lluis, Gorgas Torner, Maria Q, Miarons, Marta, Larrosa-Garcia, Maria et al.
DOI: 10.1111/tid.13677

Información biomédica en tiempos de pandemia

PMID: NOPMID0077
Journal: El Farmacéutico. Hospitales
Year: 2020
Reference: El Farmacéutico Hospitales. 2020; 219: 27-34
Impact factor: 0
Publication type: Paper in national publication
Authors: Juarez Giménez, Juan Carlos, Puyal González, Cristina et al.
DOI:

An electronic alert system increases screening for hepatitis B and C and improves management of patients with haematological disorders.

PMID: 32080253
Journal: Scientific Reports
Year: 2020
Reference: Sci Rep. 2020 Feb 20;10(1):3038. doi: 10.1038/s41598-020-59476-4.
Impact factor: 3.998
Publication type: Paper in international publication
Authors: Riveiro-Barciela, Mar, Gubern, Paula, Roade, Luisa, Abrisqueta, Pau, Carreras, Maria Jose, Farriols, Anna, Bosch, Francesc, Esteban, Rafael, Buti, Maria et al.
DOI: 10.1038/s41598-020-59476-4

Hospital pharmacist's roles and responsibilities with CAR-T medicines.

PMID: 31901059
Journal: Farmacia hospitalaria
Year: 2020
Reference: Farm Hosp. 2020 Jan 1;44(1):26-31. doi: 10.7399/fh.11333.
Impact factor: 0
Publication type: Paper in international publication
Authors: Moreno-Martinez, Maria Estela, Vinent-Genestar, Joan, Munoz-Sanchez, Carmen, Carreras-Soler, Maria Josep et al.
DOI: 10.7399/fh.11333

Survey of oncohematological pharmaceutical care situation in Spain.

PMID: 31705643
Journal: Farmacia hospitalaria : organo oficial de expresio
Year: 2019
Reference: Farm Hosp. 2019 Nov 1;43(6):194-201. doi: 10.7399/fh.11239.
Impact factor: 0
Publication type: Paper in international publication
Authors: Martinez-Bautista, Maria Jose, Mangues-Bafalluy, Irene, Cajaraville-Ordonana, Gerardo, Carreras-Soler, Maria Josep, Clopes-Estela, Ana, Moreno-Martinez, Estela et al.
DOI: 10.7399/fh.11239

Trastuzumab-related cardiotoxicity in the elderly: a role for cardiovascular risk factors.

PMID: 30624599
Journal: ANNALS OF ONCOLOGY
Year: 2019
Reference: Ann Oncol. 2019 Jul 1;30(7):1178. doi: 10.1093/annonc/mdy534.
Impact factor: 14.196
Publication type: Letter or abstract
Authors: Baselga, J, Serrano, C, Cortes, J, De Mattos-Arruda, L, Bellet, M, Gomez, P, Saura, C, Perez, J, Vidal, M, Munoz-Couselo, E et al.
DOI: 10.1093/annonc/mdy534

Evaluation of the efficiency under current use of human fibrinogen concentrate in trauma patients with life-threatening hemorrhagic disorders.

PMID: 27254440
Journal: BLOOD COAGULATION & FIBRINOLYSIS
Year: 2017
Reference: Blood Coagul Fibrinolysis. 2017 Jan;28(1):66-71. doi: 10.1097/MBC.0000000000000543.
Impact factor: 1.367
Publication type: Paper in international publication
Authors: Juarez-Gimenez, Juan C, Gonzalez-Guerrero, Celia, Lozano-Andreu, Toni, Roch-Santed, Maria, Rivera-Sanchez, Lucas, Brandariz-Nunez, David, Pasto-Cardona, Lourdes, Montoro-Ronsano, Jose B et al.
DOI: 10.1097/MBC.0000000000000543

Pancreatic cancer heterogeneity and response to Mek inhibition.

PMID: 28581516
Journal: ONCOGENE
Year: 2017
Reference: Oncogene. 2017 Oct 5;36(40):5639-5647. doi: 10.1038/onc.2017.174. Epub 2017 Jun 5.
Impact factor: 7.519
Publication type: Paper in international publication
Authors: Pedersen, K, Bilal, F, Bernado Morales, C, Salcedo, M T, Macarulla, T, Masso-Valles, D, Mohan, V, Vivancos, A, Carreras, M-J, Serres, X et al.
DOI: 10.1038/onc.2017.174

[Pharmacological interactions: a professional challenge].

PMID: 24951899
Journal: Farmacia hospitalaria : organo oficial de expresio
Year: 2014
Reference: Farm Hosp. 2014 May 1;38(3):151-3. doi: 10.7399/fh.2014.38.3.7494.
Impact factor: 0
Publication type: Editorial in national publication
Authors: Lalueza Broto, P, Girona Brumos, L, Juarez Gimenez, J C et al.
DOI: 10.7399/fh.2014.38.3.7494

[Recommendations for the use of social networks by hospital pharmacists (12 advises that one should consider before jumping into the network)].

PMID: 24669891
Journal: Farmacia hospitalaria : organo oficial de expresio
Year: 2014
Reference: Farm Hosp. 2014 Jan 1;38(2):86-8.
Impact factor: 0
Publication type: Editorial in national publication
Authors: Juarez Gimenez, J C, Fernandez Lison, L C, Monte Boquet, E et al.
DOI:

[Review of evidence of thalidomide and lenalidomide in different hematological diseases: chronic lymphocytic leukemia, primary amyloidosis, myelofibrosis and syndrome myelodysplastic].

PMID: 24010694
Journal: Farmacia hospitalaria : organo oficial de expresio
Year: 2013
Reference: Farm Hosp. 2013 Jul-Aug;37(4):322-34. doi: 10.7399/FH.2013.37.4.677.
Impact factor: 0
Publication type: Review in national publication
Authors: Jimenez Lozano, I, Juarez Jimenez, J C et al.
DOI: 10.7399/FH.2013.37.4.677

A phase I pharmacokinetic study of PM00104 (Zalypsis) administered as a 24-h intravenous infusion every 3 weeks in patients with advanced solid tumors.

PMID: 23455428
Journal: CANCER CHEMOTHERAPY AND PHARMACOLOGY
Year: 2013
Reference: Cancer Chemother Pharmacol. 2013 May;71(5):1247-54. doi: 10.1007/s00280-013-2119-8. Epub 2013 Mar 2.
Impact factor: 2.795
Publication type: Paper in international publication
Authors: Capdevila, J, Clive, S, Casado, E, Michie, C, Piera, A, Sicart, E, Carreras, M J, Coronado, C, Kahatt, C, Soto Matos-Pita, A et al.
DOI: 10.1007/s00280-013-2119-8

Trastuzumab-related cardiotoxicity in the elderly: a role for cardiovascular risk factors.

PMID: 21828361
Journal: ANNALS OF ONCOLOGY
Year: 2012
Reference: Ann Oncol. 2012 Apr;23(4):897-902. Epub 2011 Aug 9.
Impact factor: 6.425
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1093/annonc/mdr348

Application of the Technology Web 2.0 in a drug information centre.

PMID: 22035600
Journal: Farmacia hospitalaria : organo oficial de expresio
Year: 2011
Reference: Farm Hosp. 2011 Nov-Dec;35(6):315.e1-5. doi: 10.1016/j.farma.2011.07.001. Epub 2011 Oct 27.
Impact factor: 0
Publication type: Letter whit IF
Authors: Juarez Gimenez, J C, Puyal Gonzalez, C, Valdivia Vadell, C, Palacio Lacambra, M E, Vidal Otero, J, Cerqueira Dapena, M J et al.
DOI: 10.1016/j.farma.2011.07.001

Aprataxin tumor levels predict response of colorectal cancer patients to irinotecan-based treatment.

PMID: 20371676
Journal: CLINICAL CANCER RESEARCH
Year: 2010
Reference: Clin Cancer Res. 2010 Apr 15;16(8):2375-82. Epub 2010 Apr 6.
Impact factor: 6.747
Publication type: Paper in international publication
Authors: Dopeso, Higinio, Mateo-Lozano, Silvia, Elez, Elena, Landolfi, Stefania, Ramos Pascual, Francisco Javier, Hernandez-Losa, Javier, Mazzolini, Rocco, Rodrigues, Paulo, Bazzocco, Sarah, Carreras, Maria Josep et al.
DOI: 10.1158/1078-0432.CCR-09-3275

[Optimisation of the prescription of medication for patients undergoing elective surgery].

PMID: 19401096
Journal: Farmacia hospitalaria : organo oficial de expresio
Year: 2009
Reference: Farm Hosp. 2009 Jan-Feb;33(1):37-42.
Impact factor: 0
Publication type: Paper in national publication
Authors: Girona Brumos, L, Lalueza Broto, M P, Juarez Gimenez, J C, Candela Custardoy, A et al.
DOI: https://doi.org/10.1016/S2173-5085(09)70067-X

Thesis

Influencia del tipo de lípidos de la nutrición parenteral sobre la retinopatía de la prematuridad

PhD student: Maria José Cabañas Poy
Director/s: J. Bruno Montoro Ronsano, Félix Castillo Salinas
University: Universitat de Barcelona
Year: 2022

Anàlisi de la despesa farmacèutica en el tractament de tumors sòlids a l’Hospital Universitari Vall d’Hebron i la seva contribució a la sostenibilitat del sistema sanitari

PhD student: Maria Josep Carreras Soler
Director/s: Josep Tabernero Caturla
University: Universidad Autònoma de Barcelona
Year: 2020

Blog

News

Within the framework of a clinical trial, the first 3D printed medicine in Europe in the pediatric field will be tested.