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Basic, Translational and Clinical Pharmacy Research

The work of our group is mainly focused on personalized medicine, including chemical-functional stability studies of drugs in individualized preparations to be administered both orally and parenterally, as well as parenteral nutrition;  research focused on the evaluation and/or design of population pharmacokinetic/pharmacodynamic (PK/PD) models and the characterization of the pharmacokinetics of certain drugs of therapeutic interest in the general population or in certain population groups; and research focused on pharmacogenetics and pharmacogenomics. Our research is also focused on advanced interventions: drug evaluation studies (effectiveness, safety and economic studies); and mobile health and telepharmacy.

Team

Africa Hontalba Rifa

Africa Hontalba Rifa

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Andrea Pérez Manrique

Andrea Pérez Manrique

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Arevalo Bernabé, Angel

Arevalo Bernabé, Angel

Predoctoral researcher
Basic, Translational and Clinical Pharmacy Research
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Arnau Mariscal Puig

Arnau Mariscal Puig

Research technician
Basic, Translational and Clinical Pharmacy Research
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Carla Obón Vazquez

Carla Obón Vazquez

Research technician
Basic, Translational and Clinical Pharmacy Research
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Carme Garcia Esquerda

Carme Garcia Esquerda

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Africa Hontalba Rifa

Africa Hontalba Rifa

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Andrea Pérez Manrique

Andrea Pérez Manrique

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Arevalo Bernabé, Angel

Arevalo Bernabé, Angel

Predoctoral researcher
Basic, Translational and Clinical Pharmacy Research
Read more
Arnau Mariscal Puig

Arnau Mariscal Puig

Research technician
Basic, Translational and Clinical Pharmacy Research
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Carla Obón Vazquez

Carla Obón Vazquez

Research technician
Basic, Translational and Clinical Pharmacy Research
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Carme Garcia Esquerda

Carme Garcia Esquerda

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Publications

Expert consensus statements and summary of proceedings from the International Safety and Quality of Parenteral Nutrition Summit.

PMID: 38869255
Journal: AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
Year: 2024
Reference: Am J Health Syst Pharm. 2024 Jun 13;81(Supplement_3):S75-S88. doi: 10.1093/ajhp/zxae078.
Impact factor:
Publication type: Paper in international publication
Authors: Ayers, Phil; Berger, Mette M; Berlana, David; Cogle, Sarah V; De Cloet, Joeri; Gray, Brenda; Klek, Stanislaw; Kumpf, Vanessa J; Monczka, Jessica; Wischmeyer, Paul E et al.
DOI: 10.1093/ajhp/zxae078

Parenteral nutrition in the hospital setting/short-term parenteral nutrition.

PMID: 38869256
Journal: AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
Year: 2024
Reference: Am J Health Syst Pharm. 2024 Jun 13;81(Supplement_3):S102-S111. doi: 10.1093/ajhp/zxae080.
Impact factor:
Publication type: Paper in international publication
Authors: Ayers, Phil; Berger, Mette M; Berlana, David; Cogle, Sarah V; De Cloet, Joeri; Wischmeyer, Paul E; Ybarra, Joe; Zeraschi, Sarah et al.
DOI: 10.1093/ajhp/zxae080

Parenteral nutrition in clinical practice: International challenges and strategies.

PMID: 38869257
Journal: AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
Year: 2024
Reference: Am J Health Syst Pharm. 2024 Jun 13;81(Supplement_3):S89-S101. doi: 10.1093/ajhp/zxae079.
Impact factor:
Publication type: Paper in international publication
Authors: Ayers, Phil; Berger, Mette M; Berlana, David; Gray, Brenda; Klek, Stanislaw; Wischmeyer, Paul E; Ybarra, Joe et al.
DOI: 10.1093/ajhp/zxae079

Delabelling beta-lactam allergy.

PMID: 38994200
Journal: Frontiers in Pharmacology
Year: 2024
Reference: Front Pharmacol. 2024 Jun 27;15:1423719. doi: 10.3389/fphar.2024.1423719. eCollection 2024.
Impact factor:
Publication type: Paper in international publication
Authors: Agusti, Antonia; Andres-Lopez, Blanca; Cardona, Victoria; Escobar, Carolina; Esteso, Olga; Garnica Velandia, Diana Rocio; Gomez-Ganda, Laura; Jurgens, Yanina; Marin-Asensio, Laura; Molina-Molina, Gustavo-Jorge et al.
DOI: 10.3389/fphar.2024.1423719

Population Pharmacokinetic modeling of fibrinogen in patients with congenital or acquired -chronic or acute- hypofibrinogenemia.

PMID: 37041125
Journal: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
Year: 2023
Reference: Br J Clin Pharmacol. 2023 Sep;89(9):2703-2713. doi: 10.1111/bcp.15741. Epub 2023 May 2.
Impact factor:
Publication type: Paper in international publication
Authors: Arevalo, Angel Guillermo; Blasi, Annabel; Cendros, Josep Maria; Colom, Helena; Montoro, Bruno; Sabate, Antoni et al.
DOI: 10.1111/bcp.15741

VHrare study: Prevalence, clinical features and management of severe rare bleeding disorders in a large cohort.

PMID: 37206292
Journal: EJHaem
Year: 2023
Reference: EJHaem. 2023 Mar 9;4(2):476-482. doi: 10.1002/jha2.664. eCollection 2023 May.
Impact factor:
Publication type: Review in international publication
Authors: Benitez Hidalgo, Olga; Comes Fernandez, Natalia; Comes Fernandez, Natalia; Corrrales Insa, Irene; Corrrales Insa, Irene; Cortina Giner, Vicente; Cortina Giner, Vicente; Fernandez-Caballero, Mariana; Fernandez-Caballero, Mariana; Juarez Gimenez, Juan Carlos et al.
DOI: 10.1002/jha2.664

A PET-CT score for discriminating malignant from benign pleural effusions.

PMID: 37487808
Journal: MEDICINA CLINICA
Year: 2023
Reference: Med Clin (Barc). 2023 Jul 22:S0025-7753(23)00368-8. doi: 10.1016/j.medcli.2023.06.011.
Impact factor:
Publication type: Paper in national publication
Authors: Aleman, Carmen; Montoro, Bruno; Persiva, Oscar; Sanchez, Leire; Sanchez, Leire; Sansano, Irene; Simo, Marc; Vazquez, Ana et al.
DOI: 10.1016/j.medcli.2023.06.011

Recommendations for the Implementation of the Self-Administration of Alpha-1 Antitrypsin.

PMID: 37559832
Journal: International Journal of Chronic Obstructive Pulmonary Disease
Year: 2023
Reference: Int J Chron Obstruct Pulmon Dis. 2023 Aug 4;18:1691-1700. doi: 10.2147/COPD.S410611. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Amaro Rodriguez, Rosanel; Barrecheguren, Miriam; Barrio Guirado, Maria Angeles; Calle Rubio, Myriam; Callejas-Gonzalez, Francisco Javier; Casas-Maldonado, Francisco; Diab-Caceres, Layla; Garcia-Meseguer, Pilar; Hernandez-Perez, Jose Maria; Lazaro-Asegurado, Lourdes et al.
DOI: 10.2147/COPD.S410611

Shorter versus longer corticosteroid duration and recurrent immune checkpoint inhibitor-associated AKI.

PMID: 36137651
Journal: Journal for ImmunoTherapy of Cancer
Year: 2022
Reference: J Immunother Cancer. 2022 Sep;10(9). pii: jitc-2022-005646. doi: 10.1136/jitc-2022-005646.
Impact factor:
Publication type: Paper in international publication
Authors: Abudayyeh, Ala; Abudayyeh, Ala; Aggarwal, Vikram; Aggarwal, Vikram; Albert, Nicole; Anand, Shuchi; Bagnis, Corinne Isnard; Beckerman, Pazit; Beckerman, Pazit; Ben Sprangers, Els Wauters et al.
DOI: 10.1136/jitc-2022-005646

Ceftazidime-Avibactam plus Aztreonam for the Treatment of Infections by VIM-Type-Producing Gram-Negative Bacteria.

PMID: 36102635
Journal: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Year: 2022
Reference: Antimicrob Agents Chemother. 2022 Oct 18;66(10):e0075122. doi: 10.1128/aac.00751-22. Epub 2022 Sep 14.
Impact factor:
Publication type: Paper in international publication
Authors: Almirante, Benito; Campany, David; Escola-Verge, Laura; Fernandez-Hidalgo, Nuria; Gonzalez-Lopez, Juan Jose; Larrosa, Nieves; Los-Arcos, Ibai; Nuvials, Xavier; Rodriguez-Pardo, Dolors; Sempere, Abiu et al.
DOI: 10.1128/aac.00751-22

Incidence and characteristics of adverse drug reactions in a cohort of patients treated with PD-1/PD-L1 inhibitors in real-world practice.

PMID: 36072949
Journal: Frontiers in Medicine
Year: 2022
Reference: Front Med (Lausanne). 2022 Aug 22;9:891179. doi: 10.3389/fmed.2022.891179. eCollection 2022.
Impact factor:
Publication type: Paper in international publication
Authors: Agusti Escasany, Antonia; Brana, Irene; Carles Galceran, Joan; Carreras Soler, Maria-Josep; Farriols Danes, Anna; Felip, Enriqueta; Garcia Dolade, Nuria; Morales Barrera, Rafael; Munoz-Couselo, Eva; Perez Esquirol, Eulalia et al.
DOI: 10.3389/fmed.2022.891179

Reply.

PMID: 35945056
Journal: MEDICINA CLINICA
Year: 2022
Reference: Med Clin (Barc). 2022 Oct 28;159(8):e55. doi: 10.1016/j.medcli.2022.06.001. Epub 2022 Jul 20.
Impact factor:
Publication type: Letter or abstract
Authors: Berlana, David; Cardona-Pascual, Ignacio; Montoro-Ronsano, J Bruno et al.
DOI: 10.1016/j.medcli.2022.06.001

Influencia del aporte proteico parenteral en las alteraciones electrolíticas en recién nacidos prematuros

PMID: 33036923
Journal: ANALES DE PEDIATRIA
Year: 2021
Reference: An Pediatr (Barc). 2021 Sep;95(3):139-146. doi: 10.1016/j.anpedi.2020.03.022. Epub 2020 Oct 6.
Impact factor:
Publication type: Paper in national publication
Authors: Blanco-Grau, Albert; Clemente-Bautista, Susana; Garcia-Palop, Beatriz; Gomez-Ganda, Laura; Lines-Palazon, Marcos; Montoro-Ronsano, Jose Bruno; Parramon-Teixido, Carlos Javier et al.
DOI: 10.1016/j.anpedi.2020.03.022

Voriconazole and tamsulosin: A clinically relevant drug-drug interaction.

PMID: 34353519
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2021
Reference: Enferm Infecc Microbiol Clin (Engl Ed). 2021 Aug-Sep;39(7):361-363. doi: 10.1016/j.eimce.2021.05.005. Epub 2021 May 15.
Impact factor:
Publication type: Letter whit IF
Authors: Burgos, Joaquin; Campany, David; Parramon-Teixido, Carlos Javier; Pau-Parra, Alba et al.
DOI: 10.1016/j.eimce.2021.05.005

Voriconazole and tamsulosin: A clinically relevant drug- drug interaction.

PMID: 33160711
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2021
Reference: Enferm Infecc Microbiol Clin. 2021 Aug-Sep;39(7):361-363. doi: 10.1016/j.eimc.2020.10.003. Epub 2020 Nov 5.
Impact factor:
Publication type: Letter whit IF
Authors: Burgos, Joaquin; Campany, David; Parramon-Teixido, Carlos Javier; Pau-Parra, Alba et al.
DOI: 10.1016/j.eimc.2020.10.003

Myositis and myasteniform syndrome related to pembrolizumab.

PMID: 34290006
Journal: BMJ case reports
Year: 2021
Reference: BMJ Case Rep. 2021 Jul 21;14(7). pii: 14/7/e241766. doi: 10.1136/bcr-2021-241766.
Impact factor:
Publication type: Letter or abstract
Authors: Montoro, Bruno; Ros, Javier; Ros, Javier; Sanchez-Sancho, Pablo; Selva-O'Callaghan, Albert; Trallero-Araguas, Ernesto et al.
DOI: 10.1136/bcr-2021-241766

Registry of patients and treatments of hospital medicines in Catalonia: 10 years of clinical data.

PMID: 31759696
Journal: MEDICINA CLINICA
Year: 2020
Reference: Med Clin (Barc). 2020 Mar 13;154(5):185-191. doi: 10.1016/j.medcli.2019.09.009. Epub 2019 Nov 20.
Impact factor:
Publication type: Paper in national publication
Authors: Gorgas Torner, Maria Queralt; Pontes Garcia, Caridad; Prat Casanovas, Maria Alba; Roig Izquierdo, Marta et al.
DOI: 10.1016/j.medcli.2019.09.009

Cost-effectiveness of myocardial perfusion SPECT and stress test according to coronary revascularization therapy, cardiac events and total mortality: Register of 8,496 patients.

PMID: 32273238
Journal: Revista Espanola de Medicina Nuclear e Imagen Molecular
Year: 2020
Reference: Rev Esp Med Nucl Imagen Mol. 2020 Jul - Aug;39(4):212-219. doi: 10.1016/j.remn.2020.01.006. Epub 2020 Apr 6.
Impact factor:
Publication type: Paper in national publication
Authors: Aguade-Bruix, S; Candell-Riera, J; Montoro-Ronsano, J B; Romero-Farina, G et al.
DOI: 10.1016/j.remn.2020.01.006

Ammonium tetrathiomolybdate in the decoppering phase treatment of Wilson's disease with neurological symptoms: A case series.

PMID: 32202078
Journal: Brain and Behavior
Year: 2020
Reference: Brain Behav. 2020 May;10(5):e01596. doi: 10.1002/brb3.1596. Epub 2020 Mar 22.
Impact factor:
Publication type: Paper in international publication
Authors: Auger, Cristina; Cardona, Ignasi; De Fabregues, Oriol; Palasi, Antoni; Quintana, Manuel; Vargas, Victor; Vinas, Jaume et al.
DOI: 10.1002/brb3.1596

An electronic alert system increases screening for hepatitis B and C and improves management of patients with haematological disorders.

PMID: 32080253
Journal: Scientific Reports
Year: 2020
Reference: Sci Rep. 2020 Feb 20;10(1):3038. doi: 10.1038/s41598-020-59476-4.
Impact factor:
Publication type: Paper in international publication
Authors: Abrisqueta, Pau; Bosch, Francesc; Buti, Maria; Carreras, Maria Jose; Esteban, Rafael; Farriols, Anna; Gubern, Paula; Riveiro-Barciela, Mar; Roade, Luisa et al.
DOI: 10.1038/s41598-020-59476-4

Survey of oncohematological pharmaceutical care situation in Spain.

PMID: 31705643
Journal: Farmacia hospitalaria : organo oficial de expresio
Year: 2019
Reference: Farm Hosp. 2019 Nov 1;43(6):194-201. doi: 10.7399/fh.11239.
Impact factor: 0
Publication type: Paper in international publication
Authors: Martinez-Bautista, Maria Jose, Mangues-Bafalluy, Irene, Cajaraville-Ordonana, Gerardo, Carreras-Soler, Maria Josep, Clopes-Estela, Ana, Moreno-Martinez, Estela et al.
DOI: 10.7399/fh.11239

Trastuzumab-related cardiotoxicity in the elderly: a role for cardiovascular risk factors.

PMID: 30624599
Journal: ANNALS OF ONCOLOGY
Year: 2019
Reference: Ann Oncol. 2019 Jul 1;30(7):1178. doi: 10.1093/annonc/mdy534.
Impact factor: 14.196
Publication type: Letter or abstract
Authors: Baselga, J, Serrano, C, Cortes, J, De Mattos-Arruda, L, Bellet, M, Gomez, P, Saura, C, Perez, J, Vidal, M, Munoz-Couselo, E et al.
DOI: 10.1093/annonc/mdy534

A phase I pharmacokinetic study of PM00104 (Zalypsis) administered as a 24-h intravenous infusion every 3 weeks in patients with advanced solid tumors.

PMID: 23455428
Journal: CANCER CHEMOTHERAPY AND PHARMACOLOGY
Year: 2013
Reference: Cancer Chemother Pharmacol. 2013 May;71(5):1247-54. doi: 10.1007/s00280-013-2119-8. Epub 2013 Mar 2.
Impact factor:
Publication type: Paper in international publication
Authors: Capdevila, J; Carreras, M J; Casado, E; Clive, S; Coronado, C; Cullell-Young, M; Fernandez Teruel, C; Kahatt, C; Michie, C; Piera, A et al.
DOI: 10.1007/s00280-013-2119-8

[Therapy adherence to immunomodulator treatment in patients with multiple sclerosis].

PMID: 23250676
Journal: Revista de neurologia
Year: 2013
Reference: Rev Neurol. 2013 Jan 1;56(1):8-12.
Impact factor:
Publication type: Paper in national publication
Authors: Cardona-Pascual, I; Gomez-Domingo, M R; Lopez-Mendez, P; Montalban, X; Perez-Ricart, A; Rio, J; Sastre-Garriga, J; Tintore, M et al.
DOI:

[Review of evidence of thalidomide and lenalidomide in different hematological diseases: chronic lymphocytic leukemia, primary amyloidosis, myelofibrosis and syndrome myelodysplastic].

PMID: 24010694
Journal: Farmacia hospitalaria : organo oficial de expresio
Year: 2013
Reference: Farm Hosp. 2013 Jul-Aug;37(4):322-34. doi: 10.7399/FH.2013.37.4.677.
Impact factor: 0
Publication type: Review in national publication
Authors: Jimenez Lozano, I, Juarez Jimenez, J C et al.
DOI: 10.7399/FH.2013.37.4.677

A phase I pharmacokinetic study of PM00104 (Zalypsis) administered as a 24-h intravenous infusion every 3 weeks in patients with advanced solid tumors.

PMID: 23455428
Journal: CANCER CHEMOTHERAPY AND PHARMACOLOGY
Year: 2013
Reference: Cancer Chemother Pharmacol. 2013 May;71(5):1247-54. doi: 10.1007/s00280-013-2119-8. Epub 2013 Mar 2.
Impact factor: 2.795
Publication type: Paper in international publication
Authors: Capdevila, J, Clive, S, Casado, E, Michie, C, Piera, A, Sicart, E, Carreras, M J, Coronado, C, Kahatt, C, Soto Matos-Pita, A et al.
DOI: 10.1007/s00280-013-2119-8

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Within the framework of a clinical trial, the first 3D printed medicine in Europe in the pediatric field will be tested.