Bioengineering, Cell Therapy and Surgery in Congenital Malformations

The research group is composed by clinical researchers (pediatric surgeons, traumatologists, neonatologists and obstetricians) and basic researchers (biochemists, biotechnologists and biologists). Our multidisciplinary team has an extensive expertise in the field of biomedical research and a strong translational spirit to the human clinic. The main objectives of our research are addressed to:

The study of the causes and pathophysiology of human congenital malformations.
The development of new treatments based on innovative surgical techniques, bioengineering and cell therapy focused on tissue regeneration and addressed to the treatment of these severe pathologies.

In addition, our research team has extensive experience in the field of regenerative medicine and nanomedicine especially focused on the development of new therapeutic strategies for the treatment of musculoskeletal and osteoarticular pathologies and we are currently participating in highly innovative projects both at national and international level.

Team

Laura Vidal Fornells

Predoctoral researcher
Bioengineering, Cell Therapy and Surgery in Congenital Malformations
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Montserrat Aguilera Pujabet

Bioengineering, Cell Therapy and Surgery in Congenital Malformations
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Pamela Dominguez Baez

Research technician
Bioengineering, Cell Therapy and Surgery in Congenital Malformations
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Abadias Cortada, Esther

Research technician
Bioengineering, Cell Therapy and Surgery in Congenital Malformations
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Ana Lain Fernandez

Bioengineering, Cell Therapy and Surgery in Congenital Malformations
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Anabel Sacristan Ruiz

Research technician
Bioengineering, Cell Therapy and Surgery in Congenital Malformations
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Laura Vidal Fornells

Predoctoral researcher
Bioengineering, Cell Therapy and Surgery in Congenital Malformations
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Montserrat Aguilera Pujabet

Bioengineering, Cell Therapy and Surgery in Congenital Malformations
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Pamela Dominguez Baez

Research technician
Bioengineering, Cell Therapy and Surgery in Congenital Malformations
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Abadias Cortada, Esther

Research technician
Bioengineering, Cell Therapy and Surgery in Congenital Malformations
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Ana Lain Fernandez

Bioengineering, Cell Therapy and Surgery in Congenital Malformations
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Anabel Sacristan Ruiz

Research technician
Bioengineering, Cell Therapy and Surgery in Congenital Malformations
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Projects

Desentrañando las vías protectoras de los SGLT2i y GLP-1RA en la enfermedad renal diabética: papel de las proteínas adaptadoras MAP17 y D-AKAP-2 en ratones db/db y organoides renales humanos.

IP: Maria Jose Soler Romeo
Collaborators: Mario Alonso Narvaez Barros, Pamela Dominguez Baez, Vergara Arana, Ander, Sheila Bermejo Garcia, Alejandra Planas Vilaseca, Concepció Jacobs Cachá, Juan Carlos León Román
Funding agency: Instituto de Salud Carlos III
Funding: 122210
Reference: PI21/01292
Duration: 01/01/2022 - 31/12/2024

Publications

Fetal abdominal cysts: Predicting adverse outcomes.

PMID: 37194337
Journal: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
Year: 2023
Reference: Acta Obstet Gynecol Scand. 2023 May 16. doi: 10.1111/aogs.14584.
Impact factor:
Publication type: Paper in international publication
Authors: Arevalo, Silvia; Carreras, Elena; Garcia-Aguilar, Paula; Garcia-Manau, Pablo; Guillen, Gabriela; Maiz, Nerea; Molino, Jose Andres; Rodo, Carlota et al.
DOI: 10.1111/aogs.14584

Antibody-drug conjugates, immune-checkpoint inhibitors, and their combination in advanced non-small cell lung cancer.

PMID: 37172552
Journal: Cancer treatment and research communications
Year: 2023
Reference: Cancer Treat Res Commun. 2023 Apr 28;36:100713. doi: 10.1016/j.ctarc.2023.100713.
Impact factor:
Publication type: Review in international publication
Authors: Berraondo, Maria; Chico, Isagani; Peiro, Sandra; Quintana, Angela; Ramkissoon, Shakti; Remon, Jordi; Saini, Kamal S; Salifu, Idoko; Salifu, Stephanie; Severson, Eric et al.
DOI: 10.1016/j.ctarc.2023.100713

Shoulder extension impairment with residual neonatal brachial plexus injury.

PMID: 37178959
Journal: JOURNAL OF SHOULDER AND ELBOW SURGERY
Year: 2023
Reference: J Shoulder Elbow Surg. 2023 May 11:S1058-2746(23)00368-3. doi: 10.1016/j.jse.2023.03.036.
Impact factor:
Publication type: Paper in international publication
Authors: Blasco-Casado, Ferran; Dragos, Hutanu; Gonzalez-Morgado, Diego; Jambrina-Abasolo, Unai; Rojas-Neira, Juliana; Soldado, Francisco et al.
DOI: 10.1016/j.jse.2023.03.036

Intestinal perforation after pediatric liver transplantation: risk factors and management.

PMID: 37093116
Journal: Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica
Year: 2023
Reference: Cir Pediatr. 2023 Apr 1;36(2):73-77. doi: 10.54847/cp.2023.02.14.
Impact factor:
Publication type: Paper in national publication
Authors: Barila, P; Bilbao, I; Charco, R; Hidalgo, E; Juamperez, J; Mercadal-Hally, M; Molino, J A; Ortega, J; Quintero, J et al.
DOI: 10.54847/cp.2023.02.14

Page kidney after pediatric kidney transplantation: a case report.

PMID: 35485759
Journal: Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica
Year: 2022
Reference: Cir Pediatr. 2022 Apr 1;35(2):94-98. doi: 10.54847/cp.2022.02.19.
Impact factor: 0
Publication type: Letter or abstract
Authors: Gander, R, Asensio, M, Royo, G F, Lopez, M, Coma, A, Munoz, M, Cruz, A, Rios, H, Ariceta, G, Molino, J A et al.
DOI: 10.54847/cp.2022.02.19

Minimally invasive surgery for pediatric dumbbell neuroblastoma: systematic literature review and report of a single-stage neurosurgical and thoracoscopic approach.

PMID: 34718957
Journal: Clinical & Translational Oncology
Year: 2022
Reference: Clin Transl Oncol. 2022 May;24(5):950-957. doi: 10.1007/s12094-021-02724-4. Epub 2021 Oct 30.
Impact factor: 3.405
Publication type: Review in international publication
Authors: Guillen, G, Hladun, R, Martos, M, Cano, P, Molino, J A, Lopez-Fernandez, S, Lopez, M et al.
DOI: 10.1007/s12094-021-02724-4

Elevated Serum Triglyceride Levels in Acute Pancreatitis: A Parameter to be Measured and Considered Early.

PMID: 35355100
Journal: WORLD JOURNAL OF SURGERY
Year: 2022
Reference: World J Surg. 2022 Jul;46(7):1758-1767. doi: 10.1007/s00268-022-06533-w. Epub 2022 Mar 30.
Impact factor: 3.352
Publication type: Paper in international publication
Authors: Charco, Ramon, Balsells, Joaquim, Molero, Xavier, Tasayco, Stephanie, Blanco, Laia, Hidalgo, Nils Jimmy, Pando, Elizabeth, Alberti, Piero, Vidal, Laura, Mata, Rodrigo et al.
DOI: 10.1007/s00268-022-06533-w

Pediatric laparoscopic mitrofanoff procedure- preliminary results of a simplified technique.

PMID: 35063366
Journal: Journal of Pediatric Urology
Year: 2022
Reference: J Pediatr Urol. 2022 Apr;18(2):112.e1-112.e7. doi: 10.1016/j.jpurol.2021.12.018. Epub 2022 Jan 7.
Impact factor: 1.83
Publication type: Review in international publication
Authors: Gander, Romy, Asensio, Marino, Royo, Gloria Fatou, Lopez, Manuel et al.
DOI: 10.1016/j.jpurol.2021.12.018

Muscle Precursor Cells Enhance Functional Muscle Recovery and Show Synergistic Effects With Postinjury Treadmill Exercise in a Muscle Injury Model in Rats.

PMID: 33719605
Journal: AMERICAN JOURNAL OF SPORTS MEDICINE
Year: 2021
Reference: Am J Sports Med. 2021 Mar;49(4):1073-1085. doi: 10.1177/0363546521989235.
Impact factor: 6.203
Publication type: Paper in international publication
Authors: Contreras-Munoz, Paola, Torrella, Joan Ramon, Venegas, Vanessa, Serres, Xavier, Vidal, Laura, Vila, Ingrid, Lahtinen, Ilmari, Martinez-Ibanez, Vicente, Peiro, Jose Luis, Jarvinen, Tero A H et al.
DOI: 10.1177/0363546521989235

Analysis of skull bone thickness during growth: an anatomical guide for safe pin placement in halo fixation.

PMID: 32248506
Journal: EUROPEAN SPINE JOURNAL
Year: 2021
Reference: Eur Spine J. 2021 Feb;30(2):410-415. doi: 10.1007/s00586-020-06367-x. Epub 2020 Apr 4.
Impact factor: 3.134
Publication type: Paper in international publication
Authors: Pedro, Domenech-Fernandez, Junichi, Yamane, Julio, Domenech, Carlos, Barrios, Francisco, Soldado-Carrera, Jorge, Knorr, Federico, Canavese et al.
DOI: 10.1007/s00586-020-06367-x

Prescription quality of prolonged antibiotherapy in pediatrics. Impact of ASP program interventions.

PMID: 32229130
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2021
Reference: Enferm Infecc Microbiol Clin. 2021 Mar;39(3):134-138. doi: 10.1016/j.eimc.2020.02.015. Epub 2020 Mar 27.
Impact factor: 1.731
Publication type: Paper in national publication
Authors: Melendo, Susana, Fernandez-Polo, Aurora, Castellnou Asens, Ivette, Mendoza-Palomar, Natalia, Barnes-Mayolas, Meritxell, Soler-Palacin, Pere, Soler Palacin, Pere, Melendo Perez, Susana, Mendoza Palomar, Natalia, Nieves Larrosa Escartin, M et al.
DOI: 10.1016/j.eimc.2020.02.015

Arthroscopic Calcaneonavicular Coalition and Too-long Anterior Process of the Calcaneus Resection in Children.

PMID: 33461922
Journal: Journal of Foot & Ankle Surgery
Year: 2021
Reference: J Foot Ankle Surg. 2021 Mar-Apr;60(2):228-232. doi: 10.1053/j.jfas.2019.03.020. Epub 2021 Jan 16.
Impact factor: 1.286
Publication type: Paper in international publication
Authors: Knorr, Jorge, Diaz-Gallardo, Paula, Soldado, Francisco, Domenech, Pedro, Torres-Perez, Ana, Sales de Gauzy, Jerome, Bergua-Domingo, Josep Maria et al.
DOI: 10.1053/j.jfas.2019.03.020

Modelling the skeletal muscle injury recovery using in vivo contrast-enhanced micro-CT: a proof-of-concept study in a rat model.

PMID: 32488324
Journal: European radiology experimental
Year: 2020
Reference: Eur Radiol Exp. 2020 Jun 3;4(1):33. doi: 10.1186/s41747-020-00163-4.
Impact factor: 0
Publication type: Paper in international publication
Authors: Paun, Bruno, Leon, Daniel Garcia, Cabello, Alex Claveria, Pages, Roso Mares, de la Calle Vargas, Elena, Munoz, Paola Contreras, Garcia, Vanessa Venegas, Castell-Conesa, Joan, Baleriola, Mario Marotta, Camacho, Jose Raul Herance et al.
DOI: 10.1186/s41747-020-00163-4

Treatment of balanitis xerotica obliterans in pediatric patients.

PMID: 32250071
Journal: Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica
Year: 2020
Reference: Cir Pediatr. 2020 Apr 1;33(2):79-83.
Impact factor: 0
Publication type: Paper in national publication
Authors: Leganes Villanueva, C, Gander, R, Royo Gomes, G, Ezzeddine Ezzeddine, M, Lopez Paredes, M, Asensio Llorente, M et al.
DOI:

Outcomes after Split Abdominal Wall Muscle Flap Repair for Large Congenital Diaphragmatic Hernias.

PMID: 31022755
Journal: EUROPEAN JOURNAL OF PEDIATRIC SURGERY
Year: 2020
Reference: Eur J Pediatr Surg. 2020 Apr;30(2):210-214. doi: 10.1055/s-0039-1687867. Epub 2019 Apr 25.
Impact factor: 1.703
Publication type: Paper in international publication
Authors: Molino, Jose A, Garcia Martinez, Laura, Guillen Burrieza, Gabriela, Peiro Ibanez, Jose Luis, Lopez-Fernandez, Sergio, Lain, Ana, Ruiz Campillo, Cesar, Lloret Roca, Josep, Lopez, Manuel et al.
DOI: 10.1055/s-0039-1687867

Laparoscopic Extravesical Ureteral Reimplantation for Correction of Primary and Secondary Megaureters: Preliminary Report of a New Simplified Technique.

PMID: 31326110
Journal: JOURNAL OF PEDIATRIC SURGERY
Year: 2020
Reference: J Pediatr Surg. 2020 Mar;55(3):564-569. doi: 10.1016/j.jpedsurg.2019.05.028. Epub 2019 Jul 5.
Impact factor: 1.919
Publication type: Paper in international publication
Authors: Gander, Romy, Asensio, Marino, Royo, Gloria Fatou, Lopez, Manuel et al.
DOI: 10.1016/j.jpedsurg.2019.05.028

[Pilot experience with indocyanine green navigation in pediatric surgery].

PMID: 31486303
Journal: Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica
Year: 2019
Reference: Cir Pediatr. 2019 Jul 29;32(3):121-127.
Impact factor: 0
Publication type: Paper in national publication
Authors: Lopez-Fernandez, S, Molino, J A, Bueno, J, Lopez, M, Guillen, G et al.
DOI:

Outcome of kidney transplantation from young pediatric donors (aged less than 6 years) to young size-matched recipients.

PMID: 31005637
Journal: Journal of Pediatric Urology
Year: 2019
Reference: J Pediatr Urol. 2019 May;15(3):213-220. doi: 10.1016/j.jpurol.2019.03.015. Epub 2019 Mar 28.
Impact factor: 1.736
Publication type: Review in international publication
Authors: Gander, R, Asensio, M, Molino, J A, Lara, L E, Lopez, M, Lopez, M, Ariceta, G, Royo, G F et al.
DOI: 10.1016/j.jpurol.2019.03.015

Maternal anaesthesia in open and fetoscopic surgery of foetal open spinal neural tube defects: A 6-year observational study.

PMID: 30507621
Journal: EUROPEAN JOURNAL OF ANAESTHESIOLOGY
Year: 2019
Reference: Eur J Anaesthesiol. 2019 Mar;36(3):175-184. doi: 10.1097/EJA.0000000000000930.
Impact factor: 4.14
Publication type: Paper in international publication
Authors: Manrique, Susana, Maiz, Nerea, Garcia, Irene, Pascual, Montserrat, Perera, Remei, Arevalo, Silvia, Gine, Carles, Molino, Jose Andres, Lopez, Manuel, Blanco, Domingo et al.
DOI: 10.1097/EJA.0000000000000930

"Non-Touch" Vena Cava Technique as an Improvement in Combined Lung and Liver Procurement in Controlled Donation After Circulatory Death.

PMID: 30655141
Journal: TRANSPLANTATION PROCEEDINGS
Year: 2019
Reference: Transplant Proc. 2019 Jan - Feb;51(1):9-11. doi: 10.1016/j.transproceed.2018.02.216. Epub 2019 Jan 14.
Impact factor: 0.959
Publication type: Paper in international publication
Authors: Sole, J, Caralt, M, Bello, I, Sandiumenge, A, Dopazo, C, Pando, E, Molino, J A, Lazaro, J L, Bilbao, I, Pont, T et al.
DOI: 10.1016/j.transproceed.2018.02.216

Management of neonates with right-sided aortic arch and esophageal atresia: International survey on IPEG AND ESPES members experience.

PMID: 29241961
Journal: JOURNAL OF PEDIATRIC SURGERY
Year: 2018
Reference: J Pediatr Surg. 2018 Oct;53(10):1923-1927. doi: 10.1016/j.jpedsurg.2017.11.051. Epub 2017 Nov 23.
Impact factor: 2.128
Publication type: Review in national publication
Authors: Aguilera-Pujabet, Monserrat, Gahete, Jose Andres Molino, Guillen, Gabriela, Lopez-Fernandez, Sergio, Martin-Gimenez, Marta Patricia, Lloret, Josep, Lopez, Manuel et al.
DOI: 10.1016/j.jpedsurg.2017.11.051

Measured dynamic compression for pectus carinatum: A systematic review.

PMID: 30078489
Journal: Seminars in Pediatric Surgery
Year: 2018
Reference: Semin Pediatr Surg. 2018 Jun;27(3):175-182. doi: 10.1053/j.sempedsurg.2018.06.001. Epub 2018 Jun 15.
Impact factor: 1.645
Publication type: Paper in international publication
Authors: de Beer, Sjoerd A, Blom, Yael E, Lopez, Manuel, de Jong, Justin R et al.
DOI: 10.1053/j.sempedsurg.2018.06.001

Fetoscopic Two-Layers Closure of Open Neural Tube Defects.

PMID: 29876992
Journal: ULTRASOUND IN OBSTETRICS & GYNECOLOGY
Year: 2018
Reference: Ultrasound Obstet Gynecol. 2018 Oct;52(4):452-457. doi: 10.1002/uog.19104. Epub 2018 Sep 10.
Impact factor: 5.654
Publication type: Paper in international publication
Authors: Gine, C, Arevalo, S, Maiz, N, Rodo, C, Manrique, S, Poca, A, Molino, J A, Carreras, E, Lopez, M et al.
DOI: 10.1002/uog.19104

Role of Biodegradable Stents as Part of Treatment of Biliary Strictures after Pediatric and Adult Liver Transplantation: An Observational Single-Center Study.

PMID: 29798761
Journal: JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
Year: 2018
Reference: J Vasc Interv Radiol. 2018 Jun;29(6):899-904. doi: 10.1016/j.jvir.2018.02.007.
Impact factor: 2.758
Publication type: Paper in international publication
Authors: Dopazo, Cristina, Diez, Iratxe, Quintero, Jesus, Curell, Anna, Gonzalez-Junyent, Carla, Caralt, Mireia, Pando, Elizabeth, Lazaro, Jose Luis, Molino, Jose Andres, Juamperez, Javier et al.
DOI: 10.1016/j.jvir.2018.02.007

Isolation, characterization, and differentiation of multipotent neural progenitor cells from human cerebrospinal fluid in fetal cystic myelomeningocele.

PMID: 28578005
Journal: Stem Cell Research
Year: 2017
Reference: Stem Cell Res. 2017 Jul;22:33-42. doi: 10.1016/j.scr.2017.05.003. Epub 2017 May 15.
Impact factor: 3.494
Publication type: Paper in international publication
Authors: Belfort, Michael A, Pelizzo, Gloria, Peiro, Jose L, Carreras, Elena, Martinez-Ibanez, Vicente, Gine, Carles, Fontecha, Cesar G, Marotta, Mario, Fernandez-Martin, Alejandra, Oria, Marc et al.
DOI: 10.1016/j.scr.2017.05.003

Kidney transplantation in children weighing 15 kg or less is challenging but associated with good outcome.

PMID: 28359777
Journal: Journal of Pediatric Urology
Year: 2017
Reference: J Pediatr Urol. 2017 Jun;13(3):279.e1-279.e7. doi: 10.1016/j.jpurol.2017.02.025. Epub 2017 Mar 18.
Impact factor: 1.611
Publication type: Editorail in international publication
Authors: Gander, Romy, Asensio, Marino, Royo, Gloria Fatou, Molino, Jose Andres, Ariceta, Gema, Lara, Luis Enrique, Lloret, Josep et al.
DOI: 10.1016/j.jpurol.2017.02.025

Thoracic wall reconstruction with bioabsorbable plates in pediatric malignant thoracic wall tumors.

PMID: 27653461
Journal: JOURNAL OF PEDIATRIC SURGERY
Year: 2017
Reference: J Pediatr Surg. 2017 Mar;52(3):377-381. doi: 10.1016/j.jpedsurg.2016.08.018. Epub 2016 Aug 31.
Impact factor: 1.976
Publication type: Paper in international publication
Authors: Guillen, G, Garcia, L, Marhuenda, C, Pellise, F, Molino, J A, Fontecha, C G, Lopez, S, Lloret, J et al.
DOI: 10.1016/j.jpedsurg.2016.08.018

Treatment of Post-Transplant Lymphocele in Children.

PMID: 28132852
Journal: UROLOGY
Year: 2017
Reference: Urology. 2017 May;103:218-223. doi: 10.1016/j.urology.2016.12.039. Epub 2017 Jan 26.
Impact factor: 2.309
Publication type: Paper in international publication
Authors: Ariceta, Gema, Perez, Mercedes, Coma, Ana, Vilalta, Ramon, Molino, Jose Andres, Gander, Romy, Asensio, Marino, Royo, Gloria Fatou et al.
DOI: 10.1016/j.urology.2016.12.039

[Current anesthesia risk of anterior mediastinal masses].

PMID: 28481065
Journal: Cirugia pediatrica : organo oficial de la Sociedad
Year: 2016
Reference: Cir Pediatr. 2016 Oct 10;29(4):142-148.
Impact factor: 0
Publication type: Paper in national publication
Authors: Aguilera-Pujabet, M, Guillen, G, Montferrer, N, Lopez-Fernandez, S, Molino, J A, Lloret, J et al.
DOI:

[Vascular interventional radiology: a fundamental procedure for the management of paediatric trauma].

PMID: 27911067
Journal: Cirugia pediatrica : organo oficial de la Sociedad
Year: 2016
Reference: Cir Pediatr. 2016 Jan 25;29(1):25-30.
Impact factor: 0
Publication type: Paper in national publication
Authors: Bordon Cabrera, E, Lain, A, Gander, R, Perez Lafuente, M, Diez Miranda, I, Fontecha, C G, Seidler, L, Delgado, I, Canadas Palazon, S, Lloret, J et al.
DOI:

[Congenital portosistemic shunt. Importance of early treatment].

PMID: 27775284
Journal: Cirugia pediatrica : organo oficial de la Sociedad
Year: 2016
Reference: Cir Pediatr. 2016 Jan 15;28(2):67-73.
Impact factor: 0
Publication type: Paper in national publication
Authors: Perez, M, Gander, R, Segarra, A, Leganes, C, Bueno, J, Vicente, N et al.
DOI:

The quantitative lung index and the prediction of survival in fetuses with congenital diaphragmatic hernia.

PMID: 26871273
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology
Year: 2016
Reference: Eur J Obstet Gynecol Reprod Biol. 2016 Mar;198:145-8. doi: 10.1016/j.ejogrb.2016.01.011. Epub 2016 Jan 11.
Impact factor: 1.662
Publication type: Paper in international publication
Authors: Illescas, Tamara, Rodo, Carlota, Arevalo, Silvia, Gine, Carles, Peiro, Jose L, Carreras, Elena et al.
DOI: 10.1016/j.ejogrb.2016.01.011

Logistics and Strategy of Multiorgan Procurement Involving Total Face Allograft.

PMID: 21443675
Journal: AMERICAN JOURNAL OF TRANSPLANTATION
Year: 2011
Reference: Am J Transplant. 2011 May;11(5):1091-7. doi: 10.1111/j.1600-6143.2011.03489.x. Epub 2011 Mar 28.
Impact factor: 6.048
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1111/j.1600-6143.2011.03489.x

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