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Bioengineering, Cell Therapy and Surgery in Congenital Malformations

The research group is composed by clinical researchers (pediatric surgeons, traumatologists, neonatologists and obstetricians) and basic researchers (biochemists, biotechnologists and biologists). Our multidisciplinary team has an extensive expertise in the field of biomedical research and a strong translational spirit to the human clinic. The main objectives of our research are addressed to:

  • The study of the causes and pathophysiology of human congenital malformations.
  • The development of new treatments based on innovative surgical techniques, bioengineering and cell therapy focused on tissue regeneration and addressed to the treatment of these severe pathologies.

In addition, our research team has extensive experience in the field of regenerative medicine and nanomedicine especially focused on the development of new therapeutic strategies for the treatment of musculoskeletal and osteoarticular pathologies and we are currently participating in highly innovative projects both at national and international level.

Team

Sergio Lopez Fernandez

Sergio Lopez Fernandez

Predoctoral researcher
Bioengineering, Cell Therapy and Surgery in Congenital Malformations
Read more
Sergio Lopez Fernandez

Sergio Lopez Fernandez

Predoctoral researcher
Bioengineering, Cell Therapy and Surgery in Congenital Malformations
Read more

Publications

Duodenal atresia with apple peel associated with congenital diaphragmatic hernia: an exceptional case and a literature review.

PMID: 35037438
Journal: Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica
Year: 2022
Reference: Cir Pediatr. 2022 Jan 1;35(1):31-35. doi: 10.54847/cp.2022.01.16.
Impact factor:
Publication type: Letter or abstract
Authors: Boix, H; Guillen, G; Lopez Fernandez, S; Lopez, M; Molino Gahete, J A; Oliver, B; Rocha, O et al.
DOI: 10.54847/cp.2022.01.16

Percutaneous or Endoscopic Treatment of Peripheral Bile Duct Leaks: Initial Experience with an Innovative Approach of Microcatheter-Delivered Argon Plasma Coagulation.

PMID: 35037087
Journal: CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
Year: 2022
Reference: Cardiovasc Intervent Radiol. 2022 Mar;45(3):365-370. doi: 10.1007/s00270-021-03016-8. Epub 2022 Jan 17.
Impact factor:
Publication type: Paper in international publication
Authors: Armengol Bertroli, Jordi; Armengol Miro, Josep Ramon; Bueno Recio, Francisco Javier; Camacho Oviedo, John Alexander; Diez Miranda, Iratxe; Dot Bach, Joan; Gramegna, Laura Ludovica; Molino Gahete, Jose Andres; Perez Lafuente, Mercedes; Tomasello, Alejandro et al.
DOI: 10.1007/s00270-021-03016-8

Delayed sequential abdominal wall closure in pediatric liver transplantation to overcome "large for size" scenarios.

PMID: 34472687
Journal: PEDIATRIC TRANSPLANTATION
Year: 2022
Reference: Pediatr Transplant. 2022 Feb;26(1):e14132. doi: 10.1111/petr.14132. Epub 2021 Sep 2.
Impact factor:
Publication type: Paper in international publication
Authors: Bilbao, Itxarone; Caralt, Mireia; Charco, Ramon; Coma, Ana; Dopazo, Cristina; Gomez-Gavara, Concepcion; Hidalgo, Ernest; Juamperez, Javier; Mercadal-Hally, Maria; Molino, Jose Andres et al.
DOI: 10.1111/petr.14132

Perinatal palliative care.

PMID: 34998731
Journal: ANALES DE PEDIATRIA
Year: 2022
Reference: An Pediatr (Engl Ed). 2022 Jan;96(1):60.e1-60.e7. doi: 10.1016/j.anpede.2021.10.003. Epub 2022 Jan 5.
Impact factor:
Publication type: Paper in international publication
Authors: Boix, Hector; Cernada, Maria; Couce, Maria Luz; Espinosa Fernandez, Maria Gracia; Gonzalez-Pacheco, Noelia; Martin-Ancel, Ana; Perez-Munuzuri, Alejandro; Sanchez-Redondo, Maria Dolores et al.
DOI: 10.1016/j.anpede.2021.10.003

Anastomosis near to the ileocecal valve in neonates with focal intestinal perforation, is it safe.

PMID: 34096446
Journal: Journal of Maternal-Fetal & Neonatal Medicine
Year: 2021
Reference: J Matern Fetal Neonatal Med. 2021 Jun 6:1-4. doi: 10.1080/14767058.2021.1934444.
Impact factor: 2.398
Publication type: Paper in international publication
Authors: Martos Rodriguez, Marta, Guillen, Gabriela, Lopez-Fernandez, Sergio, Martin Gimenez, Marta, Ruiz, Cesar W, Ribes, Carmen, Lopez, Manuel, Molino, Jose Andres et al.
DOI: 10.1080/14767058.2021.1934444

Transesophageal echocardiography during pectus excavatum correction in children: What happens to the heart?

PMID: 32660778
Journal: JOURNAL OF PEDIATRIC SURGERY
Year: 2021
Reference: J Pediatr Surg. 2021 May;56(5):988-994. doi: 10.1016/j.jpedsurg.2020.06.009. Epub 2020 Jun 12.
Impact factor: 2.545
Publication type: Paper in international publication
Authors: Gine, Carlos, Garcia Martinez, Laura, Villaverde, Ivan, Lopez, Manuel, Giralt, Gemma, Lain, Ana et al.
DOI: 10.1016/j.jpedsurg.2020.06.009

Muscle Precursor Cells Enhance Functional Muscle Recovery and Show Synergistic Effects With Postinjury Treadmill Exercise in a Muscle Injury Model in Rats.

PMID: 33719605
Journal: AMERICAN JOURNAL OF SPORTS MEDICINE
Year: 2021
Reference: Am J Sports Med. 2021 Mar;49(4):1073-1085. doi: 10.1177/0363546521989235.
Impact factor: 6.203
Publication type: Paper in international publication
Authors: Contreras-Munoz, Paola, Torrella, Joan Ramon, Venegas, Vanessa, Serres, Xavier, Vidal, Laura, Vila, Ingrid, Lahtinen, Ilmari, Martinez-Ibanez, Vicente, Peiro, Jose Luis, Jarvinen, Tero A H et al.
DOI: 10.1177/0363546521989235

Analysis of skull bone thickness during growth: an anatomical guide for safe pin placement in halo fixation.

PMID: 32248506
Journal: EUROPEAN SPINE JOURNAL
Year: 2021
Reference: Eur Spine J. 2021 Feb;30(2):410-415. doi: 10.1007/s00586-020-06367-x. Epub 2020 Apr 4.
Impact factor: 3.134
Publication type: Paper in international publication
Authors: Pedro, Domenech-Fernandez, Junichi, Yamane, Julio, Domenech, Carlos, Barrios, Francisco, Soldado-Carrera, Jorge, Knorr, Federico, Canavese et al.
DOI: 10.1007/s00586-020-06367-x

Less Invasive Surfactant Administration in Spain: A Survey Regarding Its Practice, the Target Population, and Premedication Use.

PMID: 30716788
Journal: AMERICAN JOURNAL OF PERINATOLOGY
Year: 2020
Reference: Am J Perinatol. 2020 Feb;37(3):277-280. doi: 10.1055/s-0039-1678534. Epub 2019 Feb 4.
Impact factor:
Publication type: Paper in international publication
Authors: Boix, Hector; Camba, Fatima; Castillo, Felix; Comunas, Juan Jose; Fernandez, Cristina et al.
DOI: 10.1055/s-0039-1678534

Endoscopic variceal ligation as primary prophylaxis for upper GI bleeding in children.

PMID: 32119939
Journal: GASTROINTESTINAL ENDOSCOPY
Year: 2020
Reference: Gastrointest Endosc. 2020 Aug;92(2):269-275. doi: 10.1016/j.gie.2020.02.035. Epub 2020 Feb 29.
Impact factor:
Publication type: Paper in international publication
Authors: Abu-Suboh, Monder; Armengol, Josep Ramon; Bernabeu, Jesus Quintero; Charco, Ramon; Dot, Joan; Juamperez, Javier; King, Mauricio Larrarte; Mercadal-Hally, Maria; Molino, Jose A; Montferrer, Nuria et al.
DOI: 10.1016/j.gie.2020.02.035

Radiological and surgical differences between congenital end-to-side (Abernethy malformation) and side-to-side portocaval shunts.

PMID: 32067808
Journal: JOURNAL OF PEDIATRIC SURGERY
Year: 2020
Reference: J Pediatr Surg. 2020 Sep;55(9):1897-1902. doi: 10.1016/j.jpedsurg.2020.01.053. Epub 2020 Feb 1.
Impact factor:
Publication type: Paper in international publication
Authors: Bueno, Javier; Diez, Iratxe; Guillen, Gabriela; Lopez, Manuel; Lopez, Sergio; Lopez-Ben, Santiago; Molino, Jose A; Perez, Mercedes; Venturi, Carla et al.
DOI: 10.1016/j.jpedsurg.2020.01.053

Congenital extrahepatic portosystemic shunts (Abernethy malformation): An international observational study.

PMID: 31211875
Journal: HEPATOLOGY
Year: 2020
Reference: Hepatology. 2020 Feb;71(2):658-669. doi: 10.1002/hep.30817. Epub 2019 Aug 19.
Impact factor:
Publication type: Paper in international publication
Authors: Ahmed, Munawwar; Alvarez-Navascues, Carmen; Arulkumar, S; Baiges, Anna; Belmonte, Ernest; Bueno, Javier; Carrilho Flair, Jose; Coenen, Sandra; Darnell, Anna; De Gottardi, Andrea et al.
DOI: 10.1002/hep.30817

Total Hip Arthroplasty or Hemiarthroplasty for Hip Fracture.

PMID: 31557429
Journal: NEW ENGLAND JOURNAL OF MEDICINE
Year: 2019
Reference: N Engl J Med. 2019 Dec 5;381(23):2199-2208. doi: 10.1056/NEJMoa1906190. Epub 2019 Sep 26.
Impact factor: 70.67
Publication type: Paper in international publication
Authors: Heels-Ansdell, Diane, Thabane, Lehana, Walter, Stephen D, Devereaux, P J, HEALTH investigators, Guerra Farfan, Ernesto Melchor, Teixidor Serra, Jordi, Tomás Hernández, Jordi, Molero García, Vicent, Selga Marsà, Jordi et al.
DOI: 10.1056/NEJMoa1906190

[Pilot experience with indocyanine green navigation in pediatric surgery].

PMID: 31486303
Journal: Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica
Year: 2019
Reference: Cir Pediatr. 2019 Jul 29;32(3):121-127.
Impact factor: 0
Publication type: Paper in national publication
Authors: Lopez-Fernandez, S, Molino, J A, Bueno, J, Lopez, M, Guillen, G et al.
DOI:

Outcome of kidney transplantation from young pediatric donors (aged less than 6 years) to young size-matched recipients.

PMID: 31005637
Journal: Journal of Pediatric Urology
Year: 2019
Reference: J Pediatr Urol. 2019 May;15(3):213-220. doi: 10.1016/j.jpurol.2019.03.015. Epub 2019 Mar 28.
Impact factor: 1.736
Publication type: Review in international publication
Authors: Gander, R, Asensio, M, Molino, J A, Lara, L E, Lopez, M, Lopez, M, Ariceta, G, Royo, G F et al.
DOI: 10.1016/j.jpurol.2019.03.015

Maternal anaesthesia in open and fetoscopic surgery of foetal open spinal neural tube defects: A 6-year observational study.

PMID: 30507621
Journal: EUROPEAN JOURNAL OF ANAESTHESIOLOGY
Year: 2019
Reference: Eur J Anaesthesiol. 2019 Mar;36(3):175-184. doi: 10.1097/EJA.0000000000000930.
Impact factor: 4.14
Publication type: Paper in international publication
Authors: Manrique, Susana, Maiz, Nerea, Garcia, Irene, Pascual, Montserrat, Perera, Remei, Arevalo, Silvia, Gine, Carles, Molino, Jose Andres, Lopez, Manuel, Blanco, Domingo et al.
DOI: 10.1097/EJA.0000000000000930

Duodenal lengthening in an adult with ultra-short bowel syndrome. A case report.

PMID: 29106286
Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
Year: 2018
Reference: Rev Esp Enferm Dig. 2018 Jan;110(1):59-62. doi: 10.17235/reed.2017.5187/2017.
Impact factor:
Publication type: Paper in international publication
Authors: Balsells, Joaquin; Bueno, Javier; Burgos, Rosa; Lopez, Manuel; Redecillas, Susana et al.
DOI: 10.17235/reed.2017.5187/2017

Successful long-term outcome of pediatric liver-kidney transplantation: a single-center study.

PMID: 28842757
Journal: PEDIATRIC NEPHROLOGY
Year: 2018
Reference: Pediatr Nephrol. 2018 Feb;33(2):351-358. doi: 10.1007/s00467-017-3782-5. Epub 2017 Aug 25.
Impact factor:
Publication type: Paper in international publication
Authors: Ariceta, Gema; Asensio, Marino; Bilbao, Itxarone; Charco, Ramon; Juamperez, Javier; Molino, Jose A; Munoz, Marina; Quintero Bernabeu, Jesus; Rodrigo, Carlos; Rodriguez, Olalla et al.
DOI: 10.1007/s00467-017-3782-5

Acute periprosthetic joint infection due to Fusobacterium nucleatum in a non-immunocompromised patient. Failure using a Debridement, Antibiotics + Implant retention approach.

PMID: 29307651
Journal: ANAEROBE
Year: 2018
Reference: Anaerobe. 2018 Feb;49:116-120. doi: 10.1016/j.anaerobe.2017.12.010. Epub 2018 Jan 5.
Impact factor:
Publication type: Paper in international publication
Authors: Amat, Carles; Carrera, Luis; Corona, Pablo S; Lung, Mayli; Pigrau, Carles; Rodriguez-Pardo, Dolors; Soldado, Francisco et al.
DOI: 10.1016/j.anaerobe.2017.12.010

Conversion from twice-daily to once-daily tacrolimus formulation in pediatric liver transplant recipients.

PMID: 28833714
Journal: TRANSPLANT INTERNATIONAL
Year: 2018
Reference: Transpl Int. 2018 Jan;31(1):38-44. doi: 10.1111/tri.13037. Epub 2017 Sep 27.
Impact factor:
Publication type: Paper in international publication
Authors: Bilbao, Itxarone; Castells, Lluis; Charco, Ramon; Juamperez, Javier; Molino, Jose A; Ortega, Juan; Quintero, Jesus; Rodrigo, Carlos et al.
DOI: 10.1111/tri.13037

New Methods for Imaging Evaluation of Chest Wall Deformities.

PMID: 29255700
Journal: Frontiers in Pediatrics
Year: 2017
Reference: Front Pediatr. 2017 Dec 4;5:257. doi: 10.3389/fped.2017.00257. eCollection 2017.
Impact factor: 2.172
Publication type: Paper in international publication
Authors: Lain, Ana, Garcia, Laura, Gine, Carlos, Tiffet, Olivier, Lopez, Manuel et al.
DOI: 10.3389/fped.2017.00257

Tethered cord in patients affected by anorectal malformations: a survey from the ARM-Net Consortium.

PMID: 28674920
Journal: PEDIATRIC SURGERY INTERNATIONAL
Year: 2017
Reference: Pediatr Surg Int. 2017 Aug;33(8):849-854. doi: 10.1007/s00383-017-4105-4. Epub 2017 Jul 3.
Impact factor: 1.181
Publication type: Paper in international publication
Authors: Miserez, Marc, Midrio, P, Aminoff, Dalia, Bagolan, Piero, De Blaauw, Ivo, Deluggi, Stefan, Fanjul, Maria, Fascetti Leon, Francesco, Garcia, Araceli, Gine, Carles et al.
DOI: 10.1007/s00383-017-4105-4

Laparoscopic-Assisted Extravesical Ureteral Reimplantation and Extracorporeal Ureteral Tapering Repair for Primary Obstructive Megaureter in Children.

PMID: 28594594
Journal: Journal of Laparoendoscopic & Advanced Surgical Techniques
Year: 2017
Reference: J Laparoendosc Adv Surg Tech A. 2017 Aug;27(8):851-857. doi: 10.1089/lap.2016.0456. Epub 2017 Jun 8.
Impact factor: 1.255
Publication type: Paper in international publication
Authors: Lopez, Manuel, Gander, Romy, Royo, Gloria, Varlet, Francois, Asensio, Marino et al.
DOI: 10.1089/lap.2016.0456

Isolation, characterization, and differentiation of multipotent neural progenitor cells from human cerebrospinal fluid in fetal cystic myelomeningocele.

PMID: 28578005
Journal: Stem Cell Research
Year: 2017
Reference: Stem Cell Res. 2017 Jul;22:33-42. doi: 10.1016/j.scr.2017.05.003. Epub 2017 May 15.
Impact factor: 3.494
Publication type: Paper in international publication
Authors: Belfort, Michael A, Pelizzo, Gloria, Peiro, Jose L, Carreras, Elena, Martinez-Ibanez, Vicente, Gine, Carles, Fontecha, Cesar G, Marotta, Mario, Fernandez-Martin, Alejandra, Oria, Marc et al.
DOI: 10.1016/j.scr.2017.05.003

Prematurity and fetal lung response after tracheal occlusion in fetuses with severe congenital diaphragmatic hernia.

PMID: 26633729
Journal: Journal of Maternal-Fetal & Neonatal Medicine
Year: 2016
Reference: J Matern Fetal Neonatal Med. 2016 Sep;29(18):3030-4. doi: 10.3109/14767058.2015.1114080. Epub 2015 Dec 2.
Impact factor:
Publication type: Paper in international publication
Authors: Britto, Ingrid Schwach Werneck; Carreras, Elena; Favre, Romain; Gaudineau, Adrien; Joal, Arnaud; Peiro, Jose Luis; Rodo, Carlota; Ruano, Rodrigo; Sananes, Nicolas; Sangi-Haghpeykar, Haleh et al.
DOI: 10.3109/14767058.2015.1114080

Surgical Decompression of Exertional Compartment Syndrome of the Forearm in Professional Motorcycling Racers: Comparative Long-term Results of Wide-Open Versus Mini-Open Fasciotomy.

PMID: 26196496
Journal: CLINICAL JOURNAL OF SPORT MEDICINE
Year: 2016
Reference: Clin J Sport Med. 2016 Mar;26(2):108-14. doi: 10.1097/JSM.0000000000000216.
Impact factor:
Publication type: Paper in international publication
Authors: Barrera-Ochoa, Sergi; Correa-Vazquez, Eva; Font Segura, Jordi; Gil, Emilia; Haddad, Sleiman; Lluch, Alex; Mir-Bullo, Xavier; Soldado, Francisco et al.
DOI: 10.1097/JSM.0000000000000216

Primary Cutaneous Aspergillosis in a Preterm Infant.

PMID: 26974892
Journal: PEDIATRIC INFECTIOUS DISEASE JOURNAL
Year: 2016
Reference: Pediatr Infect Dis J. 2016 Jun;35(6):704-6. doi: 10.1097/INF.0000000000001136.
Impact factor:
Publication type: Paper in international publication
Authors: Boix, Hector; Frick, Marie Antoinette; Longueira, Fatima Camba; Martin-Gomez, M Teresa; Rodrigo-Pendas, Jose Angel; Soler-Palacin, Pere et al.
DOI: 10.1097/INF.0000000000001136

The quantitative lung index and the prediction of survival in fetuses with congenital diaphragmatic hernia.

PMID: 26871273
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology
Year: 2016
Reference: Eur J Obstet Gynecol Reprod Biol. 2016 Mar;198:145-8. doi: 10.1016/j.ejogrb.2016.01.011. Epub 2016 Jan 11.
Impact factor:
Publication type: Paper in international publication
Authors: Arevalo, Silvia; Carreras, Elena; Gine, Carles; Illescas, Tamara; Peiro, Jose L; Rodo, Carlota et al.
DOI: 10.1016/j.ejogrb.2016.01.011

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Divuit hores de programa solidari recull més de 8 milions d'euros per lluitar contra les malalties del cor. A Catalunya, una de cada quatre persones moren a causa d'una malaltia del cor o un ictus