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Cardiovascular Diseases

Cardiovascular Diseases group is a translational research group within the Cardiology Department of Vall d’Hebron Hospital that performs laboratory, clinical and epidemiological research. In the CIBERCV network we are within the topic of descriptor 2 “Arterial disease, thrombosis and myocardial ischemia-reperfusion injury”. Our contributions in these topics address the following lines: 

  • Myocardial ischemia-reperfusion injury (i.e. mechanisms of endogenous cardioprotection, ischemic conditioning and remodeling), 
  • Coronary artery disease (i.e. genetic factors involved in coronary artery disease, determinants of thrombotic complications and prognosis), 
  • Aortic diseases (i.e. determinants of aorta dilatation, aortic biomechanics abnormalities in Marfan´s syndrome, and new imaging methods), 
  • Congenital/familiar heart diseases (i.e. genetic determinants and prognosis factors). 

In the CIBERESP network, our group is interested in the study of effectiveness/cost-effectiveness of cardiovascular interventions, health outcome research and methods in clinical research. The group has 19 principal investigators, 32 active projects and clinical trial and has been done 142 publications in 2020.

Publications

The effects of cardiac stretch on atrial fibroblasts: Analysis of the evidence and potential role in atrial fibrillation.

PMID: 33576384
Journal: CARDIOVASCULAR RESEARCH
Year: 2022
Reference: Cardiovasc Res. 2022 Jan 29;118(2):440-460. doi: 10.1093/cvr/cvab035.
Impact factor: 10.787
Publication type: Paper in international publication
Authors: Li, Xixiao, Garcia-Elias, Anna, Benito, Begona, Nattel, Stanley et al.
DOI: 10.1093/cvr/cvab035

When Time Is Not Muscle, Yet It Still May Be Important.

PMID: 35086653
Journal: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Year: 2022
Reference: J Am Coll Cardiol. 2022 Feb 1;79(4):324-326. doi: 10.1016/j.jacc.2021.11.037.
Impact factor: 24.093
Publication type: Editorail in international publication
Authors: Barrabes, Jose A, Soriano-Colome, Toni, Ferreira-Gonzalez, Ignacio et al.
DOI: 10.1016/j.jacc.2021.11.037

Antioxidant Roles of SGLT2 Inhibitors in the Kidney.

PMID: 35053290
Journal: Biomolecules
Year: 2022
Reference: Biomolecules. 2022 Jan 16;12(1). pii: biom12010143. doi: 10.3390/biom12010143.
Impact factor: 4.879
Publication type: Review in international publication
Authors: Llorens-Cebria, Carmen, Molina-Van den Bosch, Mireia, Vergara, Ander, Jacobs-Cacha, Conxita, Soler, Maria Jose et al.
DOI: 10.3390/biom12010143

Unraveling Bicuspid Aortic Valve Enigmas by Multimodality Imaging: Clinical Implications.

PMID: 35054153
Journal: Journal of Clinical Medicine
Year: 2022
Reference: J Clin Med. 2022 Jan 17;11(2). pii: jcm11020456. doi: 10.3390/jcm11020456.
Impact factor: 4.242
Publication type: Review in international publication
Authors: Evangelista Masip, Arturo, Galian-Gay, Laura, Guala, Andrea, Lopez-Sainz, Angela, Teixido-Tura, Gisela, Ruiz Munoz, Aroa, Valente, Filipa, Gutierrez, Laura, Fernandez-Galera, Ruben, Casas, Guillem et al.
DOI: 10.3390/jcm11020456

Cardiac biometric variables and arrhythmic events during COVID-19 pandemic lockdown in patients with an implantable cardiac monitor for syncope work-up.

PMID: 33642036
Journal: MEDICINA CLINICA
Year: 2021
Reference: Med Clin (Barc). 2021 May 21;156(10):496-499. doi: 10.1016/j.medcli.2020.12.005. Epub 2021 Feb 26.
Impact factor: 1.725
Publication type: Letter or abstract
Authors: Francisco-Pascual, Jaume, Rivas-Gandara, Nuria, Santos-Ortega, Alba, Perez-Rodon, Jordi, Benito, Begona, Belahnech, Yassin, Ferreira-Gonzalez, Ignacio et al.
DOI: 10.1016/j.medcli.2020.12.005

Risk predictors in a Spanish cohort with cardiac laminopathies. The REDLAMINA registry.

PMID: 32616434
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2021
Reference: Rev Esp Cardiol. 2021 Mar;74(3):216-224. doi: 10.1016/j.rec.2020.03.026. Epub 2020 Jun 29.
Impact factor: 4.753
Publication type: Paper in national publication
Authors: Diez-Lopez, Carles, Barriales-Villa, Roberto, Ochoa, Juan P, Larranaga-Moreira, Jose M, Salazar-Mendiguchia, Joel, Garcia-Pavia, Pablo, Ortiz-Genga, Martin, Monserrat, Lorenzo, Ripoll-Vera, Tomas, Zorio, Esther et al.
DOI: 10.1016/j.rec.2020.03.026

Changes in the diagnosis and management of acute aortic syndrome and associated mortality in the last 20 years.

PMID: 32499017
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2021
Reference: Rev Esp Cardiol. 2021 Mar;74(3):257-262. doi: 10.1016/j.rec.2020.02.015. Epub 2020 Jun 1.
Impact factor: 4.753
Publication type: Paper in national publication
Authors: Evangelista, Arturo, Barrabes, Jose A, Lidon, Rosa-Maria, Rodriguez-Lecoq, Rafael, Maeso, Jordi, Bellmunt, Sergi, Lopez-Sainz, Angela, Sureda, Carlos, Teixido-Tura, Gisela, Gonzalez-Alujas, Teresa et al.
DOI: 10.1016/j.rec.2020.02.015

Atrial thrombus aspiration through the AngioVac system: an alternative when surgery and anticoagulation are not an option.

PMID: 33637474
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2021
Reference: Rev Esp Cardiol (Engl Ed). 2021 Jul;74(7):626-628. doi: 10.1016/j.rec.2020.12.012. Epub 2021 Feb 23.
Impact factor: 4.753
Publication type: Letter whit IF
Authors: Azpiroz-Franch, Maria Josefa, Rello-Sabate, Pau, Oristrell-Santamaria, Gerard, Gonzalez-Alujas, Teresa, Marti-Aguasca, Gerard, Soriano-Colome, Toni et al.
DOI: 10.1016/j.rec.2020.12.012

Translational issues for mitoprotective agents as adjunct to reperfusion therapy in patients with ST-segment elevation myocardial infarction.

PMID: 31967733
Journal: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Year: 2020
Reference: J Cell Mol Med. 2020 Mar;24(5):2717-2729. doi: 10.1111/jcmm.14953. Epub 2020 Jan 22.
Impact factor: 4.486
Publication type: Review in international publication
Authors: Botker, Hans Erik, Cabrera-Fuentes, Hector Alejandro, Ruiz-Meana, Marisol, Heusch, Gerd, Ovize, Michel et al.
DOI: 10.1111/jcmm.14953

Mosaic Bioprostheses May Mimic Infective Endocarditis by PET/CTA: Trust the Uptake Pattern to Avoid Misdiagnosis.

PMID: 31954645
Journal: JACC-Cardiovascular Imaging
Year: 2020
Reference: JACC Cardiovasc Imaging. 2020 Oct;13(10):2239-2244. doi: 10.1016/j.jcmg.2019.11.019. Epub 2020 Jan 15.
Impact factor: 12.74
Publication type: Paper in international publication
Authors: Cuellar-Calabria, Hug, Tornos, Pilar, Roque, Albert, Pizzi, Maria N, Fernandez-Hidalgo, Nuria, Gonzalez-Alujas, Maria Teresa, Rios, Remedios, Castell-Conesa, Joan, Escobar, Manuel, Ferreira-Gonzalez, Ignacio et al.
DOI: 10.1016/j.jcmg.2019.11.019

Modified LAMPOON technique.

PMID: 31932236
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2020
Reference: Rev Esp Cardiol (Engl Ed). 2020 Jul;73(7):579. doi: 10.1016/j.rec.2019.10.021. Epub 2020 Jan 10.
Impact factor: 4.642
Publication type: Paper in national publication
Authors: Gonzalez Sucarrats, Silvia, Serra Garcia, Vicenc, Marti Aguasca, Gerard et al.
DOI: 10.1016/j.rec.2019.10.021

Polymer-free sirolimus-eluting stent use in Europe and Asia: Ethnic differences in demographics and clinical outcomes.

PMID: 31929543
Journal: PLoS One
Year: 2020
Reference: PLoS One. 2020 Jan 13;15(1):e0226606. doi: 10.1371/journal.pone.0226606. eCollection 2020.
Impact factor: 2.74
Publication type: Paper in international publication
Authors: Ahn, Tae Hoon, Leschke, Matthias, Pansieri, Michel, Sebagh, Laurent, Krackhardt, Florian, Waliszewski, Matthias, Wan Ahmad, Wan Azman, Kocka, Viktor, Tousek, Petr, Janek, Bronislav et al.
DOI: 10.1371/journal.pone.0226606

MAGnesium-based bioresorbable scaffold and vasomotor function in patients with acute ST segment elevation myocardial infarction: The MAGSTEMI trial: Rationale and design.

PMID: 30196572
Journal: CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
Year: 2019
Reference: Catheter Cardiovasc Interv. 2019 Jan 1;93(1):64-70. doi: 10.1002/ccd.27825. Epub 2018 Sep 9.
Impact factor: 2.551
Publication type: Paper in international publication
Authors: Sabate, Manel, Brugaletta, Salvatore, Cequier, Angel, Alfonso, Fernando, Iniguez, Andres, Romani, Sebastian, Serra, Antonio, Salinas, Pablo, Goicolea, Javier, Bordes, Pascual et al.
DOI: 10.1002/ccd.27825

Clinical and Administrative Data on the Research of Acute Coronary Syndrome in Spain. Minimum Basic Data Set Validity.

PMID: 29747944
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2019
Reference: Rev Esp Cardiol (Engl Ed). 2019 Jan;72(1):56-62. doi: 10.1016/j.rec.2018.01.026. Epub 2018 May 7.
Impact factor: 5.078
Publication type: Paper in national publication
Authors: Bernal, Jose Luis, Barrabes, Jose A, Iniguez, Andres, Fernandez-Ortiz, Antonio, Fernandez-Perez, Cristina, Bardaji, Alfredo, Elola, Francisco Javier et al.
DOI: 10.1016/j.recesp.2018.01.007

Acute aortic dissections with entry tear in the arch: A report from the International Registry of Acute Aortic Dissection.

PMID: 30396735
Journal: JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
Year: 2019
Reference: J Thorac Cardiovasc Surg. 2019 Jan;157(1):66-73. doi: 10.1016/j.jtcvs.2018.07.101. Epub 2018 Sep 21.
Impact factor: 5.261
Publication type: Paper in international publication
Authors: Trimarchi, Santi, de Beaufort, Hector W L, Tolenaar, Jip L, Bavaria, Joseph E, Desai, Nimesh D, Di Eusanio, Marco, Di Bartolomeo, Roberto, Peterson, Mark D, Ehrlich, Marek, Evangelista, Arturo et al.
DOI: 10.1016/j.jtcvs.2018.07.101

Reverse, stationary and progressive left ventricular dilatation in dilated and nondilated ventricles on admission following first anterior STEMI.

PMID: 30383552
Journal: CORONARY ARTERY DISEASE
Year: 2019
Reference: Coron Artery Dis. 2019 Jan;30(1):11-19. doi: 10.1097/MCA.0000000000000665.
Impact factor: 1.554
Publication type: Paper in international publication
Authors: Figueras, Jaume, Baneras, Jordi, Gruosso, Domenico, Palomares, Jose R, Barrabes, Jose A, Garcia-Dorado, David et al.
DOI: 10.1097/MCA.0000000000000665

Short-term exposure to air pollutants increases the risk of ST elevation myocardial infarction and of infarct-related ventricular arrhythmias and mortality.

PMID: 29056239
Journal: INTERNATIONAL JOURNAL OF CARDIOLOGY
Year: 2018
Reference: Int J Cardiol. 2018 Jan 1;250:35-42. doi: 10.1016/j.ijcard.2017.10.004. Epub 2017 Oct 5.
Impact factor: 4.034
Publication type: Paper in international publication
Authors: Baneras, Jordi, Ferreira-Gonzalez, Ignacio, Marsal, Josep Ramon, Barrabes, Jose A, Ribera, Aida, Lidon, Rosa Maria, Domingo, Enric, Marti, Gerard, Garcia-Dorado, David et al.
DOI: 10.1016/j.ijcard.2017.10.004

Mitochondrial Cx43, an important component of cardiac preconditioning.

PMID: 28642043
Journal: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Year: 2018
Reference: Biochim Biophys Acta Biomembr. 2018 Jan;1860(1):174-181. doi: 10.1016/j.bbamem.2017.06.011. Epub 2017 Jun 20.
Impact factor: 3.438
Publication type: Review in international publication
Authors: Rodriguez-Sinovas, Antonio, Ruiz-Meana, Marisol, Denuc, Amanda, Garcia-Dorado, David et al.
DOI: 10.1016/j.bbamem.2017.06.011

Hospital and 4-Year Mortality Predictors in Patients With Acute Pulmonary Edema With and Without Coronary Artery Disease.

PMID: 26883921
Journal: Journal of the American Heart Association
Year: 2016
Reference: J Am Heart Assoc. 2016 Feb 16;5(2). pii: e002581. doi: 10.1161/JAHA.115.002581.
Impact factor: 5.117
Publication type: Paper in international publication
Authors: Figueras, Jaume, Baneras, Jordi, Pena-Gil, Carlos, Barrabes, Jose A, Rodriguez Palomares, Jose, Garcia Dorado, David et al.
DOI: 10.1161/JAHA.115.002581

[Infective endocarditis in adult patients with congenital heart disease. Experience from a reference centre].

PMID: 26860418
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2016
Reference: Enferm Infecc Microbiol Clin. 2016 Dec;34(10):626-632. doi: 10.1016/j.eimc.2016.01.004. Epub 2016 Feb 6.
Impact factor: 1.53
Publication type: Paper in international publication
Authors: Loureiro-Amigo, Jose, Fernandez-Hidalgo, Nuria, Pijuan-Domenech, Antonia, Dos-Subira, Laura, Subirana-Domenech, Teresa, Gonzalez-Alujas, Teresa, Gonzalez-Lopez, Juan Jose, Tornos-Mas, Pilar, Garcia-Dorado, David, Almirante, Benito et al.
DOI: 10.1016/j.eimc.2016.01.004

Lifeguard Inhibits Fas Ligand-mediated Endoplasmic Reticulum-Calcium Release Mandatory for Apoptosis in Type II Apoptotic Cells.

PMID: 26582200
Journal: JOURNAL OF BIOLOGICAL CHEMISTRY
Year: 2016
Reference: J Biol Chem. 2016 Jan 15;291(3):1221-34. doi: 10.1074/jbc.M115.677682. Epub 2015 Nov 18.
Impact factor: 4.258
Publication type: Paper in international publication
Authors: Urresti, Jorge, Ruiz-Meana, Marisol, Coccia, Elena, Arevalo, Juan Carlos, Castellano, Jose, Fernandez-Sanz, Celia, Galenkamp, Koen M O, Planells-Ferrer, Laura, Moubarak, Rana S, Llecha-Cano, Nuria et al.
DOI: 10.1074/jbc.M115.677682

DianaHealth.com, an On-Line Database Containing Appraisals of the Clinical Value and Appropriateness of Healthcare Interventions: Database Development and Retrospective Analysis.

PMID: 26840451
Journal: PLoS One
Year: 2016
Reference: PLoS One. 2016 Feb 3;11(2):e0147943. doi: 10.1371/journal.pone.0147943. eCollection 2016.
Impact factor: 3.057
Publication type: Paper in international publication
Authors: Bonfill, Xavier, Osorio, Dimelza, Sola, Ivan, Pijoan, Jose Ignacio, Balasso, Valentina, Quintana, Maria Jesus, Puig, Teresa, Bolibar, Ignasi, Urrutia, Gerard, Zamora, Javier et al.
DOI: 10.1371/journal.pone.0147943

Blog

News

The European project, in which Vall d'Hebron participates, will favor personalized diagnosis and innovative therapeutic strategies in patients with the disease.

In total, different projects of six research groups will be promoted, focusing on precision medicine and advanced therapies.

The Cardiovascular Diseases and Neurovascular Diseases groups at VHIR will investigate new therapeutic strategies for heart failure, nanomedicine in stroke and the prevention of cardiovascular toxicity in the case of oncological treatments.

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