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Cardiovascular Diseases

Cardiovascular Diseases group is a translational research group within the Cardiology Department of Vall d’Hebron Hospital that performs laboratory, clinical and epidemiological research. In the CIBERCV network we are within the topic of descriptor 2 “Arterial disease, thrombosis and myocardial ischemia-reperfusion injury”. Our contributions in these topics address the following lines: 

  • Myocardial ischemia-reperfusion injury (i.e. mechanisms of endogenous cardioprotection, ischemic conditioning and remodeling), 
  • Coronary artery disease (i.e. genetic factors involved in coronary artery disease, determinants of thrombotic complications and prognosis), 
  • Aortic diseases (i.e. determinants of aorta dilatation, aortic biomechanics abnormalities in Marfan´s syndrome, and new imaging methods), 
  • Congenital/familiar heart diseases (i.e. genetic determinants and prognosis factors). 

In the CIBERESP network, our group is interested in the study of effectiveness/cost-effectiveness of cardiovascular interventions, health outcome research and methods in clinical research. The group has 19 principal investigators, 32 active projects and clinical trial and has been done 142 publications in 2020.

Publications

Clinical Features and Natural History of Preadolescent Nonsyndromic Hypertrophic Cardiomyopathy.

PMID: 35589160
Journal: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Year: 2022
Reference: J Am Coll Cardiol. 2022 May 24;79(20):1986-1997. doi: 10.1016/j.jacc.2022.03.347.
Impact factor: 24.093
Publication type: Paper in international publication
Authors: Linter, Katie, Marrone, Chiara, Bokenkamp, Regina, Baban, Anwar, Kubus, Peter, Daubeney, Piers E F, Sarquella-Brugada, Georgia, Cesar, Sergi, Klaassen, Sabine, Ojala, Tiina H et al.
DOI: 10.1016/j.jacc.2022.03.347

Dynamics of Emergency Cardiovascular Hospital Admissions and In-Hospital Mortality During the COVID-19 Pandemic: Time Series Analysis and Impact of Socioeconomic Factors.

PMID: 35557541
Journal: Frontiers in Cardiovascular Medicine
Year: 2022
Reference: Front Cardiovasc Med. 2022 Apr 26;9:827212. doi: 10.3389/fcvm.2022.827212. eCollection 2022.
Impact factor: 6.05
Publication type: Paper in international publication
Authors: Alvarez-Martin, Claudia, Ribera, Aida, Marsal, Josep Ramon, Ariza-Sole, Albert, Perez-Hoyos, Santiago, Oristrell, Gerard, Soriano-Colome, Toni, Romaguera, Rafael, Pijoan, Jose Ignacio, Lidon, Rosa M et al.
DOI: 10.3389/fcvm.2022.827212

Spanish Registry of Acute Aortic Syndrome (RESA). Changes in therapeutic management and lower mortality in acute aortic syndrome.

PMID: 35527170
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2022
Reference: Rev Esp Cardiol (Engl Ed). 2022 May 5. pii: S1885-5857(22)00070-6. doi: 10.1016/j.rec.2022.01.017.
Impact factor: 4.753
Publication type: Paper in national publication
Authors: Revilla Orodea, Ana, Evangelista Masip, Artur, Lopez-Sainz, Angela, Barros Membrilla, Antonio Jose, Calvo Iglesias, Francisco, Lopez Ayerbe, Jordi, Azqueta Molluna, Manel, Mosquera Rodriguez, Victor X, Arregui Montoya, Francisco, Tarrio Fernandez, Ruben et al.
DOI: 10.1016/j.rec.2022.01.017

Hemodynamic optimization in patients with a long-term ventricular assist device. A diagnostic and therapeutic challenge.

PMID: 35523669
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2022
Reference: Rev Esp Cardiol (Engl Ed). 2022 May 3. pii: S1885-5857(22)00065-2. doi: 10.1016/j.rec.2022.01.016.
Impact factor: 4.753
Publication type: Paper in national publication
Authors: Uribarri, Aitor et al.
DOI: 10.1016/j.rec.2022.01.016

Right ventricular resynchronization in a patient with repaired tetralogy of Fallot and severe ventricular dysfunction.

PMID: 34414585
Journal: PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
Year: 2021
Reference: Pacing Clin Electrophysiol. 2021 Dec;44(12):2119-2123. doi: 10.1111/pace.14340. Epub 2021 Aug 28.
Impact factor: 1.976
Publication type: Letter or abstract
Authors: Rodriguez-Garcia, Julian, Pijuan-Domenech, Antonia, Dos-Subira, Laura, Miranda-Barrio, Berta, Santos-Ortega, Alba, Rivas-Gandara, Nuria, Francisco-Pascual, Jaume et al.
DOI: 10.1111/pace.14340

Myocardial Geometry and Dysfunction in Morbidly Obese Adolescents (BMI 35-40 kg/m(2)).

PMID: 34392890
Journal: AMERICAN JOURNAL OF CARDIOLOGY
Year: 2021
Reference: Am J Cardiol. 2021 Oct 15;157:128-134. doi: 10.1016/j.amjcard.2021.07.026. Epub 2021 Aug 13.
Impact factor: 2.778
Publication type: Paper in international publication
Authors: Ventura, Paula S, Yeste, Diego, Riaza-Martin, Lucia, Arciniegas, Larry, Clemente, Maria, Torres, Marisa, Amigo, Nuria, Giralt, Gemma, Roses-Noguer, Ferran, Sabate-Rotes, Anna et al.
DOI: 10.1016/j.amjcard.2021.07.026

Clinical Risk Prediction in Patients With Left Ventricular Myocardial Noncompaction.

PMID: 34384546
Journal: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Year: 2021
Reference: J Am Coll Cardiol. 2021 Aug 17;78(7):643-662. doi: 10.1016/j.jacc.2021.06.016.
Impact factor: 24.093
Publication type: Paper in international publication
Authors: Limeres, Javier, Casas, Guillem, Bogaert, Jan, Aquaro, Giovanni D, Gimeno-Blanes, Juan Ramon, Zorio, Esther, Garcia-Pavia, Pablo, Barriales-Villa, Roberto, Evangelista, Artur, Masci, Pier Giorgio et al.
DOI: 10.1016/j.jacc.2021.06.016

Implications of Iron Deficiency in STEMI Patients and in a Murine Model of Myocardial Infarction.

PMID: 34368505
Journal: JACC-Basic to Translational Science
Year: 2021
Reference: JACC Basic Transl Sci. 2021 Jul 26;6(7):567-580. doi: 10.1016/j.jacbts.2021.05.004. eCollection 2021 Jul.
Impact factor: 8.648
Publication type: Paper in international publication
Authors: Rodriguez-Sinovas, Antonio, Benito, Begona, Buera, Irene, Delgado-Tomas, Sara, Beneitez, David, Ferreira-Gonzalez, Ignacio, Ruiz-Meana, Marisol, Rafecas, Agnes, Sambola, Antonia, Inserte, Javier et al.
DOI: 10.1016/j.jacbts.2021.05.004

Intrapatient Randomization to Study Strut Coverage in Polymer-Free Versus Biodegradable-Polymer Sirolimus-Eluting Stent Implantations.

PMID: 32273102
Journal: JACC-Cardiovascular Interventions
Year: 2020
Reference: JACC Cardiovasc Interv. 2020 Apr 13;13(7):899-900. doi: 10.1016/j.jcin.2019.11.020.
Impact factor: 8.432
Publication type: Letter whit IF
Authors: Sabate, Manel, Marti, Gerard, Bellera, Neus, Serra, Bernat, Garcia Del Blanco, Bruno, Ferreira Gonzalez, Ignacio, Lopez-Benito, Maria, Massotti, Monica, Otaegui, Imanol, Perez de Prado, Armando et al.
DOI: 10.1016/j.jcin.2019.11.020

Cost-effectiveness of myocardial perfusion SPECT and stress test according to coronary revascularization therapy, cardiac events and total mortality: Register of 8,496 patients.

PMID: 32273238
Journal: Revista Espanola de Medicina Nuclear e Imagen Molecular
Year: 2020
Reference: Rev Esp Med Nucl Imagen Mol. 2020 Jul - Aug;39(4):212-219. doi: 10.1016/j.remn.2020.01.006. Epub 2020 Apr 6.
Impact factor: 1.09
Publication type: Paper in national publication
Authors: Romero-Farina, G, Montoro-Ronsano, J B, Aguade-Bruix, S, Candell-Riera, J et al.
DOI: 10.1016/j.remn.2020.01.006

Fluid-structure interaction simulations outperform computational fluid dynamics in the description of thoracic aorta haemodynamics and in the differentiation of progressive dilation in Marfan syndrome patients.

PMID: 32257331
Journal: Royal Society Open Science
Year: 2020
Reference: R Soc Open Sci. 2020 Feb 5;7(2):191752. doi: 10.1098/rsos.191752. eCollection 2020 Feb.
Impact factor: 2.647
Publication type: Paper in international publication
Authors: Pons, R, Guala, A, Rodriguez-Palomares, J F, Cajas, J C, Dux-Santoy, L, Teixido-Tura, G, Molins, J J, Vazquez, M, Evangelista, A, Martorell, J et al.
DOI: 10.1098/rsos.191752

Enhancing Glycolysis Protects against Ischemia-Reperfusion Injury by Reducing ROS Production.

PMID: 32235559
Journal: Metabolites
Year: 2020
Reference: Metabolites. 2020 Mar 30;10(4). pii: metabo10040132. doi: 10.3390/metabo10040132.
Impact factor: 4.097
Publication type: Paper in international publication
Authors: Beltran, Claudia, Pardo, Rosario, Bou-Teen, Diana, Ruiz-Meana, Marisol, Villena, Josep A, Ferreira-Gonzalez, Ignacio, Barba, Ignasi et al.
DOI: 10.3390/metabo10040132

Pulmonary hypertension associated with left heart disease: efforts to improve the meaning of haemodynamic phenotypes.

PMID: 30846447
Journal: EUROPEAN RESPIRATORY JOURNAL
Year: 2019
Reference: Eur Respir J. 2019 Mar 7;53(3). pii: 53/3/1801894. doi: 10.1183/13993003.01894-2018. Print 2019 Mar.
Impact factor: 11.807
Publication type: Letter or abstract
Authors: Grignola, Juan C, Trujillo, Pedro, Domingo, Enric et al.
DOI: 10.1183/13993003.01894-2018

Impact of revascularization versus medical therapy alone for chronic total occlusion management in older patients.

PMID: 30828975
Journal: CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
Year: 2019
Reference: Catheter Cardiovasc Interv. 2019 Oct 1;94(4):527-535. doi: 10.1002/ccd.28163. Epub 2019 Mar 3.
Impact factor: 2.551
Publication type: Paper in international publication
Authors: Flores-Umanzor, Eduardo Josue, Vazquez, Sara, Cepas-Guillen, Pedro, Ivey-Miranda, Juan, Caldentey, Guillem, Jimenez-Britez, Gustavo, Regueiro, Ander, Freixa, Xavier, Andrea, Rut, Ferreira-Gonzalez, Ignacio et al.
DOI: 10.1002/ccd.28163

Sex differences in the (1)H NMR metabolic profile of serum in cardiovascular risk patients.

PMID: 30787362
Journal: Scientific Reports
Year: 2019
Reference: Sci Rep. 2019 Feb 20;9(1):2380. doi: 10.1038/s41598-019-38881-4.
Impact factor: 4.011
Publication type: Paper in international publication
Authors: Barba, Ignasi, Andres, Mireia, Picon, Irene, Aguade-Bruix, Santiago, Garcia-Dorado, David et al.
DOI: 10.1038/s41598-019-38881-4

Outcomes From Transcatheter Aortic Valve Replacement in Patients With Low-Flow, Low-Gradient Aortic Stenosis and Left Ventricular Ejection Fraction Less Than 30%: A Substudy From the TOPAS-TAVI Registry.

PMID: 30566185
Journal: JAMA Cardiology
Year: 2019
Reference: JAMA Cardiol. 2019 Jan 1;4(1):64-70. doi: 10.1001/jamacardio.2018.4320.
Impact factor: 11.866
Publication type: Paper in international publication
Authors: Le Ven, Florent, Maes, Frederic, Lerakis, Stamatios, Barbosa Ribeiro, Henrique, Gilard, Martine, Cavalcante, Joao L, Makkar, Raj, Herrmann, Howard C, Windecker, Stephan, Enriquez-Sarano, Maurice et al.
DOI: 10.1001/jamacardio.2018.4320

Selection of the Best of 2017 on the Usefulness of Cardiac Stimulation in the Treatment of Vasovagal Syncope.

PMID: 29422268
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2018
Reference: Rev Esp Cardiol (Engl Ed). 2018 Mar;71(3):228-229. doi: 10.1016/j.rec.2017.10.053. Epub 2018 Feb 13.
Impact factor: 5.166
Publication type: Editorial in national publication
Authors: Baron-Esquivias, Gonzalo, Morillo, Carlos A, Moya-Mitjans, Angel, Martinez-Alday, Jesus, Ruiz-Granell, Ricardo, Lacunza-Ruiz, Javier et al.
DOI: 10.1016/j.rec.2017.10.053

Long-Term Outcomes in Patients With New Permanent Pacemaker Implantation Following Transcatheter Aortic Valve Replacement.

PMID: 29413244
Journal: JACC-Cardiovascular Interventions
Year: 2018
Reference: JACC Cardiovasc Interv. 2018 Feb 12;11(3):301-310. doi: 10.1016/j.jcin.2017.10.032.
Impact factor: 9.881
Publication type: Paper in international publication
Authors: Rodes-Cabau, Josep, Cote, Melanie, Chamandi, Chekrallah, Barbanti, Marco, Munoz-Garcia, Antonio, Latib, Azeem, Nombela-Franco, Luis, Gutierrez-Ibanez, Enrique, Veiga-Fernandez, Gabriela, Cheema, Asim N et al.
DOI: 10.1016/j.jcin.2017.10.032

Intra-atrial re-entrant tachycardia in congenital heart disease: types and relation of isthmus to atrial voltage.

PMID: 29016802
Journal: EUROPACE
Year: 2018
Reference: Europace. 2018 Feb 1;20(2):353-361. doi: 10.1093/europace/eux250.
Impact factor: 5.231
Publication type: Paper in international publication
Authors: Mitjans, Angel Moya, Garcia-Dorado Garcia, David, Roca-Luque, Ivo, Dos Subira, Laura, Pascual, Jaume Francisco, Domenech, Antonia Pijuan, Perez-Rodon, Jordi, Subirana, M Teresa, Santos Ortega, Alba, Miranda, Berta et al.
DOI: 10.1093/europace/eux250

Selective Inhibition of Succinate Dehydrogenase in Reperfused Myocardium with Intracoronary Malonate Reduces Infarct Size.

PMID: 29402957
Journal: Scientific Reports
Year: 2018
Reference: Sci Rep. 2018 Feb 5;8(1):2442. doi: 10.1038/s41598-018-20866-4.
Impact factor: 4.122
Publication type: Paper in international publication
Authors: Miro-Casas, Elisabet, Ruiz-Meana, Marisol, Rodriguez-Sinovas, Antonio, Garcia-Dorado, David, Barba, Ignasi, Valls-Lacalle, Laura et al.
DOI: 10.1038/s41598-018-20866-4

Lifeguard Inhibits Fas Ligand-mediated Endoplasmic Reticulum-Calcium Release Mandatory for Apoptosis in Type II Apoptotic Cells.

PMID: 26582200
Journal: JOURNAL OF BIOLOGICAL CHEMISTRY
Year: 2016
Reference: J Biol Chem. 2016 Jan 15;291(3):1221-34. doi: 10.1074/jbc.M115.677682. Epub 2015 Nov 18.
Impact factor: 4.258
Publication type: Paper in international publication
Authors: Urresti, Jorge, Ruiz-Meana, Marisol, Coccia, Elena, Arevalo, Juan Carlos, Castellano, Jose, Fernandez-Sanz, Celia, Galenkamp, Koen M O, Planells-Ferrer, Laura, Moubarak, Rana S, Llecha-Cano, Nuria et al.
DOI: 10.1074/jbc.M115.677682

DianaHealth.com, an On-Line Database Containing Appraisals of the Clinical Value and Appropriateness of Healthcare Interventions: Database Development and Retrospective Analysis.

PMID: 26840451
Journal: PLoS One
Year: 2016
Reference: PLoS One. 2016 Feb 3;11(2):e0147943. doi: 10.1371/journal.pone.0147943. eCollection 2016.
Impact factor: 3.057
Publication type: Paper in international publication
Authors: Bonfill, Xavier, Osorio, Dimelza, Sola, Ivan, Pijoan, Jose Ignacio, Balasso, Valentina, Quintana, Maria Jesus, Puig, Teresa, Bolibar, Ignasi, Urrutia, Gerard, Zamora, Javier et al.
DOI: 10.1371/journal.pone.0147943

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The consensus document is the result of multidisciplinary work that takes into account the risks associated with all stages of women's lives and the differences compared to men.

The study, which involved Vall d'Hebron, developed an action plan to efficiently allocate resources to patients most at risk of suffering this complication.

In light of this evidence, hospitals such as Vall d'Hebron have already started to include warnings about environmental pollution in their hospital discharge plans after a myocardial infarction.