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Cardiovascular Diseases

Cardiovascular Diseases group is a translational research group within the Cardiology Department of Vall d’Hebron Hospital that performs laboratory, clinical and epidemiological research. In the CIBERCV network we are within the topic of descriptor 2 “Arterial disease, thrombosis and myocardial ischemia-reperfusion injury”. Our contributions in these topics address the following lines: 

  • Myocardial ischemia-reperfusion injury (i.e. mechanisms of endogenous cardioprotection, ischemic conditioning and remodeling), 
  • Coronary artery disease (i.e. genetic factors involved in coronary artery disease, determinants of thrombotic complications and prognosis), 
  • Aortic diseases (i.e. determinants of aorta dilatation, aortic biomechanics abnormalities in Marfan´s syndrome, and new imaging methods), 
  • Congenital/familiar heart diseases (i.e. genetic determinants and prognosis factors). 

In the CIBERESP network, our group is interested in the study of effectiveness/cost-effectiveness of cardiovascular interventions, health outcome research and methods in clinical research. The group has 19 principal investigators, 32 active projects and clinical trial and has been done 142 publications in 2020.

Publications

Identification of hemodynamic biomarkers for bicuspid aortic valve induced aortic dilation using machine learning.

PMID: 34929463
Journal: COMPUTERS IN BIOLOGY AND MEDICINE
Year: 2022
Reference: Comput Biol Med. 2022 Feb;141:105147. doi: 10.1016/j.compbiomed.2021.105147. Epub 2021 Dec 16.
Impact factor: 4.589
Publication type: Paper in international publication
Authors: Franco, Pamela, Sotelo, Julio, Guala, Andrea, Dux-Santoy, Lydia, Evangelista, Arturo, Rodriguez-Palomares, Jose, Mery, Domingo, Uribe, Sergio, Salas, Rodrigo et al.
DOI: 10.1016/j.compbiomed.2021.105147

The effects of cardiac stretch on atrial fibroblasts: Analysis of the evidence and potential role in atrial fibrillation.

PMID: 33576384
Journal: CARDIOVASCULAR RESEARCH
Year: 2022
Reference: Cardiovasc Res. 2022 Jan 29;118(2):440-460. doi: 10.1093/cvr/cvab035.
Impact factor: 10.787
Publication type: Paper in international publication
Authors: Li, Xixiao, Garcia-Elias, Anna, Benito, Begona, Nattel, Stanley et al.
DOI: 10.1093/cvr/cvab035

When Time Is Not Muscle, Yet It Still May Be Important.

PMID: 35086653
Journal: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Year: 2022
Reference: J Am Coll Cardiol. 2022 Feb 1;79(4):324-326. doi: 10.1016/j.jacc.2021.11.037.
Impact factor: 24.093
Publication type: Editorail in international publication
Authors: Barrabes, Jose A, Soriano-Colome, Toni, Ferreira-Gonzalez, Ignacio et al.
DOI: 10.1016/j.jacc.2021.11.037

Unraveling Bicuspid Aortic Valve Enigmas by Multimodality Imaging: Clinical Implications.

PMID: 35054153
Journal: Journal of Clinical Medicine
Year: 2022
Reference: J Clin Med. 2022 Jan 17;11(2). pii: jcm11020456. doi: 10.3390/jcm11020456.
Impact factor: 4.242
Publication type: Review in international publication
Authors: Evangelista Masip, Arturo, Galian-Gay, Laura, Guala, Andrea, Lopez-Sainz, Angela, Teixido-Tura, Gisela, Ruiz Munoz, Aroa, Valente, Filipa, Gutierrez, Laura, Fernandez-Galera, Ruben, Casas, Guillem et al.
DOI: 10.3390/jcm11020456

Leaflet fusion length is associated with aortic dilation and flow alterations in non-dysfunctional bicuspid aortic valve.

PMID: 33977309
Journal: EUROPEAN RADIOLOGY
Year: 2021
Reference: Eur Radiol. 2021 Dec;31(12):9262-9272. doi: 10.1007/s00330-021-08016-3. Epub 2021 May 12.
Impact factor: 5.315
Publication type: Paper in international publication
Authors: Rodriguez-Palomares, Jose F, Ferreira-Gonzalez, Ignacio, Guala, Andrea, Evangelista, Arturo, Teixido-Tura, Gisela, Dux-Santoy, Lydia, Ruiz-Munoz, Aroa, Valente, Filipa, Galian-Gay, Laura, Gutierrez, Laura et al.
DOI: 10.1007/s00330-021-08016-3

Progress in aorta and peripheral cardiovascular disease research.

PMID: 33892507
Journal: CARDIOVASCULAR RESEARCH
Year: 2021
Reference: Cardiovasc Res. 2021 Jul 27;117(9):2045-2053. doi: 10.1093/cvr/cvab144.
Impact factor: 10.787
Publication type: Review in international publication
Authors: Mazzolai, Lucia, Alatri, Adriano, Riviere, Alessandra Bura, De Carlo, Marco, Heiss, Christian, Espinola-Klein, Christine, Schlager, Oliver, Sillesen, Henrik, Staub, Daniel, Palomares, Jose R et al.
DOI: 10.1093/cvr/cvab144

Chronic chest pain after percutaneous atrial septal defect closure.

PMID: 33303044
Journal: CARDIOLOGY IN THE YOUNG
Year: 2021
Reference: Cardiol Young. 2021 Apr;31(4):671-672. doi: 10.1017/S1047951120004539. Epub 2020 Dec 11.
Impact factor: 1.093
Publication type: Letter or abstract
Authors: Figueras-Coll, Marc, Betrian-Blasco, Pedro, Marti-Aguasca, Gerard et al.
DOI: 10.1017/S1047951120004539

Aortic Stenosis in Bicuspid and Tricuspid Valves: A Different Spectrum of the Disease With Clinical Implications.

PMID: 33865791
Journal: JACC-Cardiovascular Imaging
Year: 2021
Reference: JACC Cardiovasc Imaging. 2021 Jun;14(6):1127-1129. doi: 10.1016/j.jcmg.2021.02.016. Epub 2021 Apr 14.
Impact factor: 14.805
Publication type: Editorail in international publication
Authors: Evangelista, Artur et al.
DOI: 10.1016/j.jcmg.2021.02.016

Raphe in bicuspid aortic valve without significant aortic valve disease is unrelated to aortic hemodynamics and stiffness.

PMID: 31377144
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2020
Reference: Rev Esp Cardiol (Engl Ed). 2020 Jan;73(1):89-90. doi: 10.1016/j.rec.2019.06.005. Epub 2019 Jul 31.
Impact factor: 4.642
Publication type: Letter whit IF
Authors: Guala, Andrea, Dux-Santoy, Lydia, Teixido-Tura, Gisela, Johnson, Kevin M, Evangelista, Arturo, Rodriguez-Palomares, Jose et al.
DOI: 10.1016/j.recesp.2019.06.018

Low and Oscillatory Wall Shear Stress Is Not Related to Aortic Dilation in Patients With Bicuspid Aortic Valve: A Time-Resolved 3-Dimensional Phase-Contrast Magnetic Resonance Imaging Study.

PMID: 31801375
Journal: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Year: 2020
Reference: Arterioscler Thromb Vasc Biol. 2020 Jan;40(1):e10-e20. doi: 10.1161/ATVBAHA.119.313636. Epub 2019 Dec 5.
Impact factor: 6.604
Publication type: Paper in international publication
Authors: Ferreira, Ignacio, Evangelista, Arturo, Rodriguez-Palomares, Jose F, Wieben, Oliver, Johnson, Kevin M, Gutierrez, Laura, Dux-Santoy, Lydia, Guala, Andrea, Sotelo, Julio, Uribe, Sergio et al.
DOI: 10.1161/ATVBAHA.119.313636

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The consensus document is the result of multidisciplinary work that takes into account the risks associated with all stages of women's lives and the differences compared to men.

The study, which involved Vall d'Hebron, developed an action plan to efficiently allocate resources to patients most at risk of suffering this complication.

In light of this evidence, hospitals such as Vall d'Hebron have already started to include warnings about environmental pollution in their hospital discharge plans after a myocardial infarction.