About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The research group is focused on finding new molecular therapeutic targets and biomarkers based on knowledge of the biology of paediatric tumours, leukemias and hematologic diseases. The experience of the group in recent years has permitted the identification of new molecular targets that are very close to the clinical phase. In this stage, we have consolidated collaborations with the biotechnological industry in order to develop small molecules able to inhibit pro-oncogenic processes such as invasion or proliferation, with the aim of providing patients with innovative and more specific biological evidence-based therapies.
Another line of research is based on the study of liquid biopsy to develop a system based on NGS to monitor the probability of relapses.
Furthermore, we have implemented a personalized medicine program to guide the management of patients based on the molecular alterations of their tumours
IP: M Mar Mañu Pereira Collaborators: Ali Haidar, Reidel , Sara Isabel, Sara Isabel Reidel Funding agency: EUROPEAN COMMISSION Funding: 253750 Reference: IMPACT-AML_HE--MISS-CANCER2022 Duration: 01/04/2023 - 31/03/2028
IP: Lucas Moreno Martín-Retortillo Collaborators: Luís Gros Subias, Raquel Andreu Vilarroig, Andrea Vilaplana Blanes, Pablo Velasco Puyó, Laura Murillo Sanjuán, Maria Isabel Benitez Carabante, Aroa Soriano Fernández, Guillem Pons Barcons, Jose Miguel Lizcano De Vega, Maria Cristina Díaz de Heredia Rubio, Maria Luz Uría Oficialdegui, Maria Jose Pérez García, Miguel Segura Ginard, M Mar Mañu Pereira, Lorena Valero Arrese, Thaïs Murciano Carrillo, Constantino Sábado Álvarez, Anna Llort Sales, Elisabet Megías Roda, Raquel Hladun Alvaro, Grup de Recerca Emergent (GRE) Childood Cancer & Blood disorders, Carlota Aguilera Ordoñez, Adria Molero Valenzuela, Júlia Sansa Girona, Gabriela Guillén Burrieza, Laura Alonso Garcia, Victoria Gutierrez Valle, Idoia Bolinaga Ayala, Josep Roma Castanyer, Sergio Espinosa Gil, Elena Andretta, Claire Diot, Amira Idrizovic Funding agency: Agència Gestió Ajuts Universitaris i de Recerca Funding: 60000 Reference: 2021 SGR 00638 Duration: 01/01/2022 - 30/06/2025
IP: Lucas Moreno Martín-Retortillo Collaborators: Judit Álvarez González, María Paula Pérez Albert Funding agency: Instituto de Salud Carlos III Funding: 65000 Reference: CM22/00241 Duration: 01/01/2023 - 31/12/2024
IP: M Mar Mañu Pereira Collaborators: Reidel , Sara Isabel, Ali Haidar, Sara Isabel Reidel Funding agency: EUROPEAN COMMISSION Funding: 435938 Reference: SYNTHEMA_HE-HLTH22_IND13 Duration: 01/12/2022 - 30/11/2026
PMID: 37723198 Journal: Communications Biology Year: 2023 Reference: Commun Biol. 2023 Sep 18;6(1):949. doi: 10.1038/s42003-023-05320-0. Impact factor: Publication type: Paper in international publication Authors: Berlanga, Pablo; Cairo, Stefano; Calvo, Julien; Casanova, Michela; Chastagner, Pascal; Cherkaoui, Sarah; Daudigeos-Dubus, Estelle; Delattre, Olivier; Dessen, Philippe; Droit, Robin et al. DOI: 10.1038/s42003-023-05320-0
PMID: 37769113 Journal: CANCER Year: 2023 Reference: Cancer. 2023 Sep 28. doi: 10.1002/cncr.35036. Impact factor: Publication type: Paper in international publication Authors: Arvis, Pierre; Brega, Nicoletta; Casanova, Michela; Demetri, George D; Dowlati, Afshin; Drilon, Alexander; Hong, David S; Keedy, Vicki L; Kummar, Shivaani; Lassen, Ulrik N et al. DOI: 10.1002/cncr.35036
PMID: 37795968 Journal: PEDIATRIC BLOOD & CANCER Year: 2023 Reference: Pediatr Blood Cancer. 2023 Oct 5:e30662. doi: 10.1002/pbc.30662. Impact factor: Publication type: Paper in international publication Authors: Daugherty, Claire; Gallardo, Eva; Gros, Luis; Gros, Luis; Hill, Christon; Janeway, Katherine A; Rizzari, Carmelo; Schwartz, Stefan; Schwartz, Stefan; Thomas, Emma et al. DOI: 10.1002/pbc.30662
PMID: 37800011 Journal: Frontiers in Pediatrics Year: 2023 Reference: Front Pediatr. 2023 Sep 20;11:1269560. doi: 10.3389/fped.2023.1269560. eCollection 2023. Impact factor: Publication type: Paper in international publication Authors: Aguilar, Yurena; Alvarez, Federico; Bautista, Francisco; Bueno, Clara; Camos, Mireia; Chulian, Salvador; Cirillo, Davide; Dapena, Jose L; Dapena, Jose L; Escudero, Adela et al. DOI: 10.3389/fped.2023.1269560
PMID: 35686139 Journal: HemaSphere Year: 2022 Reference: Hemasphere. 2022 Jun 6;6(6):e739. doi: 10.1097/HS9.0000000000000739. eCollection 2022 Jun. Impact factor: 0 Publication type: Paper in international publication Authors: Roy, Noemi B A, Da Costa, Lydie, Russo, Roberta, Bianchi, Paola, Del Mar Manu-Pereira, Maria, Fermo, Elisa, Andolfo, Immacolata, Clark, Barnaby, Proven, Melanie, Sanchez, Mayka et al. DOI: 10.1097/HS9.0000000000000739
PMID: 35671096 Journal: JOURNAL OF CLINICAL INVESTIGATION Year: 2022 Reference: J Clin Invest. 2022 Jun 7. pii: 142842. doi: 10.1172/JCI142842. Impact factor: 14.808 Publication type: Paper in international publication Authors: Casado, Jose A, Valeri, Antonio, Sanchez-Dominguez, Rebeca, Vela, Paula, Lopez, Andrea, Navarro, Susana, Alberquilla, Omaira, Hanenberg, Helmut, Pujol, Roser, Segovia, Jose C et al. DOI: 10.1172/JCI142842
PMID: 35661144 Journal: BRITISH JOURNAL OF HAEMATOLOGY Year: 2022 Reference: Br J Haematol. 2022 Jun 6. doi: 10.1111/bjh.18191. Impact factor: 6.998 Publication type: Paper in international publication Authors: Russo, Roberta, Roy, Noemi B A, Da Costa, Lydie, Fermo, Elisa, Andolfo, Immacolata, Clark, Barnaby, Proven, Melanie, Sanchez, Mayka, van Wijk, Richard, van der Zwaag, Bert et al. DOI: 10.1111/bjh.18191
PMID: 34850167 Journal: NEURO-ONCOLOGY Year: 2022 Reference: Neuro Oncol. 2022 Jun 1;24(6):997-1007. doi: 10.1093/neuonc/noab274. Impact factor: 12.3 Publication type: Paper in international publication Authors: Doz, Francois, van Tilburg, Cornelis M, Geoerger, Birgit, Hojgaard, Martin, Ora, Ingrid, Boni, Valentina, Capra, Michael, Chisholm, Julia, Chung, Hyun Cheol, DuBois, Steven G et al. DOI: 10.1093/neuonc/noab274
PMID: 34395344 Journal: Frontiers in Pediatrics Year: 2021 Reference: Front Pediatr. 2021 Jul 29;9:705179. doi: 10.3389/fped.2021.705179. eCollection 2021. Impact factor: 3.418 Publication type: Paper in international publication Authors: Yaniv, Isaac, Bonig, Halvard, Kuhlen, Michaela, Ansari, Marc, Nava, Tiago, Dalle, Jean-Hugues, Diaz-de-Heredia, Cristina, Trigoso, Eugenia, Falkenberg, Ulrike, Hartmann, Mihaela et al. DOI: 10.3389/fped.2021.705179
PMID: 34385068 Journal: EUROPEAN JOURNAL OF CANCER Year: 2021 Reference: Eur J Cancer. 2021 Sep;155:155-162. doi: 10.1016/j.ejca.2021.07.006. Epub 2021 Aug 9. Impact factor: 9.162 Publication type: Paper in international publication Authors: Mercolini, Federico, Zucchetta, Pietro, Jehanno, Nina, Corradini, Nadege, Van Rijn, Rick R, Rogers, Timothy, Cameron, Alison, Scarzello, Giovanni, Coppadoro, Beatrice, Minard-Colin, Veronique et al. DOI: 10.1016/j.ejca.2021.07.006
PMID: 34343032 Journal: JOURNAL OF CLINICAL ONCOLOGY Year: 2021 Reference: J Clin Oncol. 2021 Sep 20;39(27):2979-2990. doi: 10.1200/JCO.21.00124. Epub 2021 Aug 3. Impact factor: 44.544 Publication type: Letter whit IF Authors: Casanova, Michela, Defachelles, Anne-Sophie, Bogart, Emilie, Calareso, Giuseppina, Gallego Melcon, Soledad, Gatz, Susanne Andrea, Le Deley, Marie-Cecile, McHugh, Kieran, Probst, Alicia, Rocourt, Nathalie et al. DOI: 10.1200/JCO.21.00124
PMID: 34200506 Journal: Journal of Fungi Year: 2021 Reference: J Fungi (Basel). 2021 Jun 7;7(6). pii: jof7060456. doi: 10.3390/jof7060456. Impact factor: 5.816 Publication type: Paper in international publication Authors: Soler-Palacin, Pere, Valle-T-Figueras, Jose Maria, Renedo Miro, Berta, Benitez Carabante, Maria Isabel, Diaz-de-Heredia, Cristina, Vima Bofarull, Jaume, Mendoza-Palomar, Natalia, Martin-Gomez, Maria Teresa et al. DOI: 10.3390/jof7060456
PMID: 31257135 Journal: ANALES DE PEDIATRIA Year: 2020 Reference: An Pediatr (Barc). 2020 Jul;93(1):16-23. doi: 10.1016/j.anpedi.2019.05.014. Epub 2019 Jun 27. Impact factor: 1.313 Publication type: Paper in national publication Authors: Garcia Iniguez, Juan Pablo, Samper Villagrasa, Maria Pilar, Calvo Escribano, Carlota, Murillo Sanjuan, Laura, Sanz de Miguel, Maria Pilar, Rodriguez-Vigil Iturrate, Carmen, Martinez Faci, Cristina et al. DOI: 10.1016/j.anpedi.2019.05.014
PMID: 32653773 Journal: EUROPEAN JOURNAL OF CANCER Year: 2020 Reference: Eur J Cancer. 2020 Sep;136:52-68. doi: 10.1016/j.ejca.2020.05.010. Epub 2020 Jul 9. Impact factor: 7.275 Publication type: Review in international publication Authors: Moreno, Lucas, Barone, Giuseppe, DuBois, Steven G, Molenaar, Jan, Fischer, Matthias, Poon, Evon, Shay, Jerry W, Tonelli, Roberto, Valteau-Couanet, Dominique, Vassal, Gilles et al. DOI: 10.1016/j.ejca.2020.05.010
PMID: 32638196 Journal: JOURNAL OF CLINICAL IMMUNOLOGY Year: 2020 Reference: J Clin Immunol. 2020 Aug;40(6):901-916. doi: 10.1007/s10875-020-00814-6. Epub 2020 Jul 7. Impact factor: 6.78 Publication type: Paper in international publication Authors: Ehl, Stephan, Elmaksoud, Marwa Abd, Astigarraga, Itziar, Kurjane, Natalja, Bulina, Inita, Kenina, Viktorija, Bryceson, Yenan, Rascon, Jelena, Lortie, Anne, Goldstein, Gal et al. DOI: 10.1007/s10875-020-00814-6
PMID: 32595135 Journal: CANCER RESEARCH Year: 2020 Reference: Cancer Res. 2020 Aug 15;80(16):3424-3435. doi: 10.1158/0008-5472.CAN-20-0133. Epub 2020 Jun 28. Impact factor: 9.727 Publication type: Paper in international publication Authors: Carceller, Fernando, Koers, Alexander, Barone, Giuseppe, Pearson, Andrew D J, Moreno, Lucas, Anderson, John, Sebire, Neil, McHugh, Kieran, Koh, Dow-Mu, Chesler, Louis et al. DOI: 10.1158/0008-5472.CAN-20-0133
PMID: 30546069 Journal: BONE MARROW TRANSPLANTATION Year: 2019 Reference: Bone Marrow Transplant. 2019 Jul;54(7):1133-1137. doi: 10.1038/s41409-018-0422-z. Epub 2018 Dec 13. Impact factor: 4.674 Publication type: Paper in international publication Authors: Sanchez-Ortega, Isabel, Alonso, Laura, Sisinni, Luisa, Fox, Laura, Villacampa, Guillermo, Badell, Isabel, de Heredia, Cristina Diaz, Parody, Rocio, Ferra, Christelle, Solano, Carlos et al. DOI: 10.1038/s41409-018-0422-z
PMID: 31099923 Journal: PEDIATRIC DERMATOLOGY Year: 2019 Reference: Pediatr Dermatol. 2019 May;36(3):e69-e70. doi: 10.1111/pde.13760. Impact factor: 1.178 Publication type: Paper in international publication Authors: Giacaman, Aniza, Salinas Sanz, Jose Antonio, Navarro Noguera, Samuel, Diaz de Heredia Rubio, Cristina, Martin-Santiago, Ana et al. DOI: 10.1111/pde.13760
PMID: 31040790 Journal: Frontiers in Physiology Year: 2019 Reference: Front Physiol. 2019 Apr 16;10:386. doi: 10.3389/fphys.2019.00386. eCollection 2019. Impact factor: 3.201 Publication type: Paper in international publication Authors: Petkova-Kirova, Polina, Hertz, Laura, Danielczok, Jens, Huisjes, Rick, Makhro, Asya, Bogdanova, Anna, Manu-Pereira, Maria Del Mar, Vives Corrons, Joan-Lluis, van Wijk, Richard, Kaestner, Lars et al. DOI: 10.3389/fphys.2019.00386
PMID: 30995915 Journal: Orphanet Journal of Rare Diseases Year: 2019 Reference: Orphanet J Rare Dis. 2019 Apr 17;14(1):82. doi: 10.1186/s13023-019-1046-0. Impact factor: 3.687 Publication type: Paper in international publication Authors: Arias-Salgado, Elena G, Galvez, Eva, Planas-Cerezales, Lurdes, Vallespin, Elena, Pintado-Berninches, Laura, Sastre, Leandro, Molina-Molina, Maria, Martinez, Pilar, Carrillo, Jaime, Iarriccio, Laura et al. DOI: 10.1186/s13023-019-1046-0
PMID: 29700278 Journal: EXPERIMENTAL AND MOLECULAR MEDICINE Year: 2018 Reference: Exp Mol Med. 2018 Apr 27;50(4):51. doi: 10.1038/s12276-018-0077-2. Impact factor: 5.584 Publication type: Review in international publication Authors: Jimenez, Carlos, Jubierre, Luz, Sabado, Constantino, Gros, Luis, Llort, Anna, Hladun, Raquel, Roma, Josep, Toledo, Josep Sanchez de, Gallego, Soledad, Segura, Miguel F et al. DOI: 10.1038/s12276-018-0077-2
PMID: 29615461 Journal: CLINICAL CANCER RESEARCH Year: 2018 Reference: Clin Cancer Res. 2018 Jun 15;24(12):2812-2819. doi: 10.1158/1078-0432.CCR-17-3800. Epub 2018 Apr 3. Impact factor: 10.199 Publication type: Paper in international publication Authors: Poca, Maria A, Martinez-Ricarte, Francisco, Mayor, Regina, Martinez-Saez, Elena, Rubio-Perez, Carlota, Pineda, Estela, Cordero, Esteban, Cicuendez, Marta, Vieito, Maria, Carles, Joan et al. DOI: 10.1158/1078-0432.CCR-17-3800
PMID: 29573905 Journal: TRANSFUSION MEDICINE REVIEWS Year: 2018 Reference: Transfusion Medicine Reviews. 2018 Jul;32(3):179-85. doi: 10.1016/j.tmrv.2018.02.005. Impact factor: 4.111 Publication type: Paper in international publication Authors: Gonzalez-Vicent, Marta, Sanz, Jaime, Fuster, Jose Luis, Cid, Joan, de Heredia, Cristina Diaz, Morillo, Daniel, Fernandez, Jose Maria, Pascual, Antonia, Badell, Isabel, Serrano, David et al. DOI: 10.1016/j.tmrv.2018.02.005
PMID: 29526774 Journal: EXPERIMENTAL HEMATOLOGY Year: 2018 Reference: Exp Hematol. 2018 Jun;62:24-32. doi: 10.1016/j.exphem.2018.03.002. Epub 2018 Mar 8. Impact factor: 2.436 Publication type: Paper in international publication Authors: Parody, Rocio, Sanz, Miguel Angel, Sierra, Jorge, Pinana, Jose Luis, Querol, Sergi, Valcarcel, David, Diaz de Heredia, Cristina, Ferra, Christelle, Badell, Isabel, Salamero, Olga et al. DOI: 10.1016/j.exphem.2018.03.002
PMID: 28754820 Journal: CLINICAL CANCER RESEARCH Year: 2017 Reference: Clin Cancer Res. 2017 Nov 1;23(21):6478-6486. doi: 10.1158/1078-0432.CCR-17-0489. Epub 2017 Jul 28. Impact factor: 9.619 Publication type: Paper in international publication Authors: Shouval, Roni, Ruggeri, Annalisa, Labopin, Myriam, Mohty, Mohamad, Sanz, Guillermo, Michel, Gerard, Kuball, Jurgen, Chevallier, Patrice, Al-Seraihy, Amal, Milpied, Noel-Jean et al. DOI: 10.1158/1078-0432.CCR-17-0489
PMID: 28737775 Journal: BONE MARROW TRANSPLANTATION Year: 2017 Reference: Bone Marrow Transplant. 2017 Oct;52(10):1406-1415. doi: 10.1038/bmt.2017.147. Epub 2017 Jul 24. Impact factor: 3.874 Publication type: Paper in international publication Authors: Ahler, A, Balduzzi, A, Dalle, J-H, Jahnukainen, K, von Wolff, M, Lucchini, G, Ifversen, M, Macklon, K T, Poirot, C, Diesch, T et al. DOI: 10.1038/bmt.2017.147
PMID: 28557976 Journal: BRITISH JOURNAL OF CANCER Year: 2017 Reference: Br J Cancer. 2017 Jul 11;117(2):256-265. doi: 10.1038/bjc.2017.152. Epub 2017 May 30. Impact factor: 6.176 Publication type: Paper in international publication Authors: Forero-Castro, Maribel, Robledo, Cristina, Benito, Rocio, Bodega-Mayor, Irene, Rapado, Inmaculada, Hernandez-Sanchez, Maria, Abaigar, Maria, Maria Hernandez-Sanchez, Jesus, Quijada-Alamo, Miguel, Maria Sanchez-Pina, Jose et al. DOI: 10.1038/bjc.2017.152
PMID: 28438676 Journal: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION Year: 2017 Reference: Biol Blood Marrow Transplant. 2017 Aug;23(8):1350-1358. doi: 10.1016/j.bbmt.2017.04.015. Epub 2017 Apr 21. Impact factor: 4.704 Publication type: Paper in international publication Authors: Page, Kristin M, Labopin, Myriam, Ruggeri, Annalisa, Michel, Gerard, Diaz de Heredia, Cristina, O'Brien, Tracey, Picardi, Alessandra, Ayas, Mouhab, Bittencourt, Henrique, Vora, Ajay J et al. DOI: 10.1016/j.bbmt.2017.04.015
The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.
A study jointly led by the Hospital Clínic of Barcelona and the Vall d'Hebron Research Institute (VHIR) confirms the effectiveness of neonatal screening in reducing morbidity among children with sickle cell disease (SCD).
Active participation by patients and families in studies helps identify more effective therapies that improve quality of life and survival.
