About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The research group is focused on finding new molecular therapeutic targets and biomarkers based on knowledge of the biology of paediatric tumours, leukemias and hematologic diseases. The experience of the group in recent years has permitted the identification of new molecular targets that are very close to the clinical phase. In this stage, we have consolidated collaborations with the biotechnological industry in order to develop small molecules able to inhibit pro-oncogenic processes such as invasion or proliferation, with the aim of providing patients with innovative and more specific biological evidence-based therapies.
Another line of research is based on the study of liquid biopsy to develop a system based on NGS to monitor the probability of relapses.
Furthermore, we have implemented a personalized medicine program to guide the management of patients based on the molecular alterations of their tumours
IP: Lucas Moreno Martín-Retortillo Collaborators: Aroa Soriano Fernández, Marta Garrido Pontnou, Miguel Segura Ginard, Lorena Valero Arrese, Raquel Hladun Alvaro, Elena Antima Martinez Saez, Marta Sese Faustino, Gabriela Guillén Burrieza, Josep Roma Castanyer, Andrea Vilaplana Blanes, Sergio Manresa Vera, Margarita Ortega Blanco, María Rosario Pérez- Torres Lobato, Asbleidy Carolina Torres Barbosa Funding agency: Instituto de Salud Carlos III Funding: 369260 Reference: PMP21/00073 Duration: 01/01/2022 - 31/12/2025
PMID: 35289066 Journal: JOURNAL OF THROMBOSIS AND HAEMOSTASIS Year: 2022 Reference: J Thromb Haemost. 2022 Jun;20(6):1390-1399. doi: 10.1111/jth.15699. Epub 2022 Mar 27. Impact factor: 5.824 Publication type: Paper in international publication Authors: Vagace, Jose Manuel, Ruiz-Llobet, Anna, Gassiot, Susanna, Sarrate, Edurne, Zubicaray, Josune, Dapena, Jose Luis, Rives, Susana, Sevilla, Julian, Menarguez Lopez, Angela, Panesso Romero, Melissa et al. DOI: 10.1111/jth.15699
PMID: 35241283 Journal: MEDICINA CLINICA Year: 2022 Reference: Med Clin (Barc). 2022 Feb 28. pii: S0025-7753(22)00055-0. doi: 10.1016/j.medcli.2022.01.009. Impact factor: 1.725 Publication type: Paper in national publication Authors: Galan-Gomez, Victor, Mestre, Carmen, Gonzalez-Vicent, Marta, Pascual, Antonia, Alonso, Laura, Regueiro, Alexandra, Plaza, Mercedes, Perez Hurtado, Jose Maria, Benito, Ana, Fuster, Jose Luis et al. DOI: 10.1016/j.medcli.2022.01.009
PMID: 34781360 Journal: Blood Advances Year: 2022 Reference: Blood Adv. 2022 Mar 8;6(5):1512-1524. doi: 10.1182/bloodadvances.2021005294. Impact factor: 6.799 Publication type: Paper in international publication Authors: Kapoor, Neena, Chiesa, Robert, Boelens, Jaap Jan, Duncan, Christine N, Kuhl, Jorn-Sven, Sevin, Caroline, Jones, Simon A, Amartino, Hernan M, Algeri, Mattia, Bunin, Nancy et al. DOI: 10.1182/bloodadvances.2021005294
PMID: 35170748 Journal: ACTA PSYCHIATRICA SCANDINAVICA Year: 2022 Reference: Acta Psychiatr Scand. 2022 Jul;146(1):36-50. doi: 10.1111/acps.13415. Epub 2022 Feb 25. Impact factor: 6.392 Publication type: Paper in international publication Authors: Salagre, Estela, Aedo, Alberto, Salgado-Pineda, Pilar, Montoro Salvatierra, Irene, Sanchez Gistau, Vanessa, Pomarol-Clotet, Edith, Ramos-Quiroga, Josep Antoni, Carvalho, Andre F, Garcia-Rizo, Clemente, Undurraga, Juan et al. DOI: 10.1111/acps.13415
PMID: 33303901 Journal: BONE MARROW TRANSPLANTATION Year: 2021 Reference: Bone Marrow Transplant. 2021 May;56(5):1213-1216. doi: 10.1038/s41409-020-01172-y. Epub 2020 Dec 10. Impact factor: 5.483 Publication type: Paper in international publication Authors: Murillo-Sanjuan, L, Gonzalez-Vicent, M, Argiles Aparicio, B, Badell Serra, I, Rodriguez Villa, A, Uria Oficialdegui, M L, Lopez-Duarte, M, Belendez-Bieler, C, Sastre Urgelles, A, Sevilla Navarro, J et al. DOI: 10.1038/s41409-020-01172-y
PMID: 33827367 Journal: LEUKEMIA & LYMPHOMA Year: 2021 Reference: Leuk Lymphoma. 2021 Sep;62(9):2202-2210. doi: 10.1080/10428194.2021.1907375. Epub 2021 Apr 7. Impact factor: 3.28 Publication type: Review in international publication Authors: Hidalgo-Gomez, Gloria, Palacio-Garcia, Carlos, Gallur, Laura, Blanco, Adoracion, Tazon-Vega, Barbara, Saumell, Silvia, Martinez, Noemi, Murillo, Laura, Murciano, Thais, Velasco, Pablo et al. DOI: 10.1080/10428194.2021.1907375
PMID: 33781716 Journal: ANALES DE PEDIATRIA Year: 2021 Reference: An Pediatr (Engl Ed). 2021 Mar 26. pii: S1695-4033(21)00148-X. doi: 10.1016/j.anpedi.2021.02.015. Impact factor: 1.5 Publication type: Paper in national publication Authors: Galan Gomez, Victor, de la Fuente Regano, Lydia, Rodriguez Villa, Antonia, Diaz de Heredia Rubio, Cristina, Gonzalez Vicent, Marta, Badell Serra, Isabel, Fernandez, Jose Maria, Pascual Martinez, Antonia Isabel, Perez Hurtado, Jose Maria, Lopez Duarte, Monica et al. DOI: 10.1016/j.anpedi.2021.02.015
PMID: 32979154 Journal: INFECTION Year: 2021 Reference: Infection. 2021 Apr;49(2):215-231. doi: 10.1007/s15010-020-01521-5. Epub 2020 Sep 26. Impact factor: 3.553 Publication type: Review in international publication Authors: Los-Arcos, Ibai, Alsina-Manrique, Laia, Diaz de Heredia, Cristina, Fortuny-Guasch, Claudia, Garcia-Cadenas, Irene, Garcia-Vidal, Carolina, Gonzalez-Vicent, Marta, Hernani, Rafael, Kwon, Mi, Machado, Marina et al. DOI: 10.1007/s15010-020-01521-5
PMID: 31799703 Journal: CLINICAL AND EXPERIMENTAL IMMUNOLOGY Year: 2020 Reference: Clin Exp Immunol. 2020 Apr;200(1):61-72. doi: 10.1111/cei.13405. Epub 2020 Jan 19. Impact factor: 3.532 Publication type: Paper in international publication Authors: Alonso, Laura, Riviere, Jacques G, Soler-Palacin, Pere, Colobran, Roger, Sayos, Joan, Martinez-Gallo, Monica, Franco-Jarava, Clara, Ossowski, Stephan, Drechsel, Oliver, Magallon-Lorenz, Miriam et al. DOI: 10.1111/cei.13405
PMID: 31586946 Journal: JOURNAL OF MEDICAL GENETICS Year: 2020 Reference: J Med Genet. 2020 Apr;57(4):258-268. doi: 10.1136/jmedgenet-2019-106249. Epub 2019 Oct 5. Impact factor: 4.943 Publication type: Paper in international publication Authors: Molines, Antonio, Perez de Soto, Inmaculada, Hernando, Ines, Munoz, Juan Antonio, Del Rosario Marin, Maria, Balmana, Judith, Stjepanovic, Neda, Carrasco, Estela, Cuesta, Isabel, Cosuelo, Jose Miguel et al. DOI: 10.1136/jmedgenet-2019-106249
PMID: 32273586 Journal: BONE MARROW TRANSPLANTATION Year: 2020 Reference: Bone Marrow Transplant. 2020 Sep;55(9):1884. doi: 10.1038/s41409-020-0901-x. Impact factor: 4.725 Publication type: Letter or abstract Authors: Gungor, Tayfun, Salim, Rahuman, Tischer, Johanna, Tecchio, Cristina, Russell, Nigel, Chybicka, Alicja, Styczynski, Jan, Krivan, Gergely, Smith, Owen, Stein, Jerry et al. DOI: 10.1038/s41409-020-0901-x
PMID: 32203263 Journal: BONE MARROW TRANSPLANTATION Year: 2020 Reference: Bone Marrow Transplant. 2020 Aug;55(8):1540-1551. doi: 10.1038/s41409-020-0854-0. Epub 2020 Mar 17. Impact factor: 4.725 Publication type: Paper in international publication Authors: Willasch, Andre Manfred, Peters, Christina, Sedlacek, Petr, Dalle, Jean-Hugues, Kitra-Roussou, Vassiliki, Yesilipek, Akif, Wachowiak, Jacek, Lankester, Arjan, Prete, Arcangelo, Hamidieh, Amir Ali et al. DOI: 10.1038/s41409-020-0854-0
"Generation of a bank of surgical orthotopic PDX (patient-derived xenografts) models within the framework of a personalized medicine program in pediatric cancer" was the awarded work, of the Childhood Cancer and Hematological Diseases Group of VHIR.
A study, co-led by Vall d’Hebron, has analysed the evolution of clinical trials with children and adolescents with cancer over the last 15 years, with the aim of optimising efficacy and defining lines for further progress.
The research team has shown that inhibiting the TRIB3 protein slows the growth of rhabdomyosarcoma and improves survival in animal models.
