About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The research group is focused on finding new molecular therapeutic targets and biomarkers based on knowledge of the biology of paediatric tumours, leukemias and hematologic diseases. The experience of the group in recent years has permitted the identification of new molecular targets that are very close to the clinical phase. In this stage, we have consolidated collaborations with the biotechnological industry in order to develop small molecules able to inhibit pro-oncogenic processes such as invasion or proliferation, with the aim of providing patients with innovative and more specific biological evidence-based therapies.
Another line of research is based on the study of liquid biopsy to develop a system based on NGS to monitor the probability of relapses.
Furthermore, we have implemented a personalized medicine program to guide the management of patients based on the molecular alterations of their tumours
PMID: 34786859 Journal: Small Year: 2022 Reference: Small. 2022 Jan;18(3):e2101959. doi: 10.1002/smll.202101959. Epub 2021 Nov 16. Impact factor: Publication type: Paper in international publication Authors: Abutbul-Ionita, Inbal; Albertazzi, Lorenzo; Boloix, Ariadna; Cordoba, Alba; Danino, Dganit; de Toledo, Josep Sanchez; Feiner-Gracia, Natalia; Foradada, Laia; Gallego, Soledad; Kober, Mariana et al. DOI: 10.1002/smll.202101959
PMID: 35029330 Journal: PEDIATRIC BLOOD & CANCER Year: 2022 Reference: Pediatr Blood Cancer. 2022 Aug;69(8):e29551. doi: 10.1002/pbc.29551. Epub 2022 Jan 14. Impact factor: Publication type: Paper in international publication Authors: Bautista, Francisco; Carceller, Fernando; Cortes, Marta; Moreno, Lucas; Rubio-San-Simon, Alba; Vaidya, Sucheta J et al. DOI: 10.1002/pbc.29551
PMID: 34582098 Journal: PEDIATRIC BLOOD & CANCER Year: 2022 Reference: Pediatr Blood Cancer. 2022 Feb;69(2):e29376. doi: 10.1002/pbc.29376. Epub 2021 Sep 28. Impact factor: Publication type: Paper in international publication Authors: Alaggio, Rita; Arush, Myriam Ben; Bisogno, Gianni; Coppadoro, Beatrice; Daragjati, Julia; Gallego, Soledad; Merks, Johannes H M; Minard-Colin, Veronique; Mudry, Peter; Slater, Olga et al. DOI: 10.1002/pbc.29376
PMID: 34865946 Journal: EUROPEAN JOURNAL OF CANCER Year: 2022 Reference: Eur J Cancer. 2022 Jan;160:206-214. doi: 10.1016/j.ejca.2021.10.031. Epub 2021 Dec 2. Impact factor: Publication type: Paper in international publication Authors: Bisogno, Gianni; Cesen, Maja; Coppadoro, Beatrice; De Corti, Federica; Ferrari, Andrea; Gains, Jennifer E; Gallego, Soledad; Gaze, Mark N; Glosli, Heidi; Jenney, Meriel et al. DOI: 10.1016/j.ejca.2021.10.031
PMID: 33718801 Journal: HemaSphere Year: 2021 Reference: Hemasphere. 2021 Mar 9;5(4):e539. doi: 10.1097/HS9.0000000000000539. eCollection 2021 Apr. Impact factor: Publication type: Paper in international publication Authors: Arias-Salgado, Elena G; Badell, Isabel; Belendez, Cristina; Bogliolo, Massimo; Bueren, Juan; Catala, Albert; Diaz de Heredia, Cristina; Galera, Ana; Galvez, Eva; Gimenez, Yari et al. DOI: 10.1097/HS9.0000000000000539
PMID: 33720495 Journal: PEDIATRIC BLOOD & CANCER Year: 2021 Reference: Pediatr Blood Cancer. 2021 Jun;68(6):e28963. doi: 10.1002/pbc.28963. Epub 2021 Mar 15. Impact factor: Publication type: Paper in international publication Authors: Abbink, Floor C H; Aerts, Isabelle; Atalay, Hatice Tuba; Bechrakis, Nikolaos E; Biewald, Eva; Brecht, Ines B; Caspi, Shani; Cassoux, Nathalie; Castela, Guilherme; Chantada, Guillermo et al. DOI: 10.1002/pbc.28963
PMID: 33661711 Journal: PEDIATRIC HEMATOLOGY AND ONCOLOGY Year: 2021 Reference: Pediatr Hematol Oncol. 2021 May;38(4):331-345. doi: 10.1080/08880018.2020.1868637. Epub 2021 Mar 4. Impact factor: Publication type: Paper in international publication Authors: Alonso, Laura; Benitez-Carabante, Maria Isabel; Bueno, David; Escudero, Adela; Fernandez-Arroyo, Alba; Heredia, Cristina Diaz de; Losantos, Itsaso; Martinez, Antonio Perez; Mestre-Duran, Carmen; Mozo, Yasmina et al. DOI: 10.1080/08880018.2020.1868637
PMID: 33277309 Journal: Cancer Discovery Year: 2021 Reference: Cancer Discov. 2021 Mar;11(3):545-559. doi: 10.1158/2159-8290.CD-20-0779. Epub 2020 Dec 4. Impact factor: Publication type: Review in international publication Authors: Bender, Julia Glade; DuBois, Steven G; Laetsch, Theodore W; Macy, Margaret E; Moreno, Lucas et al. DOI: 10.1158/2159-8290.CD-20-0779
PMID: 32107177 Journal: ANALES DE PEDIATRIA Year: 2020 Reference: An Pediatr (Barc). 2020 Jul;93(1):59.e1-59.e10. doi: 10.1016/j.anpedi.2019.12.014. Epub 2020 Feb 24. Impact factor: Publication type: Paper in national publication Authors: Alonso, Laura; Alonso, Marta M; Anguita, Javier; Blanquer, Miguel; Diaz, Miguel Angel; Fuster, Jose Luis; Garcia-Castro, Javier; Garcia-Morin, Marina; Gonzalez, Marta; Guerra-Garcia, Pilar et al. DOI: 10.1016/j.anpedi.2019.12.014
PMID: 32080355 Journal: BONE MARROW TRANSPLANTATION Year: 2020 Reference: Bone Marrow Transplant. 2020 Jun;55(6):1214. doi: 10.1038/s41409-020-0838-0. Impact factor: Publication type: Letter or abstract Authors: Ansari, Marc; Bader, Peter; Bakhtiar, Shahrzad; Balduzzi, Adriana; Bertaina, Alice; Boenig, Halvard; Buechner, Jochen; Cesaro, Simone; Corbacioglu, Selim; Dalissier, Arnaud et al. DOI: 10.1038/s41409-020-0838-0
PMID: 32067808 Journal: JOURNAL OF PEDIATRIC SURGERY Year: 2020 Reference: J Pediatr Surg. 2020 Sep;55(9):1897-1902. doi: 10.1016/j.jpedsurg.2020.01.053. Epub 2020 Feb 1. Impact factor: Publication type: Paper in international publication Authors: Bueno, Javier; Diez, Iratxe; Guillen, Gabriela; Lopez, Manuel; Lopez, Sergio; Lopez-Ben, Santiago; Molino, Jose A; Perez, Mercedes; Venturi, Carla et al. DOI: 10.1016/j.jpedsurg.2020.01.053
PMID: 32029909 Journal: BONE MARROW TRANSPLANTATION Year: 2020 Reference: Bone Marrow Transplant. 2020 Jun;55(6):1126-1136. doi: 10.1038/s41409-020-0818-4. Epub 2020 Feb 6. Impact factor: Publication type: Paper in international publication Authors: Ansari, Marc; Bader, Peter; Bakhtiar, Shahrzad; Balduzzi, Adriana; Bertaina, Alice; Boenig, Halvard; Buchner, Jochen; Cesaro, Simone; Corbacioglu, Selim; Dalissier, Arnaud et al. DOI: 10.1038/s41409-020-0818-4
PMID: 31493701 Journal: LEUKEMIA RESEARCH Year: 2019 Reference: Leuk Res. 2019 Oct;85:106217. doi: 10.1016/j.leukres.2019.106217. Epub 2019 Aug 13. Impact factor: 2.066 Publication type: Paper in international publication Authors: Carceller, Fernando, Hirsch, Steffen G, Khabra, Komel, Petterson, Toni, Malik, Rubina, Guerra-Garcia, Pilar, Moreno, Lucas, Marshall, Lynley V, Taj, Mary, Atra, Ayad et al. DOI: 10.1016/j.leukres.2019.106217
PMID: 30546069 Journal: BONE MARROW TRANSPLANTATION Year: 2019 Reference: Bone Marrow Transplant. 2019 Jul;54(7):1133-1137. doi: 10.1038/s41409-018-0422-z. Epub 2018 Dec 13. Impact factor: 4.674 Publication type: Paper in international publication Authors: Sanchez-Ortega, Isabel, Alonso, Laura, Sisinni, Luisa, Fox, Laura, Villacampa, Guillermo, Badell, Isabel, de Heredia, Cristina Diaz, Parody, Rocio, Ferra, Christelle, Solano, Carlos et al. DOI: 10.1038/s41409-018-0422-z
PMID: 31099923 Journal: PEDIATRIC DERMATOLOGY Year: 2019 Reference: Pediatr Dermatol. 2019 May;36(3):e69-e70. doi: 10.1111/pde.13760. Impact factor: 1.178 Publication type: Paper in international publication Authors: Giacaman, Aniza, Salinas Sanz, Jose Antonio, Navarro Noguera, Samuel, Diaz de Heredia Rubio, Cristina, Martin-Santiago, Ana et al. DOI: 10.1111/pde.13760
PMID: 31040790 Journal: Frontiers in Physiology Year: 2019 Reference: Front Physiol. 2019 Apr 16;10:386. doi: 10.3389/fphys.2019.00386. eCollection 2019. Impact factor: 3.201 Publication type: Paper in international publication Authors: Petkova-Kirova, Polina, Hertz, Laura, Danielczok, Jens, Huisjes, Rick, Makhro, Asya, Bogdanova, Anna, Manu-Pereira, Maria Del Mar, Vives Corrons, Joan-Lluis, van Wijk, Richard, Kaestner, Lars et al. DOI: 10.3389/fphys.2019.00386
PMID: 28287638 Journal: BONE MARROW TRANSPLANTATION Year: 2017 Reference: Bone Marrow Transplant. 2017 Jul;52(7):1029-1035. doi: 10.1038/bmt.2017.21. Epub 2017 Mar 13. Impact factor: 3.874 Publication type: Paper in international publication Authors: Dalle, J-H, Lucchini, G, Balduzzi, A, Ifversen, M, Jahnukainen, K, Macklon, K T, Ahler, A, Jarisch, A, Ansari, M, Beohou, E et al. DOI: 10.1038/bmt.2017.21
PMID: 28279690 Journal: ANALES DE PEDIATRIA Year: 2017 Reference: An Pediatr (Barc). 2017 Sep;87(3):155-163. doi: 10.1016/j.anpedi.2016.07.007. Epub 2017 Mar 6. Impact factor: 1.14 Publication type: Review in national publication Authors: Hladun, Raquel, Juan Ribelles, Antonio, Madero, Luis, Ramirez, Manuel, Fernandez Delgado, Rafael, Perez-Martinez, Antonio, Mata, Cristina, Llort, Anna, Martin Broto, Javier, Cela, Maria Elena et al. DOI: 10.1016/j.anpedi.2016.07.007
PMID: 28243259 Journal: Stem Cells International Year: 2017 Reference: Stem Cells Int. 2017;2017:7507380. doi: 10.1155/2017/7507380. Epub 2017 Jan 24. Impact factor: 3.54 Publication type: Paper in international publication Authors: Almazan-Moga, Ana, Zarzosa, Patricia, Vidal, Isaac, Molist, Carla, Giralt, Irina, Navarro, Natalia, Soriano, Aroa, Segura, Miguel F, Alfranca, Arantza, Garcia-Castro, Javier et al. DOI: 10.1155/2017/7507380
PMID: 28205365 Journal: PEDIATRIC BLOOD & CANCER Year: 2017 Reference: Pediatr Blood Cancer. 2017 Sep;64(9). doi: 10.1002/pbc.26486. Epub 2017 Feb 16. Impact factor: 2.513 Publication type: Paper in international publication Authors: Rogers, Timothy, Minard-Colin, Veronique, Cozic, Nathalie, Jenney, Meriel, Merks, Johannes H M, Gallego, Soledad, Devalck, Christine, Gaze, Mark N, Kelsey, Anna, Oberlin, Odile et al. DOI: 10.1002/pbc.26486
The association, once again, has shown its commitment to oncological research with a donation of €19,197 to the Cancer and Hematological Diseases Group for Children at VHIR.
The prestigious journal The Lancet has published the results of this study, which is the result of more than 20 years of pre-clinical research and 7 years of patient follow-up.
During the meeting, the role of the Vall d'Hebron Paediatric Research Hub in promoting research on children and adolescents was highlighted.
