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Childhood Cancer and Blood Disorders

The research group is focused on finding new molecular therapeutic targets and biomarkers based on knowledge of the biology of paediatric tumours, leukemias and hematologic diseases. The experience of the group in recent years has permitted the identification of new molecular targets that are very close to the clinical phase. In this stage, we have consolidated collaborations with the biotechnological industry in order to develop small molecules able to inhibit pro-oncogenic processes such as invasion or proliferation, with the aim of providing patients with innovative and more specific biological evidence-based therapies.

Another line of research is based on the study of liquid biopsy to develop a system based on NGS to monitor the probability of relapses.

Furthermore, we have implemented a personalized medicine program to guide the management of patients based on the molecular alterations of their tumours

Team

Amalia Varo Rodriguez

Amalia Varo Rodriguez

Senior researcher
Childhood Cancer and Blood Disorders
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Ángela Menárguez López

Ángela Menárguez López

Predoctoral researcher
Childhood Cancer and Blood Disorders
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Anna Collado Gimbert

Anna Collado Gimbert

Predoctoral researcher
Childhood Cancer and Blood Disorders
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Braulio Andrés Ortega Quesada

Braulio Andrés Ortega Quesada

Postdoctoral researcher
Childhood Cancer and Blood Disorders
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Claire Diot

Claire Diot

Administration and Management
Childhood Cancer and Blood Disorders
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Clara Rey Valenzuela

Clara Rey Valenzuela

Research technician
Childhood Cancer and Blood Disorders
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Amalia Varo Rodriguez

Amalia Varo Rodriguez

Senior researcher
Childhood Cancer and Blood Disorders
Read more
Ángela Menárguez López

Ángela Menárguez López

Predoctoral researcher
Childhood Cancer and Blood Disorders
Read more
Anna Collado Gimbert

Anna Collado Gimbert

Predoctoral researcher
Childhood Cancer and Blood Disorders
Read more
Braulio Andrés Ortega Quesada

Braulio Andrés Ortega Quesada

Postdoctoral researcher
Childhood Cancer and Blood Disorders
Read more
Claire Diot

Claire Diot

Administration and Management
Childhood Cancer and Blood Disorders
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Clara Rey Valenzuela

Clara Rey Valenzuela

Research technician
Childhood Cancer and Blood Disorders
Read more

Projects

La interacción entre el error innato de la inmunidad y los trastornos sanguíneos: desentrañando los defectos inmunitarios detrás de las enfermedades hematológicas comunes

IP: Pere Soler Palacín
Collaborators: Laura Batlle Masó, Maria Cristina Díaz de Heredia Rubio, Roger Colobran Oriol, Thaïs Murciano Carrillo, Constantino Sábado Álvarez, Miriam Gonzalez Amores, Janire Perurena Prieto, Andrea Martín Nalda, Lucas Moreno Martín-Retortillo, Jacques Gabriel Rivière
Funding agency: Instituto de Salud Carlos III
Funding: 179993.75
Reference: AC23_2/00033
Duration: 01/01/2024 - 31/12/2026

HELIOS: Haemoglobinopathies in European Liaison of Medicine and Science

IP: M Mar Mañu Pereira
Collaborators: -
Funding agency: EUROPEAN COMMISSION
Funding:
Reference: EC / COST-ACTION / 2022 / MAÑU
Duration: 20/09/2023 - 19/09/2027

MONALISA: A SIOPEN pragmatic clinical trial to MOnitor NeuroblastomA relapse with LIquid biopsy Sensitive Analysis

IP: Lucas Moreno Martín-Retortillo
Collaborators: Maria Jose Pérez García, Miguel Segura Ginard
Funding agency: EUROPEAN COMMISSION
Funding: 84800
Reference: MONALISA_HE-MISS2023
Duration: 01/01/2024 - 31/12/2028

TACTIC: Explorando soluciones a los retos de salud mediante ciencia disruptiva, terapias avanzadas y medicina de sistemas

IP: Begoña Benito Villabriga
Collaborators: Carmen Escudero Iriarte, Laia Ventura i Expósito, Susana Otero Romero, Ignacio Ferreira González, José Antonio Barrabés Riu, Carlos Nos Llopis, Pablo Velasco Puyó, Jose Fernando Rodríguez Palomares, Sunny Malhotra Sareen, Belen Perez Dueñas, Jaume Sastre Garriga, Joan López Hellin, Antonia Sambola Ayala, Jordi Rio Izquierdo, Nuria Rivas Gandara, Jordi Perez Rodon, Aroa Soriano Fernández, Manuel Comabella Lopez, Antonio Rodríguez Sinovas, Gisela Teixido Tura, Antonia Pijuan Domenech, Roser Ferrer Costa, Joaquin Seras Franzoso, Carmen Tur Gomez, Maria Cristina Díaz de Heredia Rubio, Laia Yañez Bisbe, Maria Jose Pérez García, Miguel Segura Ginard, Diego Baranda Martínez-Abasca, Cristina Auger Acosta, Neus Bellera Gotarda, Teresa Macarulla Mercadé, Herena Eixarch Ahufinger, M Mar Mañu Pereira, Deborah Pareto Onghena, Lorena Valero Arrese, Aitor Uribarri Gonzalez, Jordi Bañeras Rius, Alex Rovira Cañellas, Mar Tintore Subirana, Bruno García del Blanco, Ana Vivancos Prellezo, Maria Teresa Salcedo Allende, Marisol Ruiz Meana, Ana Belén Méndez Fernández, Xavier Montalban Gairín, Simon Schwartz Navarro, Anna Llort Sales, Carmen Espejo Ruiz, Raquel Hladun Alvaro, Sandra Mancilla Zamora, Ana Zabalza de Torres, Javier Inserte Igual, Luciana Midaglia Fernandez, Elizabeth Pando Rau, Gabriela Guillén Burrieza, Ana Laura Cazurro Gutierrez, David Gómez Andrés, Alvaro Cobo Calvo, Alvaro Calabuig Goena, Joaquin Castillo Justribo, Lydia Dux-Santoy Hurtado, Lucas Moreno Martín-Retortillo, Andres Miguez Gonzalez, Josep Roma Castanyer, Laura Dos Subirá, Nicolás Miguel Fissolo, Maria Nazarena Pizzi, Paolo Giovanni Nuciforo, Tian Tian, Diana Fernandes de Rafael, Andrea Guala
Funding agency: Instituto de Salud Carlos III
Funding: 2494527.53
Reference: FORT23/00034
Duration: 01/01/2024 - 31/12/2027

Blog

News

The charitable initiative created in honor of Pol is supporting a research project aimed at identifying therapeutic targets to treat a rare type of leukemia.

The charitable initiative will allocate all funds to research on pediatric nervous system tumors carried out at the Vall d’Hebron Research Institute

The study, led by Dr. Lucas Moreno and University of Birmingham shows that the combined administration of chemotherapy and immunotherapy with the antibody dinutuximab beta achieves a better treatment response.