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Childhood Cancer and Blood Disorders

The research group is focused on finding new molecular therapeutic targets and biomarkers based on knowledge of the biology of paediatric tumours, leukemias and hematologic diseases. The experience of the group in recent years has permitted the identification of new molecular targets that are very close to the clinical phase. In this stage, we have consolidated collaborations with the biotechnological industry in order to develop small molecules able to inhibit pro-oncogenic processes such as invasion or proliferation, with the aim of providing patients with innovative and more specific biological evidence-based therapies.

Another line of research is based on the study of liquid biopsy to develop a system based on NGS to monitor the probability of relapses.

Furthermore, we have implemented a personalized medicine program to guide the management of patients based on the molecular alterations of their tumours

Team

Mariona Morell Daniel

Mariona Morell Daniel

Predoctoral researcher
Childhood Cancer and Blood Disorders
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Maximo Tartaglia

Maximo Tartaglia

Research technician
Childhood Cancer and Blood Disorders
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Melissa Panesso Romero

Melissa Panesso Romero

Predoctoral researcher
Childhood Cancer and Blood Disorders
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Miera Maluenda, Marta

Miera Maluenda, Marta

Predoctoral researcher
Childhood Cancer and Blood Disorders
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Mosull del Campo, Raquel

Mosull del Campo, Raquel

Administration and Management
Childhood Cancer and Blood Disorders
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Núria Torquet i Luna

Núria Torquet i Luna

Research technician
Childhood Cancer and Blood Disorders
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Mariona Morell Daniel

Mariona Morell Daniel

Predoctoral researcher
Childhood Cancer and Blood Disorders
Read more
Maximo Tartaglia

Maximo Tartaglia

Research technician
Childhood Cancer and Blood Disorders
Read more
Melissa Panesso Romero

Melissa Panesso Romero

Predoctoral researcher
Childhood Cancer and Blood Disorders
Read more
Miera Maluenda, Marta

Miera Maluenda, Marta

Predoctoral researcher
Childhood Cancer and Blood Disorders
Read more
Mosull del Campo, Raquel

Mosull del Campo, Raquel

Administration and Management
Childhood Cancer and Blood Disorders
Read more
Núria Torquet i Luna

Núria Torquet i Luna

Research technician
Childhood Cancer and Blood Disorders
Read more

Projects

Desarrollo de nuevos fármacos basados en la inhibición de los co-receptores de la vía Hedgehog

IP: Josep Roma Castanyer
Collaborators: Soledad Gallego Melcón, Guillem Pons Barcons, Constantino Sábado Álvarez, Raquel Hladun Alvaro, Patricia Zarzosa Martinez
Funding agency: Instituto de Salud Carlos III
Funding: 122815
Reference: PI21/00640
Duration: 01/01/2022 - 31/12/2025

Next generation personalised medicine for childhood cancers

IP: Lucas Moreno Martín-Retortillo
Collaborators: Aroa Soriano Fernández, Jessica Camacho Soriano, Raquel Hladun Alvaro, Gabriela Guillén Burrieza, Andrea Vilaplana Blanes, Lorena Valero Arrese, Mariona Morell Daniel
Funding agency: Instituto de Salud Carlos III
Funding: 214170
Reference: PI21/01661
Duration: 01/01/2022 - 30/06/2026

A phase I trial of ABTL0812 in paediatric patients with advanced cancer including neuroblastoma

IP: Lucas Moreno Martín-Retortillo
Collaborators: Soledad Gallego Melcón, Cristina Gamez Cenzano, Aroa Soriano Fernández, Luis Riera Soler, Miguel Segura Ginard, Carlota Aguilera Ordoñez
Funding agency: Instituto de Salud Carlos III
Funding: 826760.77
Reference: ICI21/00076
Duration: 01/01/2022 - 31/12/2025

Implementation and new biomarker development for Personalised Medicine for Childhood Cancers in Spain

IP: Lucas Moreno Martín-Retortillo
Collaborators: Aroa Soriano Fernández, Miguel Segura Ginard, Lorena Valero Arrese, Raquel Hladun Alvaro, Elena Antima Martinez Saez, Marta Sese Faustino, Gabriela Guillén Burrieza, Josep Roma Castanyer, Andrea Vilaplana Blanes, Estela Carrasco López, Margarita Ortega Blanco, Implementation and new biomarker development for Personalised Medicine for Childhood Cancers in Spain, Asbleidy Carolina Torres Barbosa, Berta Campos Estela
Funding agency: Instituto de Salud Carlos III
Funding: 369260
Reference: PMP21/00073
Duration: 01/01/2022 - 31/12/2025

Blog

News

The charitable initiative created in honor of Pol is supporting a research project aimed at identifying therapeutic targets to treat a rare type of leukemia.

The charitable initiative will allocate all funds to research on pediatric nervous system tumors carried out at the Vall d’Hebron Research Institute

The study, led by Dr. Lucas Moreno and University of Birmingham shows that the combined administration of chemotherapy and immunotherapy with the antibody dinutuximab beta achieves a better treatment response.