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Childhood Cancer and Blood Disorders

The research group is focused on finding new molecular therapeutic targets and biomarkers based on knowledge of the biology of paediatric tumours, leukemias and hematologic diseases. The experience of the group in recent years has permitted the identification of new molecular targets that are very close to the clinical phase. In this stage, we have consolidated collaborations with the biotechnological industry in order to develop small molecules able to inhibit pro-oncogenic processes such as invasion or proliferation, with the aim of providing patients with innovative and more specific biological evidence-based therapies.

Another line of research is based on the study of liquid biopsy to develop a system based on NGS to monitor the probability of relapses.

Furthermore, we have implemented a personalized medicine program to guide the management of patients based on the molecular alterations of their tumours

Team

Martina Amanzio

Martina Amanzio

Research technician
Childhood Cancer and Blood Disorders
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Miera Maluenda, Marta

Miera Maluenda, Marta

Predoctoral researcher
Childhood Cancer and Blood Disorders
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Mosull del Campo, Raquel

Mosull del Campo, Raquel

Administration and Management
Childhood Cancer and Blood Disorders
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Ohiane Bedialauneta Somoza

Ohiane Bedialauneta Somoza

Predoctoral researcher
Childhood Cancer and Blood Disorders
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Patricia González Ruiz

Patricia González Ruiz

Administration and Management
Childhood Cancer and Blood Disorders
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Patricia Hannon Barroeta

Patricia Hannon Barroeta

Research technician
Childhood Cancer and Blood Disorders
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Martina Amanzio

Martina Amanzio

Research technician
Childhood Cancer and Blood Disorders
Read more
Miera Maluenda, Marta

Miera Maluenda, Marta

Predoctoral researcher
Childhood Cancer and Blood Disorders
Read more
Mosull del Campo, Raquel

Mosull del Campo, Raquel

Administration and Management
Childhood Cancer and Blood Disorders
Read more
Ohiane Bedialauneta Somoza

Ohiane Bedialauneta Somoza

Predoctoral researcher
Childhood Cancer and Blood Disorders
Read more
Patricia González Ruiz

Patricia González Ruiz

Administration and Management
Childhood Cancer and Blood Disorders
Read more
Patricia Hannon Barroeta

Patricia Hannon Barroeta

Research technician
Childhood Cancer and Blood Disorders
Read more

Projects

Desarrollo de nuevos fármacos basados en la inhibición de los co-receptores de la vía Hedgehog

IP: Josep Roma Castanyer
Collaborators: Soledad Gallego Melcón, Guillem Pons Barcons, Constantino Sábado Álvarez, Raquel Hladun Alvaro, Patricia Zarzosa Martinez
Funding agency: Instituto de Salud Carlos III
Funding: 122815
Reference: PI21/00640
Duration: 01/01/2022 - 31/12/2025

Next generation personalised medicine for childhood cancers

IP: Lucas Moreno Martín-Retortillo
Collaborators: Aroa Soriano Fernández, Jessica Camacho Soriano, Raquel Hladun Alvaro, Gabriela Guillén Burrieza, Andrea Vilaplana Blanes, Lorena Valero Arrese, Mariona Morell Daniel
Funding agency: Instituto de Salud Carlos III
Funding: 214170
Reference: PI21/01661
Duration: 01/01/2022 - 30/06/2026

A phase I trial of ABTL0812 in paediatric patients with advanced cancer including neuroblastoma

IP: Lucas Moreno Martín-Retortillo
Collaborators: Soledad Gallego Melcón, Cristina Gamez Cenzano, Aroa Soriano Fernández, Luis Riera Soler, Miguel Segura Ginard, Carlota Aguilera Ordoñez
Funding agency: Instituto de Salud Carlos III
Funding: 826760.77
Reference: ICI21/00076
Duration: 01/01/2022 - 31/12/2025

Implementation and new biomarker development for Personalised Medicine for Childhood Cancers in Spain

IP: Lucas Moreno Martín-Retortillo
Collaborators: Aroa Soriano Fernández, Miguel Segura Ginard, Lorena Valero Arrese, Raquel Hladun Alvaro, Elena Antima Martinez Saez, Marta Sese Faustino, Gabriela Guillén Burrieza, Josep Roma Castanyer, Andrea Vilaplana Blanes, Estela Carrasco López, Margarita Ortega Blanco, Implementation and new biomarker development for Personalised Medicine for Childhood Cancers in Spain, Asbleidy Carolina Torres Barbosa, Berta Campos Estela
Funding agency: Instituto de Salud Carlos III
Funding: 369260
Reference: PMP21/00073
Duration: 01/01/2022 - 31/12/2025

Blog

News

The integration of Patient-Reported Outcome Measures (PROMs) will make it possible to incorporate patients' experiences and quality of life into research on sickle cell disease and other rare anaemias.

The Scientific Coordinator of ERN-EuroBloodNet will lead for one year the group that defines the common strategy of the European Reference Networks to improve care for rare and complex diseases.

Vall d’Hebron participates as a reference centre in Spain for early-phase clinical trials and coordinates the national ReALLNet network, promoting research into relapsed acute lymphoblastic leukemia.