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Childhood Cancer and Blood Disorders

The research group is focused on finding new molecular therapeutic targets and biomarkers based on knowledge of the biology of paediatric tumours, leukemias and hematologic diseases. The experience of the group in recent years has permitted the identification of new molecular targets that are very close to the clinical phase. In this stage, we have consolidated collaborations with the biotechnological industry in order to develop small molecules able to inhibit pro-oncogenic processes such as invasion or proliferation, with the aim of providing patients with innovative and more specific biological evidence-based therapies.

Another line of research is based on the study of liquid biopsy to develop a system based on NGS to monitor the probability of relapses.

Furthermore, we have implemented a personalized medicine program to guide the management of patients based on the molecular alterations of their tumours

Team

David Silva Soto

David Silva Soto

Research technician
Childhood Cancer and Blood Disorders
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Esther García Pagès

Esther García Pagès

Postdoctoral researcher
Childhood Cancer and Blood Disorders
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Flors Riera Enseñat

Flors Riera Enseñat

Research technician
Childhood Cancer and Blood Disorders
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Gal·la Farreny Fernández

Gal·la Farreny Fernández

Predoctoral researcher
Childhood Cancer and Blood Disorders
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Gemma Montagut Pino

Gemma Montagut Pino

Senior researcher
Childhood Cancer and Blood Disorders
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Jorge Fernández Fernández

Jorge Fernández Fernández

Research technician
Childhood Cancer and Blood Disorders
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David Silva Soto

David Silva Soto

Research technician
Childhood Cancer and Blood Disorders
Read more
Esther García Pagès

Esther García Pagès

Postdoctoral researcher
Childhood Cancer and Blood Disorders
Read more
Flors Riera Enseñat

Flors Riera Enseñat

Research technician
Childhood Cancer and Blood Disorders
Read more
Gal·la Farreny Fernández

Gal·la Farreny Fernández

Predoctoral researcher
Childhood Cancer and Blood Disorders
Read more
Gemma Montagut Pino

Gemma Montagut Pino

Senior researcher
Childhood Cancer and Blood Disorders
Read more
Jorge Fernández Fernández

Jorge Fernández Fernández

Research technician
Childhood Cancer and Blood Disorders
Read more

Projects

HELIOS: Haemoglobinopathies in European Liaison of Medicine and Science

IP: M Mar Mañu Pereira
Collaborators: -
Funding agency: EUROPEAN COMMISSION
Funding:
Reference: EC / COST-ACTION / 2022 / MAÑU
Duration: 20/09/2023 - 19/09/2027

MONALISA: A SIOPEN pragmatic clinical trial to MOnitor NeuroblastomA relapse with LIquid biopsy Sensitive Analysis

IP: Lucas Moreno Martín-Retortillo
Collaborators: Maria Jose Pérez García, Miguel Segura Ginard
Funding agency: EUROPEAN COMMISSION
Funding: 84800
Reference: MONALISA_HE-MISS2023
Duration: 01/01/2024 - 31/12/2028

TACTIC: Explorando soluciones a los retos de salud mediante ciencia disruptiva, terapias avanzadas y medicina de sistemas

IP: Begoña Benito Villabriga
Collaborators: Carmen Escudero Iriarte, Laia Ventura i Expósito, Susana Otero Romero, Ignacio Ferreira González, José Antonio Barrabés Riu, Carlos Nos Llopis, Pablo Velasco Puyó, Jose Fernando Rodríguez Palomares, Belen Perez Dueñas, Jaume Sastre Garriga, Joan López Hellin, Antonia Sambola Ayala, Jordi Rio Izquierdo, Nuria Rivas Gandara, Jordi Perez Rodon, Aroa Soriano Fernández, Manuel Comabella Lopez, Antonio Rodríguez Sinovas, Gisela Teixido i Tura, Antonia Pijuan Domenech, Roser Ferrer Costa, Carmen Tur Gomez, Maria Cristina Díaz de Heredia Rubio, Laia Yañez Bisbe, Maria Jose Pérez García, Miguel Segura Ginard, TACTIC: Explorando soluciones a los retos de salud mediante ciencia disruptiva, terapias avanzadas y medicina de sistemas, Cristina Auger Acosta, Neus Bellera Gotarda, TACTIC: Explorando soluciones a los retos de salud mediante ciencia disruptiva, terapias avanzadas y medicina de sistemas, Herena Eixarch Ahufinger, M Mar Mañu Pereira, Deborah Pareto Onghena, Lorena Valero Arrese, Aitor Uribarri Gonzalez, Jordi Bañeras Rius, Alex Rovira Cañellas, Mar Tintore Subirana, Bruno Garcia del Blanco, Ana Vivancos Prellezo, Maria Teresa Salcedo Allende, Marisol Ruiz Meana, Ana Belén Méndez Fernández, Anna Llort Sales, Carmen Espejo Ruiz, Raquel Hladun Alvaro, Sandra Mancilla Zamora, Ana Zabalza de Torres, Marc Miquel Moltó Abad, Javier Inserte Igual, Luciana Midaglia Fernandez, Gabriela Guillén Burrieza, David Gómez Andrés, Alvaro Cobo Calvo, Alvaro Calabuig Goena, Joaquin Castillo Justribo, Lucas Moreno Martín-Retortillo, Andres Miguez Gonzalez, Josep Roma Castanyer, Laura Dos Subirá, Jaume Capdevila Castillon, Nicolás Miguel Fissolo , Maria Nazarena Pizzi, Paolo Giovanni Nuciforo, Tian Tian, Andrea Guala , Juan Pablo Betancur Rengifo
Funding agency: Instituto de Salud Carlos III
Funding: 2494527.53
Reference: FORT23/00034
Duration: 01/01/2024 - 31/12/2027

Development of epigenetic therapies for the treatment of pediatric tumors of the nervous system

IP: Miguel Segura Ginard
Collaborators: Marta Miera Maluenda, Development of epigenetic therapies for the treatment of pediatric tumors of the nervous system
Funding agency: Fundació Institut de Recerca HUVH
Funding: 102820.06
Reference: VHIR-PHD-2023-003
Duration: 01/12/2023 - 30/11/2027

Blog

News

The projects, selected under the 2026 Health Research and CaixaImpulse Health Innovation calls, address topics ranging from new therapies for childhood neurological disorders and Parkinson’s disease to the treatment of mitochondrial diseases and cancer.

A new publication describes the creation of this initiative, which has facilitated access to genomic studies for more than 900 pediatric patients with cancer from across Spain.

The families of the professionals had the opportunity to visit the facilities and discover how we work at the institution.