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Childhood Cancer and Blood Disorders

The research group is focused on finding new molecular therapeutic targets and biomarkers based on knowledge of the biology of paediatric tumours, leukemias and hematologic diseases. The experience of the group in recent years has permitted the identification of new molecular targets that are very close to the clinical phase. In this stage, we have consolidated collaborations with the biotechnological industry in order to develop small molecules able to inhibit pro-oncogenic processes such as invasion or proliferation, with the aim of providing patients with innovative and more specific biological evidence-based therapies.

Another line of research is based on the study of liquid biopsy to develop a system based on NGS to monitor the probability of relapses.

Furthermore, we have implemented a personalized medicine program to guide the management of patients based on the molecular alterations of their tumours

Team

María Dolores Fernández González

María Dolores Fernández González

Administration and Management
Childhood Cancer and Blood Disorders
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Maria Gallego Rodriguez

Maria Gallego Rodriguez

Predoctoral researcher
Childhood Cancer and Blood Disorders
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Maria Jesus Rodríguez Rodríguez

Maria Jesus Rodríguez Rodríguez

Research technician
Childhood Cancer and Blood Disorders
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Maria Luz Uría Oficialdegui

Maria Luz Uría Oficialdegui

Predoctoral researcher
Childhood Cancer and Blood Disorders
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Maria Paula Pérez Albert

Maria Paula Pérez Albert

Main researcher
Childhood Cancer and Blood Disorders
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Mariona Morell Daniel

Mariona Morell Daniel

Predoctoral researcher
Childhood Cancer and Blood Disorders
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María Dolores Fernández González

María Dolores Fernández González

Administration and Management
Childhood Cancer and Blood Disorders
Read more
Maria Gallego Rodriguez

Maria Gallego Rodriguez

Predoctoral researcher
Childhood Cancer and Blood Disorders
Read more
Maria Jesus Rodríguez Rodríguez

Maria Jesus Rodríguez Rodríguez

Research technician
Childhood Cancer and Blood Disorders
Read more
Maria Luz Uría Oficialdegui

Maria Luz Uría Oficialdegui

Predoctoral researcher
Childhood Cancer and Blood Disorders
Read more
Maria Paula Pérez Albert

Maria Paula Pérez Albert

Main researcher
Childhood Cancer and Blood Disorders
Read more
Mariona Morell Daniel

Mariona Morell Daniel

Predoctoral researcher
Childhood Cancer and Blood Disorders
Read more

Projects

International integrated analysis to identify markers of poor survival in high-risk neuroblastoma

IP: Lucas Moreno Martín-Retortillo
Collaborators: Andrea Vilaplana Blanes, Andrea Vilaplana Blanes, Mariona Morell Daniel
Funding agency: Solving Kids’ Cancer
Funding: 131766.91
Reference: BORNEO_L.MORENO_AEFR_2020
Duration: 02/11/2020 - 30/06/2026

Next generation personalised medicine for childhood cancers

IP: Lucas Moreno Martín-Retortillo
Collaborators: Andrea Vilaplana Blanes, Aroa Soriano Fernández, Jessica Camacho Soriano, Lorena Valero Arrese, Raquel Hladun Alvaro, Mariona Morell Daniel, Gabriela Guillén Burrieza
Funding agency: Instituto de Salud Carlos III
Funding: 214170
Reference: PI21/01661
Duration: 01/01/2022 - 30/06/2026

A phase I trial of ABTL0812 in paediatric patients with advanced cancer including neuroblastoma

IP: Lucas Moreno Martín-Retortillo
Collaborators: Soledad Gallego Melcón, Cristina Gamez Cenzano, Aroa Soriano Fernández, Luis Riera Soler, Miguel Segura Ginard, Carlota Aguilera Ordoñez
Funding agency: Instituto de Salud Carlos III
Funding: 826760.77
Reference: ICI21/00076
Duration: 01/01/2022 - 30/06/2026

Implementation and new biomarker development for Personalised Medicine for Childhood Cancers in Spain

IP: Lucas Moreno Martín-Retortillo
Collaborators: Andrea Vilaplana Blanes, Aroa Soriano Fernández, Aroa Soriano Fernández, Margarita Ortega Blanco, Miguel Segura Ginard, Lorena Valero Arrese, Berta Campos Estela, Raquel Hladun Alvaro, Elena Antima Martinez Saez, Marta Sese Faustino, Estela Carrasco López, Gabriela Guillén Burrieza, Josep Roma Castanyer
Funding agency: Instituto de Salud Carlos III
Funding: 369260
Reference: PMP21/00073
Duration: 01/01/2022 - 30/06/2026

Blog

News

The projects, selected under the 2026 Health Research and CaixaImpulse Health Innovation calls, address topics ranging from new therapies for childhood neurological disorders and Parkinson’s disease to the treatment of mitochondrial diseases and cancer.

A new publication describes the creation of this initiative, which has facilitated access to genomic studies for more than 900 pediatric patients with cancer from across Spain.

The families of the professionals had the opportunity to visit the facilities and discover how we work at the institution.