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Clinical Biochemistry, Drug Delivery & Therapy

The Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT) group arises from the merger of two VHIR groups, the Clinical Biochemistry group and the Drug Delivery and Targeting group, which they develop preclinical and clinical research in the diagnosis and therapy of different diseases.

With a direct link to the Clinical Biochemistry service of the Vall d'Hebron Hospital, our scope of action ranges from the analysis of massive data coming from the service, the development of diagnostic and prognostic biomarkers, evaluation of existing therapies and the development of new therapeutic strategies based on nanotechnology.

In terms of specific pathologies or indications, the group has an extensive track record in basic and applied research in cancer (new biomarkers, therapeutic targets and new treatments), metabolopathies (biomarkers and improvements in enzyme replacement therapy), kidney disease and liver disease.

Publications

Olaparib for the Treatment of Patients With Metastatic Castration-Resistant Prostate Cancer and Alterations in BRCA1 and/or BRCA2 in the PROfound Trial.

PMID: 37963304
Journal: JOURNAL OF CLINICAL ONCOLOGY
Year: 2023
Reference: J Clin Oncol. 2023 Nov 14:JCO2300339. doi: 10.1200/JCO.23.00339.
Impact factor:
Publication type: Paper in international publication
Authors: Agarwal, Neeraj; Augustin, Salvador; Barnicle, Alan; Chi, Kim N; Ciudin, Andreea; de Bono, Johann S; Ferrer-Costa, Roser; Fizazi, Karim; Gabriel-Medina, Pablo; Hussain, Maha et al.
DOI: 10.1200/JCO.23.00339

Formation of an invasion-permissive matrix requires TGFbeta/SNAIL1-regulated alternative splicing of fibronectin.

PMID: 37964360
Journal: BREAST CANCER RESEARCH
Year: 2023
Reference: Breast Cancer Res. 2023 Nov 14;25(1):143. doi: 10.1186/s13058-023-01736-y.
Impact factor:
Publication type: Paper in international publication
Authors: Baulida, Josep; Benitez-Carbante, Maria Isabel; Benitez-Carbante, Maria Isabel; Diaz de Heredia, Cristina; Eyras, Eduardo; Fernandez Ledesma, Berta; Fernandez Ledesma, Berta; Fernandez-Polo, Aurora; Franco-Valls, Hector; Garcia de Herreros, Antonio et al.
DOI: 10.1186/s13058-023-01736-y

Reference ranges of thyroid hormones during the first trimester in Catalan women using the Atellica(R) IM Solution Immunoassay Analyzer.

PMID: 37996255
Journal: ANNALS OF CLINICAL BIOCHEMISTRY
Year: 2023
Reference: Ann Clin Biochem. 2023 Nov 23:45632231219387. doi: 10.1177/00045632231219387.
Impact factor:
Publication type: Paper in international publication
Authors: Andrade, Monica Viegas; Blanco, Albert; Bracarense, Henrique; Braga, Paulo Estevao Franco; Comas, Immaculada; Conesa, Laura; de Miranda, Maria Carolina Correa; de Souza, Aline; Diaz-Troyano, Noelia; Ferrer, Roser et al.
DOI: 10.1177/00045632231219387

Electronic health records (EHRs) in clinical research and platform trials: application of the innovative EHR-based methods developed by EU-PEARL.

PMID: 38000766
Journal: JOURNAL OF BIOMEDICAL INFORMATICS
Year: 2023
Reference: J Biomed Inform. 2023 Nov 22:104553. doi: 10.1016/j.jbi.2023.104553.
Impact factor:
Publication type: Paper in international publication
Authors: Amasi-Hartoonian, Nare; Ammour, Nadir; Begum, Amina; Blanco, Albert; Brown, Mollie; Comas, Immaculada; Conesa, Laura; Couvert, Camille; Diaz-Troyano, Noelia; Didden, Eva-Maria et al.
DOI: 10.1016/j.jbi.2023.104553

The frequency of defective genomes in Omicron differs from that of the Alpha, Beta and Delta variants.

PMID: 36581627
Journal: Scientific Reports
Year: 2022
Reference: Sci Rep. 2022 Dec 29;12(1):22571. doi: 10.1038/s41598-022-24918-8.
Impact factor:
Publication type: Paper in international publication
Authors: Adombi, Caroline Melanie; Andres, Cristina; Anton, Andres; Borras, Blanca; Campos, Carolina; Codina, Maria Gema; Colomer-Castell, Sergi; Esperalba, Juliana; Esteban, Juan Ignacio; Garcia-Cehic, Damir et al.
DOI: 10.1038/s41598-022-24918-8

Rapid and accurate method for quantifying busulfan in plasma samples by isocratic liquid chromatography-tandem mass spectrometry (LC-MS/MS)

PMID: NOPMID0100
Journal: Advances in Laboratory Medicine
Year: 2022
Reference: Adv Lab Med / Av en Med Lab. 2022;3(3):263-271. doi:10.1515/almed-2022-0016
Impact factor:
Publication type: Paper in national publication
Authors: Barquin Del Pino , Raquel ; Benitez Carabante, Maria Isabel ; Casis Saenz, Ernesto; Castellote Bellés, Laura; Ferrer Costa, Roser; López Hellin, Joan; Martinez Sánchez, Luisa; Miarons Font , Marta; Paciucci Barzanti, Rosanna; Rodríguez Frias, Francisco et al.
DOI: 10.1515/almed-2022-0016

Scanning pulsed laser ablation in liquids: An alternative route to obtaining biocompatible YbFe nanoparticles as multiplatform contrast agents for combined MRI and CT imaging

PMID: NOPMID0101
Journal: Ceramics International
Year: 2022
Reference: Ceram Int. 2023;49(6):9324-9337. doi:10.1016/j.ceramint.2022.11.099
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Bomati-Miguel, Óscar; Felix, Eduardo; Fernández-Ponce, Cecilia; García-Cózar, Francisco; Kriwet, Jürgen; Lahoz, Ruth; Litrán, Rocío; Llaguno-Munive, Monserrat; Mánuel, Jose M et al.
DOI: 10.1016/j.ceramint.2022.11.099

Enzyme replacement therapy: current challenges and drug delivery prospects via extracellular vesicles

PMID: PMID0102
Journal: Rare Disease and Orphan Drugs Journal
Year: 2022
Reference: Rare Dis Orphan Drugs J. 2022;1(3):13. doi:10.20517/rdodj.2022.09
Impact factor:
Publication type: Editorail in international publication
Authors: Abasolo, Ibane; Gazeau, Florence; K. A. Silva, Amanda; Sagné, Corinne et al.
DOI: 10.20517/rdodj.2022.09

Extracellular vesicles from recombinant cell factories improve the activity and efficacy of enzymes defective in lysosomal storage disorders.

PMID: 33738082
Journal: Journal of Extracellular Vesicles
Year: 2021
Reference: J Extracell Vesicles. 2021 Mar;10(5):e12058. doi: 10.1002/jev2.12058. Epub 2021 Mar 12.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Albertazzi, Lorenzo; Boullosa, Ana; Casas, Josefina; Corchero, Jose Luis; Diaz-Riascos, Zamira V; Garcia-Aranda, Natalia; Garcia-Fruitos, Elena; Gonzalez, Patricia; Grayston, Alba et al.
DOI: 10.1002/jev2.12058

Resistance-associated substitutions after sofosbuvir/velpatasvir/voxilaprevir triple therapy failure.

PMID: 33720484
Journal: JOURNAL OF VIRAL HEPATITIS
Year: 2021
Reference: J Viral Hepat. 2021 Sep;28(9):1319-1324. doi: 10.1111/jvh.13497. Epub 2021 Mar 22.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Campos, Carolina; Canizares, Angelina; Carrion, Jose Antonio; Castro-Iglesias, Angeles; Costa, Juan Garcia; Esteban, Juan Ignacio; Garcia-Cehic, Damir; Gregori, Josep; Macenlle, Ramiro et al.
DOI: 10.1111/jvh.13497

A Bibliometric Evaluation of the Top 100 Cited Dimethyl Fumarate Articles.

PMID: 33669498
Journal: MOLECULES
Year: 2021
Reference: Molecules. 2021 Feb 19;26(4). pii: molecules26041085. doi: 10.3390/molecules26041085.
Impact factor:
Publication type: Paper in international publication
Authors: Galindo, Maria F; Garcia-Fernandez, Alba Estela; Garcia-Fernandez, Francisco Javier; Ikuta, Ichiro; Jordan, Joaquin; Nava, Eduardo; Solis Garcia Del Pozo, Julian et al.
DOI: 10.3390/molecules26041085

Challenges in primary focal segmental glomerulosclerosis diagnosis: from the diagnostic algorithm to novel biomarkers.

PMID: 33623672
Journal: Clinical Kidney Journal
Year: 2021
Reference: Clin Kidney J. 2020 Aug 11;14(2):482-491. doi: 10.1093/ckj/sfaa110. eCollection 2021 Feb.
Impact factor:
Publication type: Review in international publication
Authors: Agraz, Irene; Ariceta, Gema; Garcia-Carro, Clara; Jacobs-Cacha, Conxita; Lopez-Hellin, Joan; Moreso, Francesc; Seron, Daniel; Soler, Maria Jose; Toapanta-Gaibor, Nestor; Vergara, Ander et al.
DOI: 10.1093/ckj/sfaa110

Blog

News

Based on the study led by VHIR, a clinical trial has been approved for patients with locally advanced pancreatic cancer.

Vall d'Hebron participates in a project to develop innovative microsampling technology, making blood collection more accessible and patient-centered.

Researchers from all over Europe gathered to kick off the SPM4.0 project, an innovative Marie Curie Skłodowska (MSCA-DN) doctoral network that promotes the development of autonomous Scanning Probe Microscopy with AI.