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Clinical Neuroimmunology

The group of Clinical Neuroimmunology - Centre d'Esclerosi Múltiple de Catalunya (Cemcat) at the Vall d'Hebron Institut de Recerca (VHIR) is a multidisciplinary group dedicated to clinical assistance, physical and cognitive rehabilitation, and clinical and basic research on multiple sclerosis (MS). Cemcat is a national but also an international reference center in the clinical assistance of MS patients. The research performed in the group is divided and further combined in clinical and basic research. In addition, basic research has a marked translational character since the ultimate goal of the group is to improve the quality of life of patients suffering from MS, through in-depth knowledge of the pathogenic mechanisms of the disease and the development of new and more effective therapeutic approaches. 

Team

Carlos Nos  Llopis

Carlos Nos Llopis

Senior researcher
Clinical Neuroimmunology
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Carme Santoyo Medina

Carme Santoyo Medina

Main researcher
Clinical Neuroimmunology
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Carmen Tur Gomez

Carmen Tur Gomez

Main researcher
Clinical Neuroimmunology
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Cristina Vetoret Vázquez

Cristina Vetoret Vázquez

Research assistant
Clinical Neuroimmunology
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Dunia Muñoz Valdivielso

Dunia Muñoz Valdivielso

Administration and Management
Clinical Neuroimmunology
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Edwin Roger Meza Murillo

Edwin Roger Meza Murillo

Predoctoral researcher
Clinical Neuroimmunology
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Carlos Nos  Llopis

Carlos Nos Llopis

Senior researcher
Clinical Neuroimmunology
Read more
Carme Santoyo Medina

Carme Santoyo Medina

Main researcher
Clinical Neuroimmunology
Read more
Carmen Tur Gomez

Carmen Tur Gomez

Main researcher
Clinical Neuroimmunology
Read more
Cristina Vetoret Vázquez

Cristina Vetoret Vázquez

Research assistant
Clinical Neuroimmunology
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Dunia Muñoz Valdivielso

Dunia Muñoz Valdivielso

Administration and Management
Clinical Neuroimmunology
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Edwin Roger Meza Murillo

Edwin Roger Meza Murillo

Predoctoral researcher
Clinical Neuroimmunology
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Projects

Liquid biopsy in multiple sclerosis: A non-invasive approach for disease prognosis and drug discovery...

IP: Sunny Malhotra Sareen
Collaborators: Jordi Rio Izquierdo, Ana Zabalza de Torres, Rucsanda Pinteac
Funding agency: Instituto de Salud Carlos III
Funding: 140360
Reference: PI20/01697
Duration: 01/01/2021 - 30/06/2025

Search of immune signatures associated with multiple sclerosis disease phenotypes

IP: Nicolás Miguel Fissolo
Collaborators: Luciana Midaglia Fernandez, Breogan Rodriguez Acevedo
Funding agency: Instituto de Salud Carlos III
Funding: 169400
Reference: PI20/00276
Duration: 01/01/2021 - 30/06/2025

Deciphering clinical features and pathogenesis of myelin oligodendrocyte glycoprotein (MOG) antibodies in adult patients with a first demyelinating syndrome

IP: Alvaro Cobo Calvo
Collaborators: Rosalia Horno Ocaña, Cristina Auger Acosta, Marta Rodríguez Barranco, Luciana Midaglia Fernandez, Breogan Rodriguez Acevedo, Mireia Castillo Juarez
Funding agency: Instituto de Salud Carlos III
Funding: 134915
Reference: PI20/00800
Duration: 01/01/2021 - 30/06/2025

Caracterización de patrones espaciotemporales de daño tisular cerebral en esclerosis múltiple mediante técnicas de aprendizaje profundo no supervisado

IP: Carmen Tur Gomez
Collaborators: -
Funding agency: Fundación Merck Salud
Funding: 30000
Reference: MERK/INVESTIGACION/2020/TUR
Duration: 15/06/2021 - 15/06/2024

Publications

Assessment of Upper Extremity Function in Multiple Sclerosis: Feasibility of a Digital Pinching Test.

PMID: 37782540
Journal: JMIR formative research
Year: 2023
Reference: JMIR Form Res. 2023 Oct 2;7:e46521. doi: 10.2196/46521.
Impact factor:
Publication type: Paper in international publication
Authors: Bernasconi, Corrado; Dondelinger, Frank; Elantkowski, Marcin; Graves, Jennifer S; Lindemann, Michael; Lipsmeier, Florian; Midaglia, Luciana; Montalban, Xavier; Zhang, Yan-Ping et al.
DOI: 10.2196/46521

Global and Regional Deep Learning Models for Multiple Sclerosis Stratification From MRI.

PMID: 37803817
Journal: JOURNAL OF MAGNETIC RESONANCE IMAGING
Year: 2023
Reference: J Magn Reson Imaging. 2023 Oct 6. doi: 10.1002/jmri.29046.
Impact factor:
Publication type: Paper in international publication
Authors: Alberich, Manel; Alberich, Manel; Arrambide, Georgina; Auger, Cristina; Auger, Cristina; Carbonell-Mirabent, Pere; Castillo, Joaqui N; Cobo-Calvo, Alvaro; Cobo-Calvo, Alvaro; Coll, Llucia et al.
DOI: 10.1002/jmri.29046

The OSCAR-MP Consensus Criteria for Quality Assessment of Retinal Optical Coherence Tomography Angiography.

PMID: 37813596
Journal: Neurology-Neuroimmunology & Neuroinflammation
Year: 2023
Reference: Neurol Neuroimmunol Neuroinflamm. 2023 Oct 9;10(6):e200169. doi: 10.1212/NXI.0000000000200169. Print 2023 Nov.
Impact factor:
Publication type: Paper in international publication
Authors: Al-Louzi, Omar; Albrecht, Philipp; Aly, Lilian; Banze, Nicolas; Baumann, Carmen; Cabello, Sergio; Calabresi, Peter A; Ciccarelli, Olga; Feucht, Nikolaus; Garcia-Martin, Elena et al.
DOI: 10.1212/NXI.0000000000200169

The CYP24A1 gene variant rs2762943 is associated with low serum 1,25-dihydroxyvitamin D levels in multiple sclerosis patients.

PMID: 37183562
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2023
Reference: Eur J Neurol. 2023 May 14. doi: 10.1111/ene.15866.
Impact factor:
Publication type: Paper in international publication
Authors: Chuquisana, Omar; Comabella, Manuel; Ferrer, Roser; Fissolo, Nicolas; Gil-Varea, Elia; Giralt, Marina; Lunemann, Jan D; Malhotra, Sunny; Midaglia, Luciana; Montalban, Xavier et al.
DOI: 10.1111/ene.15866

Is humoral and cellular response to SARS-CoV-2 vaccine modified by DMT in patients with multiple sclerosis and other autoimmune diseases?

PMID: 35475363
Journal: Multiple Sclerosis Journal
Year: 2022
Reference: Mult Scler. 2022 Jun;28(7):1138-1145. doi: 10.1177/13524585221089540. Epub 2022 Apr 27.
Impact factor: 6.312
Publication type: Paper in international publication
Authors: Arrambide, Georgina, Otero-Romero, Susana, Pappolla, Agustin, Tagliani, Paula, Lopez-Maza, Samuel, Cardenas-Robledo, Simon, Esperalba, Juliana, Fernandez-Naval, Candela, Martinez-Gallo, Monica, Castillo, Mireia et al.
DOI: 10.1177/13524585221089540

Oral contraceptives do not modify the risk of a second attack and disability accrual in a prospective cohort of women with a clinically isolated syndrome and early multiple sclerosis.

PMID: 34841948
Journal: Multiple Sclerosis Journal
Year: 2022
Reference: Mult Scler. 2022 May;28(6):950-957. doi: 10.1177/13524585211053001. Epub 2021 Nov 29.
Impact factor: 6.312
Publication type: Paper in international publication
Authors: Rodriguez, Marta, Otero-Romero, Susana, Carbonell-Mirabent, Pere, Midaglia, Luciana, Zuluaga, Maria, Galan, Ingrid, Cobo-Calvo, Alvaro, Rio, Jordi, Arrambide, Georgina, Vidal-Jordana, Angela et al.
DOI: 10.1177/13524585211053001

The impact of the COVID-19 pandemic on physical therapy practice for people with multiple sclerosis: A multicenter survey study of the RIMS network.

PMID: 35428030
Journal: Multiple Sclerosis and Related Disorders
Year: 2022
Reference: Mult Scler Relat Disord. 2022 Jun;62:103799. doi: 10.1016/j.msard.2022.103799. Epub 2022 Apr 10.
Impact factor: 4.339
Publication type: Paper in international publication
Authors: Rasova, Kamila, Jonsdottir, Johanna, Medina, Carme Santoyo, Kos, Daphne, Coote, Susan, Tacchino, Andrea, Smedal, Tori, Arntzen, Ellen Christin, Quinn, Gillian, Learmonth, Yvonne et al.
DOI: 10.1016/j.msard.2022.103799

Can cognitive training reignite compensatory mechanisms in advanced multiple sclerosis patients? An explorative morphological network approach.

PMID: 35364228
Journal: NEUROSCIENCE
Year: 2022
Reference: Neuroscience. 2022 Jul 15;495:86-96. doi: 10.1016/j.neuroscience.2022.03.031. Epub 2022 Mar 29.
Impact factor: 3.59
Publication type: Paper in international publication
Authors: Frieske, Joana, Cuypers, Koen, Meesen, Raf L J, Alonso, Juli, Arevalo, Maria Jesus, Galan, Ingrid, Renom, Marta, Vidal-Jordana, Angela, Auger, Cristina, Montalban, Xavier et al.
DOI: 10.1016/j.neuroscience.2022.03.031

[12th Post-ECTRIMS Meeting: review of the novelties from the 2019 ECTRIMS Congress (I)].

PMID: 32390131
Journal: REVISTA DE NEUROLOGIA
Year: 2020
Reference: Rev Neurol. 2020 May 16;70(10):379-390. doi: 10.33588/rn.7010.2020121.
Impact factor: 0.562
Publication type: Review in national publication
Authors: Prieto, J M, Fernandez, O, Aladro, Y, Arroyo, R, Brieva, Ll, Calles-Hernandez, M C, Carrascal, P, Comabella, M, Costa-Frossard, L, Eichau, S et al.
DOI: 10.33588/rn.7010.2020121

Reduced dynamics of functional connectivity and cognitive impairment in multiple sclerosis.

PMID: 30887862
Journal: Multiple Sclerosis Journal
Year: 2020
Reference: Mult Scler. 2020 Apr;26(4):476-488. doi: 10.1177/1352458519837707. Epub 2019 Mar 19.
Impact factor: 5.412
Publication type: Paper in international publication
Authors: Koini, Marisa, d'Ambrosio, Alessandro, Valsasina, Paola, Gallo, Antonio, De Stefano, Nicola, Pareto, Deborah, Barkhof, Frederik, Ciccarelli, Olga, Enzinger, Christian, Tedeschi, Gioacchino et al.
DOI: 10.1177/1352458519837707

A validation study of manual atrophy measures in patients with Multiple Sclerosis.

PMID: 32246177
Journal: NEURORADIOLOGY
Year: 2020
Reference: Neuroradiology. 2020 Aug;62(8):955-964. doi: 10.1007/s00234-020-02401-3. Epub 2020 Apr 3.
Impact factor: 2.238
Publication type: Paper in international publication
Authors: Cappelle, Sarah, Pareto, Deborah, Tintore, Mar, Alyafeai, Rumaiza, Vidal-Jordana, Angela, Alberich, Manel, Sastre-Garriga, Jaume, Auger, Cristina, Montalban, Xavier, Rovira, Alex et al.
DOI: 10.1007/s00234-020-02401-3

Testing the Food Experience in Healthy Human Volunteers: a Proof-of-Concept Study.

PMID: 32176761
Journal: Journal of Gastrointestinal and Liver Diseases
Year: 2020
Reference: J Gastrointestin Liver Dis. 2020 Mar 13;29(1):65-68. doi: 10.15403/jgld-806.
Impact factor: 2.351
Publication type: Paper in international publication
Authors: Pribic, Teodora, Lopez, Quiro, Lucas, Eduardo, Livovsky, Dan M, Rovira, Alex, Accarino, Anna, Azpiroz, Fernando, Pareto, Deborah et al.
DOI: 10.15403/jgld-806

Blog

News

In total, different projects of six research groups will be promoted, focusing on precision medicine and advanced therapies.

Dr. Carmen Espejo and Dr. Georgina Arrambide, researchers at Cemcat and Vall d'Hebron Research Institute, are the first authors of the article.

The research findings propose to modify the McDonald 2017 criteria, only in those in whom diagnosis using the current criteria is not possible.

Job offers

Predoctoral Researcher Position
Start date:
18/01/2022
End date:
28/02/2022
Document: Download
Postdoctoral Researcher Position
Start date:
18/01/2022
End date:
02/02/2022
Document: Download
Laboratory FP or higher Position-Clinical Neuroimmunology Group
Start date:
25/11/2021
End date:
15/12/2021
Document: Download

Rates

Simoa HD1 equipment

We are seeking healthy volunteers for a study to find biomarkers of multiple sclerosis

We are looking for 100 healthy volunteers aged 18 or over to participate in a project where the usefulness of biomarkers in serum will be evaluated to predict the prognosis of the disease and the response to treatments.

More information