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Clinical Neuroimmunology

The group of Clinical Neuroimmunology - Centre d'Esclerosi Múltiple de Catalunya (Cemcat) at the Vall d'Hebron Institut de Recerca (VHIR) is a multidisciplinary group dedicated to clinical assistance, physical and cognitive rehabilitation, and clinical and basic research on multiple sclerosis (MS). Cemcat is a national but also an international reference center in the clinical assistance of MS patients. The research performed in the group is divided and further combined in clinical and basic research. In addition, basic research has a marked translational character since the ultimate goal of the group is to improve the quality of life of patients suffering from MS, through in-depth knowledge of the pathogenic mechanisms of the disease and the development of new and more effective therapeutic approaches. 

Team

Carme Santoyo Medina

Carme Santoyo Medina

Main researcher
Clinical Neuroimmunology
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Carmen Tur Gomez

Carmen Tur Gomez

Main researcher
Clinical Neuroimmunology
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Cristina Vetoret Vázquez

Cristina Vetoret Vázquez

Research assistant
Clinical Neuroimmunology
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Dunia Muñoz Valdivielso

Dunia Muñoz Valdivielso

Administration and Management
Clinical Neuroimmunology
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Edwin Roger Meza Murillo

Edwin Roger Meza Murillo

Predoctoral researcher
Clinical Neuroimmunology
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Eila Rivera Boix

Eila Rivera Boix

Clinical Neuroimmunology
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Carme Santoyo Medina

Carme Santoyo Medina

Main researcher
Clinical Neuroimmunology
Read more
Carmen Tur Gomez

Carmen Tur Gomez

Main researcher
Clinical Neuroimmunology
Read more
Cristina Vetoret Vázquez

Cristina Vetoret Vázquez

Research assistant
Clinical Neuroimmunology
Read more
Dunia Muñoz Valdivielso

Dunia Muñoz Valdivielso

Administration and Management
Clinical Neuroimmunology
Read more
Edwin Roger Meza Murillo

Edwin Roger Meza Murillo

Predoctoral researcher
Clinical Neuroimmunology
Read more
Eila Rivera Boix

Eila Rivera Boix

Clinical Neuroimmunology
Read more

Projects

Desvelando los mecanismos que llevan al aumento irreversible de discapacidad en esclerosis múltiple mediante resonancia magnética multi-modal cuantitativa

IP: Carmen Tur Gomez
Collaborators: Jordi Rio Izquierdo, Oscar Persiva Morenza, Elena Huerga Núñez
Funding agency: Instituto de Salud Carlos III
Funding: 150040
Reference: PI21/01860
Duration: 01/01/2022 - 31/12/2024

Rejuvenation of the immune system as a therapeutic approach for progressive multiple sclerosis.

IP: Carmen Espejo Ruiz
Collaborators: Rosalia Horno Ocaña, Herena Eixarch Ahufinger, Breogan Rodriguez Acevedo, Mireia Castillo Juarez
Funding agency: Instituto de Salud Carlos III
Funding: 159720
Reference: PI21/01682
Duration: 01/01/2022 - 31/12/2024

Determinación de biomarcadores de lesión neuronal y astrocitaria en suero de paciente con encefalopatía hepática

IP: Macarena Simon-Talero Horga
Collaborators: Victor Manuel Vargas Blasco, Joaquin Castillo Justribo, Mònica Pons Delgado
Funding agency: Instituto de Salud Carlos III
Funding: 60500
Reference: PI21/00312
Duration: 01/01/2022 - 31/12/2024

Human induced pluripotent stem cell-based chimeric mice to study astrocyte pathology and neuroprotective strategies in multiple sclerosis patients

IP: Manuel Comabella Lopez
Collaborators: Andres Miguez Gonzalez, Rucsanda Pinteac, Sira Rodrigo Bosch
Funding agency: Instituto de Salud Carlos III
Funding: 286770
Reference: PI21/01611
Duration: 01/01/2022 - 31/12/2024

Publications

Alcohol-related liver disease phenotype impacts survival after an acute variceal bleeding episode.

PMID: 37183551
Journal: LIVER INTERNATIONAL
Year: 2023
Reference: Liver Int. 2023 May 15. doi: 10.1111/liv.15606.
Impact factor:
Publication type: Paper in international publication
Authors: Abraldes, Juan G; Albillos, Agustin; Alvarado, Edilmar; Amitrano, Lucio; Banares, Rafael; Bataller, Ramon; Bosch, Jaime; Bureau, Christophe; Calleja, Jose L; Canete, Nuria et al.
DOI: 10.1111/liv.15606

Autonomic response to walk tests is useful for assessing outcome measures in people with multiple sclerosis.

PMID: 37089424
Journal: Frontiers in Physiology
Year: 2023
Reference: Front Physiol. 2023 Apr 6;14:1145818. doi: 10.3389/fphys.2023.1145818. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Bailon, Raquel; Buron, Mathias Due; Comi, Giancarlo; Costa, Gloria Dalla; Cummins, Nicholas; Dobson, Richard J B; Folarin, Amos A; Garcia, Esther; Guerrero, Ana Isabel; Hotopf, Matthew et al.
DOI: 10.3389/fphys.2023.1145818

Validation of the Spanish version of DYsphagia in MUltiple Sclerosis questionnaire (DYMUS).

PMID: 37086636
Journal: Multiple Sclerosis and Related Disorders
Year: 2023
Reference: Mult Scler Relat Disord. 2023 Apr 17;74:104724. doi: 10.1016/j.msard.2023.104724.
Impact factor:
Publication type: Paper in international publication
Authors: Aldevert, Mireia; Anglada, Elisenda; Arevalo, Maria Jesus; Bascunana, Helena; Curto, Gemma; Feliu, Patricia; Galan, Ingrid; Garcia, Itziar; Garcia, Montserrat; Gonzalo, Lorena et al.
DOI: 10.1016/j.msard.2023.104724

Agreement Between Published Reference Resources for Neurofilament Light Chain Levels in People With Multiple Sclerosis.

PMID: 37816633
Journal: NEUROLOGY
Year: 2023
Reference: Neurology. 2023 Oct 10:10.1212/WNL.0000000000207957. doi: 10.1212/WNL.0000000000207957.
Impact factor:
Publication type: Paper in international publication
Authors: Aguayo-Ortiz, Rafael; Akgun, Katja; Arrambide, Georgina; Bassas-Freixas, Patricia; Bermel, Robert A; Bernia-Petit, Eduardo; Bonfill-Orti, Montserrat; Calabresi, Peter A; Canueto, Javier; Deza, Gustavo et al.
DOI: 10.1212/WNL.0000000000207957

Cross-Country Adaptation of a Psychological Flexibility Measure: The Comprehensive Assessment of Acceptance and Commitment Therapy Processes.

PMID: 35328838
Journal: International Journal of Environmental Research and Public Health
Year: 2022
Reference: Int J Environ Res Public Health. 2022 Mar 8;19(6). pii: ijerph19063150. doi: 10.3390/ijerph19063150.
Impact factor: 3.39
Publication type: Paper in international publication
Authors: Giovannetti, Ambra Mara, Pottgen, Jana, Menendez, Rebeca, Hoyer, Jurgen, Giordano, Andrea, Pakenham, Kenneth Ian, Galan, Ingrid, Solari, Alessandra, Anglada, Elisenda et al.
DOI: 10.3390/ijerph19063150

SWI as an Alternative to Contrast-Enhanced Imaging to Detect Acute MS Lesions.

PMID: 35332015
Journal: AMERICAN JOURNAL OF NEURORADIOLOGY
Year: 2022
Reference: AJNR Am J Neuroradiol. 2022 Apr;43(4):534-539. doi: 10.3174/ajnr.A7474. Epub 2022 Mar 24.
Impact factor: 3.825
Publication type: Paper in international publication
Authors: Caruana, G, Auger, C, Pessini, L M, Calderon, W, de Barros, A, Salerno, A, Sastre-Garriga, J, Montalban, X, Rovira, A et al.
DOI: 10.3174/ajnr.A7474

A smartphone sensor-based digital outcome assessment of multiple sclerosis.

PMID: 34259588
Journal: Multiple Sclerosis Journal
Year: 2022
Reference: Mult Scler. 2022 Apr;28(4):654-664. doi: 10.1177/13524585211028561. Epub 2021 Jul 14.
Impact factor: 6.312
Publication type: Paper in international publication
Authors: Julian, Laura, Montalban, Xavier, Graves, Jennifer, Midaglia, Luciana, Mulero, Patricia, Gossens, Christian, Ganzetti, Marco, Scotland, Alf, Lipsmeier, Florian, van Beek, Johan et al.
DOI: 10.1177/13524585211028561

Menopause does not modify disability trajectories in a longitudinal cohort of women with CIS and MS followed from disease onset.

PMID: 33609298
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2022
Reference: Eur J Neurol. 2022 Apr;29(4):1075-1081. doi: 10.1111/ene.14782. Epub 2021 Mar 17.
Impact factor: 6.089
Publication type: Paper in international publication
Authors: Carbonell-Mirabent, Pere, Zuluaga, Maria, Galan, Ingrid, Rio, Jordi, Arrambide, Georgina, Rodriguez-Barranco, Marta, Vidal-Jordana, Angela, Castillo, Joaquin, Rodriguez-Acevedo, Breogan, Zabalza, Ana et al.
DOI: 10.1111/ene.14782

Ratio of T1-Weighted to T2-Weighted Signal Intensity as a Measure of Tissue Integrity: Comparison with Magnetization Transfer Ratio in Patients with Multiple Sclerosis.

PMID: 32139431
Journal: AMERICAN JOURNAL OF NEURORADIOLOGY
Year: 2020
Reference: AJNR Am J Neuroradiol. 2020 Mar;41(3):461-463. doi: 10.3174/ajnr.A6481. Epub 2020 Mar 5.
Impact factor: 3.381
Publication type: Paper in international publication
Authors: Pareto, D, Garcia-Vidal, A, Alberich, M, Auger, C, Montalban, X, Tintore, M, Sastre-Garriga, J, Rovira, A et al.
DOI: 10.3174/ajnr.A6481

A fully convolutional neural network for new T2-w lesion detection in multiple sclerosis.

PMID: 31918065
Journal: NeuroImage-Clinical
Year: 2020
Reference: Neuroimage Clin. 2020;25:102149. doi: 10.1016/j.nicl.2019.102149. Epub 2019 Dec 28.
Impact factor: 4.35
Publication type: Paper in international publication
Authors: Salem, Mostafa, Valverde, Sergi, Cabezas, Mariano, Pareto, Deborah, Oliver, Arnau, Salvi, Joaquim, Rovira, Alex, Llado, Xavier et al.
DOI: 10.1016/j.nicl.2019.102149

MAGNIMS consensus recommendations on the use of brain and spinal cord atrophy measures in clinical practice.

PMID: 32094485
Journal: Nature Reviews Neurology
Year: 2020
Reference: Nat Rev Neurol. 2020 Mar;16(3):171-182. doi: 10.1038/s41582-020-0314-x. Epub 2020 Feb 24.
Impact factor: 27
Publication type: Review in international publication
Authors: Palace, Jackie, Sastre-Garriga, Jaume, Pareto, Deborah, Battaglini, Marco, Rocca, Maria A, Ciccarelli, Olga, Enzinger, Christian, Wuerfel, Jens, Sormani, Maria P, Barkhof, Frederik et al.
DOI: 10.1038/s41582-020-0314-x

Sudden Recanalization: A Game-Changing Factor in Endovascular Treatment of Large Vessel Occlusion Strokes.

PMID: 32078495
Journal: STROKE
Year: 2020
Reference: Stroke. 2020 Apr;51(4):1313-1316. doi: 10.1161/STROKEAHA.119.028787. Epub 2020 Feb 14.
Impact factor: 7.19
Publication type: Paper in international publication
Authors: Garcia-Tornel, Alvaro, Rubiera, Marta, Requena, Manuel, Muchada, Marian, Pagola, Jorge, Rodriguez-Luna, David, Deck, Matias, Juega, Jesus, Rodriguez-Villatoro, Noelia, Boned, Sandra et al.
DOI: 10.1161/STROKEAHA.119.028787

Blog

News

In total, different projects of six research groups will be promoted, focusing on precision medicine and advanced therapies.

Dr. Carmen Espejo and Dr. Georgina Arrambide, researchers at Cemcat and Vall d'Hebron Research Institute, are the first authors of the article.

The research findings propose to modify the McDonald 2017 criteria, only in those in whom diagnosis using the current criteria is not possible.

Job offers

Image analysis/computer technician position
Start date:
12/11/2021
End date:
27/11/2021
Document: Download
Research Nursing - Multiple Sclerosis Centre of Catalonia-VHIR.
Start date:
08/11/2021
End date:
30/11/2021
Document: Download
PhD position - Clinical Neuroimmunology Research Group.
Start date:
04/11/2021
End date:
15/12/2021
Document: Download

Rates

Simoa HD1 equipment

We are seeking healthy volunteers for a study to find biomarkers of multiple sclerosis

We are looking for 100 healthy volunteers aged 18 or over to participate in a project where the usefulness of biomarkers in serum will be evaluated to predict the prognosis of the disease and the response to treatments.

More information