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Clinical Neuroimmunology

The group of Clinical Neuroimmunology - Centre d'Esclerosi Múltiple de Catalunya (Cemcat) at the Vall d'Hebron Institut de Recerca (VHIR) is a multidisciplinary group dedicated to clinical assistance, physical and cognitive rehabilitation, and clinical and basic research on multiple sclerosis (MS). Cemcat is a national but also an international reference center in the clinical assistance of MS patients. The research performed in the group is divided and further combined in clinical and basic research. In addition, basic research has a marked translational character since the ultimate goal of the group is to improve the quality of life of patients suffering from MS, through in-depth knowledge of the pathogenic mechanisms of the disease and the development of new and more effective therapeutic approaches. 

Team

Margarita Navarro Pérez

Margarita Navarro Pérez

Administration and Management
Clinical Neuroimmunology
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Milagros Fraga Pereira

Milagros Fraga Pereira

Research assistant
Clinical Neuroimmunology
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Mireia Castillo Juarez

Mireia Castillo Juarez

Research technician
Clinical Neuroimmunology
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Mireia Resina Salles

Mireia Resina Salles

Clinical Neuroimmunology
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Montserrat García Serqueda

Montserrat García Serqueda

Research assistant
Clinical Neuroimmunology
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Montserrat Janer Cabo

Montserrat Janer Cabo

Research assistant
Clinical Neuroimmunology
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Margarita Navarro Pérez

Margarita Navarro Pérez

Administration and Management
Clinical Neuroimmunology
Read more
Milagros Fraga Pereira

Milagros Fraga Pereira

Research assistant
Clinical Neuroimmunology
Read more
Mireia Castillo Juarez

Mireia Castillo Juarez

Research technician
Clinical Neuroimmunology
Read more
Mireia Resina Salles

Mireia Resina Salles

Clinical Neuroimmunology
Read more
Montserrat García Serqueda

Montserrat García Serqueda

Research assistant
Clinical Neuroimmunology
Read more
Montserrat Janer Cabo

Montserrat Janer Cabo

Research assistant
Clinical Neuroimmunology
Read more

Publications

Multiple sclerosis: emerging epidemiological trends and redefining the clinical course.

PMID: 39444703
Journal: Lancet Regional Health-Europe
Year: 2024
Reference: Lancet Reg Health Eur. 2024 Aug 22;44:100977. doi: 10.1016/j.lanepe.2024.100977. eCollection 2024 Sep.
Impact factor:
Publication type: Paper in international publication
Authors: Amato, Maria Pia; Brochet, Bruno; Di Filippo, Massimiliano; Havrdova, Eva Kubala; Magyari, Melinda; Montalban, Xavier; Portaccio, Emilio; Ruet, Aurelie; Scalfari, Antonio; Tur, Carmen et al.
DOI: 10.1016/j.lanepe.2024.100977

Silent brain ischemia within the TAXINOMISIS framework: association with clinical and advanced ultrasound metrics.

PMID: 39474371
Journal: Frontiers in Neurology
Year: 2024
Reference: Front Neurol. 2024 Oct 11;15:1424362. doi: 10.3389/fneur.2024.1424362. eCollection 2024.
Impact factor:
Publication type: Paper in international publication
Authors: Carrozzi, Alessandro; Cirillo, Luigi; de Borst, Gert J; Faggioli, Gianluca; Fotiadis, Dimitros I; Galyfos, George; Gramegna, Laura Ludovica; Jovanovic, Marija; Kallmayer, Michael; Kigka, Vassiliki et al.
DOI: 10.3389/fneur.2024.1424362

Big data and artificial intelligence applied to blood and CSF fluid biomarkers in multiple sclerosis.

PMID: 39493759
Journal: Frontiers in Immunology
Year: 2024
Reference: Front Immunol. 2024 Oct 18;15:1459502. doi: 10.3389/fimmu.2024.1459502. eCollection 2024.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Comabella, Manuel; Tur, Carmen et al.
DOI: 10.3389/fimmu.2024.1459502

Disentangling Neurodegeneration From Aging in Multiple Sclerosis Using Deep Learning: The Brain-Predicted Disease Duration Gap.

PMID: 39496109
Journal: NEUROLOGY
Year: 2024
Reference: Neurology. 2024 Nov 26;103(10):e209976. doi: 10.1212/WNL.0000000000209976. Epub 2024 Nov 4.
Impact factor:
Publication type: Paper in international publication
Authors: Abdel-Mannan, Omar; Al-Araji, Sarmad; Barkhof, Frederik; Bellenberg, Barbara; Bianchi, Alessia; Bisecco, Alvino; Brownlee, Wallace J; Brunetti, Arturo; Cagol, Alessandro; Calabrese, Massimiliano et al.
DOI: 10.1212/WNL.0000000000209976

Teaching NeuroImage: Paraneoplastic Cerebellar Degeneration and Antibodies to TRIM 9 and 67 Secondary to Melanoma.

PMID: 37580164
Journal: NEUROLOGY
Year: 2023
Reference: Neurology. 2023 Aug 14:10.1212/WNL.0000000000207702. doi: 10.1212/WNL.0000000000207702.
Impact factor:
Publication type: Paper in international publication
Authors: Auger, Cristina; Gonzalez, Victoria; Martinez-Saez, Elena; Naranjo, Laura; Ruiz-Garcia, Raquel; Vilaseca, Andreu; Vilaseca, Andreu et al.
DOI: 10.1212/WNL.0000000000207702

Immunotherapy for Colorectal Cancer with High Microsatellite Instability: The Ongoing Search for Biomarkers.

PMID: 37686520
Journal: Cancers
Year: 2023
Reference: Cancers (Basel). 2023 Aug 24;15(17):4245. doi: 10.3390/cancers15174245.
Impact factor:
Publication type: Review in international publication
Authors: Baraibar, Iosune; Baraibar, Iosune; Elez, Elena; Elez, Elena; Rodriguez, Marta; Rodriguez, Marta; Ros, Javier; Salva, Francesc; Salva, Francesc; Saoudi, Nadia et al.
DOI: 10.3390/cancers15174245

Do the current MS clinical course descriptors need to change and if so how? A survey of the MS community.

PMID: 37691493
Journal: Multiple Sclerosis Journal
Year: 2023
Reference: Mult Scler. 2023 Sep 11:13524585231196786. doi: 10.1177/13524585231196786.
Impact factor:
Publication type: Paper in international publication
Authors: Amato, Maria Pia; Calabresi, Peter A; Coetzee, Timothy; Finlayson, Marcia; Hawton, Annie; Lublin, Fred D; Marrie, Ruth Ann; Moccia, Marcello; Montalban, Xavier; Panzara, Michael et al.
DOI: 10.1177/13524585231196786

Hepatitis B reactivation is a rare event among patients with resolved infection undergoing anti-CD20 antibodies in monotherapy without antiviral prophylaxis: results from the HEBEM study.

PMID: 37695530
Journal: JOURNAL OF NEUROLOGY
Year: 2023
Reference: J Neurol. 2023 Sep 11. doi: 10.1007/s00415-023-11973-y.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Buti, Maria; Castillo, Joaquin; Marzo, Blanca; Montalban, Xavier; Otero-Romero, Susana; Otero-Romero, Susana; Riveiro-Barciela, Mar; Riveiro-Barciela, Mar; Robles-Sanchez, Miguel-Angel et al.
DOI: 10.1007/s00415-023-11973-y

COVID-19 Outcomes and Vaccination in People with Relapsing Multiple Sclerosis Treated with Ofatumumab.

PMID: 35284994
Journal: Neurology and Therapy
Year: 2022
Reference: Neurol Ther. 2022 Mar 13. pii: 10.1007/s40120-022-00341-z. doi: 10.1007/s40120-022-00341-z.
Impact factor:
Publication type: Paper in international publication
Authors: Cree, Bruce A C; Cross, Anne H; Davydovskaya, Maria; Delgado, Silvia; Gupta, Ayan Das; Habek, Mario; Hu, Xixi; Mancione, Linda; Montalban, Xavier; Pingili, Ratnakar et al.
DOI: 10.1007/s40120-022-00341-z

Efficacy and safety of ofatumumab in recently diagnosed, treatment-naive patients with multiple sclerosis: Results from ASCLEPIOS I and II.

PMID: 35266417
Journal: Multiple Sclerosis Journal
Year: 2022
Reference: Mult Scler. 2022 Mar 10:13524585221078825. doi: 10.1177/13524585221078825.
Impact factor:
Publication type: Paper in international publication
Authors: Bar-Or, Amit; Cohen, Jeffrey A; Cross, Anne H; Deiva, Kumaran; Ganjgahi, Habib; Gartner, Jutta; Haring, Dieter A; Hauser, Stephen L; Kappos, Ludwig; Kieseier, Bernd et al.
DOI: 10.1177/13524585221078825

Risk of requiring a wheelchair in primary progressive multiple sclerosis: Data from the ORATORIO trial and the MSBase registry.

PMID: 33724638
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2022
Reference: Eur J Neurol. 2022 Apr;29(4):1082-1090. doi: 10.1111/ene.14824. Epub 2021 May 6.
Impact factor:
Publication type: Paper in international publication
Authors: Butzkueven, Helmut; Craveiro, Licinio; Freitas, Rita; Giovannoni, Gavin; Girard, Marc; Grand'Maison, Francois; Hauser, Stephen L; Horakova, Dana; Hughes, Stella; Hupperts, Raymond et al.
DOI: 10.1111/ene.14824

Menopause does not modify disability trajectories in a longitudinal cohort of women with CIS and MS followed from disease onset.

PMID: 33609298
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2022
Reference: Eur J Neurol. 2022 Apr;29(4):1075-1081. doi: 10.1111/ene.14782. Epub 2021 Mar 17.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Auger, Cristina; Carbonell-Mirabent, Pere; Castillo, Joaquin; Comabella Lopez, Manuel; Galan, Ingrid; Midaglia, Luciana; Montalban, Xavier; Mulero, Patricia; Nos, Carlos et al.
DOI: 10.1111/ene.14782

Scoring the 10-year risk of ambulatory disability in multiple sclerosis: the RoAD score.

PMID: 33786942
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2021
Reference: Eur J Neurol. 2021 Aug;28(8):2533-2542. doi: 10.1111/ene.14845. Epub 2021 Apr 19.
Impact factor:
Publication type: Paper in international publication
Authors: Capra, Ruggero; Galgani, Simonetta; Gasperini, Claudio; Haggiag, Shalom; Montalban, Xavier; Pozzilli, Carlo; Prosperini, Luca; Rio, Jordi; Rovira, Alex; Sastre-Garriga, Jaume et al.
DOI: 10.1111/ene.14845

Ponesimod Compared With Teriflunomide in Patients With Relapsing Multiple Sclerosis in the Active-Comparator Phase 3 OPTIMUM Study: A Randomized Clinical Trial.

PMID: 33779698
Journal: JAMA Neurology
Year: 2021
Reference: JAMA Neurol. 2021 May 1;78(5):558-567. doi: 10.1001/jamaneurol.2021.0405.
Impact factor:
Publication type: Paper in international publication
Authors: Burcklen, Michel; D'Ambrosio, Daniele; Fox, Robert J; Freedman, Mark S; Havrdova, Eva K; Hennessy, Brian; Hohlfeld, Reinhard; Kappos, Ludwig; Kracker, Hilke; Linscheid, Philippe et al.
DOI: 10.1001/jamaneurol.2021.0405

Prioritizing progressive MS rehabilitation research: A call from the International Progressive MS Alliance.

PMID: 33720795
Journal: Multiple Sclerosis Journal
Year: 2021
Reference: Mult Scler. 2021 Jun;27(7):989-1001. doi: 10.1177/1352458521999970. Epub 2021 Mar 15.
Impact factor:
Publication type: Paper in international publication
Authors: Brichetto, Giampaolo; Centonze, Diego; Dalgas, Ulrik; DeLuca, John; Ehde, Dawn; Elgott, Sara; Fanning, Vanessa; Feinstein, Anthony; Feys, Peter; Finlayson, Marcia et al.
DOI: 10.1177/1352458521999970

Diagnosis of Progressive Multiple Sclerosis From the Imaging Perspective: A Review.

PMID: 33315071
Journal: JAMA Neurology
Year: 2021
Reference: JAMA Neurol. 2021 Mar 1;78(3):351-364. doi: 10.1001/jamaneurol.2020.4689.
Impact factor:
Publication type: Review in international publication
Authors: Banwell, Brenda L; Barkhof, Frederik; Chard, Declan T; De Stefano, Nicola; Filippi, Massimo; Fox, Robert J; Gasperini, Claudio; Kappos, Ludwig; Montalban, Xavier; Moraal, Bastiaan et al.
DOI: 10.1001/jamaneurol.2020.4689

A Polymorphism Within the MBP Gene Is Associated With a Higher Relapse Number in Male Patients of Multiple Sclerosis.

PMID: 32431704
Journal: Frontiers in Immunology
Year: 2020
Reference: Front Immunol. 2020 May 5;11:771. doi: 10.3389/fimmu.2020.00771. eCollection 2020.
Impact factor:
Publication type: Paper in international publication
Authors: Agudo-Jimenez, Teresa; Alvarez-Lafuente, Roberto; Comabella, Manuel; Dieli-Crimi, Romina; Dieli-Crimi, Romina; Dominguez-Mozo, Maria Inmaculada; Espino-Paisan, Laura; Garcia-Martinez, Maria Angel; Lopez-Cotarelo, Pilar; Perez-Perez, Silvia et al.
DOI: 10.3389/fimmu.2020.00771

An Expert Patient Program as a Tool to Empower People With Multiple Sclerosis.

PMID: 32398626
Journal: JOURNAL OF NEUROSCIENCE NURSING
Year: 2020
Reference: J Neurosci Nurs. 2020 Aug;52(4):166-171. doi: 10.1097/JNN.0000000000000514.
Impact factor:
Publication type: Paper in international publication
Authors: Amil-Bujan, Paloma; Bertran-Noguer, Carme; Cruz-Diaz, Veronica; Ramio-Torrenta, Lluis; Robles-Sanchez, Miguel-Angel; Sastre-Garriga, Jaume et al.
DOI: 10.1097/JNN.0000000000000514

[12th Post-ECTRIMS Meeting: review of the novelties from the 2019 ECTRIMS Congress (I)].

PMID: 32390131
Journal: REVISTA DE NEUROLOGIA
Year: 2020
Reference: Rev Neurol. 2020 May 16;70(10):379-390. doi: 10.33588/rn.7010.2020121.
Impact factor:
Publication type: Review in national publication
Authors: Aladro, Y; Arroyo, R; Brieva, Ll; Calles-Hernandez, M C; Carrascal, P; Comabella, M; Costa-Frossard, L; Eichau, S; Fernandez, O; Garcia-Merino, J A et al.
DOI: 10.33588/rn.7010.2020121

Chitinase 3-like 1 is neurotoxic in primary cultured neurons.

PMID: 32346016
Journal: Scientific Reports
Year: 2020
Reference: Sci Rep. 2020 Apr 28;10(1):7118. doi: 10.1038/s41598-020-64093-2.
Impact factor:
Publication type: Paper in international publication
Authors: Calvo-Barreiro, Laura; Carballo-Carbajal, Iria; Comabella, Manuel; Gonzalo, Ricardo; Matute-Blanch, Clara; Montalban, Xavier; Sanchez, Alex; Vila, Miquel et al.
DOI: 10.1038/s41598-020-64093-2

Expression of Bone Morphogenetic Proteins In Multiple Sclerosis Lesions.

PMID: 30553833
Journal: AMERICAN JOURNAL OF PATHOLOGY
Year: 2019
Reference: Am J Pathol. 2019 Mar;189(3):665-676. doi: 10.1016/j.ajpath.2018.11.007. Epub 2018 Dec 13.
Impact factor:
Publication type: Paper in international publication
Authors: Calucho, Maite; Calvo-Barreiro, Laura; Castro, Zoraida; Costa, Carme; Eixarch, Herena; Espejo, Carmen; Martinez-Saez, Elena; Montalban, Xavier; Ortega-Aznar, Arantxa; Ramon Y Cajal, Santiago et al.
DOI: 10.1016/j.ajpath.2018.11.007

Simultaneous CMV and Listeria infection following alemtuzumab treatment for multiple sclerosis.

PMID: 30587519
Journal: NEUROLOGY
Year: 2019
Reference: Neurology. 2019 Feb 5;92(6):296-298. doi: 10.1212/WNL.0000000000006801. Epub 2018 Dec 26.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Boix Rodriguez, Claudia P; Camps, Isabel Ruiz; Castillo, Joaquin; Comabella, Manuel; Galan, Ingrid; Lung, Maiylyi; Midaglia, Luciana; Montalban, Xavier; Mulero, Patricia et al.
DOI: 10.1212/WNL.0000000000006801

[Progressive multifocal leukoencephalopathy and non-specific immune dysfunction].

PMID: 30687923
Journal: REVISTA DE NEUROLOGIA
Year: 2019
Reference: Rev Neurol. 2019 Feb 1;68(3):132-133.
Impact factor:
Publication type: Letter whit IF
Authors: Ballve-Martin, A; Campos-Fernandez, D; Llaurado-Gayete, A; Olive-Gadea, M; Rio, J; Rovira, A; Santamarina, E et al.
DOI: 10.33588/rn.6803.2018377

Spinal cord involvement in multiple sclerosis and neuromyelitis optica spectrum disorders.

PMID: 30663608
Journal: LANCET NEUROLOGY
Year: 2019
Reference: Lancet Neurol. 2019 Feb;18(2):185-197. doi: 10.1016/S1474-4422(18)30460-5.
Impact factor:
Publication type: Review in international publication
Authors: Amato, Maria Pia; Banwell, Brenda; Barkhof, Frederik; Bebo, Bruce; Becher, Burkhard; Bethoux, Francois; Brandt, Alexander; Brownlee, Wallace; Calabresi, Peter; Chatway, Jeremy et al.
DOI: 10.1016/S1474-4422(18)30460-5

The value of oligoclonal bands in the multiple sclerosis diagnostic criteria.

PMID: 29462277
Journal: BRAIN
Year: 2018
Reference: Brain. 2018 Apr 1;141(4):1075-1084. doi: 10.1093/brain/awy006.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Auger, Cristina; Castillo, Joaquin; Castillo, Mireia; Comabella, Manuel; de Barros, Andrea; Espejo, Carmen; Galan, Ingrid; Midaglia, Luciana; Mitjana, Raquel et al.
DOI: 10.1093/brain/awy006

Diagnosis of multiple sclerosis: a multicentre study to compare revised McDonald-2010 and Filippi-2010 criteria.

PMID: 28724720
Journal: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Year: 2018
Reference: J Neurol Neurosurg Psychiatry. 2018 Mar;89(3):316-318. doi: 10.1136/jnnp-2017-315863. Epub 2017 Jul 19.
Impact factor:
Publication type: Letter or abstract
Authors: Calabrese, Massimiliano; Droby, Amgad; Drulovic, Jelena; Dujmovic-Basuroski, Irena; Filippi, Massimo; Meani, Alessandro; Mesaros, Sarlota; Montalban, Xavier; Preziosa, Paolo; Rocca, Maria A et al.
DOI: 10.1136/jnnp-2017-315863

The optic nerve should be included as one of the typical CNS regions for establishing dissemination in space when diagnosing MS - No.

PMID: 29059000
Journal: Multiple Sclerosis Journal
Year: 2018
Reference: Mult Scler. 2018 Feb;24(2):123-125. doi: 10.1177/1352458517729451. Epub 2017 Oct 23.
Impact factor:
Publication type: Editorail in international publication
Authors: Montalban, Xavier; Tintore, Mar et al.
DOI: 10.1177/1352458517729451

Radiologically isolated syndrome or subclinical multiple sclerosis: MAGNIMS consensus recommendations.

PMID: 29451440
Journal: Multiple Sclerosis Journal
Year: 2018
Reference: Mult Scler. 2018 Feb;24(2):214-221. doi: 10.1177/1352458517717808.
Impact factor:
Publication type: Paper in international publication
Authors: Ciccarelli, Olga; De Stefano, Nicola; Enzinger, Christian; Filippi, Massimo; Frederiksen, Jette; Giorgio, Antonio; Kappos, Ludwig; Palace, Jacqueline; Pia Amato, Maria; Rocca, Maria A et al.
DOI: 10.1177/1352458517717808

Lesion topographies in multiple sclerosis diagnosis: A reappraisal.

PMID: 29101276
Journal: NEUROLOGY
Year: 2017
Reference: Neurology. 2017 Dec 5;89(23):2351-2356. doi: 10.1212/WNL.0000000000004715. Epub 2017 Nov 3.
Impact factor: 8.32
Publication type: Paper in international publication
Authors: Rio, Jordi, Castillo, Joaquin, Vidal-Jordana, Angela, Galan, Ingrid, Nos, Carlos, Comabella, Manuel, Mitjana, Raquel, Mulero, Patricia, de Barros, Andrea, Rodriguez-Acevedo, Breogan et al.
DOI: 10.1212/WNL.0000000000004715

Clinical and Histopathological Amelioration of Experimental Autoimmune Encephalomyelitis by AAV Vectors Expressing a Soluble Interleukin-23 Receptor.

PMID: 28593439
Journal: Neurotherapeutics
Year: 2017
Reference: Neurotherapeutics. 2017 Oct;14(4):1095-1106. doi: 10.1007/s13311-017-0545-8.
Impact factor: 5.166
Publication type: Paper in international publication
Authors: Eixarch, Herena, Tejero, Marcos, Costa, Carme, Hirota, Keiji, Castano, A Raul, Puig, Meritxell, Stockinger, Gitta, Montalban, Xavier, Bosch, Assumpcio, Espejo, Carmen et al.
DOI: 10.1007/s13311-017-0545-8

Evaluating the effect of multiple sclerosis lesions on automatic brain structure segmentation.

PMID: 28540179
Journal: NeuroImage-Clinical
Year: 2017
Reference: Neuroimage Clin. 2017 May 8;15:228-238. doi: 10.1016/j.nicl.2017.05.003. eCollection 2017.
Impact factor: 4.348
Publication type: Paper in international publication
Authors: Pareto, Deborah, Vilanova, Joan C, Ramio-Torrenta, Lluis, Rovira, Alex, Oliver, Arnau, Llado, Xavier, Cabezas, Mariano, Valverde, Sergi, Gonzalez-Villa, Sandra et al.
DOI: 10.1016/j.nicl.2017.05.003

Improving automated multiple sclerosis lesion segmentation with a cascaded 3D convolutional neural network approach.

PMID: 28435096
Journal: NEUROIMAGE
Year: 2017
Reference: Neuroimage. 2017 Jul 15;155:159-168. doi: 10.1016/j.neuroimage.2017.04.034. Epub 2017 Apr 19.
Impact factor: 5.835
Publication type: Paper in international publication
Authors: Valverde, Sergi, Cabezas, Mariano, Roura, Eloy, Gonzalez-Villa, Sandra, Pareto, Deborah, Vilanova, Joan C, Ramio-Torrenta, Lluis, Rovira, Alex, Oliver, Arnau, Llado, Xavier et al.
DOI: 10.1016/j.neuroimage.2017.04.034

Baseline clinical status as a predictor of methylprednisolone response in multiple sclerosis relapses.

PMID: 26540732
Journal: Multiple Sclerosis Journal
Year: 2016
Reference: Mult Scler. 2016 Jan;22(1):117-21. doi: 10.1177/1352458515590648. Epub 2015 Jun 25.
Impact factor:
Publication type: Paper in international publication
Authors: Brieva, Luis; Cano, Antonio; Carmona, Olga; Grau-Lopez, Laia; Hervas, Jose V; Ramio-Torrenta, Luis; Ramo-Tello, Cristina; Rovira, Alex; Saiz, Albert; Tintore, Mar et al.
DOI: 10.1177/1352458515590648

Oral fingolimod in primary progressive multiple sclerosis (INFORMS): a phase 3, randomised, double-blind, placebo-controlled trial.

PMID: 26827074
Journal: LANCET
Year: 2016
Reference: Lancet. 2016 Mar 12;387(10023):1075-84. doi: 10.1016/S0140-6736(15)01314-8. Epub 2016 Jan 28.
Impact factor:
Publication type: Paper in international publication
Authors: Cree, Bruce A C; Freedman, Mark S; Haring, Dieter A; Hartung, Hans-Peter; Kappos, Ludwig; Li, Bingbing; Liu, Fonda C; Lubetzki, Catherine; Lublin, Fred; Merschhemke, Martin et al.
DOI: 10.1016/S0140-6736(15)01314-8

MRI criteria for the diagnosis of multiple sclerosis: MAGNIMS consensus guidelines.

PMID: 26822746
Journal: LANCET NEUROLOGY
Year: 2016
Reference: Lancet Neurol. 2016 Mar;15(3):292-303. doi: 10.1016/S1474-4422(15)00393-2. Epub 2016 Jan 26.
Impact factor:
Publication type: Review in national publication
Authors: Banwell, Brenda; Barkhof, Frederik; Ciccarelli, Olga; De Stefano, Nicola; Evangelou, Nikos; Filippi, Massimo; Frederiksen, Jette L; Gasperini, Claudio; Kappos, Ludwig; Montalban, Xavier et al.
DOI: 10.1016/S1474-4422(15)00393-2

Teriflunomide in Patients with Relapsing-Remitting Forms of Multiple Sclerosis.

PMID: 26758290
Journal: CNS DRUGS
Year: 2016
Reference: CNS Drugs. 2016 Jan;30(1):41-51. doi: 10.1007/s40263-015-0299-y.
Impact factor:
Publication type: Paper in international publication
Authors: Chan, Andrew; Comabella, Manuel; de Seze, Jerome et al.
DOI: 10.1007/s40263-015-0299-y

Secondary progressive NMO, or concomitant NMO and a primary neurodegenerative disorder?

PMID: 26359280
Journal: MULT SCLER J
Year: 2015
Reference: Mult Scler. 2015 Dec;21(14):1876-8. doi: 10.1177/1352458515604746. Epub 2015 Sep 10.
Impact factor:
Publication type: Paper in international publication
Authors: Montalban, Xavier; Rovira, Alex; Tur, Carmen et al.
DOI: 10.1177/1352458515604746

Pharmacogenomic study in patients with multiple sclerosis: Responders and nonresponders to IFN-beta.

PMID: 26445728
Journal: Neurology(R) neuroimmunology & neuroinflammation
Year: 2015
Reference: Neurol Neuroimmunol Neuroinflamm. 2015 Sep 24;2(5):e154. eCollection 2015 Oct.
Impact factor:
Publication type: Letter or abstract
Authors: Alvarez-Cermeno, Jose Carlos; Alvarez-Lafuente, Roberto; Brassat, David; Bustamante, Marta F; Chan, Andrew; Comabella, Manuel; Drulovic, Jelena S; Farre, Xavier; Fernandez, Oscar; Garcia-Merino, Juan Antonio et al.
DOI: 10.1212/NXI.0000000000000154

Expression of semaphorin 3A, semaphorin 7A and their receptors in multiple sclerosis lesions.

PMID: 26432853
Journal: MULT SCLER J
Year: 2015
Reference: Mult Scler. 2015 Nov;21(13):1632-43. doi: 10.1177/1352458515599848. Epub 2015 Oct 2.
Impact factor:
Publication type: Paper in international publication
Authors: Castro, Z; Costa, C; Eixarch, H; Espejo, C; Gutierrez-Franco, A; Martinez-Saez, E; Montalban, X; Ortega-Aznar, A; Ramon Y Cajal, S et al.
DOI: 10.1177/1352458515599848

NLRP3 inflammasome is associated with the response to IFN-beta in patients with multiple sclerosis.

PMID: 25586466
Journal: BRAIN
Year: 2015
Reference: Brain. 2015 Mar;138(Pt 3):644-52. doi: 10.1093/brain/awu388. Epub 2015 Jan 12.
Impact factor:
Publication type: Paper in international publication
Authors: Brassat, David; Bustamante, Marta F; Chan, Andrew; Comabella, Manuel; Drulovic, Jelena; Fernandez, Oscar; Garcia-Merino, Antonio; Killestein, Joep; Lechner-Scott, Jeannette; Malhotra, Sunny et al.
DOI: 10.1093/brain/awu388

Vitamin d as an early predictor of multiple sclerosis activity and progression.

PMID: 24445558
Journal: JAMA Neurology
Year: 2014
Reference: JAMA Neurol. 2014 Mar 1;71(3):306-14. doi: 10.1001/jamaneurol.2013.5993.
Impact factor:
Publication type: Letter or abstract
Authors: Ascherio, Alberto; Barkhof, Frederik; Edan, Gilles; Freedman, Mark S; Hartung, Hans-Peter; Kappos, Ludwig; Kochert, Karl; Miller, David H; Montalban, Xavier; Munger, Kassandra L et al.
DOI: 10.1001/jamaneurol.2013.5993

Pregnancy, sex and hormonal factors in multiple sclerosis.

PMID: 24446387
Journal: Multiple Sclerosis Journal
Year: 2014
Reference: Mult Scler. 2014 Apr;20(5):527-36. doi: 10.1177/1352458513519840. Epub 2014 Jan 20.
Impact factor:
Publication type: Paper in international publication
Authors: Fazekas, Franz; Miller, David H; Montalban, Xavier; Reingold, Stephen C; Trojano, Maria et al.
DOI: 10.1177/1352458513519840

Radiologically isolated syndrome: 5-year risk for an initial clinical event.

PMID: 24598783
Journal: PLoS One
Year: 2014
Reference: PLoS One. 2014 Mar 5;9(3):e90509. doi: 10.1371/journal.pone.0090509. eCollection 2014.
Impact factor:
Publication type: Paper in international publication
Authors: Amato, Maria Pia; Brassat, David; Brochet, Bruno; de Seze, Jerome; De Stefano, Nicola; Donlon, Stacy; Hua, Le H; Inglese, Matilde; Kantarci, Orhun; Katz, Ilana et al.
DOI: 10.1371/journal.pone.0090509

A case of neuromyelitis optica harboring both anti-aquaporin-4 antibodies and a pathogenic mitochondrial DNA mutation for Leber's hereditary optic neuropathy: clinical commentary.

PMID: 24323818
Journal: Multiple Sclerosis Journal
Year: 2014
Reference: Mult Scler. 2014 Feb;20(2):261. doi: 10.1177/1352458513512711. Epub 2013 Dec 9.
Impact factor:
Publication type: Paper in international publication
Authors: Comabella, Manuel et al.
DOI: 10.1177/1352458513512711

Genome-wide significant association of ANKRD55 rs6859219 and multiple sclerosis risk.

PMID: 23315543
Journal: JOURNAL OF MEDICAL GENETICS
Year: 2013
Reference: J Med Genet. 2013 Mar;50(3):140-3. doi: 10.1136/jmedgenet-2012-101411. Epub 2013 Jan 12.
Impact factor:
Publication type: Paper in international publication
Authors: Akkad, Denis A; Aktas, Orhan; Alcina, Antonio; Antiguedad, Alfredo; Bertram, Lars; Blaschke, Paul; Buttmann, Mathias; Chan, Andrew; Comabella, Manuel; Corcia, Philippe et al.
DOI: 10.1136/jmedgenet-2012-101411

Early brain pseudoatrophy while on natalizumab therapy is due to white matter volume changes.

PMID: 23319072
Journal: Multiple Sclerosis Journal
Year: 2013
Reference: Mult Scler. 2013 Aug;19(9):1175-81. doi: 10.1177/1352458512473190. Epub 2013 Jan 14.
Impact factor:
Publication type: Paper in international publication
Authors: Arevalo, Maria J; Auger, Cristina; Castillo, Joaquin; Edo, Mari C; Horga, Alejandro; Montalban, Xavier; Nos, Carlos; Perez-Miralles, Francisco; Rio, Jordi; Rovira, Alex et al.
DOI: 10.1177/1352458512473190

Increase in the prevalence of multiple sclerosis over a 17-year period in Osona, Catalonia, Spain.

PMID: 22546846
Journal: Multiple Sclerosis Journal
Year: 2013
Reference: Mult Scler. 2013 Feb;19(2):245-8. doi: 10.1177/1352458512444751. Epub 2012 Apr 30.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; et al.
DOI: 10.1177/1352458512444751

Identification of a functional variant in the KIF5A-CYP27B1-METTL1-FAM119B locus associated with multiple sclerosis.

PMID: 23160276
Journal: JOURNAL OF MEDICAL GENETICS
Year: 2013
Reference: J Med Genet. 2013 Jan;50(1):25-33. doi: 10.1136/jmedgenet-2012-101085. Epub 2012 Nov 17.
Impact factor:
Publication type: Paper in international publication
Authors: Abad-Grau, Maria Del Mar; Alcina, Antonio; Alloza, Iraide; Antiguedad, Alfredo; Arroyo, Rafael; Blanco, Yolanda; Comabella, Manuel; de la Hera, Belen; Fedetz, Maria; Fernandez, Oscar et al.
DOI: 10.1136/jmedgenet-2012-101085

Natalizumab discontinuation after PML risk stratification: outcome from a shared and informed decision.

PMID: 22383232
Journal: Multiple Sclerosis Journal
Year: 2012
Reference: Mult Scler. 2012 Aug;18(8):1193-6. doi: 10.1177/1352458512439238. Epub 2012 Mar 1.
Impact factor: 4.255
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1177/1352458512439238

Change in the clinical activity of multiple sclerosis after treatment switch for suboptimal response.

PMID: 22289050
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2012
Reference: Eur J Neurol. 2012 Jun;19(6):899-904. doi: 10.1111/j.1468-1331.2011.03648.x. Epub 2012 Jan 31.
Impact factor: 3.692
Publication type: Paper in international publication
Authors: , , , , , , , et al.
DOI: 10.1111/j.1468-1331.2011.03648.x

Search for Specific Biomarkers of IFNbeta Bioactivity in Patients with Multiple Sclerosis.

PMID: 21886806
Journal: PLoS One
Year: 2011
Reference: PLoS One. 2011;6(8):e23634. Epub 2011 Aug 23.
Impact factor: 4.411
Publication type: Paper in international publication
Authors: Malhotra, Sunny, Bustamante, Marta F, Perez-Miralles, Francisco, Rio, Jordi, Ruiz de Villa, Mari Carmen, Vegas, Esteban, Nonell, Lara, Deisenhammer, Florian, Fissolo, Nicolas, Nurtdinov, Ramil N et al.
DOI: 10.1371/journal.pone.0023634

IL28B polymorphisms are not associated with the response to interferon-beta in multiple sclerosis.

PMID: 21889215
Journal: JOURNAL OF NEUROIMMUNOLOGY
Year: 2011
Reference: J Neuroimmunol. 2011 Oct 28;239(1-2):101-4. Epub 2011 Sep 1.
Impact factor: 2.901
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1016/j.jneuroim.2011.08.004

Multiple sclerosis: current treatment algorithms.

PMID: 21499098
Journal: CURRENT OPINION IN NEUROLOGY
Year: 2011
Reference: Curr Opin Neurol. 2011 Jun;24(3):230-7.
Impact factor: 5.021
Publication type: Paper in international publication
Authors: Rio, Jordi, Comabella, Manuel, Montalban, Xavier et al.
DOI: 10.1097/WCO.0b013e328346bf66

[An observational study of the effectiveness and safety of natalizumab in the treatment of multiple sclerosis.]

PMID: 21387248
Journal: REVISTA DE NEUROLOGIA
Year: 2011
Reference: Rev Neurol. 2011 Mar 16;52(6):321-330.
Impact factor: 1.218
Publication type: Paper in national publication
Authors: , , , , , , , , , et al.
DOI:

[Natalizumab in multiple sclerosis]

PMID: 19714558
Journal: REVISTA DE NEUROLOGIA
Year: 2009
Reference: Rev Neurol. 2009 Sep 1-15;49(5):265-9.
Impact factor: 1.083
Publication type: Review in national publication
Authors: Rio-Izquierdo, J, Montalban, X et al.
DOI:

Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis.

PMID: 19667218
Journal: ARCHIVES OF NEUROLOGY
Year: 2009
Reference: Arch Neurol. 2009 Aug;66(8):972-8.
Impact factor: 5.874
Publication type: Paper in international publication
Authors: Comabella, Manuel, Craig, David W, Morcillo-Suarez, Carlos, Rio, Jordi, Navarro, Arcadi, Fernandez, Marta, Martin, Roland, Montalban, Xavier et al.
DOI: 10.1001/archneurol.2009.150

Predicting responders to therapies for multiple sclerosis.

PMID: 19794514
Journal: Nat Rev Neurol
Year: 2009
Reference: Nat Rev Neurol. 2009 Oct;5(10):553-60.
Impact factor:
Publication type: Letter or abstract
Authors: Rio, Jordi, Comabella, Manuel, Montalban, Xavier et al.
DOI: 10.1038/nrneurol.2009.139

A single-centre, randomized, double-blind, placebo-controlled study of interferon beta-1b on primary progressive and transitional multiple sclerosis.

PMID: 19797261
Journal: MULTIPLE SCLEROSIS
Year: 2009
Reference: Mult Scler. 2009 Oct;15(10):1195-205.
Impact factor: 3.312
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1177/1352458509106937

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In total, different projects of six research groups will be promoted, focusing on precision medicine and advanced therapies.

Dr. Carmen Espejo and Dr. Georgina Arrambide, researchers at Cemcat and Vall d'Hebron Research Institute, are the first authors of the article.

The research findings propose to modify the McDonald 2017 criteria, only in those in whom diagnosis using the current criteria is not possible.

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Simoa HD1 equipment

We are seeking healthy volunteers for a study to find biomarkers of multiple sclerosis

We are looking for 100 healthy volunteers aged 18 or over to participate in a project where the usefulness of biomarkers in serum will be evaluated to predict the prognosis of the disease and the response to treatments.

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