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Clinical Pharmacology

The aim of our group is to investigate the use of medicines and evaluate its benefit/risk relationship in usual clinical practice. Our group coordinates the Catalan centre of the Spanish System of Pharmacovigilance. Research activities on pharmacology and pharmacoepidemiology are coupled with undergraduate teaching at the Autonomous University of Barcelona Medical School, training of specialists in clinical pharmacology, and continuous education of health professionals on therapeutics.

The group is a Special Group of Research recognized by AGAUR GenCat.  It is a partner of “The European Consortium “EU PE&PV Network” (European Pharmacoepidemiology and Pharmacovigilance Network)” and it is part of the European Network of Centres for Pharmacoepidemiology and Pharmacovigilance (ENCePP). It gives institutional support to the Clinical Research Ethical Committee of the University hospital Vall d’Hebron (UHVH), the Drug and Pharmacotherapeutic Committee of the UHVH, and also to the Drug and Pharmacotherapeutic Committee of the Institut Català de la Salut. 

Team

Héctor Carmona Díez

Héctor Carmona Díez

Research assistant
Clinical Pharmacology
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Jose J Barroso García

Jose J Barroso García

Research technician
Clinical Pharmacology
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Lourdes Vendrell Bosch

Lourdes Vendrell Bosch

Senior researcher
Clinical Pharmacology
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Maria Elena Ballarin Alins

Maria Elena Ballarin Alins

Clinical Pharmacology
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Maria Francesca Eugenia Filippi Arriaga

Maria Francesca Eugenia Filippi Arriaga

Research technician
Clinical Pharmacology
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María Gloria Cereza García

María Gloria Cereza García

Clinical Pharmacology
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Héctor Carmona Díez

Héctor Carmona Díez

Research assistant
Clinical Pharmacology
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Jose J Barroso García

Jose J Barroso García

Research technician
Clinical Pharmacology
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Lourdes Vendrell Bosch

Lourdes Vendrell Bosch

Senior researcher
Clinical Pharmacology
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Maria Elena Ballarin Alins

Maria Elena Ballarin Alins

Clinical Pharmacology
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Maria Francesca Eugenia Filippi Arriaga

Maria Francesca Eugenia Filippi Arriaga

Research technician
Clinical Pharmacology
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María Gloria Cereza García

María Gloria Cereza García

Clinical Pharmacology
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Publications

Developing a model to predict the early risk of hypertriglyceridemia based on inhibiting lipoprotein lipase (LPL): a translational study.

PMID: 38114521
Journal: Scientific Reports
Year: 2023
Reference: Sci Rep. 2023 Dec 19;13(1):22646. doi: 10.1038/s41598-023-49277-w.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilera, Cristina; Alcaide-Hidalgo, Juan Maria; Baselga-Escudero, Laura; Beghin, Delphine; Bera, Annie Pierre Jonville; Bermejo-Sanchez, Eva; Bosch, Montserrat; Cassina, Matteo; Chomiciute, Gertruda; Chouchana, Laurent et al.
DOI: 10.1038/s41598-023-49277-w

Advances and Pitfalls of Specialized Pain Care through Public and Private Health Care Providers in Catalonia and the Balearic Islands: A Physician's Survey.

PMID: 35637851
Journal: Pain Research & Management
Year: 2022
Reference: Pain Res Manag. 2022 May 21;2022:4077139. doi: 10.1155/2022/4077139. eCollection 2022.
Impact factor:
Publication type: Paper in international publication
Authors: Batet, Carme; Bella, Susana; Boada, Sergi; Ferrandiz, Marta; Lorente, Lluis; Medel, Javier; Monerris, Maria-Del-Mar; Montes, Antonio; Ribera, Maria-Victoria; Serrano, Ancor et al.
DOI: 10.1155/2022/4077139

Prevalence of Gabapentinoids and Central Nervous System Depressant Drugs, and Their Association with Risk Factors for Respiratory Depression in Primary Care Patients.

PMID: 35446006
Journal: CLINICAL DRUG INVESTIGATION
Year: 2022
Reference: Clin Drug Investig. 2022 May;42(5):417-426. doi: 10.1007/s40261-022-01144-8. Epub 2022 Apr 21.
Impact factor:
Publication type: Paper in international publication
Authors: Barcelo-Colomer, Maria Estrella; Fernandez-Liz, Eladio; Gomez-Ganda, Laura; Hortelano-Garcia, Maria Angeles; Lalueza-Broto, Pilar; Martin-Gracia, Elisabeth; Medel-Rebollo, Francisco Javier; Varon-Galcera, Carlota et al.
DOI: 10.1007/s40261-022-01144-8

Impact of a system to assist in clinical decision-making in primary healthcare in Catalonia: prescription Self Audit.

PMID: 35305620
Journal: BMC Medical Informatics and Decision Making
Year: 2022
Reference: BMC Med Inform Decis Mak. 2022 Mar 19;22(1):70. doi: 10.1186/s12911-022-01809-6.
Impact factor:
Publication type: Paper in international publication
Authors: Diogene-Fadini, Eduard; Figueras, Albert; Oms-Arias, Miriam; Pons-Mesquida, M Angels et al.
DOI: 10.1186/s12911-022-01809-6

Real-world evidence of brexucabtagene autoleucel for the treatment of relapsed or refractory mantle cell lymphoma.

PMID: 35271707
Journal: Blood Advances
Year: 2022
Reference: Blood Adv. 2022 Jun 28;6(12):3606-3610. doi: 10.1182/bloodadvances.2021006922.
Impact factor:
Publication type: Letter whit IF
Authors: Barba, Pere; Bonifazi, Francesca; Bramanti, Stefania; Camacho-Arteaga, Lina; Camacho-Arteaga, Lina; Chiappella, Annalisa; Corradini, Paolo; Iacoboni, Gloria; Kersten, Marie Jose; Kwon, Mi et al.
DOI: 10.1182/bloodadvances.2021006922

A multicenter case-control study of the effect of e-nos VNTR polymorphism on upper gastrointestinal hemorrhage in NSAID users.

PMID: 34620931
Journal: Scientific Reports
Year: 2021
Reference: Sci Rep. 2021 Oct 7;11(1):19923. doi: 10.1038/s41598-021-99402-w.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirre, Carmelo; Figueiras, Adolfo; Gil, Maria Sainz; Ibanez, Luisa; Ibarra-Garcia, Eguzkine; Iglesias Garcia, Julio; Macias Garcia, Fernando; Mallah, Narmeen; Martin-Arias, Luis; Palacios-Zabalza, Itziar et al.
DOI: 10.1038/s41598-021-99402-w

Factors associated with primary nonadherence to newly initiated direct oral anticoagulants in patients with nonvalvular atrial fibrillation.

PMID: 34464214
Journal: Journal of Managed Care & Specialty Pharmacy
Year: 2021
Reference: J Manag Care Spec Pharm. 2021 Sep;27(9):1210-1220. doi: 10.18553/jmcp.2021.27.9.1210.
Impact factor:
Publication type: Paper in international publication
Authors: Bailarin, Elena; Charlton, Alethea; Ibanez, Luisa; Martinez, Lina Maria Leguizamo; Sabate, Monica; Vidal, Xavier et al.
DOI: 10.18553/jmcp.2021.27.9.1210

Spontaneously Reported Adverse Drug Reactions and Their Description in Hospital Discharge Reports: A Retrospective Study.

PMID: 34362076
Journal: Journal of Clinical Medicine
Year: 2021
Reference: J Clin Med. 2021 Jul 26;10(15). pii: jcm10153293. doi: 10.3390/jcm10153293.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilera, Cristina; Agusti, Antonia; Danes, Immaculada; Diogene, Eduard; Gracia, Rosa M; Perez, Eulalia et al.
DOI: 10.3390/jcm10153293

Establishing and Evaluating a Study Questionnaire on Knowledge and Attitudes of Healthcare Professionals Towards Recreational and Medical Cannabis Across Europe.

PMID: 34232478
Journal: CLINICAL DRUG INVESTIGATION
Year: 2021
Reference: Clin Drug Investig. 2021 Aug;41(8):701-710. doi: 10.1007/s40261-021-01058-x. Epub 2021 Jul 7.
Impact factor:
Publication type: Paper in international publication
Authors: Alcubilla, Pau; Ekheden, Isabella; Freixo, Cristiana; Guillen, Elena; Javid, Farideh A; Jouanjus, Emilie; Leclerc, Vincent; Mainoli, Beatrice; Mazhar, Faizan; Nicolaou, Persoulla et al.
DOI: 10.1007/s40261-021-01058-x

Bloqueo del ganglio impar para tratamiento del dolor crónico pediátrico. A propósito de un caso

PMID: NOPMID0096
Journal: Dolor: Investigación, clínica & terapéutica
Year: 2019
Reference: Dolor: Investigación, clínica & terapéutica, ISSN 0214-0659, Vol. 34, Nº. 3, 2019, págs. 113-116
Impact factor:
Publication type: Letter or abstract
Authors: Aznar De legarra, Macarena; Barbara Ferreras, Antonio; Medel Rebollo, Francisco Javier; Mesas Idáñez, Ángeles; Server Salvà, Anna et al.
DOI:

Spanish list of potentially inappropriate drugs in the elderly (ES-PIA project).

PMID: 31065742
Journal: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
Year: 2019
Reference: Eur J Clin Pharmacol. 2019 Aug;75(8):1161-1176. doi: 10.1007/s00228-019-02684-3. Epub 2019 May 8.
Impact factor: 2.774
Publication type: Paper in international publication
Authors: Alonso Ramírez, Javier, Fernández Oropesa, Carlos, López Varona, Mª José, Acín Gerico, Mª Teresa, Sanz Alvarez, Emilio, Martín de la Sierra, María Ángeles, Peñalver, María José, Falomir Gómez, Teresa, Ruiz Salazar, Jesús, Rivas, Gabriela Elizondo et al.
DOI: 10.1007/s00228-019-02684-3

Workshop on the Italian Pharmacovigilance System in the International Context: Critical Issues and Perspectives.

PMID: 30565019
Journal: DRUG SAFETY
Year: 2019
Reference: Drug Saf. 2019 May;42(5):683-687. doi: 10.1007/s40264-018-0768-6.
Impact factor: 3.526
Publication type: Paper in international publication
Authors: Sultana, Janet, Moretti, Ugo, Addis, Antonio, Caduff, Pia, Capuano, Annalisa, Kant, Agnes, Laporte, Joan-Ramon, Lindquist, Marie, Raine, June, Sartori, Daniele et al.
DOI: 10.1007/s40264-018-0768-6

Vaccines that should be administered to patients receiving treatment with immunosuppressive, immunomodulatory and/or biological drugs.

PMID: 29887173
Journal: MEDICINA CLINICA
Year: 2018
Reference: Med Clin (Barc). 2018 Dec 21;151(12):498-502. doi: 10.1016/j.medcli.2018.05.008. Epub 2018 Jun 7.
Impact factor: 1.168
Publication type: Paper in national publication
Authors: Peremiquel-Trillas, Paula, Leguizamo, Lina Maria, Asensio Ostos, Carmen, Martinez-Gomez, Xavier et al.
DOI: 10.1016/j.medcli.2018.05.008

Prevalence of use of antipsychotic drugs in the elderly in Catalonia.

PMID: 29796874
Journal: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
Year: 2018
Reference: Eur J Clin Pharmacol. 2018 Sep;74(9):1185-1186. doi: 10.1007/s00228-018-2469-6. Epub 2018 May 23.
Impact factor: 2.679
Publication type: Letter or abstract
Authors: Asensio, Carmen, Escoda, Nuria, Sabate, Monica, Carbonell, Pere, Lopez, Pilar, Laporte, Joan-Ramon et al.
DOI: 10.1007/s00228-018-2469-6

Lack of essential information in spontaneous reports of adverse drug reactions in Catalonia-a restraint to the potentiality for signal detection.

PMID: 28251276
Journal: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
Year: 2017
Reference: Eur J Clin Pharmacol. 2017 Jun;73(6):751-758. doi: 10.1007/s00228-017-2223-5. Epub 2017 Mar 1.
Impact factor:
Publication type: Paper in international publication
Authors: Cereza, Gloria; Figueras, Albert; Garcia, Nuria; Gomez, Ainhoa; Plessis, Lorraine et al.
DOI: 10.1007/s00228-017-2223-5

Genetic variants associated with antithyroid drug-induced agranulocytosis: a genome-wide association study in a European population.

PMID: 27157822
Journal: Lancet Diabetes & Endocrinology
Year: 2016
Reference: Lancet Diabetes Endocrinol. 2016 Jun;4(6):507-16. doi: 10.1016/S2213-8587(16)00113-3. Epub 2016 May 3.
Impact factor:
Publication type: Paper in international publication
Authors: Axelsson, Tomas; Bondon-Guitton, Emmanuelle; Carvajal, Alfonso; Eriksson, Niclas; Hallberg, Par; Ibanez, Luisa; Kreutz, Reinhold; Lucena, M Isabel; Magnusson, Patrik K E; Martin, Javier et al.
DOI: 10.1016/S2213-8587(16)00113-3

Impact of implementing a protocol on the perioperative management in patients treated with anti-thrombotics admitted for hip fracture surgery: an observational study.

PMID: 27151175
Journal: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
Year: 2016
Reference: Basic Clin Pharmacol Toxicol. 2016 Nov;119(5):476-484. doi: 10.1111/bcpt.12615. Epub 2016 May 25.
Impact factor:
Publication type: Paper in international publication
Authors: Agusti, Antonia; Biarnes, Alfons; Bosch, Montse; Camps, Angels; Castella, Dolors; Iavecchia, Lujan; Lalueza, Pilar; Pons, Veronica; Sabate, Monica; Safiya, Ahmad et al.
DOI: 10.1111/bcpt.12615

Effectiveness, safety and costs of thromboembolic prevention in patients with non-valvular atrial fibrillation: phase I ESC-FA protocol study and baseline characteristics of a cohort from a primary care electronic database.

PMID: 26823179
Journal: BMJ Open
Year: 2016
Reference: BMJ Open. 2016 Jan 28;6(1):e010144. doi: 10.1136/bmjopen-2015-010144.
Impact factor:
Publication type: Paper in international publication
Authors: Bolibar, Bonaventura; Capella, Dolors; Casajuana, Marc; Castells, Xavier; Diogene, Eduard; Elorza, Josep M; Ferreira-Gonzalez, Ignacio; Giner-Soriano, Maria; Morros, Rosa; Roso-Llorach, Albert et al.
DOI: 10.1136/bmjopen-2015-010144

Elderly patients treated with psychotropic medicines admitted to hospital: associated characteristics and inappropriate use.

PMID: 26944419
Journal: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
Year: 2016
Reference: Eur J Clin Pharmacol. 2016 Jun;72(6):755-64. doi: 10.1007/s00228-016-2032-2. Epub 2016 Mar 5.
Impact factor:
Publication type: Paper in international publication
Authors: Agusti, Antonia; Barbe, Jose; Formiga, Francesc; Garcia, Juana; Lopez-Soto, Alfonso; Moyano, Antonio Fernandez; Ramirez-Duque, Nieves; San-Jose, Antonio; Torres, Olga H; Vallano, Antoni et al.
DOI: 10.1007/s00228-016-2032-2

Neutrophil gelatinase-associated lipocalin as a biomarker for lupus nephritis.

PMID: 24711435
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2014
Reference: Nephrol Dial Transplant. 2014 Sep;29(9):1740-9. doi: 10.1093/ndt/gfu062. Epub 2014 Apr 7.
Impact factor:
Publication type: Paper in international publication
Authors: Cortes-Hernandez, Josefina; Ordi-Ros, Josep; Pedrosa Anna; Torres-Salido, Maria Teresa; Vidal, Xavier; Vilardell-Tarres, Miquel et al.
DOI: 10.1093/ndt/gfu062

MRI-based Morphometric Analysis of Posterior Cranial Fossa in the Diagnosis of Chiari Malformation Type I.

PMID: 23324118
Journal: JOURNAL OF NEUROIMAGING
Year: 2014
Reference: J Neuroimaging. 2014 May-Jun;24(3):250-6. doi: 10.1111/jon.12007. Epub 2013 Jan 16.
Impact factor:
Publication type: Paper in international publication
Authors: Macaya, Alfons; Poca, Maria-Antonia; Rovira, Alex; Sahuquillo, Juan; Urbizu, Aintzane; Vidal, Xavier et al.
DOI: 10.1111/jon.12007

An inter-rater reliability study of the prescribing indicated medications quality indicators of the Assessing Care Of Vulnerable Elders (ACOVE) 3 criteria as a potentially inappropriate prescribing tool.

PMID: 24438879
Journal: ARCHIVES OF GERONTOLOGY AND GERIATRICS
Year: 2014
Reference: Arch Gerontol Geriatr. 2014 May-Jun;58(3):460-4. doi: 10.1016/j.archger.2013.12.006. Epub 2014 Jan 2.
Impact factor:
Publication type: Paper in international publication
Authors: Agusti, Antonia; Barbe, Jose; Fernandez-Moyano, Antonio; Formiga, Francesc; Garcia, Juana; Lopez-Soto, Alfonso; Ramirez-Duque, Nieves; San-Jose, Antonio; Torres, Olga H; Vidal, Xavier et al.
DOI: 10.1016/j.archger.2013.12.006

A compilation of research working groups on drug utilisation across Europe.

PMID: 24625054
Journal: BMC research notes
Year: 2014
Reference: BMC Res Notes. 2014 Mar 13;7:143. doi: 10.1186/1756-0500-7-143.
Impact factor:
Publication type: Letter or abstract
Authors: Reynolds, R F, Sabate, Monica, Pacheco, Juan Fernando, Ballarin, Elena, Ferrer, Pili, Petri, Hans, Hasford, Joerg, Schoonen, Marieke Wilma, Rottenkolber, Marietta, Fortuny, Joan et al.
DOI: 10.1186/1756-0500-7-143

Exposure to medicines among patients admitted for hip fracture and the case-fatality rate at 1 year: a longitudinal study.

PMID: 22527343
Journal: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
Year: 2012
Reference: Eur J Clin Pharmacol. 2012 Nov;68(11):1525-31. doi: 10.1007/s00228-012-1273-y. Epub 2012 Apr 15.
Impact factor: 2.845
Publication type: Paper in international publication
Authors: , , , , , , , , et al.
DOI: 10.1007/s00228-012-1273-y

Separating the wheat from the chaff: essential information in therapeutics.

PMID: 22015580
Journal: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
Year: 2012
Reference: Eur J Clin Pharmacol. 2012 Apr;68(4):335-7. Epub 2011 Oct 21.
Impact factor: 2.845
Publication type: Editorail in international publication
Authors: , , , et al.
DOI: 10.1007/s00228-011-1135-z

Meta-analysis of passive immunoprophylaxis in paediatric patients at risk of severe RSV infection.

PMID: 20950412
Journal: ACTA PAEDIATRICA
Year: 2011
Reference: Acta Paediatr. 2011 Mar;100(3):324-9. doi: 10.1111/j.1651-2227.2010.02059.x. Epub 2010 Nov 9.
Impact factor:
Publication type: Review in international publication
Authors: ; ; ; ; ; et al.
DOI: 10.1111/j.1651-2227.2010.02059.x

[Nephrogenic systemic fibrosis and gadolinium contrast agents.]

PMID: 21397280
Journal: MEDICINA CLINICA
Year: 2011
Reference: Med Clin (Barc). 2011 May 21;136(14):643-5. Epub 2011 Mar 11.
Impact factor:
Publication type: Editorial in national publication
Authors: ; et al.
DOI: 10.1016/j.medcli.2010.11.027

Efficacy of methylphenidate for adults with attention-deficit hyperactivity disorder: a meta-regression analysis.

PMID: 21254791
Journal: CNS DRUGS
Year: 2011
Reference: CNS Drugs. 2011 Feb 1;25(2):157-69. doi: 10.2165/11539440-000000000-00000.
Impact factor:
Publication type: Paper in international publication
Authors: Bosch, Rosa; Casas, Miguel; Castells, Xavier; Nogueira, Mariana; Ramos-Quiroga, Josep Antoni; Rigau, David; Vidal, Xavier et al.
DOI: 10.2165/11539440-000000000-00000

The case-population study design: an analysis of its application in pharmacovigilance.

PMID: 21879780
Journal: DRUG SAFETY
Year: 2011
Reference: Drug Saf. 2011 Oct 1;34(10):861-8. doi: 10.2165/11592140-000000000-00000.
Impact factor: 3.599
Publication type: Paper in international publication
Authors: Theophile, Helene, Laporte, Joan-Ramon, Moore, Nicholas, Martin, Karin-Latry, Begaud, Bernard et al.
DOI: 10.2165/11592140-000000000-00000

Antifibrinolytic therapy in complex spine surgery: a case-control study comparing aprotinin and tranexamic acid.

PMID: 19301800
Journal: ORTHOPEDICS
Year: 2009
Reference: Orthopedics. 2009 Feb;32(2):91.
Impact factor:
Publication type: Paper in international publication
Authors: Bago, Joan; Colomina, Maria J; Mora, Lidia; Pellise, Ferran; Vidal, Xavi et al.
DOI:

An intervention to improve spontaneous adverse drug reaction reporting by hospital physicians: a time series analysis in Spain.

PMID: 19132807
Journal: DRUG SAFETY
Year: 2009
Reference: Drug Saf. 2009;32(1):77-83.
Impact factor: 3.537
Publication type: Paper in international publication
Authors: Pedros, Consuelo, Vallano, Antoni, Cereza, Gloria, Mendoza-Aran, Gemma, Agusti, Antonia, Aguilera, Cristina, Danes, Immaculada, Arnau, Josep M, Vidal, Xavier et al.
DOI: 10.2165/00002018-200932010-00007

Blog

News

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