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Diabetes and Metabolism

The Diabetes and Metabolism Research Group is search is lead by Dr. Rafael Simó (Hirsch index:54), Head of the Endocrinology Department, Professor of Medicine & Endocrinology at UAB and current President of the European Association for the Study of Diabetes-Eye Complications. The group consists of 7 senior clinical investigators, 4 basic post-doctoral researchers, 4 pre-doc researchers, 3 laboratory technicians and one coordinator of clinical assays.  

The group belongs to “CIBER” of Diabetes and Associated Metabolic Diseases (CIBERDEM. ISCIII) and has been recognized as consolidated group by the Generalitat de Catalunya (AQU/AGAUR).

Since 2014 this group has been qualified as outstanding in the evaluations performed by the ANEP, CIBERDEM and the external Scientific Advisory Board of VHIR. 

The main lines of research are:

  • Complications of diabetes (in particular diabetic retinopathy)
  • Obesity and its co-morbidities
  • Type 2 diabetes and cognitive impairment
  • Thyroid diseases
  • Hospital Nutrition. 

Publications

Implications of Heterogeneity of Epithelial-Mesenchymal States in Acromegaly Therapeutic Pharmacologic Response.

PMID: 35203668
Journal: Biomedicines
Year: 2022
Reference: Biomedicines. 2022 Feb 16;10(2). pii: biomedicines10020460. doi: 10.3390/biomedicines10020460.
Impact factor:
Publication type: Paper in international publication
Authors: Bernabeu, Ignacio; Biagetti, Betina; Camara, Rosa; Carrato, Cristina; Fajardo-Montanana, Carmen; Garcia-Martinez, Araceli; Gil, Joan; Hostalot, Cristina; Jorda, Mireia; Lamas, Cristina et al.
DOI: 10.3390/biomedicines10020460

The Impact of Bariatric Surgery on the Muscle Mass in Patients with Obesity: 2-Year Follow-up.

PMID: 34846686
Journal: OBESITY SURGERY
Year: 2022
Reference: Obes Surg. 2022 Mar;32(3):625-633. doi: 10.1007/s11695-021-05815-x. Epub 2021 Nov 30.
Impact factor:
Publication type: Paper in international publication
Authors: Burgos, Rosa; Candia, Fiorella Palmas; Ciudin, Andreea; Cordero, Efrain; Eguinoa, Alba Zabalegui; Filippi, Francesca; Hernandez, Irene; Martinez, Marta Comas; Meli, Enzamaria Fidilio; Simo, Rafael et al.
DOI: 10.1007/s11695-021-05815-x

Pancreatitis crónica para el clínico. Parte 1: Etiología y Diagnóstico. Documento de posicionamiento interdisciplinar de la Societat Catalana de Digestologia y la Societat Catalana de Pàncrees (versión castellana)

PMID: 34157366
Journal: Gastroenterologia y Hepatologia
Year: 2022
Reference: Gastroenterol Hepatol. 2022 Mar;45(3):231-248. doi: 10.1016/j.gastrohep.2021.05.017. Epub 2021 Jun 19.
Impact factor:
Publication type: Paper in national publication
Authors: Ayuso, Juan Ramon; Balsells, Joaquim; Boadas, Jaume; Borobia, Francisco Garcia; Busquets, Juli; Casteras, Anna; Concepcion, Mar; Cuatrecasas, Miriam; Esparrach, Gloria Fernandez; Fort, Esther et al.
DOI: 10.1016/j.gastrohep.2021.05.017

Perinatal famine is associated with excess risk of proliferative retinopathy in patients with type 2 diabetes.

PMID: 34169655
Journal: ACTA OPHTHALMOLOGICA
Year: 2022
Reference: Acta Ophthalmol. 2022 Mar;100(2):e539-e545. doi: 10.1111/aos.14948. Epub 2021 Jun 24.
Impact factor:
Publication type: Paper in international publication
Authors: Artner, Isabella; Buldenko, Tetiana; Chan, Juliana; Cherviakova, Liubov; Fedotkina, Olena; Hernandez, Cristina; Jain, Deepak; Jain, Ruchi; Khalangot, Mykola D; Khalimon, Nadiya et al.
DOI: 10.1111/aos.14948

Relationship between adiponectin, TNFalpha, and SHBG in prepubertal children with obesity.

PMID: 33689083
Journal: Molecular and cellular pediatrics
Year: 2021
Reference: Mol Cell Pediatr. 2021 Mar 10;8(1):3. doi: 10.1186/s40348-021-00113-z.
Impact factor:
Publication type: Paper in international publication
Authors: Amat-Bou, Montse; Leal-Witt, Maria Jesus; Lerin, Carles; Osorio-Conles, Oscar; Ramon-Krauel, Marta; Selva, David M et al.
DOI: 10.1186/s40348-021-00113-z

Calorie restriction and SIRT1 overexpression induce different gene expression profiles in white adipose tissue in association with metabolic improvement.

PMID: 33686759
Journal: MOLECULAR NUTRITION & FOOD RESEARCH
Year: 2021
Reference: Mol Nutr Food Res. 2021 May;65(9):e2000672. doi: 10.1002/mnfr.202000672. Epub 2021 Mar 19.
Impact factor:
Publication type: Paper in international publication
Authors: Cervela, Luis; Herrero, Laura; Pardo, Rosario; Ribeiro, Marcelo L; Simo, Rafael; Velilla, Marc; Villena, Josep A et al.
DOI: 10.1002/mnfr.202000672

Metabolic footprint of aging and obesity in red blood cells.

PMID: 33609087
Journal: Aging-US
Year: 2021
Reference: Aging (Albany NY). 2021 Feb 19;13(4):4850-4880. doi: 10.18632/aging.202693. Epub 2021 Feb 19.
Impact factor:
Publication type: Paper in international publication
Authors: Ciudin, Andreea; Domingo-Orti, Ines; Herance, Jose Raul; Hernandez, Cristina; Lamas-Domingo, Ruben; Palomino-Schatzlein, Martina; Pineda-Lucena, Antonio et al.
DOI: 10.18632/aging.202693

Impact of Intensive Glucose Control on Brain Health: Meta-Analysis of Cumulative Data from 16,584 Patients with Type 2 Diabetes Mellitus.

PMID: 33548021
Journal: Diabetes Therapy
Year: 2021
Reference: Diabetes Ther. 2021 Mar;12(3):765-779. doi: 10.1007/s13300-021-01009-x. Epub 2021 Feb 6.
Impact factor:
Publication type: Paper in international publication
Authors: Cardoso, Marly A; Simo, Rafael; Tang, Xingyao; Yang, Jinkui; Zhou, Jian-Bo et al.
DOI: 10.1007/s13300-021-01009-x

Recognizing the reviewer's contribution. How can we improve?

PMID: 32131021
Journal: Endocrinologia Diabetes y Nutricion
Year: 2020
Reference: Endocrinol Diabetes Nutr. 2020 Mar;67(3):153-154. doi: 10.1016/j.endinu.2020.02.001.
Impact factor: 1.18
Publication type: Editorial in national publication
Authors: Zafon, C, Jimenez, A, Fajardo, C, Ballesteros, M D, Gimeno, J A, Wagner, A M et al.
DOI: 10.1016/j.endinu.2020.02.001

A role for Oncostatin M in the impairment of glucose homeostasis in obesity.

PMID: 31606738
Journal: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Year: 2020
Reference: J Clin Endocrinol Metab. 2020 Mar 1;105(3). pii: 5586710. doi: 10.1210/clinem/dgz090.
Impact factor: 5.399
Publication type: Paper in international publication
Authors: Gonzalez, Lorena, Reyes, Marjorie, Rodriguez-Fernandez, Silvia, Vives-Pi, Marta, Lerin, Carles, Elks, Carrie M, Stephens, Jacqueline M, Puig-Domingo, Manel, Villarroya, Francesc, Villena, Josep A et al.
DOI: 10.1210/clinem/dgz090

Thigh muscle fat infiltration is associated with impaired physical performance despite remission in Cushing's syndrome.

PMID: 31912154
Journal: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Year: 2020
Reference: J Clin Endocrinol Metab. 2020 May 1;105(5). pii: 5698174. doi: 10.1210/clinem/dgz329.
Impact factor: 5.399
Publication type: Paper in international publication
Authors: Martel, Luciana, Alonso, Alicia, Bascunana, Helena, Diaz-Manera, Jordi, Llauger, Jaume, Nunez-Peralta, Claudia, Biagetti, Betina, Montesinos, Paula, Webb, Susan M, Valassi, Elena et al.
DOI: 10.1210/clinem/dgz329

IDENTIFICATION OF EXPRESSION PROFILES DEFINING DISTINCT PROGNOSTIC SUBSETS OF RADIOACTIVE-IODINE REFRACTORY DIFFERENTIATED THYROID CANCER FROM THE DECISION TRIAL.

PMID: 31540966
Journal: MOLECULAR CANCER THERAPEUTICS
Year: 2020
Reference: Mol Cancer Ther. 2020 Jan;19(1):312-317. doi: 10.1158/1535-7163.MCT-19-0211. Epub 2019 Sep 20.
Impact factor: 5.615
Publication type: Paper in international publication
Authors: Capdevila, Jaume, Matos, Ignacio, Mancuso, Francesco M, Iglesias, Carmela, Nuciforo, Paolo, Zafon, Carles, Palmer, Hector G, Ogbah, Zighereda, Muinos, Laura, Villacampa, Guillermo et al.
DOI: 10.1158/1535-7163.MCT-19-0211

Diabetic retinopathy as an independent predictor of subclinical cardiovascular disease: baseline results of the PRECISED study.

PMID: 31908800
Journal: BMJ Open Diabetes Research & Care
Year: 2019
Reference: BMJ Open Diabetes Res Care. 2019 Dec 29;7(1):e000845. doi: 10.1136/bmjdrc-2019-000845. eCollection 2019.
Impact factor: 5.067
Publication type: Paper in international publication
Authors: Simo, Rafael, Baneras, Jordi, Hernandez, Cristina, Rodriguez-Palomares, Jose, Valente, Filipa, Gutierrez, Laura, Gonzalez-Alujas, Teresa, Ferreira, Ignacio, Aguade-Bruix, Santiago, Seron, Daniel et al.
DOI: 10.1136/bmjdrc-2019-000845

Retinal Microperimetry: A Useful Tool for Detecting Insulin Resistance-Related Cognitive Impairment in Morbid Obesity.

PMID: 31835729
Journal: Journal of Clinical Medicine
Year: 2019
Reference: J Clin Med. 2019 Dec 11;8(12). pii: jcm8122181. doi: 10.3390/jcm8122181.
Impact factor: 5.688
Publication type: Paper in international publication
Authors: Ciudin, Andreea, Ortiz, Angel Michael, Fidilio, Enzamaria, Romero, Diana, Sanchez, Marta, Comas, Marta, Gonzalez, Oscar, Vilallonga, Ramon, Simo-Servat, Olga, Hernandez, Cristina et al.
DOI: 10.3390/jcm8122181

Correction to: Prevalence and risk factors for hypoparathyroidism following total thyroidectomy in Spain: a multicentric and nation-wide retrospective analysis.

PMID: 31641934
Journal: ENDOCRINE
Year: 2019
Reference: Endocrine. 2019 Nov;66(2):416. doi: 10.1007/s12020-019-02108-3.
Impact factor: 3.296
Publication type: Letter or abstract
Authors: Paja, Miguel, Sambo, Marcel, Santiago Fernandez, Piedad, Blanco Carrera, Concepcion, Galofre, Juan Carlos, Navarro, Elena, Zafon, Carles, Sanz, Eva, Oleaga, Amelia, Bandres, Orosia et al.
DOI: 10.1007/s12020-019-02108-3

Metabolic Fingerprint of Acromegaly and its Potential Usefulness in Clinical Practice.

PMID: 31561638
Journal: Journal of Clinical Medicine
Year: 2019
Reference: J Clin Med. 2019 Sep 26;8(10). pii: jcm8101549. doi: 10.3390/jcm8101549.
Impact factor: 5.688
Publication type: Paper in international publication
Authors: Biagetti, Betina, Herance, J R, Ferrer, Roser, Aulinas, Anna, Palomino-Schatzlein, Martina, Mesa, Jordi, Castano, J P, Luque, Raul M, Simo, Rafael et al.
DOI: 10.3390/jcm8101549

Mycobacterium branderi infection: Case report and literature review of an unusual and difficult-to-treat non-tuberculous mycobacterium.

PMID: 28268125
Journal: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
Year: 2017
Reference: Int J Infect Dis. 2017 May;58:65-67. doi: 10.1016/j.ijid.2017.03.002. Epub 2017 Mar 6.
Impact factor:
Publication type: Paper in international publication
Authors: Cervera, Carlos; Doucette, Karen; Hernandez, Cristina; Kabbani, Dima; Turvey, Shannon L; Tyrrell, Gregory J et al.
DOI: 10.1016/j.ijid.2017.03.002

Shared Medical Appointments for Adolescent Breast Reduction.

PMID: 28570465
Journal: ANNALS OF PLASTIC SURGERY
Year: 2017
Reference: Ann Plast Surg. 2017 Sep;79(3):253-258. doi: 10.1097/SAP.0000000000001118.
Impact factor:
Publication type: Paper in international publication
Authors: Braun, Tara L; Hernandez, Cristina; Kaufman, Matthew G; Monson, Laura A et al.
DOI: 10.1097/SAP.0000000000001118

Regeneration of hyaline cartilage promoted by xenogeneic mesenchymal stromal cells embedded within elastin-like recombinamer-based bioactive hydrogels.

PMID: 28647792
Journal: JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
Year: 2017
Reference: J Mater Sci Mater Med. 2017 Aug;28(8):115. doi: 10.1007/s10856-017-5928-1. Epub 2017 Jun 24.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Matilde; Arias, Francisco Javier; Blanco, Juan Francisco; Brinon, Jesus G; Del Canizo, Maria Consuelo; Girotti, Alessandra; Hernandez, Cristina; Ibanez-Fonseca, Arturo; Muntion, Sandra; Pescador, David et al.
DOI: 10.1007/s10856-017-5928-1

Spanish consensus for the management of patients with anaplastic cell thyroid carcinoma.

PMID: 27048161
Journal: Clinical & Translational Oncology
Year: 2017
Reference: Clin Transl Oncol. 2017 Jan;19(1):12-20. doi: 10.1007/s12094-016-1506-0. Epub 2016 Apr 5.
Impact factor: 2.353
Publication type: Review in international publication
Authors: Jimenez-Fonseca, P, Gomez Saez, J M, Santamaria Sandi, J, Capdevila, J, Navarro Gonzalez, E, Zafon Llopis, C, Ramon Y Cajal Asensio, T, Riesco-Eizaguirre, G, Grande, E, Galofre, J C et al.
DOI: 10.1007/s12094-016-1506-0

Concordance study between one-step nucleic acid amplification and morphologic techniques to detect lymph node metastasis in papillary carcinoma of the thyroid.

PMID: 26614398
Journal: HUMAN PATHOLOGY
Year: 2016
Reference: Hum Pathol. 2016 Feb;48:132-41. doi: 10.1016/j.humpath.2015.09.020. Epub 2015 Oct 3.
Impact factor: 2.791
Publication type: Paper in international publication
Authors: Del Carmen, Sofia, Gatius, Sonia, Franch-Arcas, Guzman, Baena, Jose Antonio, Gonzalez, Oscar, Zafon, Carlos, Cuevas, Dolors, Valls, Joan, Perez, Angustias, Martinez, Mercedes et al.
DOI: 10.1016/j.humpath.2015.09.020

Diabetic and dyslipidaemic morbidly obese exhibit more liver alterations compared with healthy morbidly obese.

PMID: 27051590
Journal: BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
Year: 2016
Reference: BBA Clin. 2016 Jan 8;5:54-65. doi: 10.1016/j.bbacli.2015.12.002. eCollection 2016 Jun.
Impact factor: 4.864
Publication type: Paper in international publication
Authors: Pardina, Eva, Ferrer, Roser, Baena-Fustegueras, Juan Antonio, Lecube, Albert, Fort, Jose Manuel, Caubet, Enric, Gonzalez, Oscar, Vilallonga, Ramon, Vargas, Victor, Balibrea, Jose Maria et al.
DOI: 10.1016/j.bbacli.2015.12.002

Fenofibrate prevents the disruption of the outer blood retinal barrier through downregulation of NF-kappaB activity.

PMID: 25936740
Journal: ACTA DIABETOLOGICA
Year: 2016
Reference: Acta Diabetol. 2016 Feb;53(1):109-18. doi: 10.1007/s00592-015-0759-3. Epub 2015 May 5.
Impact factor: 3.074
Publication type: Paper in international publication
Authors: Garcia-Ramirez, Marta, Hernandez, Cristina, Palomer, Xavier, Vazquez-Carrera, Manuel, Simo, Rafael et al.
DOI: 10.1007/s00592-015-0759-3

geoRge: A Computational Tool To Detect the Presence of Stable Isotope Labeling in LC/MS-Based Untargeted Metabolomics.

PMID: 26639619
Journal: ANALYTICAL CHEMISTRY
Year: 2016
Reference: Anal Chem. 2016 Jan 5;88(1):621-8. doi: 10.1021/acs.analchem.5b03628. Epub 2015 Dec 18.
Impact factor: 5.886
Publication type: Paper in international publication
Authors: Yanes, Oscar, Vinaixa, Maria, Capellades, Jordi, Navarro, Miriam, Samino, Sara, Garcia-Ramirez, Marta, Hernandez, Cristina, Simo, Rafael et al.
DOI: 10.1021/acs.analchem.5b03628

Type 2 diabetes and the lung: a bidirectional relationship.

PMID: 22265762
Journal: Endocrinología y nutrición
Year: 2012
Reference: Endocrinol Nutr. 2012 Feb;59(2):95-7. doi: 10.1016/j.endonu.2011.12.003. Epub 2012 Jan 21.
Impact factor:
Publication type: Letter or abstract
Authors: , et al.
DOI: 10.1016/j.endonu.2011.12.003

Preoperative thyrotropin serum concentrations gradually increase from benign thyroid nodules to papillary thyroid microcarcinomas then to papillary thyroid cancers of larger size.

PMID: 21860806
Journal: Journal of thyroid research
Year: 2012
Reference: J Thyroid Res. 2012;2012:530721. Epub 2011 Jul 19.
Impact factor:
Publication type: Letter or abstract
Authors: Zafon, Carles, Obiols, Gabriel, Baena, Juan Antonio, Castellvi, Josep, Dalama, Belen, Mesa, Jordi et al.
DOI: 10.1155/2012/530721

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