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Diabetes and Metabolism

The Diabetes and Metabolism Research Group is search is lead by Dr. Rafael Simó (Hirsch index:54), Head of the Endocrinology Department, Professor of Medicine & Endocrinology at UAB and current President of the European Association for the Study of Diabetes-Eye Complications. The group consists of 7 senior clinical investigators, 4 basic post-doctoral researchers, 4 pre-doc researchers, 3 laboratory technicians and one coordinator of clinical assays.  

The group belongs to “CIBER” of Diabetes and Associated Metabolic Diseases (CIBERDEM. ISCIII) and has been recognized as consolidated group by the Generalitat de Catalunya (AQU/AGAUR).

Since 2014 this group has been qualified as outstanding in the evaluations performed by the ANEP, CIBERDEM and the external Scientific Advisory Board of VHIR. 

The main lines of research are:

  • Complications of diabetes (in particular diabetic retinopathy)
  • Obesity and its co-morbidities
  • Type 2 diabetes and cognitive impairment
  • Thyroid diseases
  • Hospital Nutrition. 

Publications

Phenotyping Type 2 Diabetes in Terms of Myocardial Insulin Resistance and Its Potential Cardiovascular Consequences: A New Strategy Based on (18)F-FDG PET/CT.

PMID: 35055345
Journal: Journal of Personalized Medicine
Year: 2022
Reference: J Pers Med. 2022 Jan 2;12(1). pii: jpm12010030. doi: 10.3390/jpm12010030.
Impact factor:
Publication type: Paper in international publication
Authors: Aguade-Bruix, Santiago; Aparicio, Carolina; Castell-Conesa, Joan; Garcia-Leon, Daniel; Herance, Jose Raul; Hernandez, Cristina; Mares, Roso; Paun, Bruno; Simo, Rafael; Simo-Servat, Olga et al.
DOI: 10.3390/jpm12010030

Association between diabetic retinopathy, brain structural abnormalities and cognitive impairment for accumulated evidence in observational studies.

PMID: 35063409
Journal: AMERICAN JOURNAL OF OPHTHALMOLOGY
Year: 2022
Reference: Am J Ophthalmol. 2022 Jul;239:37-53. doi: 10.1016/j.ajo.2022.01.011. Epub 2022 Jan 19.
Impact factor:
Publication type: Review in international publication
Authors: Chai, Yin-He; Gong, Hong-Jian; Liu, Wei; Patel, Ikramulhaq; Qiao, Yu-Shun; She, Hai-Cheng; Simo, Rafael; Stehouwer, Coen D A; Xu, Hui; Zhang, Yong-Peng et al.
DOI: 10.1016/j.ajo.2022.01.011

Diabetic Retinopathy Predicts Risk of Alzheimer's Disease: A Danish Registry-Based Nationwide Cohort Study.

PMID: 35068460
Journal: JOURNAL OF ALZHEIMERS DISEASE
Year: 2022
Reference: J Alzheimers Dis. 2022;86(1):451-460. doi: 10.3233/JAD-215313.
Impact factor:
Publication type: Paper in international publication
Authors: Andersen, Nis; Andresen, Jens; Bek, Toke; Frydkjaer-Olsen, Ulrik; Grauslund, Jakob; Hajari, Javad Nouri; Hass Rubin, Katrine; Heegaard, Steffen; Hojlund, Kurt; Kawasaki, Ryo et al.
DOI: 10.3233/JAD-215313

Liraglutide Improves Forced Vital Capacity in Individuals With Type 2 Diabetes: Data From the Randomized Cross-Over LIRALUNG Study.

PMID: 34737187
Journal: DIABETES
Year: 2022
Reference: Diabetes. 2022 Feb 1;71(2):315-320. doi: 10.2337/db21-0688.
Impact factor:
Publication type: Paper in international publication
Authors: Barbe, Ferran; Carolina, Lopez-Cano; Ciudin, Andreea; Dalmases, Mireia; Gaeta, Anna Michaela; Garcia-Ramirez, Marta; Hernandez, Cristina; Lecube, Albert; Marti, Raquel; Pellitero, Silvia et al.
DOI: 10.2337/db21-0688

The SEEN comprehensive clinical survey of adult obesity: Executive summary.

PMID: 32933882
Journal: Endocrinologia Diabetes y Nutricion
Year: 2021
Reference: Endocrinol Diabetes Nutr. 2021 Feb;68(2):130-136. doi: 10.1016/j.endinu.2020.05.003. Epub 2020 Sep 12.
Impact factor:
Publication type: Paper in national publication
Authors: Ballesteros Pomar, Maria D; Barahona, Maria Jose; Breton Lesmes, Irene; Bueno, Marta; Caixas, Assumpta; Calanas Continente, Alfonso; Ciudin, Andreea; Cordido, Fernando; de Hollanda, Ana; Diaz, Maria Jesus et al.
DOI: 10.1016/j.endinu.2020.05.003

Rate of non-invasive follicular thyroid neoplasms with papillary-like nuclear features depends on pathologist's criteria: a multicentre retrospective Southern European study with prolonged follow-up.

PMID: 33484411
Journal: ENDOCRINE
Year: 2021
Reference: Endocrine. 2021 Jul;73(1):131-140. doi: 10.1007/s12020-021-02610-7. Epub 2021 Jan 23.
Impact factor:
Publication type: Paper in international publication
Authors: Alcazar, Victoria; Anda, Emma; Bella, Rosa M; Blanco, Concha; Cameselle-Teijeiro, Jose Manuel; Capel, Ismael; Castano, Angel; Chao, Montserrat; Echeverria, Saioa; Fernandez-Seara, Pilar et al.
DOI: 10.1007/s12020-021-02610-7

GH/IGF-1 Abnormalities and Muscle Impairment: From Basic Research to Clinical Practice.

PMID: 33401779
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2021
Reference: Int J Mol Sci. 2021 Jan 2;22(1). pii: ijms22010415. doi: 10.3390/ijms22010415.
Impact factor:
Publication type: Review in international publication
Authors: Biagetti, Betina; Simo, Rafael et al.
DOI: 10.3390/ijms22010415

Acromegaly: Diabetes and HOMA-IR.

PMID: 33357713
Journal: Endocrinologia, diabetes y nutricion
Year: 2021
Reference: Endocrinol Diabetes Nutr. 2021 Jan;68(1):1-2. doi: 10.1016/j.endinu.2020.11.001.
Impact factor:
Publication type: Editorial in national publication
Authors: Biagetti, Betina; Simo, Rafael et al.
DOI: 10.1016/j.endinu.2020.11.001

Hsa-miR-139-5p is a prognostic thyroid cancer marker involved in HNRNPF-mediated alternative splicing.

PMID: 31403184
Journal: INTERNATIONAL JOURNAL OF CANCER
Year: 2020
Reference: Int J Cancer. 2020 Jan 15;146(2):521-530. doi: 10.1002/ijc.32622. Epub 2019 Aug 28.
Impact factor: 5.145
Publication type: Paper in international publication
Authors: Roldan-Romero, J M, Montero-Conde, C, Grana-Castro, O, Martin-Serrano, G, Martinez-Montes, A M, Zarzuela, E, Munoz, J, Torres-Perez, R, Pita, G, Cordero-Barreal, A et al.
DOI: 10.1002/ijc.32622

MEN1-associated primary hyperparathyroidism in the Spanish registry: clinical characteristics and surgical outcomes.

PMID: 31557724
Journal: Endocrine Connections
Year: 2019
Reference: Endocr Connect. 2019 Oct;8(10):1416-1424. doi: 10.1530/EC-19-0321.
Impact factor: 2.474
Publication type: Paper in international publication
Authors: Navarro, Elena, Casteras, Anna, Portillo, Paloma, Alcazar, Victoria, Calatayud, Maria, Alvarez-Escola, Cristina, Sastre, Julia, Boix, Evangelina, Forga Llenas, Lluis, Vicente, Almudena et al.
DOI: 10.1530/EC-19-0321

delta Opioid Receptor Agonism Preserves the Retinal Pigmented Epithelial Cell Tight Junctions and Ameliorates the Retinopathy in Experimental Diabetes.

PMID: 31529081
Journal: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Year: 2019
Reference: Invest Ophthalmol Vis Sci. 2019 Sep 3;60(12):3842-3853. doi: 10.1167/iovs.19-26761.
Impact factor: 3.812
Publication type: Paper in international publication
Authors: Lopes de Faria, Jacqueline M, Duarte, Diego A, Simo, Rafael, Datilo, Marcella N, Pasqualetto, Francieli C, Lopes de Faria, Jose B, Garcia-Ramirez, Marta et al.
DOI: 10.1167/iovs.19-26761

[Parenteral domiciliary nutrition Program: 32 years of clinical experience].

PMID: 31475838
Journal: Nutricion Hospitalaria
Year: 2019
Reference: Nutr Hosp. 2019 Oct 17;36(5):1011-1018. doi: 10.20960/nh.02461.
Impact factor: 0.759
Publication type: Letter or abstract
Authors: Simo Servat, Andreu, Lopez Urdiales, Rafael, Planas-Vilaseca, Alejandra, Garcia-Sancho de la Jordana, Paula, Fernandez Alvarez, Monica, Leiva Baldosa, Elisabet, Badia Tahull, Maria B, Virgili Casas, Maria Nuria et al.
DOI: 10.20960/nh.02461

SOCS1-Derived Peptide Administered by Eye Drops Prevents Retinal Neuroinflammation and Vascular Leakage in Experimental Diabetes.

PMID: 31344857
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2019
Reference: Int J Mol Sci. 2019 Jul 24;20(15). pii: ijms20153615. doi: 10.3390/ijms20153615.
Impact factor: 4.183
Publication type: Paper in international publication
Authors: Gomez-Guerrero, Carmen, Sampedro, Joel, Sola-Adell, Cristina, Espejo, Carmen, Garcia-Ramirez, Marta, Prieto, Ignacio, Egido, Jesus, Simo, Rafael, Bogdanov, Patricia, Hernandez, Cristina et al.
DOI: 10.3390/ijms20153615

Cystatin-C and epicardial adipose tissue as noninvasive predictors of cardiovascular risk in acromegaly.

PMID: 27910111
Journal: CLINICAL ENDOCRINOLOGY
Year: 2017
Reference: Clin Endocrinol (Oxf). 2017 Feb;86(2):214-222. doi: 10.1111/cen.13273. Epub 2016 Dec 2.
Impact factor: 3.487
Publication type: Paper in international publication
Authors: Crespo, Iris, Aulinas, Anna, Urgell, Eulalia, Biagetti, Betina, Webb, Susan M, Valassi, Elena, Leta, Ruben, Vilades, David et al.
DOI: 10.1111/cen.13273

APLP2, RRM2 and PRC1: new putative markers for the differential diagnosis of thyroid follicular lesions.

PMID: 27796194
Journal: THYROID
Year: 2017
Reference: Thyroid. 2017 Jan;27(1):59-66. doi: 10.1089/thy.2016.0094. Epub 2016 Nov 30.
Impact factor: 3.784
Publication type: Paper in international publication
Authors: Castelblanco, Esmeralda, Zafon, Carles, Maravall, Javier, Gallel, Pilar, Martinez, Montserrat, Capel, Ismael, Bella-Cueto, Maria Rosa, Halperin, Irene, Temprana-Salvador, Jordi, Iglesias, Carmela et al.
DOI: 10.1089/thy.2016.0094

Association of HMGB1 with oxidative stress markers and regulators in PDR.

PMID: 29259392
Journal: MOLECULAR VISION
Year: 2017
Reference: Mol Vis. 2017 Dec 5;23:853-871. eCollection 2017.
Impact factor: 2.057
Publication type: Paper in international publication
Authors: De Hertogh, Gert, Opdenakker, Ghislain, Simo, Rafael, Mousa, Ahmed, Mohammad, Ghulam, Ahmad, Ajmal, Abu El-Asrar, Ahmed M, Alam, Kaiser, Garcia-Ramirez, Marta, Siddiquei, Mohammad Mairaj et al.
DOI:

A compartmentalized microfluidic chip with crisscross microgrooves and electrophysiological electrodes for modeling the blood-retinal barrier.

PMID: 29168876
Journal: LAB ON A CHIP
Year: 2017
Reference: Lab Chip. 2017 Dec 19;18(1):95-105. doi: 10.1039/c7lc00795g.
Impact factor: 6.045
Publication type: Paper in international publication
Authors: Villa, Rosa, Simo, Rafael, Hernandez, Cristina, Yeste, Jose, Garcia-Ramirez, Marta, Illa, Xavi, Guimera, Anton et al.
DOI: 10.1039/c7lc00795g

Blog

News

The European project, in which Vall d'Hebron participates, will favor personalized diagnosis and innovative therapeutic strategies in patients with the disease.

This investment from EIT Health in the project will enable D-Sight to progress in the clinical development of its groundbreaking treatment for the early stages of diabetic retinopathy.

This initiative of the ”la Caixa” Foundation offers the selected entrepreneurial scientists financial support and support through individual mentoring and training.