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Diabetes and Metabolism

The Diabetes and Metabolism Research Group is search is lead by Dr. Rafael Simó (Hirsch index:54), Head of the Endocrinology Department, Professor of Medicine & Endocrinology at UAB and current President of the European Association for the Study of Diabetes-Eye Complications. The group consists of 7 senior clinical investigators, 4 basic post-doctoral researchers, 4 pre-doc researchers, 3 laboratory technicians and one coordinator of clinical assays.  

The group belongs to “CIBER” of Diabetes and Associated Metabolic Diseases (CIBERDEM. ISCIII) and has been recognized as consolidated group by the Generalitat de Catalunya (AQU/AGAUR).

Since 2014 this group has been qualified as outstanding in the evaluations performed by the ANEP, CIBERDEM and the external Scientific Advisory Board of VHIR. 

The main lines of research are:

  • Complications of diabetes (in particular diabetic retinopathy)
  • Obesity and its co-morbidities
  • Type 2 diabetes and cognitive impairment
  • Thyroid diseases
  • Hospital Nutrition. 

Publications

SARS CoV-2 seropositivity in haemodialysis patients.

PMID: 36828704
Journal: NEFROLOGIA
Year: 2022
Reference: Nefrologia (Engl Ed). 2022 Nov-Dec;42(6):733-736. doi: 10.1016/j.nefroe.2021.04.015. Epub 2023 Feb 20.
Impact factor:
Publication type: Letter or abstract
Authors: Azancot, Maria; Azancot, Maria; Castaneda, Zaira; Leon-Roman, Juan; Ramos, Natalia; Soler, Maria Jose; Toapanta, Nestor; Zuniga, Jose et al.
DOI: 10.1016/j.nefroe.2021.04.015

Common pathways in dementia and diabetic retinopathy: understanding the mechanisms of diabetes-related cognitive decline.

PMID: 34794851
Journal: TRENDS IN ENDOCRINOLOGY AND METABOLISM
Year: 2022
Reference: Trends Endocrinol Metab. 2022 Jan;33(1):50-71. doi: 10.1016/j.tem.2021.10.008. Epub 2021 Nov 15.
Impact factor: 12.015
Publication type: Review in international publication
Authors: Little, Karis; Llorian-Salvador, Maria; Scullion, Sarah; Hernandez, Cristina; Simo-Servat, Olga; Del Marco, Angel; Bosma, Esmeralda; Vargas-Soria, Maria; Carranza-Naval, Maria Jose; Van Bergen, Tine et al.
DOI: 10.1016/j.tem.2021.10.008

Perinatal famine is associated with excess risk of proliferative retinopathy in patients with type 2 diabetes.

PMID: 34169655
Journal: ACTA OPHTHALMOLOGICA
Year: 2022
Reference: Acta Ophthalmol. 2022 Mar;100(2):e539-e545. doi: 10.1111/aos.14948. Epub 2021 Jun 24.
Impact factor: 3.761
Publication type: Paper in international publication
Authors: Nilsson, Peter M; Fedotkina, Olena; Luk, Andrea; Jain, Ruchi; Prasad, Rashmi B; Shungin, Dmitry; Simo-Servat, Olga; Ozgumus, Turkuler; Cherviakova, Liubov; Khalimon, Nadiya et al.
DOI: 10.1111/aos.14948

Clinical efficacy of a virtual reality tool for the treatment of obesity: study protocol of a randomised controlled trial.

PMID: 35732390
Journal: BMJ Open
Year: 2022
Reference: BMJ Open. 2022 Jun 22;12(6):e060822. doi: 10.1136/bmjopen-2022-060822.
Impact factor: 2.692
Publication type: Paper in international publication
Authors: Lusilla-Palacios, Pilar; Ramos-Quiroga, Jose Antonio; Vazquez-De Sebastian, Julia; Puig, Gemma Parramon; Ciudin, Andreea; Comas, Marta; Cano Porras, Desiderio; Spanlang, Bernhard; Slater, Mel; Anastasiadou, Dimitra et al.
DOI: 10.1136/bmjopen-2022-060822

Neuromodulation Induced by Sitagliptin: A New Strategy for Treating Diabetic Retinopathy.

PMID: 34944588
Journal: Biomedicines
Year: 2021
Reference: Biomedicines. 2021 Nov 26;9(12). pii: biomedicines9121772. doi: 10.3390/biomedicines9121772.
Impact factor: 6.081
Publication type: Paper in international publication
Authors: Ramos, Hugo, Bogdanov, Patricia, Sabater, David, Huerta, Jordi, Valeri, Marta, Hernandez, Cristina, Simo, Rafael et al.
DOI: 10.3390/biomedicines9121772

Diabetic Retinopathy and Skin Tissue Advanced Glycation End Products Are Biomarkers of Cardiovascular Events in Type 2 Diabetic Patients.

PMID: 34945815
Journal: Journal of Personalized Medicine
Year: 2021
Reference: J Pers Med. 2021 Dec 10;11(12). pii: jpm11121344. doi: 10.3390/jpm11121344.
Impact factor: 4.945
Publication type: Paper in international publication
Authors: Planas, Alejandra, Simo-Servat, Olga, Hernandez, Cristina, Ortiz-Zuniga, Angel, Marsal, Joan Ramon, Herance, Jose R, Ferreira-Gonzalez, Ignacio, Simo, Rafael et al.
DOI: 10.3390/jpm11121344

Aggressive Pituitary Macroadenoma Treated With Capecitabine and Temozolomide Chemotherapy Combination in a Patient With Nelson's Syndrome: A Case Report.

PMID: 34858324
Journal: Frontiers in Endocrinology
Year: 2021
Reference: Front Endocrinol (Lausanne). 2021 Nov 11;12:731631. doi: 10.3389/fendo.2021.731631. eCollection 2021.
Impact factor: 5.555
Publication type: Letter whit IF
Authors: Mirallas, Oriol, Filippi-Arriaga, Francesca, Hernandez Hernandez, Irene, Aubanell, Anton, Chaachou, Anas, Garcia-Alvarez, Alejandro, Hernando, Jorge, Martinez-Saez, Elena, Biagetti, Betina, Capdevila, Jaume et al.
DOI: 10.3389/fendo.2021.731631

Thyroid disorders associated with immune control point inhibitors.

PMID: 34742474
Journal: Endocrinologia Diabetes y Nutricion
Year: 2021
Reference: Endocrinol Diabetes Nutr (Engl Ed). 2021 Jun-Jul;68(6):408-415. doi: 10.1016/j.endien.2021.10.004. Epub 2021 Oct 21.
Impact factor: 1.417
Publication type: Paper in international publication
Authors: Fidilio, Enzamaria, Navarro-Gonzalez, Elena, Romero-Lluch, Ana R, Iglesias, Pedro, Diez Gomez, Juan Jose, Anda Apinaniz, Emma, Zafon, Carles, Santos Mazo, Estefania et al.
DOI: 10.1016/j.endien.2021.10.004

New Insights into the Mechanisms of Action of Topical Administration of GLP-1 in an Experimental Model of Diabetic Retinopathy.

PMID: 30862093
Journal: Journal of Clinical Medicine
Year: 2019
Reference: J Clin Med. 2019 Mar 11;8(3). pii: jcm8030339. doi: 10.3390/jcm8030339.
Impact factor: 5.688
Publication type: Paper in international publication
Authors: Sampedro, Joel, Bogdanov, Patricia, Ramos, Hugo, Sola-Adell, Cristina, Turch, Mireia, Valeri, Marta, Simo-Servat, Olga, Lagunas, Carmen, Simo, Rafael, Hernandez, Cristina et al.
DOI: 10.3390/jcm8030339

ONE-STEP NUCLEIC ACID AMPLIFICATION FOR INTRAOPERATIVE ANALYSIS OF SENTINEL LYMPH NODE IN PAPILLARY THYROID CARCINOMA.

PMID: 30400049
Journal: EUROPEAN JOURNAL OF ENDOCRINOLOGY
Year: 2019
Reference: Eur J Endocrinol. 2019 Jan 1;180(1):21-29. doi: 10.1530/EJE-18-0624.
Impact factor: 5.107
Publication type: Paper in international publication
Authors: Fort, Jose M, Pujol-Borrell, Ricardo, Ramon Y Cajal, Santiago, Gonzalez, Oscar, Castell, Joan, Mesa, Jordi, Roca, Isabel, Caubet, Enric, Iglesias Felip, Carmela, Zafon, Carles et al.
DOI: 10.1530/EJE-18-0624

Calorie restriction prevents diet-induced insulin resistance independently of PGC-1-driven mitochondrial biogenesis in white adipose tissue.

PMID: 30277821
Journal: FASEB JOURNAL
Year: 2019
Reference: FASEB J. 2019 Feb;33(2):2343-2358. doi: 10.1096/fj.201800310R. Epub 2018 Oct 2.
Impact factor: 5.391
Publication type: Paper in international publication
Authors: Vila, Maria, Cervela, Luis, de Marco, Marina, Gama-Perez, Pau, Gonzalez-Franquesa, Alba, Statuto, Lucia, Vilallonga, Ramon, Simo, Rafael, Garcia-Roves, Pablo M, Villena, Josep A et al.
DOI: 10.1096/fj.201800310R

Adipocyte MTERF4 regulates non-shivering adaptive thermogenesis and sympathetic-dependent glucose homeostasis.

PMID: 30690068
Journal: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Year: 2019
Reference: Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1298-1312. doi: 10.1016/j.bbadis.2019.01.025. Epub 2019 Jan 26.
Impact factor: 4.328
Publication type: Paper in international publication
Authors: Villena, Josep A, Nogueiras, Ruben, Simo, Rafael, Marti, Ramon, Morcillo, Miguel A, Castillo, Anna, Vila, Maria, Pedriza, Ines, Pardo, Rosario, Camara, Yolanda et al.
DOI: 10.1016/j.bbadis.2019.01.025

Calcium dobesilate prevents the oxidative stress and inflammation induced by diabetes in the retina of db/db mice.

PMID: 28847447
Journal: JOURNAL OF DIABETES AND ITS COMPLICATIONS
Year: 2017
Reference: J Diabetes Complications. 2017 Oct;31(10):1481-1490. doi: 10.1016/j.jdiacomp.2017.07.009. Epub 2017 Jul 26.
Impact factor: 2.734
Publication type: Paper in international publication
Authors: Bogdanov, Patricia, Sola-Adell, Cristina, Hernandez, Cristina, Garcia-Ramirez, Marta, Sampedro, Joel, Simo-Servat, Olga, Valeri, Marta, Pasquali, Christian, Simo, Rafael et al.
DOI: 10.1016/j.jdiacomp.2017.07.009

Topical administration of DPP-IV inhibitors prevents retinal neurodegeneration in experimental diabetes.

PMID: 28779212
Journal: DIABETOLOGIA
Year: 2017
Reference: Diabetologia. 2017 Nov;60(11):2285-2298. doi: 10.1007/s00125-017-4388-y. Epub 2017 Aug 4.
Impact factor: 6.08
Publication type: Paper in international publication
Authors: Garcia-Ramirez, Marta, Simo, Rafael, Simo-Servat, Olga, Genis, Xavier, Valeri, Marta, Sampedro, Joel, Hernandez, Cristina, Bogdanov, Patricia, Sola-Adell, Cristina et al.
DOI: 10.1007/s00125-017-4388-y

Axitinib treatment in advanced RAI-resistant differentiated thyroid cancer (DTC) and refractory medullary thyroid cancer (MTC).

PMID: 28687563
Journal: EUROPEAN JOURNAL OF ENDOCRINOLOGY
Year: 2017
Reference: Eur J Endocrinol. 2017 Oct;177(4):309-317. doi: 10.1530/EJE-17-0243. Epub 2017 Jul 7.
Impact factor: 4.101
Publication type: Paper in international publication
Authors: Lopez-Alfonso, Ana, Capdevila, Jaume, Trigo, Jose Manuel, Aller, Javier, Manzano, Jose Luis, Garcia-Adrian, Silvia, Zafon, Carles, Reig, Oscar, Bohn, Uriel, Ramon Y Cajal, Teresa et al.
DOI: 10.1530/EJE-17-0243

Nodular Thyroid Disease and Thyroid Cancer in the Era of Precision Medicine.

PMID: 28589087
Journal: European thyroid journal
Year: 2017
Reference: Eur Thyroid J. 2017 Apr;6(2):65-74. doi: 10.1159/000457793. Epub 2017 Mar 3.
Impact factor: 0
Publication type: Review in national publication
Authors: Zafon, Carles, Diez, Juan J, Galofre, Juan C, Cooper, David S et al.
DOI: 10.1159/000457793

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News

The European project, in which Vall d'Hebron participates, will favor personalized diagnosis and innovative therapeutic strategies in patients with the disease.

This investment from EIT Health in the project will enable D-Sight to progress in the clinical development of its groundbreaking treatment for the early stages of diabetic retinopathy.

This initiative of the ”la Caixa” Foundation offers the selected entrepreneurial scientists financial support and support through individual mentoring and training.