About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
Our research group is focused on studying the pathophysiology of migraine and other primary headaches using preclinical, translational and clinical research.
Migraine will allow us to define the brain’s adaptive, sensory/cognitive functions, through genetics, epigenetics, neurophysiology, neuromolecular and neuroanatomical information with an interest in developing clinical therapeutic solutions, with the goal on having an impact on suffering and increasing the well-being.
IP: Patricia Pozo Rosich Collaborators: Alicia Alpuente Ruiz, Laila Asskour, Eulalia Gine Cipres, Victor José Gallardo Lopez, Edoardo Caronna, Laura Gómez Dabó Funding agency: Instituto de Salud Carlos III Funding: 81070 Reference: PI22/01501 Duration: 01/01/2023 - 31/12/2025
PMID: 38637736 Journal: JOURNAL OF HEADACHE AND PAIN Year: 2024 Reference: J Headache Pain. 2024 Apr 18;25(1):58. doi: 10.1186/s10194-024-01772-9. Impact factor: Publication type: Paper in international publication Authors: Alpuente, Alicia; Asskour, Laila; Caronna, Edoardo; Gallardo, Victor J; Pozo-Rosich, Patricia; Torres-Ferrus, Marta et al. DOI: 10.1186/s10194-024-01772-9
PMID: 38777579 Journal: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Year: 2024 Reference: J Neurol Neurosurg Psychiatry. 2024 May 22:jnnp-2023-333295. doi: 10.1136/jnnp-2023-333295. Impact factor: Publication type: Paper in international publication Authors: Alpuente, Alicia; Alvarez Escudero, Maria Rocio; Aurilia, Cinzia; Barbanti, Piero; Beltran Blasco, Isabel; Broadhurst, Sarah; Cabral, Goncalo; Campoy, Sergio; Caronna, Edoardo; Castellanos, Candela Nieves et al. DOI: 10.1136/jnnp-2023-333295
PMID: 38787073 Journal: Toxins Year: 2024 Reference: Toxins (Basel). 2024 May 11;16(5):221. doi: 10.3390/toxins16050221. Impact factor: Publication type: Paper in international publication Authors: Alpuente, Alicia; Caronna, Edoardo; Gallardo, Victor J; Gomez-Dabo, Laura; Mas-de-Les-Valls, Rut; Pozo-Rosich, Patricia; Torres-Ferrus, Marta et al. DOI: 10.3390/toxins16050221
PMID: 39034641 Journal: EUROPEAN JOURNAL OF NEUROLOGY Year: 2024 Reference: Eur J Neurol. 2024 Jul 21:e16414. doi: 10.1111/ene.16414. Impact factor: Publication type: Paper in international publication Authors: Barandiaran, Myriam; Bengoetxea, Ana; de Munain, Estibaliz Lopez; Dias, Patricia Alves; Garcia-Martin, Valvanuz; Grozeva, Vesselina; Laspra-Solis, Carmen; Minguez-Olaondo, Ane; Vila-Pueyo, Marta; Villalba, Ines Martin et al. DOI: 10.1111/ene.16414
PMID: 36793015 Journal: JOURNAL OF HEADACHE AND PAIN Year: 2023 Reference: J Headache Pain. 2023 Feb 16;24(1):10. doi: 10.1186/s10194-023-01550-z. Impact factor: Publication type: Paper in international publication Authors: Anttila, Verneri; Artto, Ville; Belin, Andrea C; Bjornsdottir, Anna; Bjornsdottir, Gyda; Boomsma, Dorret I; Borte, Sigrid; Cao, Jin; Chalmer, Mona A; Chasman, Daniel I et al. DOI: 10.1186/s10194-023-01550-z
PMID: 36797674 Journal: JOURNAL OF HEADACHE AND PAIN Year: 2023 Reference: J Headache Pain. 2023 Feb 17;24(1):11. doi: 10.1186/s10194-023-01542-z. Impact factor: Publication type: Paper in international publication Authors: Alpuente, A; Asskour, L; Caronna, E; Gallardo, V J; Gomez-Galvan, J B; Gomez-Galvan, J B; Pozo-Rosich, P; Torres-Ferrus, M et al. DOI: 10.1186/s10194-023-01542-z
PMID: 36855951 Journal: CEPHALALGIA Year: 2023 Reference: Cephalalgia. 2023 Apr;43(4):3331024231159366. doi: 10.1177/03331024231159366. Impact factor: Publication type: Review in international publication Authors: Garcia-Azorin, David; Haghdoost, Faraidoon; Huessler, Eva-Maria; Messina, Roberta; Pozo-Rosich, Patricia; Puledda, Francesca et al. DOI: 10.1177/03331024231159366
PMID: 37038303 Journal: EUROPEAN JOURNAL OF NEUROLOGY Year: 2023 Reference: Eur J Neurol. 2023 Jul;30(7):1937-1944. doi: 10.1111/ene.15816. Epub 2023 Apr 26. Impact factor: Publication type: Paper in international publication Authors: Alpuente, Alicia; Caronna, Edoardo; Gallardo, Victor J; Gine-Cipres, Eulalia; Pozo-Rosich, Patricia; Torres-Ferrus, Marta et al. DOI: 10.1111/ene.15816
PMID: 36054144 Journal: ANNALS OF NEUROLOGY Year: 2022 Reference: Ann Neurol. 2022 Nov;92(5):846-859. doi: 10.1002/ana.26472. Epub 2022 Aug 24. Impact factor: Publication type: Paper in international publication Authors: Alpuente, Alicia; Asskour, Laila; Caronna, Edoardo; Gallardo, Victor J; Pozo-Rosich, Patricia; Torres-Ferrus, Marta et al. DOI: 10.1002/ana.26472
PMID: 36053077 Journal: HEADACHE Year: 2022 Reference: Headache. 2022 Sep;62(8):1019-1028. doi: 10.1111/head.14376. Epub 2022 Sep 2. Impact factor: Publication type: Paper in international publication Authors: Caronna, Edoardo; Gallardo, Victor J; Pozo-Rosich, Patricia; Shapiro, Robert E et al. DOI: 10.1111/head.14376
PMID: 36004408 Journal: ACTA NEUROLOGICA SCANDINAVICA Year: 2022 Reference: Acta Neurol Scand. 2022 Nov;146(5):568-572. doi: 10.1111/ane.13681. Epub 2022 Aug 11. Impact factor: Publication type: Paper in international publication Authors: Amin, Faisal Mohammad; Do, Thien Phu; Kristensen, Malene Glavind Holmsted; Pozo-Rosich, Patricia et al. DOI: 10.1111/ane.13681
PMID: 35953289 Journal: NEUROLOGY Year: 2022 Reference: Neurology. 2022 Sep 20;99(12):e1326-e1334. doi: 10.1212/WNL.0000000000200887. Epub 2022 Aug 11. Impact factor: Publication type: Paper in international publication Authors: Alpuente, Alicia; Gallardo, Victor J; Pozo-Rosich, Patricia et al. DOI: 10.1212/WNL.0000000000200887
PMID: 34564833 Journal: Pain and Therapy Year: 2021 Reference: Pain Ther. 2021 Dec;10(2):1605-1618. doi: 10.1007/s40122-021-00328-y. Epub 2021 Sep 26. Impact factor: Publication type: Paper in international publication Authors: Ahmed, Fayyaz; Alpuente, Alicia; Andreou, Anna P; Baraldi, Carlo; Brunelli, Nicoletta; Butera, Calogera; Cevoli, Sabina; Colombo, Bruno; Filatova, Elena; Filippi, Massimo et al. DOI: 10.1007/s40122-021-00328-y
PMID: 34363619 Journal: HEADACHE Year: 2021 Reference: Headache. 2021 Sep;61(8):1277-1280. doi: 10.1111/head.14197. Epub 2021 Aug 7. Impact factor: Publication type: Letter or abstract Authors: Alpuente, Alicia; Caronna, Edoardo; Pozo-Rosich, Patricia; Torres-Ferrus, Marta et al. DOI: 10.1111/head.14197
PMID: 34273945 Journal: JOURNAL OF HEADACHE AND PAIN Year: 2021 Reference: J Headache Pain. 2021 Jul 17;22(1):75. doi: 10.1186/s10194-021-01289-5. Impact factor: Publication type: Paper in international publication Authors: Alpuente, Alicia; Caronna, Edoardo; Castell-Conesa, Joan; Cuberas-Borros, Gemma; Gallardo, Victor J; Lorenzo-Bosquet, Carles; Pareto, Deborah; Pozo-Rosich, Patricia; Rovira, Alex; Torres-Ferrus, Marta et al. DOI: 10.1186/s10194-021-01289-5
PMID: 34273947 Journal: JOURNAL OF HEADACHE AND PAIN Year: 2021 Reference: J Headache Pain. 2021 Jul 17;22(1):74. doi: 10.1186/s10194-021-01267-x. Impact factor: Publication type: Paper in international publication Authors: Alberte-Woodward, Miguel; Alpuente, Alicia; Beltran, Isabel; Belvis, Robert; Cano, Antonio; Cuadrado, Elisa; de Teran, Javier Diaz; Del Rio, Margarita Sanchez; Ezpeleta, David; Gomez-Camello, Angel et al. DOI: 10.1186/s10194-021-01267-x
PMID: 32657062 Journal: Journal of Clinical Neurology Year: 2020 Reference: J Clin Neurol. 2020 Jul;16(3):416-422. doi: 10.3988/jcn.2020.16.3.416. Impact factor: Publication type: Paper in international publication Authors: Fonseca, Elena; Gallardo, Victor Jose; Macaya, Alfons; Pozo-Rosich, Patricia; Torres-Ferrus, Marta et al. DOI: 10.3988/jcn.2020.16.3.416
PMID: 32652924 Journal: JOURNAL OF HEADACHE AND PAIN Year: 2020 Reference: J Headache Pain. 2020 Jul 11;21(1):88. doi: 10.1186/s10194-020-01157-8. Impact factor: Publication type: Paper in international publication Authors: Alpuente, Alicia; Gallardo, Victor Jose; Pozo-Rosich, Patricia; Torres-Ferrus, Marta et al. DOI: 10.1186/s10194-020-01157-8
PMID: 32643853 Journal: EUROPEAN JOURNAL OF NEUROLOGY Year: 2020 Reference: Eur J Neurol. 2020 Dec;27(12):2616-2624. doi: 10.1111/ene.14431. Epub 2020 Aug 8. Impact factor: Publication type: Paper in international publication Authors: Blanch, C; Brace, O; Colomina, I; Garrido-Cumbrera, M; Irimia, P; Pozo-Rosich, P; Santos-Lasaosa, S et al. DOI: 10.1111/ene.14431
PMID: 28870392 Journal: NEUROLOGIA Year: 2020 Reference: Neurologia. 2020 Jun;35(5):323-331. doi: 10.1016/j.nrl.2017.08.002. Epub 2017 Sep 1. Impact factor: Publication type: Review in national publication Authors: Diaz de Teran, J; Gago-Veiga, A B; Gonzalez-Garcia, N; Gonzalez-Oria, C; Gonzalez-Quintanilla, V; Minguez-Olaondo, A; Pozo-Rosich, P; Santos-Lasaosa, S; Viguera Romero, J et al. DOI: 10.1016/j.nrl.2017.08.002
PMID: 31238877 Journal: JOURNAL OF HEADACHE AND PAIN Year: 2019 Reference: J Headache Pain. 2019 Jun 25;20(1):73. doi: 10.1186/s10194-019-1020-1. Impact factor: Publication type: Paper in international publication Authors: Balseiro-Gomez, Jose; Guerrero-Peral, Angel L; Ignacio, Emilio; Latorre-Gonzalez, German; Layos-Romero, Almudena; Lucas, Cesar; Martinez-Garcia, Alba; Mira, Jose J; Pascual, Julio; Porta-Etessam, Jesus et al. DOI: 10.1186/s10194-019-1020-1
PMID: 31220392 Journal: EUROPEAN JOURNAL OF NEUROLOGY Year: 2019 Reference: Eur J Neurol. 2019 Dec;26(12):1464-1470. doi: 10.1111/ene.14028. Epub 2019 Jul 18. Impact factor: Publication type: Paper in international publication Authors: Alpuente, Alicia; Alvarez-Sabin, Jose; Gallardo, Victor Jose; Pozo-Rosich, Patricia; Torres-Ferrus, Marta et al. DOI: 10.1111/ene.14028
PMID: 31030294 Journal: Odontology Year: 2019 Reference: Odontology. 2019 Oct;107(4):530-535. doi: 10.1007/s10266-019-00430-w. Epub 2019 Apr 27. Impact factor: Publication type: Paper in international publication Authors: Alvaro, Luis Carlos; Belvis, Roberto; Blanco, Juan; Cuadrado, Maria Luz; D'Aiuto, Francesco; Gago-Veiga, Ana Beatriz; Garcia-Azorin, David; Gonzalez-Oria, Carmen; Guerrero, Angel; Lainez, Jose Miguel et al. DOI: 10.1007/s10266-019-00430-w
PMID: 30950844 Journal: CURRENT OPINION IN NEUROLOGY Year: 2019 Reference: Curr Opin Neurol. 2019 Jun;32(3):395-404. doi: 10.1097/WCO.0000000000000689. Impact factor: Publication type: Paper in international publication Authors: Alpuente, Alicia; Pozo-Rosich, Patricia; Torres-Ferrus, Marta et al. DOI: 10.1097/WCO.0000000000000689
PMID: 30384104 Journal: EPILEPSY & BEHAVIOR Year: 2018 Reference: Epilepsy Behav. 2018 Dec;89:8-14. doi: 10.1016/j.yebeh.2018.09.046. Epub 2018 Oct 26. Impact factor: Publication type: Paper in international publication Authors: Abarrategui, Belen; Abraira, Laura; Alpuente, Alicia; Garcia-Morales, Irene; Gutierrez-Viedma, Alvaro; Mazuela, Gonzalo; Parejo, Beatriz; Quintana, Manuel; Salas-Puig, Xavier; Santamarina, Estevo et al. DOI: 10.1016/j.yebeh.2018.09.046
PMID: 30259200 Journal: JOURNAL OF HEADACHE AND PAIN Year: 2018 Reference: J Headache Pain. 2018 Sep 26;19(1):91. doi: 10.1186/s10194-018-0921-8. Impact factor: Publication type: Paper in international publication Authors: Ahmed, Fayyaz; Ashina, Messoud; Bendtsen, Lars; Martelletti, Paolo; Mitsikostas, Dimos; Pozo-Rosich, Patricia; Sacco, Simona et al. DOI: 10.1186/s10194-018-0921-8
PMID: 30143565 Journal: NEUROLOGY Year: 2018 Reference: Neurology. 2018 Sep 25;91(13):622-624. doi: 10.1212/WNL.0000000000006251. Epub 2018 Aug 24. Impact factor: Publication type: Paper in international publication Authors: Caronna, Edoardo; Gratacos, Margarida; Midaglia, Luciana; Montalban, Xavier; Raguer, Nuria; Sastre-Garriga, Jaume; Tintore, Mar et al. DOI: 10.1212/WNL.0000000000006251
PMID: 29575364 Journal: EUROPEAN JOURNAL OF NEUROLOGY Year: 2018 Reference: Eur J Neurol. 2018 Apr;25(4):e48. doi: 10.1111/ene.13570. Impact factor: Publication type: Letter or abstract Authors: Dominguez, C; Leira, R; Leira, Y; Pozo-Rosich, P et al. DOI: 10.1111/ene.13570
Two international studies led by Vall d'Hebron recommend early administration of specific drugs to prevent migraine to achieve a better response to therapy.
On World Clinical Trials Day, we highlight some of the studies we have participated in that confirm the efficacy of new drugs, allowing their approval by regulatory agencies.
The study, conducted in more than 770 people, concludes that atogepant reduces the frequency of migraine attacks and the need to take medication.
