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Infection and Immunity in pediatric patients

The Infection and Immunity in pediatric patients research group is a multidisciplinary pediatric research group made up of health professionals involved in translational research in the field of pediatric infectious diseases and immunodeficiencies, two related fields in terms of pathophysiology and clinical implications. It is a consolidated research group recognized by the AGAUR and is the only one with the accreditation of the Jeffrey Modell Foundation in research in the field of primary immunodeficiencies throughout the state.

The group was officially created in 2010, belongs to the area of Infectious Diseases and participates in the transversal programs of Advanced Translational Immunology and Rare Diseases and actively participates in national and international competitive projects, carries out multiple academic and industry-linked clinical trials and has increased the number and quality in recent years. In addition, it has its own laboratory specially dedicated to advanced immune studies.

Team

Belén Sánchez Fernández

Belén Sánchez Fernández

Predoctoral researcher
Infection and immunity in pediatric patients
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Giménez Sanz, Noemí

Giménez Sanz, Noemí

Infection and immunity in pediatric patients
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Maria Alvarez de Toledo López

Maria Alvarez de Toledo López

Predoctoral researcher
Infection and immunity in pediatric patients
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Maria Pinyol Sarrias

Maria Pinyol Sarrias

Predoctoral researcher
Infection and immunity in pediatric patients
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Belén Sánchez Fernández

Belén Sánchez Fernández

Predoctoral researcher
Infection and immunity in pediatric patients
Read more
Giménez Sanz, Noemí

Giménez Sanz, Noemí

Infection and immunity in pediatric patients
Read more
Maria Alvarez de Toledo López

Maria Alvarez de Toledo López

Predoctoral researcher
Infection and immunity in pediatric patients
Read more
Maria Pinyol Sarrias

Maria Pinyol Sarrias

Predoctoral researcher
Infection and immunity in pediatric patients
Read more

Projects

UNDINE: The human genetic and immunological determinants of the clinical manifestations of SARS-CoV-2 infection: Towards personalised medicine

IP: Pere Soler Palacín
Collaborators: Laura Batlle Masó
Funding agency: EUROPEAN COMMISSION
Funding: 163667.5
Reference: UNDINE_HE-HLTH-DISEASE21
Duration: 01/06/2022 - 31/05/2026

Publications

Safety and immunogenicity of the protein-based PHH-1V compared to BNT162b2 as a heterologous SARS-CoV-2 booster vaccine in adults vaccinated against COVID-19: a multicentre, randomised, double-blind, non-inferiority phase IIb trial.

PMID: 37131861
Journal: The Lancet regional health. Europe
Year: 2023
Reference: Lancet Reg Health Eur. 2023 May;28:100613. doi: 10.1016/j.lanepe.2023.100613. Epub 2023 Apr 14.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Mon, Melchor; Anagua, Jesse Omar; Arana-Arri, Eunate; Arribas, Jose R; Bailon, Lucia; Barreiro, Antonio; Benet, Susana; Blanch-Lombarte, Oscar; Blanco, Julia; Borobia, Alberto M et al.
DOI: 10.1016/j.lanepe.2023.100613

Age, Successive Waves, Immunization, and Mortality in Elderly COVID-19 Haematological Patients: EPICOVIDEHA Findings.

PMID: 37863310
Journal: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
Year: 2023
Reference: Int J Infect Dis. 2023 Oct 18:S1201-9712(23)00749-X. doi: 10.1016/j.ijid.2023.10.013.
Impact factor:
Publication type: Paper in international publication
Authors: Abu-Zeinah, Ghaith; Adzic-Vukicevic, Tatjana; Aiello, Tommaso Francesco; Ammatuna, Emanuele; Arellano, Elena; Barac, Aleksandra; Bavastro, Martina; Bergantim, Rui; Besson, Caroline; Biernat, Monika M et al.
DOI: 10.1016/j.ijid.2023.10.013

Determinants of school absences due to respiratory tract infections among children during COVID-19 pandemic: A cross-sectional study of the Sentinel Schools Network.

PMID: 37877732
Journal: Pediatric pulmonology
Year: 2023
Reference: Pediatr Pulmonol. 2023 Oct 25. doi: 10.1002/ppul.26736.
Impact factor:
Publication type: Other (letters to the editor, abstracts, corrigendum, etc.)
Authors: Alonso, Lucia; Bordas, Anna; Casabona, Jordi; Castells-Sanchez, Alba; Colom-Cadena, Andreu; Dacosta-Aguayo, Rosalia; Dimitriadis, Stavros I; Ganem, Fabiana; Garcia-Molina, Alberto; Gascon, Mireia et al.
DOI: 10.1002/ppul.26736

Novel frameshift variants expand the map of the genetic defects in IRF2BP2.

PMID: 37876937
Journal: Frontiers in Immunology
Year: 2023
Reference: Front Immunol. 2023 Oct 9;14:1279171. doi: 10.3389/fimmu.2023.1279171. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Acuna Perez, Maria Jose; Bai, Yuxian; Bhagia, Pooja; Bilici, Mehmet; Calavia, Olga; Chung, Hyun Cheol; Colobran, Roger; Garcia Ramos, Maite; Garcia-Aznar, Jose Maria; Janjigian, Yelena Y et al.
DOI: 10.3389/fimmu.2023.1279171

SARS-CoV-2 PCR negativization in respiratory sample in patients with need for recurring assistance.

PMID: 35305952
Journal: ANALES DE PEDIATRIA
Year: 2022
Reference: An Pediatr (Engl Ed). 2022 Apr;96(4):357-359. doi: 10.1016/j.anpede.2021.01.008. Epub 2022 Mar 3.
Impact factor: 1.5
Publication type: Letter whit IF
Authors: Bassets-Bosch, Alba, Raya-Munoz, Judith, Worner-Tomasa, Nuria, Melendo-Perez, Susana, Gonzalez-Peris, Sebastia et al.
DOI: 10.1016/j.anpede.2021.01.008

Dynamics of RT-PCR and Serologic Test Results in Children with SARS-CoV-2 Infection.

PMID: 34571020
Journal: JOURNAL OF PEDIATRICS
Year: 2022
Reference: J Pediatr. 2022 Feb;241:126-132.e3. doi: 10.1016/j.jpeds.2021.09.029. Epub 2021 Sep 25.
Impact factor: 4.406
Publication type: Paper in international publication
Authors: Perez, Seoane B, Tagarro, A, Sanz-Santaeufemia, F J, Grasa, C, Cobos, E, Yebra, J, Alonso-Cadenas, J A, Baquero-Artigao, F, Mesa, Guzman Jm, Reinoso, T et al.
DOI: 10.1016/j.jpeds.2021.09.029

Curation and Expansion of Human Phenotype Ontology for Defined Groups of Inborn Errors of Immunity.

PMID: 33991581
Journal: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Year: 2022
Reference: J Allergy Clin Immunol. 2022 Jan;149(1):369-378. doi: 10.1016/j.jaci.2021.04.033. Epub 2021 May 12.
Impact factor: 10.793
Publication type: Paper in international publication
Authors: Riviere, Jacques G, van der Burg, Mirjam, Gattorno, Marco, Seidel, Markus G, Burns, Siobhan, Warnatz, Klaus, Hauck, Fabian, Brogan, Paul, Gilmour, Kimberly C, Schuetz, Catharina et al.
DOI: 10.1016/j.jaci.2021.04.033

Uncovering Low-Level Maternal Gonosomal Mosaicism in X-Linked Agammaglobulinemia: Implications for Genetic Counseling.

PMID: 32117230
Journal: Frontiers in Immunology
Year: 2020
Reference: Front Immunol. 2020 Feb 12;11:46. doi: 10.3389/fimmu.2020.00046. eCollection 2020.
Impact factor: 5.085
Publication type: Paper in international publication
Authors: Riviere, Jacques G, Franco-Jarava, Clara, Martinez-Gallo, Monica, Aguilo-Cucurull, Aina, Blasco-Perez, Laura, Paramonov, Ida, Antolin, Maria, Martin-Nalda, Andrea, Soler-Palacin, Pere, Colobran, Roger et al.
DOI: 10.3389/fimmu.2020.00046

FHLdb: A Comprehensive Database on the Molecular Basis of Familial Hemophagocytic Lymphohistiocytosis.

PMID: 32076423
Journal: Frontiers in Immunology
Year: 2020
Reference: Front Immunol. 2020 Jan 31;11:107. doi: 10.3389/fimmu.2020.00107. eCollection 2020.
Impact factor: 5.085
Publication type: Paper in international publication
Authors: Vinas-Gimenez, Laura, Padilla, Natalia, Batlle-Maso, Laura, Casals, Ferran, Riviere, Jacques G, Martinez-Gallo, Monica, de la Cruz, Xavier, Colobran, Roger et al.
DOI: 10.3389/fimmu.2020.00107

Blog

News

On European Antibiotic Awareness Day, we highlight the importance of using these medications responsibly and finding innovative solutions to combat this issue.

This appointment is an international recognition of VHIR's immunodeficiency research.

So far, 240 volunteers have been recruited within all the centres set to join adolescents’ clinical trial (named HH3) to test the efficacy, tolerability, and safety of the BIMERVAX® COVID-19 vaccine in adolescents aged 12 to 17.