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Kidney Physiopathology

Our main scientific interest is to understand, from a multidisciplinary and translational approach, the molecular and cellular processes leading to renal dysfunction in several kidney pathologies. Specifically, our research lines are

  • to study the pathophysiology of inherited rare renal tubulopathies
  • to understand the mechanisms of kidney injury and regeneration
  • to study the development of clear cell renal cell carcinoma (ccRCC)
  • the study the impact of androgens on those processes.

We are experts on the following areas:

  • the generation of cellular disease models carrying specific gene alterations,
  • genetically modified animal models and gene therapies,
  • life-imaging high-resolution microscopy
  • working with patients’ samples for translational research.

To sum up, our research main objective is to combine –omic data from cellular and animal models with patients’ data to identify novel biomarkers and possible treatments for several renal diseases.

Team

Marina Muñoz López

Marina Muñoz López

Kidney Physiopathology
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Mercedes López González

Mercedes López González

Main researcher
Kidney Physiopathology
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Meritxell Ibernon Vilaró

Meritxell Ibernon Vilaró

Kidney Physiopathology
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Nicolas Jose Valdes  Figueroa

Nicolas Jose Valdes Figueroa

Predoctoral researcher
Kidney Physiopathology
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Raquel Arias Gonzalez

Raquel Arias Gonzalez

Kidney Physiopathology
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Sara Chocron de Benzaquen

Sara Chocron de Benzaquen

Research technician
Kidney Physiopathology
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Marina Muñoz López

Marina Muñoz López

Kidney Physiopathology
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Mercedes López González

Mercedes López González

Main researcher
Kidney Physiopathology
Read more
Meritxell Ibernon Vilaró

Meritxell Ibernon Vilaró

Kidney Physiopathology
Read more
Nicolas Jose Valdes  Figueroa

Nicolas Jose Valdes Figueroa

Predoctoral researcher
Kidney Physiopathology
Read more
Raquel Arias Gonzalez

Raquel Arias Gonzalez

Kidney Physiopathology
Read more
Sara Chocron de Benzaquen

Sara Chocron de Benzaquen

Research technician
Kidney Physiopathology
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Publications

Pretreatment gamma-glutamyl transferase predicts mortality in patients with chronic hepatitis B treated with nucleotide/nucleoside analogs.

PMID: 37885338
Journal: KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
Year: 2023
Reference: Kaohsiung J Med Sci. 2023 Oct 27. doi: 10.1002/kjm2.12771.
Impact factor:
Publication type: Paper in international publication
Authors: Abe, Hiroshi; Ahn, Sang Bong; Algaba, Ferran; An, Jihyun; Arai, Taeang; Atsukawa, Masanori; Buti, Maria; Cheung, Ka Shing; Cho, Yong Kyun; Chuang, Wan-Long et al.
DOI: 10.1002/kjm2.12771

Open vs. minimally invasive sublay incisional hernia repair. Is there a risk of overtreatment? EVEREG registry analysis.

PMID: 37951467
Journal: Cirugia espanola
Year: 2023
Reference: Cir Esp (Engl Ed). 2023 Nov 9:S2173-5077(23)00194-1. doi: 10.1016/j.cireng.2023.02.013.
Impact factor:
Publication type: Paper in international publication
Authors: Areny, A; Arevalo, J; Campoy, I; Cantero-Recasens, G; Duran, M; Hernandez Granados, Pilar; Lopez-Cano, Manuel; Martinez, C; Meseguer, A; Nemours, S et al.
DOI: 10.1016/j.cireng.2023.02.013

Page kidney after pediatric kidney transplantation: a case report.

PMID: 35485759
Journal: Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica
Year: 2022
Reference: Cir Pediatr. 2022 Apr 1;35(2):94-98. doi: 10.54847/cp.2022.02.19.
Impact factor: 0
Publication type: Letter or abstract
Authors: Gander, R, Asensio, M, Royo, G F, Lopez, M, Coma, A, Munoz, M, Cruz, A, Rios, H, Ariceta, G, Molino, J A et al.
DOI: 10.54847/cp.2022.02.19

Temporal and sex-dependent gene expression patterns in a renal ischemia-reperfusion injury and recovery pig model.

PMID: 35484379
Journal: Scientific Reports
Year: 2022
Reference: Sci Rep. 2022 Apr 28;12(1):6926. doi: 10.1038/s41598-022-10352-3.
Impact factor: 4.38
Publication type: Paper in international publication
Authors: Castro, Luis, Nemours, Stephane, Aranda, Miguel, Ferrer, Marina, Sanchez, Alex, Morote, Joan, Cantero-Recasens, Gerard, Meseguer, Anna, Semidey, Maria E, Ribatallada-Soriano, Didac et al.
DOI: 10.1038/s41598-022-10352-3

Clinical utility of genetic testing in early-onset kidney disease: seven genes are the main players.

PMID: 33532864
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2022
Reference: Nephrol Dial Transplant. 2022 Mar 25;37(4):687-696. doi: 10.1093/ndt/gfab019.
Impact factor: 5.992
Publication type: Paper in international publication
Authors: Domingo-Gallego, Andrea, Pybus, Marc, Bullich, Gemma, Furlano, Monica, Ejarque-Vila, Laia, Lorente-Grandoso, Laura, Ruiz, Patricia, Fraga, Gloria, Lopez Gonzalez, Mercedes, Pinero-Fernandez, Juan Alberto et al.
DOI: 10.1093/ndt/gfab019

CD44-negative parietal-epithelial cell staining in minimal change disease: association with clinical features, response to corticosteroids and kidney outcome.

PMID: 35211308
Journal: Clinical Kidney Journal
Year: 2022
Reference: Clin Kidney J. 2021 Nov 15;15(3):545-552. doi: 10.1093/ckj/sfab215. eCollection 2022 Mar.
Impact factor: 4.452
Publication type: Paper in international publication
Authors: Roca, Neus, Jatem, Elias, Abo, Anabel, Santacana, Maria, Cruz, Alejandro, Madrid, Alvaro, Fraga, Gloria, Martin, Marisa, Gonzalez, Jorge, Martinez, Cristina et al.
DOI: 10.1093/ckj/sfab215

Blog

News

The research will perform a functional analysis of phenotype-modifying genetic variants in patients affected by familial hypomagnesaemia with hypercalciuria and nephrocalcinosis (HFHNC).

The project, which has received funding from the Association for Genetic Kidney Disease Information and Research, aims to help develop new therapies for familial hypomagnesemia with hypercalciuria and nephrocalcinosis.

The association supports the Kidney Pathophysiology group at VHIR since 2015 to investigate familial hypomagnesemia with hypercalciuria and nephrocalcinosis.

Job offers

Senior Postdoctoral Position
Start date:
01/07/2020
End date:
15/07/2020
Document: Download
The Renal Physiopathology Research Group
Start date:
02/12/2019
End date:
08/12/2019
Document: Download
Support technician
Start date:
05/10/2018
End date:
11/10/2018
Document: Download