Kidney Physiopathology
Our main scientific interest is to understand, from a multidisciplinary and translational approach, the molecular and cellular processes leading to renal dysfunction in several kidney pathologies. Specifically, our research lines are
- to study the pathophysiology of inherited rare renal tubulopathies
- to understand the mechanisms of kidney injury and regeneration
- to study the development of clear cell renal cell carcinoma (ccRCC)
- the study the impact of androgens on those processes.
We are experts on the following areas:
- the generation of cellular disease models carrying specific gene alterations,
- genetically modified animal models and gene therapies,
- life-imaging high-resolution microscopy
- working with patients’ samples for translational research.
To sum up, our research main objective is to combine –omic data from cellular and animal models with patients’ data to identify novel biomarkers and possible treatments for several renal diseases.
Publications
Reversing chemorefraction in colorectal cancer cells by controlling mucin secretion.
PMID: 35131032
Journal: eLife
Year: 2022
Reference: Elife. 2022 Feb 8;11. pii: 73926. doi: 10.7554/eLife.73926.
Impact factor: 8.146
Publication type: Paper in international publication
Authors: Lobo-Jarne, Teresa; Garrido, Marta; Iglesias, Mar; Espinosa, Lluis; Malhotra, Vivek; Alonso-Maranon, Josune; Cantero-Recasens, Gerard et al.
DOI: 10.7554/eLife.73926
Parathyroid hormone and phosphate homeostasis in patients with Bartter and Gitelman syndrome: an international cross-sectional study.
PMID: 35137195
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2022
Reference: Nephrol Dial Transplant. 2022 Feb 7. pii: 6523371. doi: 10.1093/ndt/gfac029.
Impact factor: 5.992
Publication type: Paper in international publication
Authors: Decramer, Stephane; Devuyst, Olivier; van Dyck, Maria; Ferraro, Pietro Manuel; Fila, Marc; Francisco, Telma; Ghiggeri, Gian Marco; Gondra, Leire; Guarino, Stefano; Hooman, Nakysa et al.
DOI: 10.1093/ndt/gfac029
Longitudinal change in proteinuria and kidney outcomes in C3 glomerulopathy.
PMID: 33779754
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2022
Reference: Nephrol Dial Transplant. 2022 Jun 23;37(7):1270-1280. doi: 10.1093/ndt/gfab075.
Impact factor: 5.992
Publication type: Paper in international publication
Authors: Marco, Helena; Caravaca-Fontan, Fernando; Diaz-Encarnacion, Montserrat; Cabello, Virginia; Ariceta, Gema; Quintana, Luis F; Barros, Xoana; Rodriguez-Mendiola, Nuria; Mon, Carmen; Fraga, Gloria et al.
DOI: 10.1093/ndt/gfab075
Impact of coronavirus disease-2019 on pediatric nephrology practice and education: an ESPN survey.
PMID: 34971403
Journal: PEDIATRIC NEPHROLOGY
Year: 2022
Reference: Pediatr Nephrol. 2022 Aug;37(8):1867-1875. doi: 10.1007/s00467-021-05226-1. Epub 2021 Dec 31.
Impact factor: 3.714
Publication type: Paper in international publication
Authors: Jobs, K; Yazicioglu, Burcu; Bakkaloglu, Sevcan A; Abranches, M; Akman, S; Alpay, H; Ariceta, G; Atmis, B; Bael, A; Bakkaloglu, S A et al.
DOI: 10.1007/s00467-021-05226-1
Activation of the acute inflammatory phase response in idiopathic nephrotic syndrome: association with clinicopathological phenotypes and with response to corticosteroids.
PMID: 33841866
Journal: Clinical Kidney Journal
Year: 2021
Reference: Clin Kidney J. 2021 Mar 30;14(4):1207-1215. doi: 10.1093/ckj/sfaa247. eCollection 2021 Apr.
Impact factor: 4.452
Publication type: Paper in international publication
Authors: Jatem, Elias, Madrid, Alvaro, Lopez, Mercedes, Segarra, Alfons, Martinez, Cristina, Roca, Neus et al.
DOI: 10.1093/ckj/sfaa247
News
The work identifies variants in genes such as NFU1 that, combined with the disease-causing mutation, can accelerate kidney deterioration.
The communication is part of a study aimed at identifying the mechanisms of progression of Familial Hypomagnesemia with Hypercalciuria and Nephrocalcinosis, a rare disease that affects the kidneys.
"Patients with familial hypomagnesemia with hypercalciuria and nephrocalcinosis present miRNA profiles in urinary extracellular vesicles associated with disease progression" was the awarded work.