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Kidney Physiopathology

Our main scientific interest is to understand, from a multidisciplinary and translational approach, the molecular and cellular processes leading to renal dysfunction in several kidney pathologies. Specifically, our research lines are

  • to study the pathophysiology of inherited rare renal tubulopathies
  • to understand the mechanisms of kidney injury and regeneration
  • to study the development of clear cell renal cell carcinoma (ccRCC)
  • the study the impact of androgens on those processes.

We are experts on the following areas:

  • the generation of cellular disease models carrying specific gene alterations,
  • genetically modified animal models and gene therapies,
  • life-imaging high-resolution microscopy
  • working with patients’ samples for translational research.

To sum up, our research main objective is to combine –omic data from cellular and animal models with patients’ data to identify novel biomarkers and possible treatments for several renal diseases.

Team

Alvaro Domingo Madrid Aris

Alvaro Domingo Madrid Aris

Kidney Physiopathology
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Carla Burballa Tàrrega

Carla Burballa Tàrrega

Predoctoral researcher
Kidney Physiopathology
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Cristina  Cea  Arestín

Cristina Cea Arestín

Predoctoral researcher
Kidney Physiopathology
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Cristina Martínez Martínez

Cristina Martínez Martínez

Main researcher
Kidney Physiopathology
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Gema Ariceta Iraola

Gema Ariceta Iraola

Head of group
Kidney Physiopathology
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Gloria Mª Fraga Rodriguez

Gloria Mª Fraga Rodriguez

Senior researcher
Kidney Physiopathology
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Alvaro Domingo Madrid Aris

Alvaro Domingo Madrid Aris

Kidney Physiopathology
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Carla Burballa Tàrrega

Carla Burballa Tàrrega

Predoctoral researcher
Kidney Physiopathology
Read more
Cristina  Cea  Arestín

Cristina Cea Arestín

Predoctoral researcher
Kidney Physiopathology
Read more
Cristina Martínez Martínez

Cristina Martínez Martínez

Main researcher
Kidney Physiopathology
Read more
Gema Ariceta Iraola

Gema Ariceta Iraola

Head of group
Kidney Physiopathology
Read more
Gloria Mª Fraga Rodriguez

Gloria Mª Fraga Rodriguez

Senior researcher
Kidney Physiopathology
Read more

Projects

Optimización del test de deposición ex vivo de C5b9 para monitorizar la actividad y la respuesta al tratamiento en SHUa y otras glomerulopatías complejas

IP: Concepció Jacobs Cachá
Collaborators: Manuel Hernández González, Natalia Ramos Terrades, Joana Sellarés Roig, Carmen Llorens Cebriá, Mercedes López González, Janire Perurena Prieto
Funding agency: Sociedad Española de Nefrología (S.E.N.)
Funding: 24000
Reference: SENEFRO/PROJECTES/2023/JACOBS
Duration: 23/12/2023 - 22/12/2025

Fucosylation in Clear Cell Renal Cell Carcinoma. STATing novel biomarkers and therapeutic strategies

IP: Fucosylation in Clear Cell Renal Cell Carcinoma. STATing novel biomarkers and therapeutic strategies
Collaborators: Gerard Cantero Recasens, Miriam Izquierdo Sans
Funding agency: Asociación Española Contra el Cáncer
Funding: 150000
Reference: INVES234762CANT
Duration: 15/11/2023 - 14/11/2026

Unravelling CIC-5 role on glycosylation and its link with proximal tubule functioning

IP: Gerard Cantero Recasens
Collaborators: -
Funding agency: Mizutani Foundation for Glycoscience
Funding: 45000
Reference: MIZUTANI FOUNDATION FOR GLYCOSCIENCE - 2022
Duration: 01/04/2023 - 31/03/2025

Patologia Cel·lular

IP: Patologia Cel·lular
Collaborators: Gema Ariceta Iraola, Alejandro Cruz Gual, Gerard Cantero Recasens, David Lorente García, Marina Muñoz López, Mercedes López González, Hector Rios Duro, Mónica Durán Fernández, Luis Augusto Castro Sáder, Gloria Mª Fraga Rodriguez, Julieta Torchia
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 40000
Reference: 2021 SGR 01600
Duration: 01/01/2022 - 30/06/2025

Blog

News

Funding has been obtained for 43 projects under the calls for Health R&D&I Projects, Health Technology Development, and Independent Clinical Research

The aim of the project is to establish kidney organoids derived from patients with familial hypomagnesaemia with hypercalciuria and nephrocalcinosis, which will be essential tools for studying the disease and testing new treatments.

The work identifies variants in genes such as NFU1 that, combined with the disease-causing mutation, can accelerate kidney deterioration.