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Kidney Physiopathology

Our main scientific interest is to understand, from a multidisciplinary and translational approach, the molecular and cellular processes leading to renal dysfunction in several kidney pathologies. Specifically, our research lines are

  • to study the pathophysiology of inherited rare renal tubulopathies
  • to understand the mechanisms of kidney injury and regeneration
  • to study the development of clear cell renal cell carcinoma (ccRCC)
  • the study the impact of androgens on those processes.

We are experts on the following areas:

  • the generation of cellular disease models carrying specific gene alterations,
  • genetically modified animal models and gene therapies,
  • life-imaging high-resolution microscopy
  • working with patients’ samples for translational research.

To sum up, our research main objective is to combine –omic data from cellular and animal models with patients’ data to identify novel biomarkers and possible treatments for several renal diseases.

Team

Gonzalo Fernández Miranda

Gonzalo Fernández Miranda

Senior researcher
Kidney Physiopathology
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Hector Rios Duro

Hector Rios Duro

Research technician
Kidney Physiopathology
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José Ramon Jarrín Luengo

José Ramon Jarrín Luengo

Research technician
Kidney Physiopathology
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Laura Nuñez Rodrigo

Laura Nuñez Rodrigo

Kidney Physiopathology
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Luis Enrique Lara Moctezuma

Luis Enrique Lara Moctezuma

Kidney Physiopathology
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Marina Muñoz López

Marina Muñoz López

Kidney Physiopathology
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Gonzalo Fernández Miranda

Gonzalo Fernández Miranda

Senior researcher
Kidney Physiopathology
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Hector Rios Duro

Hector Rios Duro

Research technician
Kidney Physiopathology
Read more
José Ramon Jarrín Luengo

José Ramon Jarrín Luengo

Research technician
Kidney Physiopathology
Read more
Laura Nuñez Rodrigo

Laura Nuñez Rodrigo

Kidney Physiopathology
Read more
Luis Enrique Lara Moctezuma

Luis Enrique Lara Moctezuma

Kidney Physiopathology
Read more
Marina Muñoz López

Marina Muñoz López

Kidney Physiopathology
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Projects

Rercerca biomèdica en urologia

IP: Joan Morote Robles
Collaborators: Fernando Lozano Palacio, Inés de Torres Ramirez, Enric Trilla Herrera, Olga Méndez Fernández, Ana Celma Domènech, Mercè Cuadras Solé, Carlos Serrano Burgos, Albert Carrión Puig, Enric Miret Alomar, Maria Eugenia Semidey Raven, Carles Xavier Raventós Busquets, Rercerca biomèdica en urologia , Jacques Planas Morin, Richard Mast, Anna Santamaria Margalef
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 0.01
Reference: 2021 SGR 00858
Duration: 01/01/2022 - 30/06/2025

Biomarcadores, dianas y soluciones terapéuticas para mejorar el cuidado de pacientes afectados de Hipomagnesemia Familiar con Hipercalciuria y Nefrocalcinosis (HFHNC).

IP: Gema Ariceta Iraola
Collaborators: Hector Rios Duro, Mónica Durán Fernández, Gloria Mª Fraga Rodriguez, Julieta Torchia, Julieta Torchia
Funding agency: Instituto de Salud Carlos III
Funding: 202070
Reference: PI22/01946
Duration: 01/01/2023 - 31/12/2025

Papel del ClC-5 en la fibrosis renal. Identificación de posibles biomarcadores y dianas terapéuticas para la progresión de la enfermedad de Dent 1

IP: Gerard Cantero Recasens
Collaborators: Papel del ClC-5 en la fibrosis renal. Identificación de posibles biomarcadores y dianas terapéuticas para la progresión de la e, Hector Rios Duro, Mónica Durán Fernández, Gloria Mª Fraga Rodriguez, Julieta Torchia, Julieta Torchia, Andrea Casal Pardo
Funding agency: Instituto de Salud Carlos III
Funding: 123420
Reference: PI22/00741
Duration: 01/01/2023 - 31/12/2025

TRANS-GENE - Caracterización en Sangre Periférica de una Firma Génica de Rechazo Humoral Común en Trasplantes de Órganos Sólidos.

IP: Maria Antonia Emilia Meneghini
Collaborators: Lluis Castells Fusté, Joana Sellarés Roig, Jesús Quintero Bernabeu, Eva Maria Revilla Lopez, Marina Muñoz López, Meritxell Boada Perez, Laura Donadeu Casassas, Mercedes López González
Funding agency: Instituto de Salud Carlos III
Funding: 111320
Reference: PI22/00749
Duration: 01/01/2023 - 31/12/2025

Blog

News

Funding has been obtained for 43 projects under the calls for Health R&D&I Projects, Health Technology Development, and Independent Clinical Research

The aim of the project is to establish kidney organoids derived from patients with familial hypomagnesaemia with hypercalciuria and nephrocalcinosis, which will be essential tools for studying the disease and testing new treatments.

The work identifies variants in genes such as NFU1 that, combined with the disease-causing mutation, can accelerate kidney deterioration.