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Liver Diseases

The Liver Diseases group is a referent at the local, national and international level in research, and is one of the most active groups in clinical research at VHIR. The group's prominent involvement in clinical trials is a clear indication of our professionals' commitment to ensuring that patients have access to state-of-the-art therapies. Our participation and collaboration in international projects and consortiums are also a fundamental characteristic of the group. The main objective of the group is to become one of the best translational research groups in liver diseases. It is essential to be able to apply all the findings of basic research to clinical research to improve the health of patients with liver disease.

Team

Clara Sabiote Cartes

Clara Sabiote Cartes

Research technician
Liver Diseases
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Josep Gregori Font

Josep Gregori Font

Postdoctoral researcher
Liver Diseases
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Adriana Palom Agusti

Adriana Palom Agusti

Postdoctoral researcher
Liver Diseases
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Agnès Soriano Varela

Agnès Soriano Varela

Predoctoral researcher
Liver Diseases
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Cespedes Guachamboza, Carlos Milton

Cespedes Guachamboza, Carlos Milton

Predoctoral researcher
Liver Diseases
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Claudia Ana Burillo Vargas

Claudia Ana Burillo Vargas

Liver Diseases
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Clara Sabiote Cartes

Clara Sabiote Cartes

Research technician
Liver Diseases
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Josep Gregori Font

Josep Gregori Font

Postdoctoral researcher
Liver Diseases
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Adriana Palom Agusti

Adriana Palom Agusti

Postdoctoral researcher
Liver Diseases
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Agnès Soriano Varela

Agnès Soriano Varela

Predoctoral researcher
Liver Diseases
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Cespedes Guachamboza, Carlos Milton

Cespedes Guachamboza, Carlos Milton

Predoctoral researcher
Liver Diseases
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Claudia Ana Burillo Vargas

Claudia Ana Burillo Vargas

Liver Diseases
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Research lines

Malaltia hepàtica crònica avançada

Tractaments combinats per prevenir les lesions o fibrosis hepàtica en malaltia hepàtica crònica/NASH

Tractaments dirigits a cèl·lules sinusoïdals hepàtiques a través de nanopartícules biodegradables

Desenvolupament de models animals experimentals translacionals a la patologia en humans de NASH i malaltia hepàtica per alcohol

Mètodes no invasius per malaltia hepàtica crònica avançada

Hipertensió portal


Serveis o tecnologies rellevants:


Models animals de malaltia hepàtica crònica: PVL; BDL; CCL4; TAA; NAFLD; NASH; MAFLD

Determinació de paràmetres hemodinàmics en models animals: PP; MAP; SMABF; SMAR, PF; IHVR

Aïllament de cèl·lules primàries de fetge: hepatòcits; LSEC; KC; HSC

Tincions histològiques

Cultius cel·lulars

Citometria de flux

Anàlisis de proteïnes: Wb, IIHC, IF, Proteòmica diferencial

Anàlisis d'expressió gènica: RT-qPCR, ISH, Microarrays

Microscòpia confocal i Microscòpia electrònica

Administració de fàrmacs en nanopartícules: Internalizació; direccionament; biodistribució; efectivitat; assaigs MTT y MTD

IP: Maria Nieves Martell Pérez-Alcalde, Joan Genescà Ferrer

Malaltia hepàtica relacionada amb l'alcohol

Malaltia avançada: hepatitis alcohòlica, cirrosis i malaltia hepàtica crònica per alcohol (cALD)

Salut pública

Insuficiència hepàtica aguda sobre crònica (ACLF)

IP: Meritxell Ventura Cots

Malalties hepàtiques cròniques

Malalties colestàsiques

Complicacions de la cirrosi hepàtica

Insuficiència hepàtica aguda sobre crònica (ACLF)

IP: Malalties hepàtiques cròniques

Metabolisme hepàtic i infeccions (LivMI)

Epidemiologia del fetge gras no alcohòlic, biomarcadors i nous tractament

Infeccions malaltia hepàtica avançada

IP: Juan Manuel Pericàs Pulido

Projects

Búsqueda de biomarcadores (inmunológicos y/o celulares) predictivos de respuesta virológica o de control de la infección en la hepatitis crónica D.

IP: Maria Buti Ferret
Collaborators: Maria Francesca Cortese
Funding agency: Instituto de Salud Carlos III
Funding: 220000
Reference: PI23/01065
Duration: 01/01/2024 - 31/12/2026

Proyecto de formación integral en enfermedad hepática crónica avanzada

IP: Juan Manuel Pericàs Pulido
Collaborators: Miriam Izquierdo Sans
Funding agency: Instituto de Salud Carlos III
Funding: 65000
Reference: CM23/00251
Duration: 02/01/2024 - 01/01/2026

Premio Investigación Biomédica (Clínica)

IP: Maria Buti Ferret
Collaborators: -
Funding agency: Fundación Lilly de Investigación Biomédica
Funding: 40000
Reference: F.LILLY/PREMIOS/2023/BUTI
Duration: 30/03/2023 - 29/03/2024

Beca VHIR PhD

IP: Josep Quer Sivila
Collaborators: Sira Rodrigo Bosch, Laia Perez Lasarte, Carolina Campos Martinez
Funding agency: Fundació Institut de Recerca HUVH
Funding: 69188.74
Reference: VPHD/CAROLINA_C
Duration: 01/04/2023 - 31/03/2026

Publications

The pressing need for a global HEV vaccine.

PMID: 37003442
Journal: JOURNAL OF HEPATOLOGY
Year: 2023
Reference: J Hepatol. 2023 Sep;79(3):876-880. doi: 10.1016/j.jhep.2023.03.024. Epub 2023 Mar 30.
Impact factor:
Publication type: Letter or abstract
Authors: Buti, Maria; Izopet, Jacques; Larrue, Helene; Peron, Jean-Marie et al.
DOI: 10.1016/j.jhep.2023.03.024

Hepatitis D double reflex testing of all hepatitis B carriers in low-HBV- and high-HBV/HDV-prevalence countries.

PMID: 37030400
Journal: JOURNAL OF HEPATOLOGY
Year: 2023
Reference: J Hepatol. 2023 Aug;79(2):576-580. doi: 10.1016/j.jhep.2023.02.041. Epub 2023 Apr 6.
Impact factor:
Publication type: Paper in international publication
Authors: Aghemo, Alessio; Akarca, Ulus S; Al-Hamoudi, Waleed K; Alalwan, Abduljaleel M; Aleman, Soo; Alghamdi, Abdullah S; Alghamdi, Saad; Aljumah, Abdulrahman A; Altraif, Ibrahim H; Asselah, Tarik et al.
DOI: 10.1016/j.jhep.2023.02.041

[Metabolic morbidity in the prison population of Catalonia, Spain].

PMID: 37043974
Journal: Atencion Primaria
Year: 2023
Reference: Aten Primaria. 2023 Jun;55(6):102620. doi: 10.1016/j.aprim.2023.102620. Epub 2023 Apr 10.
Impact factor:
Publication type: Paper in national publication
Authors: Augustin, Salvador; Marco Mourino, Andres; Pericas, Juan M; Rivera-Esteban, Jesus; Turu Santigosa, Elisabet et al.
DOI: 10.1016/j.aprim.2023.102620

A blood microRNA classifier for the prediction of ICU mortality in COVID-19 patients: a multicenter validation study.

PMID: 37328754
Journal: RESPIRATORY RESEARCH
Year: 2023
Reference: Respir Res. 2023 Jun 17;24(1):159. doi: 10.1186/s12931-023-02462-x.
Impact factor:
Publication type: Paper in international publication
Authors: Anon, Jose M; Barbe, Ferran; Barbera, Carmen; Belmonte, Thalia; Benitez, Ivan D; Bermejo-Martin, Jesus F; Bustamante-Munguira, Elena; Caballero, Jesus; Carbonell, Nieves; Ceccato, Adrian et al.
DOI: 10.1186/s12931-023-02462-x

A year living with SARS-CoV-2: an epidemiological overview of viral lineage circulation by whole-genome sequencing in Barcelona city (Catalonia, Spain).

PMID: 34842496
Journal: Emerging Microbes & Infections
Year: 2022
Reference: Emerg Microbes Infect. 2022 Dec;11(1):172-181. doi: 10.1080/22221751.2021.2011617.
Impact factor: 7.163
Publication type: Paper in international publication
Authors: Andres, Cristina; Pinana, Maria; Borras-Bermejo, Blanca; Gonzalez-Sanchez, Alejandra; Garcia-Cehic, Damir; Esperalba, Juliana; Rando, Ariadna; Zules-Ona, Ricardo-Gabriel; Campos, Carolina; Codina, Maria Gema et al.
DOI: 10.1080/22221751.2021.2011617

Noninvasive Prediction of Outcomes in Autoimmune Hepatitis-Related Cirrhosis.

PMID: 34989164
Journal: Hepatology Communications
Year: 2022
Reference: Hepatol Commun. 2022 Jun;6(6):1392-1402. doi: 10.1002/hep4.1889. Epub 2022 Jan 6.
Impact factor: 5.073
Publication type: Paper in international publication
Authors: Gratacos-Gines, Jordi; Tellez, Luis; Gomez-Outomuro, Ana; Navascues, Carmen A; Riveiro-Barciela, Mar; Vinuesa, Raquel; Gomez-Camarero, Judith; Garcia-Retortillo, Montserrat; Diaz-Fontenla, Fernando; Salcedo, Magdalena et al.
DOI: 10.1002/hep4.1889

Reconciling short-term clinical and Immunological outcomes of SARS-CoV-2 vaccination in Solid Organ Transplant recipients.

PMID: 34554648
Journal: AMERICAN JOURNAL OF TRANSPLANTATION
Year: 2022
Reference: Am J Transplant. 2022 Feb;22(2):673-675. doi: 10.1111/ajt.16855. Epub 2021 Oct 5.
Impact factor: 8.086
Publication type: Letter or abstract
Authors: Toapanta, Nestor; Esperalba, Juliana; Campos-Varela, Isabel; Pont, Teresa; Len, Oscar; Campins, Magda; Moreso, Francesc; Crespo, Elena; Munoz, Marina; Lopez, Manuel et al.
DOI: 10.1111/ajt.16855

The MELD Score Is Superior to the Maddrey Discriminant Function Score to Predict Short-Term Mortality in Alcohol-Associated Hepatitis: A Global Study.

PMID: 34962498
Journal: AMERICAN JOURNAL OF GASTROENTEROLOGY
Year: 2022
Reference: Am J Gastroenterol. 2022 Feb 1;117(2):301-310. doi: 10.14309/ajg.0000000000001596.
Impact factor: 10.864
Publication type: Paper in international publication
Authors: Morales-Arraez, D; Ventura-Cots, M; Altamirano, J; Abraldes, J G; Cruz-Lemini, M; Thursz, M R; Atkinson, S R; Sarin, S K; Kim, W; Chavez-Araujo, R et al.
DOI: 10.14309/ajg.0000000000001596

Microorganisms as Shapers of Human Civilization, from Pandemics to Even Our Genomes: Villains or Friends? A Historical Approach.

PMID: 34946123
Journal: Microorganisms
Year: 2021
Reference: Microorganisms. 2021 Dec 6;9(12). pii: microorganisms9122518. doi: 10.3390/microorganisms9122518.
Impact factor: 4.128
Publication type: Review in international publication
Authors: Tabernero, David, Rodriguez-Frias, Francisco, Quer, Josep, Rando-Segura, Ariadna, Pumarola, Tomas, Garcia-Garcia, Selene, Cortese, Maria Francesca et al.
DOI: 10.3390/microorganisms9122518

Cross-sectional evaluation of circulating hepatitis B virus RNA and DNA: Different quasispecies?

PMID: 34887634
Journal: WORLD JOURNAL OF GASTROENTEROLOGY
Year: 2021
Reference: World J Gastroenterol. 2021 Nov 7;27(41):7144-7158. doi: 10.3748/wjg.v27.i41.7144.
Impact factor: 5.742
Publication type: Paper in international publication
Authors: Garcia-Garcia, Selene, Cortese, Maria Francesca, Tabernero, David, Gregori, Josep, Vila, Marta, Pacin, Beatriz, Quer, Josep, Casillas, Rosario, Castillo-Ribelles, Laura, Ferrer-Costa, Roser et al.
DOI: 10.3748/wjg.v27.i41.7144

Detection of non-enveloped hepatitis E virus in plasma of infected blood donors.

PMID: 34865052
Journal: JOURNAL OF INFECTIOUS DISEASES
Year: 2021
Reference: J Infect Dis. 2021 Dec 4. pii: 6449510. doi: 10.1093/infdis/jiab589.
Impact factor: 5.226
Publication type: Paper in international publication
Authors: Rico, Angie, Piron, Maria, Bes, Marta, Sauleda, Silvia, Costafreda, Maria Isabel et al.
DOI: 10.1093/infdis/jiab589

Study of Quasispecies Complexity and Liver Damage Progression after Liver Transplantation in Hepatitis C Virus Infected Patients.

PMID: 34828337
Journal: Genes
Year: 2021
Reference: Genes (Basel). 2021 Oct 28;12(11). pii: genes12111731. doi: 10.3390/genes12111731.
Impact factor: 4.096
Publication type: Paper in international publication
Authors: Bilbao, Itxarone, Quer, Josep, Esteban, Juan Ignacio, Perales, Celia, Llorens-Revull, Meritxell, Gregori, Josep, Dopazo, Cristina, Rodriguez-Frias, Francisco, Garcia-Cehic, Damir, Soria, Maria Eugenia et al.
DOI: 10.3390/genes12111731

Toxicities from immunotherapy: From clinical trials to real-world clinical practice.

PMID: 32868034
Journal: MEDICINA CLINICA
Year: 2020
Reference: Med Clin (Barc). 2020 Dec 24;155(12):541-547. doi: 10.1016/j.medcli.2020.06.057. Epub 2020 Aug 28.
Impact factor: 1.635
Publication type: Review in national publication
Authors: Trallero-Araguas, Ernesto, Martinez-Valle, Fernando, Roca-Herrera, Maria, Zamora, Ester, Barreira-Diaz, Ana, Munoz-Couselo, Eva, Riveiro-Barciela, Mar et al.
DOI: 10.1016/j.medcli.2020.06.057

Deep-sequencing reveals broad subtype-specific HCV resistance mutations associated with treatment failure.

PMID: 31857134
Journal: ANTIVIRAL RESEARCH
Year: 2020
Reference: Antiviral Res. 2020 Feb;174:104694. doi: 10.1016/j.antiviral.2019.104694. Epub 2019 Dec 16.
Impact factor: 4.101
Publication type: Paper in international publication
Authors: Niubo, Jordi, Chen, Qian, Perales, Celia, Soria, Maria Eugenia, Garcia-Cehic, Damir, Gregori, Josep, Rodriguez-Frias, Francisco, Buti, Maria, Crespo, Javier, Calleja, Jose Luis et al.
DOI: 10.1016/j.antiviral.2019.104694

Steatosis as main determinant of portal hypertension through a restriction of hepatic sinusoidal area in a dietary rat nash model.

PMID: 32770818
Journal: LIVER INTERNATIONAL
Year: 2020
Reference: Liver Int. 2020 Nov;40(11):2732-2743. doi: 10.1111/liv.14632. Epub 2020 Oct 13.
Impact factor: 5.175
Publication type: Paper in international publication
Authors: Barbera, Aurora, Raurell, Imma, Garcia-Lezana, Teresa, Torres-Arauz, Manuel, Bravo, Miren, Hide, Diana, Gil, Mar, Salcedo, Maria Teresa, Genesca, Joan, Martell, Maria et al.
DOI: 10.1111/liv.14632

Naturally occurring SARS-CoV-2 gene deletions close to the spike S1/S2 cleavage site in the viral quasispecies of COVID19 patients.

PMID: 32752979
Journal: Emerging Microbes & Infections
Year: 2020
Reference: Emerg Microbes Infect. 2020 Dec;9(1):1900-1911. doi: 10.1080/22221751.2020.1806735.
Impact factor: 5.776
Publication type: Paper in international publication
Authors: Almirante, Benito, Esteban, Juan Ignacio, Pumarola, Tomas, Anton, Andres, Quer, Josep, Ferrer, Ricard, Campins, Magda, Martin, Maria Carmen, Quer, Susanna, Andres, Cristina et al.
DOI: 10.1080/22221751.2020.1806735

Effectiveness and Safety of Sofosbuvir/Velpatasvir/ Voxilaprevir in Patients with Chronic Hepatitis C Previously Treated with DAAs.

PMID: 31203153
Journal: JOURNAL OF HEPATOLOGY
Year: 2019
Reference: J Hepatol. 2019 Oct;71(4):666-672. doi: 10.1016/j.jhep.2019.06.002. Epub 2019 Jun 14.
Impact factor: 18.946
Publication type: Paper in international publication
Authors: Marino, Zoe, Torras, Xavier, Luis Calleja, Jose, Antonio Carrion, Jose, Fernandez, Inmaculada, Maria Morillas, Rosa, Miguel Rosales, Jose, Carmona, Isabel, Fernandez-Rodriguez, Conrado, Hernandez-Guerra, Manuel et al.
DOI: 10.1016/j.jhep.2019.06.002

Whole-genome characterization and resistance-associated substitutions in a new HCV genotype 1 subtype.

PMID: 31118701
Journal: Infection and Drug Resistance
Year: 2019
Reference: Infect Drug Resist. 2019 Apr 24;12:947-955. doi: 10.2147/IDR.S195441. eCollection 2019.
Impact factor: 3
Publication type: Paper in international publication
Authors: von Massow, Georg, Garcia-Cehic, Damir, Gregori, Josep, Rodriguez-Frias, Francisco, Macia, Maria Dolores, Escarda, Ana, Esteban, Juan Ignacio, Quer, Josep et al.
DOI: 10.2147/IDR.S195441

Characterization of hepatitis B virus X gene quasispecies complexity in mono-infection and hepatitis delta virus superinfection.

PMID: 30983817
Journal: WORLD JOURNAL OF GASTROENTEROLOGY
Year: 2019
Reference: World J Gastroenterol. 2019 Apr 7;25(13):1566-1579. doi: 10.3748/wjg.v25.i13.1566.
Impact factor: 3.411
Publication type: Paper in international publication
Authors: Godoy, Cristina, Tabernero, David, Sopena, Sara, Gregori, Josep, Cortese, Maria Francesca, Gonzalez, Carolina, Casillas, Rosario, Yll, Marcal, Rando, Ariadna, Lopez-Martinez, Rosa et al.
DOI: 10.3748/wjg.v25.i13.1566

Reliable resolution of ambiguous hepatitis C virus genotype 1 results with the Abbott HCV Genotype Plus RUO assay.

PMID: 30842623
Journal: Scientific Reports
Year: 2019
Reference: Sci Rep. 2019 Mar 6;9(1):3678. doi: 10.1038/s41598-019-40099-3.
Impact factor: 4.011
Publication type: Paper in international publication
Authors: Saludes, V, Antuori, A, Reinhardt, B, Viciana, I, Clavijo, E, Schreiber, L, Tenenbaum, M, Rodriguez-Frias, F, Quer, J, Matas, L et al.
DOI: 10.1038/s41598-019-40099-3

HDV evolution-will viral resistance be an issue in HDV infection?

PMID: 30415162
Journal: Current Opinion in Virology
Year: 2018
Reference: Curr Opin Virol. 2018 Oct;32:100-107. doi: 10.1016/j.coviro.2018.10.003. Epub 2018 Nov 8.
Impact factor: 5.644
Publication type: Review in national publication
Authors: Tabernero, David, Cortese, Maria Francesca, Buti, Maria, Rodriguez-Frias, Francisco et al.
DOI: 10.1016/j.coviro.2018.10.003

Thrombotic thrombocytopenic purpura relapse induced by acute hepatitis E transmitted by cryosupernatant plasma and successfully controlled with ribavirin.

PMID: 30284732
Journal: TRANSFUSION
Year: 2018
Reference: Transfusion. 2018 Nov;58(11):2501-2505. doi: 10.1111/trf.14831. Epub 2018 Oct 4.
Impact factor: 3.423
Publication type: Letter or abstract
Authors: Riveiro-Barciela, Mar, Bes, Marta, Quer, Josep, Valcarcel, David, Piriz, Sofia, Gregori, Josep, Llorens, Meritxell, Salcedo, Maria-Teresa, Piron, Maria, Esteban, Rafael et al.
DOI: 10.1111/trf.14831

What have we learned from observational studies and clinical trials of mild to moderate COPD?

PMID: 30223834
Journal: RESPIRATORY RESEARCH
Year: 2018
Reference: Respir Res. 2018 Sep 17;19(1):177. doi: 10.1186/s12931-018-0882-0.
Impact factor: 3.751
Publication type: Review in international publication
Authors: Barrecheguren, Miriam, Gonzalez, Cruz, Miravitlles, Marc et al.
DOI: 10.1186/s12931-018-0882-0

Pipeline for specific subtype amplification and drug resistance detection in hepatitis C virus.

PMID: 30176817
Journal: BMC INFECTIOUS DISEASES
Year: 2018
Reference: BMC Infect Dis. 2018 Sep 3;18(1):446. doi: 10.1186/s12879-018-3356-6.
Impact factor: 2.62
Publication type: Paper in international publication
Authors: Domingo, Esteban, Rodriguez-Frias, Francisco, Buti, Maria, Esteban, Rafael, Esteban, Juan Ignacio, Quer, Josep, Perales, Celia, Beach, Nathan M, de Avila, Ana I, Llorens, Meritxell et al.
DOI: 10.1186/s12879-018-3356-6

Evaluation of Sensitivity and Specificity Performance of Elecsys HTLV-I/II Assay in a Multicenter Study in Europe and Japan.

PMID: 28468860
Journal: JOURNAL OF CLINICAL MICROBIOLOGY
Year: 2017
Reference: J Clin Microbiol. 2017 Jul;55(7):2180-2187. doi: 10.1128/JCM.00169-17. Epub 2017 May 3.
Impact factor: 3.712
Publication type: Paper in international publication
Authors: Laperche, Syria, Sauleda, Silvia, Piron, Maria, Muhlbacher, Annelies, Schennach, Harald, Queiros, Lucinda, Uno, Naoki, Yanagihara, Katsunori, Imdahl, Roland, Hey, Ariann et al.
DOI: 10.1128/JCM.00169-17

Sepsis code implementation at Vall d'Hebron University Hospital: rapid diagnostics key to success

PMID: NOPMID003
Journal: ICU Management
Year: 2017
Reference: ICU Management & Practice 2017:4
Impact factor: 0
Publication type: Paper in international publication
Authors: Ferrer Ricard, Juan Carlos Ruiz-Rodriguez, Larrosa Nieves, Llaneras J, Molas Emma, Juanjo Gonzalez-Lopez et al.
DOI:

Red blood cell transfusion-transmitted acute hepatitis E in an immunocompetent subject in Europe: a case report.

PMID: 27785789
Journal: TRANSFUSION
Year: 2017
Reference: Transfusion. 2017 Feb;57(2):244-247. doi: 10.1111/trf.13876. Epub 2016 Oct 26.
Impact factor: 3.042
Publication type: Paper in international publication
Authors: Riveiro-Barciela, Mar, Sauleda, Silvia, Quer, Josep, Salvador, Fernando, Gregori, Josep, Piron, Maria, Rodriguez-Frias, Francisco, Buti, Maria et al.
DOI: 10.1111/trf.13876

Gene and miRNA expression profiles in PBMCs from patients with severe and mild emphysema and PiZZ alpha1-antitrypsin deficiency.

PMID: 29238183
Journal: International Journal of Chronic Obstructive Pulmonary Disease
Year: 2017
Reference: Int J Chron Obstruct Pulmon Dis. 2017 Nov 29;12:3381-3390. doi: 10.2147/COPD.S145445. eCollection 2017.
Impact factor: 3.157
Publication type: Paper in international publication
Authors: Esquinas, Cristina, Janciauskiene, Sabina, Gonzalo, Ricardo, Mas de Xaxars, Gemma, Olejnicka, Beata, Belmonte, Irene, Barrecheguren, Miriam, Rodriguez, Esther, Nunez, Alexa, Rodriguez-Frias, Francisco et al.
DOI: 10.2147/COPD.S145445

Evidence of an Exponential Decay Pattern of the Hepatitis Delta Virus Evolution Rate and Fluctuations in Quasispecies Complexity in Long-Term Studies of Chronic Delta Infection.

PMID: 27362848
Journal: PLoS One
Year: 2016
Reference: PLoS One. 2016 Jun 30;11(6):e0158557. doi: 10.1371/journal.pone.0158557. eCollection 2016.
Impact factor: 3.057
Publication type: Paper in international publication
Authors: Ruiz, Alicia, Homs, Maria, Rodriguez-Frias, Francisco, Gregori, Josep, Tabernero, David, Godoy, Cristina, Barakat, Salma, Quer, Josep, Riveiro-Barciela, Mar, Roggendorf, Michael et al.
DOI: 10.1371/journal.pone.0158557

Correction for Quer at al., High-Resolution Hepatitis C Virus Subtyping Using NS5B Deep Sequencing and Phylogeny, an Alternative to Current Methods.

PMID: 27343299
Journal: JOURNAL OF CLINICAL MICROBIOLOGY
Year: 2016
Reference: J Clin Microbiol. 2016 Jul;54(7):1933. doi: 10.1128/JCM.01007-16.
Impact factor: 3.631
Publication type: Paper in international publication
Authors: Sauleda, Silvia, Bes, Marta, Gomez, Jordi, Briones, Carlos, Perales, Celia, Sheldon, Julie, Castells, Lluis, Viladomiu, Lluis, Salmeron, Javier, Ruiz-Extremera, Angela et al.
DOI: 10.1128/JCM.01007-16

Rapid detection of Mmalton alpha1-antitrypsin deficiency allele by real-time PCR and melting curves in whole blood, serum and dried blood spot samples.

PMID: 26154193
Journal: CLINICAL CHEMISTRY AND LABORATORY MEDICINE
Year: 2016
Reference: Clin Chem Lab Med. 2016 Feb;54(2):241-8. doi: 10.1515/cclm-2015-0297.
Impact factor: 3.017
Publication type: Paper in international publication
Authors: Belmonte, Irene, Montoto, Luciana, Miravitlles, Marc, Barrecheguren, Miriam, Esquinas, Cristina, Rodriguez, Esther, Giralt, Marina, Rodriguez-Frias, Francisco et al.
DOI: 10.1515/cclm-2015-0297

Viral quasispecies complexity measures.

PMID: 27060566
Journal: VIROLOGY
Year: 2016
Reference: Virology. 2016 Jun;493:227-37. doi: 10.1016/j.virol.2016.03.017. Epub 2016 Apr 6.
Impact factor: 3.2
Publication type: Paper in international publication
Authors: Domingo, Esteban, Quer, Josep, Gregori, Josep, Perales, Celia, Rodriguez-Frias, Francisco, Esteban, Juan I et al.
DOI: 10.1016/j.virol.2016.03.017

Hepatitis B virus quasispecies evolution after liver transplantation in patients under long-term lamivudine prophylaxis with or without hepatitis B immune globulin.

PMID: 25641570
Journal: Transplant Infectious Disease
Year: 2015
Reference: Transpl Infect Dis. 2015 Apr;17(2):208-20. doi: 10.1111/tid.12360.
Impact factor: 2.064
Publication type: Paper in international publication
Authors: Buti, M, Tabernero, D, Mas, A, Homs, M, Prieto, M, Rodriguez-Frias, F, Casafont, F, Casillas, R, Gonzalez, A, Miras, M et al.
DOI: 10.1111/tid.12360

Therapy for hepatitis C genotype 3: moving forward.

PMID: 25967352
Journal: JOURNAL OF VIRAL HEPATITIS
Year: 2015
Reference: J Viral Hepat. 2015 Sep;22(9):683-90. doi: 10.1111/jvh.12419. Epub 2015 May 13.
Impact factor: 3.909
Publication type: Paper in international publication
Authors: Buti, M, Llaneras, J, Riveiro-Barciela, M, Esteban, R et al.
DOI: 10.1111/jvh.12419

Tenofovir discontinuation after long-term viral suppression in HBeAg negative chronic hepatitis B. Can HBsAg levels be useful?

PMID: 26071338
Journal: JOURNAL OF CLINICAL VIROLOGY
Year: 2015
Reference: J Clin Virol. 2015 Jul;68:61-8. doi: 10.1016/j.jcv.2015.05.002. Epub 2015 May 8.
Impact factor: 3.016
Publication type: Paper in international publication
Authors: Buti, Maria, Casillas, Rosario, Riveiro-Barciela, Mar, Homs, Maria, Tabernero, David, Salcedo, Maria Teresa, Rodriguez-Frias, Francisco, Esteban, Rafael et al.
DOI: 10.1016/j.jcv.2015.05.002

Indications for Active Case Searches and Intravenous Alpha-1 Antitrypsin Treatment for Patients With Alpha-1 Antitrypsin Deficiency Chronic Pulmonary Obstructive Disease: An Update.

PMID: 25027067
Journal: ARCHIVOS DE BRONCONEUMOLOGIA
Year: 2015
Reference: Arch Bronconeumol. 2015 Apr;51(4):185-92. doi: 10.1016/j.arbres.2014.05.008. Epub 2014 Jul 12.
Impact factor: 1.823
Publication type: Paper in national publication
Authors: Casas, Francisco, Blanco, Ignacio, Martinez, Maria Teresa, Bustamante, Ana, Miravitlles, Marc, Cadenas, Sergio, Hernandez, Jose M, Lazaro, Lourdes, Rodriguez, Esther, Rodriguez-Frias, Francisco et al.
DOI: 10.1016/j.arbres.2014.05.008

Clinical Application of Estimating Hepatitis B Virus Quasispecies Complexity by Massive Sequencing: Correlation between Natural Evolution and On-Treatment Evolution.

PMID: 25393280
Journal: PLOS ONE
Year: 2014
Reference: PLoS One. 2014 Nov 13;9(11):e112306. doi: 10.1371/journal.pone.0112306. eCollection 2014.
Impact factor: 3.534
Publication type: Paper in international publication
Authors: Homs, Maria, Caballero, Andrea, Gregori, Josep, Tabernero, David, Quer, Josep, Nieto, Leonardo, Esteban, Rafael, Buti, Maria, Rodriguez-Frias, Francisco et al.
DOI: 10.1371/journal.pone.0112306

Cirrhosis, liver transplantation and HIV infection are risk factors associated with hepatitis E virus infection.

PMID: 25068388
Journal: PLOS ONE
Year: 2014
Reference: PLoS One. 2014 Jul 28;9(7):e103028. doi: 10.1371/journal.pone.0103028. eCollection 2014.
Impact factor: 3.534
Publication type: Paper in international publication
Authors: Riveiro-Barciela, Mar, Buti, Maria, Homs, Maria, Campos-Varela, Isabel, Cantarell, Carmen, Crespo, Manuel, Castells, Lluis, Tabernero, David, Quer, Josep, Esteban, Rafael et al.
DOI: 10.1371/journal.pone.0103028

Identification of host and viral factors involved in a dissimilar resolution of a hepatitis C virus infection.

PMID: 24134179
Journal: LIVER INT
Year: 2014
Reference: Liver Int. 2014 Jul;34(6):896-906. doi: 10.1111/liv.12362. Epub 2013 Nov 20.
Impact factor: 4.447
Publication type: Paper in international publication
Authors: Domingo, Esteban, Cubero, Maria, Gregori, Josep, Esteban, Juan I, Garcia-Cehic, Damir, Bes, Marta, Perales, Celia, Casillas, Rosario, Sanchez, Alex, Ortega, Israel et al.
DOI: 10.1111/liv.12362

Study of hepatitis B virus quasispecies by ultra-deep pyrosequencing: Resolving the nitty-gritty.

PMID: 23907754
Journal: HEPATOLOGY
Year: 2014
Reference: Hepatology. 2014 Mar;59(3):1210-2. doi: 10.1002/hep.26647. Epub 2014 Jan 13.
Impact factor: 11.19
Publication type: Letter whit IF
Authors: Rodriguez-Frias, Francisco, Tabernero, David, Esteban, Rafael, Buti, Maria et al.
DOI: 10.1002/hep.26647

A comparative study of ultra-deep pyrosequencing and cloning to quantitatively analyze the viral quasispecies using hepatitis B virus infection as a model.

PMID: 23523552
Journal: ANTIVIRAL RESEARCH
Year: 2013
Reference: Antiviral Res. 2013 May;98(2):273-83. doi: 10.1016/j.antiviral.2013.03.007. Epub 2013 Mar 20.
Impact factor: 3.925
Publication type: Paper in international publication
Authors: Ramirez, Clara, Gregori, Josep, Tabernero, David, Camos, Silvia, Casillas, Rosario, Quer, Josep, Esteban, Rafael, Homs, Maria, Rodriguez-Frias, Francisco, Buti, Maria et al.
DOI: 10.1016/j.antiviral.2013.03.007

[Absence of xenotropic murine leukaemia virus-related virus sequences in healthy blood donors and chronic fatigue syndrome patients in Catalonia, Spain.]

PMID: 23332972
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2013
Reference: Enferm Infecc Microbiol Clin. 2013 Aug-Sep;31(7):491-2. doi: 10.1016/j.eimc.2012.11.016. Epub 2013 Jan 17.
Impact factor: 1.478
Publication type: Letter whit IF
Authors: Piron, Maria, Alegre, Jose, Ribera, Esteban, Sauleda, Silvia et al.
DOI: 10.1016/j.eimc.2012.11.016

T cell responses and viral variability in blood donation candidates with occult hepatitis B infection.

PMID: 22173156
Journal: JOURNAL OF HEPATOLOGY
Year: 2012
Reference: J Hepatol. 2012 Apr;56(4):765-74. Epub 2011 Dec 13.
Impact factor: 9.264
Publication type: Paper in international publication
Authors: Bes, Marta, Vargas, Victor, Piron, Maria, Casamitjana, Natalia, Esteban, Juan Ignacio, Vilanova, Nuria, Pinacho, Asuncion, Quer, Josep, Puig, Lluis, Guardia, Jaime et al.
DOI: 10.1016/j.jhep.2011.11.011

Ultra-deep pyrosequencing detects conserved genomic sites and quantifies linkage of drug-resistant amino Acid changes in the hepatitis B virus genome.

PMID: 22666402
Journal: PLoS One
Year: 2012
Reference: PLoS One. 2012;7(5):e37874. doi: 10.1371/journal.pone.0037874. Epub 2012 May 30.
Impact factor: 4.092
Publication type: Paper in international publication
Authors: Esteban, Juan I, Rodriguez-Frias, Francisco, Tabernero, David, Quer, Josep, Cubero, Maria, Camos, Silvia, Ferrer-Costa, Carles, Sanchez, Alex, Jardi, Rosendo, Schaper, Melanie et al.
DOI: 10.1371/journal.pone.0037874

[Hepatitis E: scale of the problem in Spain.]

PMID: 22608490
Journal: Gastroenterologia y Hepatologia
Year: 2012
Reference: Gastroenterol Hepatol. 2012 Dec;35(10):719-24. doi: 10.1016/j.gastrohep.2012.03.003. Epub 2012 May 17.
Impact factor: 0.727
Publication type: Paper in national publication
Authors: , , et al.
DOI: 10.1016/j.gastrohep.2012.03.003

[Quantification of hepatitis B virus HBsAg: clinical implications.]

PMID: 21719049
Journal: MEDICINA CLINICA
Year: 2012
Reference: Med Clin (Barc). 2012 Apr 28;138(11):483-8. Epub 2011 Jun 29.
Impact factor: 1.385
Publication type: Review in national publication
Authors: Buti Ferret, Maria, Rodríguez Frias, Francisco, Esteban Mur, Rafael et al.
DOI: 10.1016/j.medcli.2011.04.024

Safety of liver transplantation performed with Chagas seropositive donors to seronegative recipients.

PMID: 21618698
Journal: LIVER TRANSPLANTATION
Year: 2011
Reference: Liver Transpl. 2011 Nov;17(11):1304-8. doi: 10.1002/lt.22346.
Impact factor: 3.068
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1002/lt.22346

Diagnosis of Alpha-1 Antitrypsin Deficiency: Limitations of Rapid Diagnostic Laboratory Tests.

PMID: 21470755
Journal: ARCHIVOS DE BRONCONEUMOLOGIA
Year: 2011
Reference: Arch Bronconeumol. 2011 Aug;47(8):415-7. Epub 2011 Apr 5.
Impact factor:
Publication type: Letter or abstract
Authors: , , , , , et al.
DOI: 10.1016/j.arbres.2011.02.005

Does pre-liver transplant HBV DNA level affect HBV recurrence or survival in liver transplant recipients receiving HBIg and nucleos(t)ide analogues?

PMID: 21502680
Journal: Annals of Hepatology
Year: 2011
Reference: Ann Hepatol. 2011 Apr 1;10(2):180-7.
Impact factor: 1.867
Publication type: Paper in international publication
Authors: Esteban, Rafael, Guardia, Jaime, Campos-Varela, Isabel, Castells, Lluis, Buti, Maria, Vargas, Victor, Bilbao, Itxarone, Rodriguez-Frias, Francisco, Jardi, Rosendo, Charco, Ramon et al.
DOI:

HBV core region variability: effect of antiviral treatments on main epitopic regions.

PMID: 21311107
Journal: ANTIVIRAL THERAPY
Year: 2011
Reference: Antivir Ther. 2011;16(1):37-49.
Impact factor: 3.774
Publication type: Paper in international publication
Authors: Fernandez-Fernandez, Pilar, Quer, Josep, Esteban, Rafael, Rodriguez-Frias, Francisco, Tabernero, David, Schaper, Melanie, Jardi, Rosendo, Homs, Maria, Buti, Maria et al.
DOI: 10.3851/IMP1701

Main mutations in the hepatitis B virus basic core promoter (A1762T/G1764A) before HBeAg loss are markers that identify patients who will require long-term treatment.

PMID: 20374224
Journal: ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Year: 2010
Reference: Aliment Pharmacol Ther. 2010 Jul;32(1):97-104. Epub 2010 Mar 31.
Impact factor: 4.357
Publication type: Paper in international publication
Authors: , , , , , , , et al.
DOI: 10.1111/j.1365-2036.2010.04319.x

Quantitative longitudinal evaluations of hepatitis delta virus RNA and hepatitis B virus DNA shows a dynamic, complex replicative profile in chronic hepatitis B and D.

PMID: 20346531
Journal: JOURNAL OF HEPATOLOGY
Year: 2010
Reference: J Hepatol. 2010 May;52(5):658-64. Epub 2010 Mar 5.
Impact factor: 7.818
Publication type: Paper in international publication
Authors: , , , , , , , , et al.
DOI: 10.1016/j.jhep.2009.10.036

Response-guided therapy for chronic hepatitis C virus infection in patients coinfected with HIV: a pilot trial.

PMID: 19275492
Journal: CLINICAL INFECTIOUS DISEASES
Year: 2009
Reference: Clin Infect Dis. 2009 Apr 15;48(8):1152-9.
Impact factor: 8.266
Publication type: Paper in international publication
Authors: Van den Eynde, Eva, Crespo, Manuel, Esteban, Juan I, Jardi, Rosend, Ribera, Esteban, Carbonell, Judit, Rodriguez-Frias, Francisco, Falco, Vicenc, Curran, Adria, Imaz, Arkaitz et al.
DOI: 10.1086/597470

Thesis

Impacto de la enfermedad hepática grasa no alcohólica a nivel poblacional y en grupos de riesgo. Papel de la elastografía de transición en el diagnóstico, estadiaje y predicción de eventos clínicos.

PhD student: Jesus Manuel Rivera Esteban
Director/s: Salvador Augustin Recio
University:
Year: 2023

Blog

News

Using computed tomography (CT), with or without contrast, it is possible to perform an accurate and safe detection of the disease without the need for biopsies and avoiding the limitations of other non-invasive diagnostic tools.

On World Clinical Trials Day, we highlight some of the studies we have participated in that confirm the efficacy of new drugs, allowing their approval by regulatory agencies.

Preliminary study results confirm that the drug resmetirom reduces the presence of fat, inflammation, cell damage and fibrosis in the liver.

Estudi sobre els patrons de consum habitual de l'alcohol en població jove

Des de Vall d'Hebron estem buscant 200 persones voluntàries sanes d'entre 18 i 30 anys per a participar en un estudi sobre els patrons de consum habitual de l'alcohol en població jove, en el marc del projecte StopALD.

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