Musculoskeletal Tissue Engineering

Our research group is a multidisciplinary team with clinical researchers from Orthopedic Surgery and Traumatology Service dedicated to preclinical translational research and members with different backgrounds in the field of biomedicine, biochemistry, biotechnology and biology from the Laboratory for the Development of Cell Therapies from the Banc de Sang i Teixits. The mission of this group is to develop cell and tissue-based therapies in the field of regenerative medicine. They are focused in design, conduct and transform preclinical efforts into clinical trials mainly in bone regeneration that could be used in different indications. The team holds a high degree of knowledge and translational experience thanks to several years working in the field and have also established successful collaboration with partners from different fields.

Projects

Aquest any no hi ha projectes actius.

Publications

Predictive factors of hospital and nursing facility admission in the fixation of low-energy ankle fractures.

PMID: 39477014
Journal:
Year: 2024
Reference: Rev Esp Cir Ortop Traumatol. 2024 Oct 28:S1888-4415(24)00172-3. doi: 10.1016/j.recot.2024.10.011.
Impact factor:
Publication type: Paper in international publication
Authors: Altayo-Carulla, Marta; Andres-Peiro, Jose-Vicente; Blasco-Casado, Ferran; Castellanos-Alonso, Sara; Garcia-Sanchez, Yaiza; Joshi-Jubert, Nayana; Minguell-Monyart, Joan; Piedra-Calle, Carlos-Alberto; Pujol-Alarcon, Oriol; Reverte-Vinaixa, Maria-Mercedes et al.
DOI: 10.1016/j.recot.2024.10.011

A management model in blood, tissue and cell establishments to ensure rapid and sustainable patient access to advanced therapy medicinal products in Europe.

PMID: 37737767
Journal: CYTOTHERAPY
Year: 2023
Reference: Cytotherapy. 2023 Sep 5:S1465-3249(23)01015-0. doi: 10.1016/j.jcyt.2023.08.001.
Impact factor:
Publication type: Review in international publication
Authors: Akker, Emile van den; Baudoux, Etienne; De Vos, John; Delgadillo, Joaquin; Delgadillo, Joaquin; Gardiner, Nicola; Kerkela, Erja; Lechanteur, Chantal; Vives, Joaquim; Waters, Allison et al.
DOI: 10.1016/j.jcyt.2023.08.001

The safety and efficacy of stem cells for the treatment of severe community-acquired bacterial pneumonia: A randomized clinical trial.

PMID: 37918129
Journal: JOURNAL OF CRITICAL CARE
Year: 2023
Reference: J Crit Care. 2023 Oct 31;79:154446. doi: 10.1016/j.jcrc.2023.154446.
Impact factor:
Publication type: Paper in international publication
Authors: Andres-Peiro, Jose-Vicente; Blasco-Casado, Ferran; Caballero, Jesus; Cadogan, Kathy-Ann; de Albert de Delas-Vigo, Matias; de la Rosa, Olga; Ferrer, Ricard; Francois, Bruno; Garcia-Albo, Enrique; Garcia-Albo, Enrique et al.
DOI: 10.1016/j.jcrc.2023.154446

Human Wharton's jelly-derived mesenchymal stromal cells promote bone formation in immunodeficient mice when administered into a bone microenvironment.

PMID: 37950242
Journal: Journal of Translational Medicine
Year: 2023
Reference: J Transl Med. 2023 Nov 10;21(1):802. doi: 10.1186/s12967-023-04672-9.
Impact factor:
Publication type: Paper in international publication
Authors: Arance, Ana M; Batlle-Morera, Laura; Beltramone, Silvia; Billan, Salem; Bratland, Ase; Cabrera-Perez, Raquel; Ge, Joy; Gonzalez, Rene; Grange, Florent; Grob, Jean-Jacques et al.
DOI: 10.1186/s12967-023-04672-9

A systematic review of potential biomarkers for bacterial burden and treatment efficacy assessment in TB platform-based clinical trials.

PMID: 37956107
Journal: JOURNAL OF INFECTIOUS DISEASES
Year: 2023
Reference: J Infect Dis. 2023 Nov 13:jiad482. doi: 10.1093/infdis/jiad482.
Impact factor:
Publication type: Paper in international publication
Authors: Alagna, Riccardo; Batlle-Morera, Laura; Beltramone, Silvia; Cabrera-Perez, Raquel; Cirillo, Daniella; Espinosa-Pereiro, Juan; Gonzalez-Moreno, Jesus; Heinrich, Norbert; Rafols-Mitjans, Alexis; Roig-Molina, Angela et al.
DOI: 10.1093/infdis/jiad482

Complex distal femoral fractures in the fragile elderly patient treated by distal femoral replacement: A report of three cases.

PMID: 35404793
Journal: Revista espanola de cirugia ortopedica y traumatol
Year: 2022
Reference: Rev Esp Cir Ortop Traumatol. 2022 Mar-Apr;66(2):149-153. doi: 10.1016/j.recot.2021.07.005. Epub 2021 Nov 18.
Impact factor:
Publication type: Letter or abstract
Authors: Joshi, N; Prat, S; Pujol, O et al.
DOI: 10.1016/j.recot.2021.07.005

Comparison of Prophylactic Intravenous Antibiotic Regimens After Endoprosthetic Reconstruction for Lower Extremity Bone Tumors: A Randomized Clinical Trial.

PMID: 34989778
Journal: JAMA Oncology
Year: 2022
Reference: JAMA Oncol. 2022 Mar 1;8(3):345-353. doi: 10.1001/jamaoncol.2021.6628.
Impact factor:
Publication type: Paper in international publication
Authors: Abdelbary, Hesham; Aboulafia, Albert J; Abraham, John; Afzal, Uzma; Agarwal, Abhinav; Agel, Julie; Agomes, Ismael; Aikens, Wendy; Albery, Kari; Albuquerque, Stacey et al.
DOI: 10.1001/jamaoncol.2021.6628

A pilot study of circulating levels of TGF-beta1 and TGF-beta2 as biomarkers of bone healing in patients with non-hypertrophic pseudoarthrosis of long bones.

PMID: 34950754
Journal: Bone reports
Year: 2022
Reference: Bone Rep. 2021 Dec 9;16:101157. doi: 10.1016/j.bonr.2021.101157. eCollection 2022 Jun.
Impact factor:
Publication type: Paper in international publication
Authors: Chaverri, Daniel; Gallardo-Villares, Santiago; Granell-Escobar, Fernando; Pinto, Javier A; Vivas, Daniel; Vives, Joaquim et al.
DOI: 10.1016/j.bonr.2021.101157

A pragmatic randomized trial evaluating pre-operative aqueous antiseptic skin solutions in open fractures (Aqueous-PREP): statistical analysis plan.

PMID: 36096826
Journal: Trials
Year: 2022
Reference: Trials. 2022 Sep 12;23(1):772. doi: 10.1186/s13063-022-06541-0.
Impact factor:
Publication type: Paper in international publication
Authors: Abbott, Harper; Acerboni-Flores, Francesc; Achor, Timothy S; Adams, John D; Ahn, James S; Al-Asiri, Jamal; Alavedra-Massana, Anna; Alnasser, Ahmad; Altman, Kyle M; Amirhekmat, Arya et al.
DOI: 10.1186/s13063-022-06541-0

Reconstruction of infected post-traumatic bone defects of the distal femur with the Compress() implant. Preliminary results of a staged non-biological strategy.

PMID: 33066985
Journal: INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
Year: 2021
Reference: Injury. 2021 Mar;52(3):606-615. doi: 10.1016/j.injury.2020.10.016. Epub 2020 Oct 6.
Impact factor:
Publication type: Paper in international publication
Authors: Altayo, Marta; Amat, Carles; Corona, Pablo S; Velez, Roberto; Vicente, Matias et al.
DOI: 10.1016/j.injury.2020.10.016

Advances in translational orthopaedic research with species-specific multipotent mesenchymal stromal cells derived from the umbilical cord.

PMID: 32914860
Journal: HISTOLOGY AND HISTOPATHOLOGY
Year: 2021
Reference: Histol Histopathol. 2021 Jan;36(1):19-30. doi: 10.14670/HH-18-249. Epub 2020 Sep 11.
Impact factor:
Publication type: Review in international publication
Authors: Aguirre, Marius; Carreras-Sanchez, Irene; Feldman, Sara; Lopez-Fernandez, Alba; Ramallo, Melina; Velez, Roberto; Vives, Joaquim et al.
DOI: 10.14670/HH-18-249

Willingness of patients with sarcoma to participate in cancer surveillance research: a cross-sectional patient survey.

PMID: 33637543
Journal: BMJ Open
Year: 2021
Reference: BMJ Open. 2021 Feb 26;11(2):e042742. doi: 10.1136/bmjopen-2020-042742.
Impact factor:
Publication type: Paper in international publication
Authors: Doung, Yee-Cheen; Ghanem, Dana; Ghert, Michelle; Giglio, Victoria; Gundle, Kenneth; Hayden, James; Isler, Marc; Jones, Kevin; Miller, Benjamin; Mottard, Sophie et al.
DOI: 10.1136/bmjopen-2020-042742

Transitioning From Preclinical Evidence to Advanced Therapy Medicinal Product: A Spanish Experience.

PMID: 33614746
Journal: Frontiers in Cardiovascular Medicine
Year: 2021
Reference: Front Cardiovasc Med. 2021 Feb 4;8:604434. doi: 10.3389/fcvm.2021.604434. eCollection 2021.
Impact factor:
Publication type: Paper in international publication
Authors: Bayes-Genis, Antoni; Coll, Ruth; Galvez-Monton, Carolina; Gastelurrutia, Paloma; Prat-Vidal, Cristina; Vives, Joaquim et al.
DOI: 10.3389/fcvm.2021.604434

First-in-human PeriCord cardiac bioimplant: Scalability and GMP manufacturing of an allogeneic engineered tissue graft.

PMID: 32304998
Journal: EBioMedicine
Year: 2020
Reference: EBioMedicine. 2020 Apr;54:102729. doi: 10.1016/j.ebiom.2020.102729. Epub 2020 Apr 15.
Impact factor:
Publication type: Paper in international publication
Authors: Agusti, Elba; Aylagas, Miriam; Bayes-Genis, Antoni; Camara-Rosell, Maria Luisa; Cediel, German; Coca, Maria Isabel; Coll, Ruth; Farre, Ramon; Galvez-Monton, Carolina; Garcia-Lopez, Joan et al.
DOI: 10.1016/j.ebiom.2020.102729

Cord blood-derived platelet concentrates as starting material for new therapeutic blood components prepared in a public cord blood bank: from product development to clinical application.

PMID: 32281925
Journal: Blood Transfusion
Year: 2020
Reference: Blood Transfus. 2020 May;18(3):208-216. doi: 10.2450/2020.0305-19. Epub 2020 Apr 3.
Impact factor:
Publication type: Paper in international publication
Authors: Azqueta, Carmen; Codinach, Margarita; Coll, Ruth; Escudero, Jose R; Farssac, Elisenda; Gaitan, Jesus; Querol, Sergio; Rodriguez, Luciano; Samarkanova, Dinara; Samarkanova, Dinara et al.
DOI: 10.2450/2020.0305-19

Characterization of a Cytomegalovirus-Specific T Lymphocyte Product Obtained Through a Rapid and Scalable Production Process for Use in Adoptive Immunotherapy.

PMID: 32161589
Journal: Frontiers in Immunology
Year: 2020
Reference: Front Immunol. 2020 Feb 25;11:271. doi: 10.3389/fimmu.2020.00271. eCollection 2020.
Impact factor:
Publication type: Paper in international publication
Authors: Barba, Pere; Canto, Ester; Grau-Vorster, Marta; Lopez-Montanes, Maria; Oliver-Vila, Irene; Querol, Sergi; Rudilla, Francesc; Vives, Joaquim et al.
DOI: 10.3389/fimmu.2020.00271

The challenge of developing human 3D organoids into medicines.

PMID: 32127036
Journal: Stem Cell Research & Therapy
Year: 2020
Reference: Stem Cell Res Ther. 2020 Mar 4;11(1):72. doi: 10.1186/s13287-020-1586-1.
Impact factor:
Publication type: Letter or abstract
Authors: Batlle-Morera, Laura; Vives, Joaquim et al.
DOI: 10.1186/s13287-020-1586-1

Opportunistic testing of BRCA1, BRCA2 and mismatch repair genes improves the yield of phenotype driven hereditary cancer gene panels.

PMID: 30927264
Journal: INTERNATIONAL JOURNAL OF CANCER
Year: 2019
Reference: Int J Cancer. 2019 Nov 15;145(10):2682-2691. doi: 10.1002/ijc.32304. Epub 2019 Apr 15.
Impact factor:
Publication type: Paper in international publication
Authors: Balmana, Judith; Brunet, Joan; Capella, Gabriel; Del Valle, Jesus; Diez, Orland; Feliubadalo, Lidia; Gonzalez, Sara; Gutierrez-Enriquez, Sara; Lazaro, Conxi; Lopez-Fernandez, Adria et al.
DOI: 10.1002/ijc.32304

Vascularized Periosteal Flaps Accelerate Osteointegration and Revascularization of Allografts in Rats.

PMID: 30810538
Journal: CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
Year: 2019
Reference: Clin Orthop Relat Res. 2019 Apr;477(4):741-755. doi: 10.1097/CORR.0000000000000400.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirre, Marius; Barrera-Ochoa, Sergi; De Albert, Matias; Gallardo-Calero, Irene; Lopez-Fernandez, Alba; Manzanares, Maria Cristina; Sallent, Andrea; Soldado, Francisco; Velez, Roberto; Vicente, Matias et al.
DOI: 10.1097/CORR.0000000000000400

The alpha-1-antitrypsin promoter improves the efficacy of an AAV vector for the treatment of MNGIE.

PMID: 30900470
Journal: HUMAN GENE THERAPY
Year: 2019
Reference: Hum Gene Ther. 2019 Aug;30(8):985-998. doi: 10.1089/hum.2018.217. Epub 2019 Apr 24.
Impact factor:
Publication type: Paper in international publication
Authors: Cabrera-Perez, Raquel; Hirano, Michio; Marti, Ramon; Mingozzi, Federico; Torres-Torronteras, Javier; Vila-Julia, Ferran et al.
DOI: 10.1089/hum.2018.217

Increased dNTP pools rescue mtDNA depletion in human POLG-deficient fibroblasts.

PMID: 30848931
Journal: FASEB JOURNAL
Year: 2019
Reference: FASEB J. 2019 Jun;33(6):7168-7179. doi: 10.1096/fj.201801591R. Epub 2019 Mar 8.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirre, Josu; Blazquez-Bermejo, Cora; Cabrera-Perez, Raquel; Camara, Yolanda; Carreno-Gago, Lidia; de la Cruz, Xavier; Dominguez-Gonzalez, Cristina; Garcia-Arumi, Elena; Lombes, Anne; Marti, Ramon et al.
DOI: 10.1096/fj.201801591R

Microanatomical Nerve Architecture of 6 Mammalian Species: Is Trans-Species Translational Anatomic Extrapolation Valid?

PMID: 29601408
Journal: REGIONAL ANESTHESIA AND PAIN MEDICINE
Year: 2018
Reference: Reg Anesth Pain Med. 2018 Jul;43(5):496-501. doi: 10.1097/AAP.0000000000000772.
Impact factor:
Publication type: Paper in international publication
Authors: Boezaart, Andre P; Esteves Coelho, Marielle; Prats-Galino, Alberto; Reina, Miguel A; Sala-Blanch, Xavier; Server, Anna et al.
DOI: 10.1097/AAP.0000000000000772

Preclinical Efficacy and Safety Evaluation of Hematopoietic Stem Cell Gene Therapy in a Mouse Model of MNGIE.

PMID: 29687034
Journal: Molecular Therapy-Methods & Clinical Development
Year: 2018
Reference: Mol Ther Methods Clin Dev. 2018 Jan 8;8:152-165. doi: 10.1016/j.omtm.2018.01.001. eCollection 2018 Mar 16.
Impact factor:
Publication type: Paper in international publication
Authors: Bernsen, Monique R; Biasco, Luca; Bogaerts, Elly; Bugiani, Marianna; Cabrera-Perez, Raquel; de Coo, Irenaeus F M; Goffart, Steffi; Haeck, Joost C; Huston, Marshall W; Jacobs, Edwin H et al.
DOI: 10.1016/j.omtm.2018.01.001

On-Top-Plasty for Atypical Thumb Duplication: A Case Report With 10 Year Follow-up.

PMID: 29682986
Journal: Hand (New York, N.Y.)
Year: 2018
Reference: Hand (N Y). 2018 Jul;13(4):NP17-NP19. doi: 10.1177/1558944718770770. Epub 2018 Apr 22.
Impact factor:
Publication type: Paper in international publication
Authors: Barrera-Ochoa, Sergi; Bergua-Domingo, Josep M; Camprubi-Garcia, Eric; Knorr, Jorge; Pons-Riverola, Albert; Soldado, Francisco et al.
DOI: 10.1177/1558944718770770

Derivation of Multipotent Mesenchymal Stromal Cells from Ovine Bone Marrow.

PMID: 29512111
Journal: Current protocols in stem cell biology
Year: 2018
Reference: Curr Protoc Stem Cell Biol. 2018 Feb 28;44:2B.9.1-2B.9.22. doi: 10.1002/cpsc.43.
Impact factor:
Publication type: Paper in international publication
Authors: Caminal, Marta; Oliver-Vila, Irene; Vivas, Daniel; Vives, Joaquim et al.
DOI: 10.1002/cpsc.43

Primary trapeziometacarpal prosthesis for complicated fracture of the base of the thumb metacarpal.

PMID: 28701068
Journal: The Journal of hand surgery, European volume
Year: 2017
Reference: J Hand Surg Eur Vol. 2017 Nov;42(9):972-974. doi: 10.1177/1753193417719371. Epub 2017 Jul 13.
Impact factor:
Publication type: Letter or abstract
Authors: Barrera-Ochoa, S; Mendez-Sanchez, G; Mir-Bullo, X et al.
DOI: 10.1177/1753193417719371

Barriers and facilitators experienced in collaborative prospective research in orthopaedic oncology: A qualitative study.

PMID: 28515060
Journal: Bone & Joint Research
Year: 2017
Reference: Bone Joint Res. 2017 May;6(5):307-314. doi: 10.1302/2046-3758.65.BJR-2016-0192.R1.
Impact factor:
Publication type: Paper in international publication
Authors: Bernthal, N; Boffano, M; Damron, T; Evaniew, N; Ferguson, P; Galli Serra, M; Ghert, M; Hettwer, W; McKay, P; Miller, B et al.
DOI: 10.1302/2046-3758.65.BJR-2016-0192.R1

Platelet-Rich Plasma Injections for Advanced Knee Osteoarthritis: A Prospective, Randomized, Double-Blinded Clinical Trial.

PMID: 28255569
Journal: Orthopaedic journal of sports medicine
Year: 2017
Reference: Orthop J Sports Med. 2017 Feb 13;5(2):2325967116689386. doi: 10.1177/2325967116689386. eCollection 2017 Feb.
Impact factor:
Publication type: Paper in international publication
Authors: Joshi Jubert, Nayana; Navarro, Aurora; Reverte-Vinaixa, Maria Mercedes; Rodriguez, Luciano et al.
DOI: 10.1177/2325967116689386

New and safe experimental model of radiation-induced neurovascular histological changes for microsurgical research.

PMID: 27357187
Journal: LAB ANIMAL
Year: 2017
Reference: Lab Anim. 2017 Apr;51(2):124-137. doi: 10.1177/0023677216656221. Epub 2016 Jul 9.
Impact factor: 0.681
Publication type: Paper in international publication
Authors: Verges, Ramona, Giralt, Jordi, Aguirre-Canyadell, Marius, Velez, Roberto, Lopez-Fernandez, Alba, Sallent, Andrea, Gallardo-Calero, Irene, Barrera-Ochoa, Sergi et al.
DOI: 10.1177/0023677216656221

Long-term restoration of thymidine phosphorylase function and nucleoside homeostasis using hematopoietic gene therapy in a murine model of MNGIE.

PMID: 27004974
Journal: HUMAN GENE THERAPY
Year: 2016
Reference: Hum Gene Ther. 2016 Sep;27(9):656-67. doi: 10.1089/hum.2015.160. Epub 2016 May 4.
Impact factor:
Publication type: Paper in international publication
Authors: Andreu, Antoni L; Barba, Ignasi; Barquinero, Jordi; Cabrera-Perez, Raquel; Camara, Yolanda; Costa, Carme; de Luna, Noemi; Hirano, Michio; Marti, Ramon; Torres-Torronteras, Javier et al.
DOI: 10.1089/hum.2015.160

Final results of a phase I-II trial using ex vivo expanded autologous Mesenchymal Stromal Cells for the treatment of osteoarthritis of the knee confirming safety and suggesting cartilage regeneration.

PMID: 26783191
Journal: KNEE
Year: 2016
Reference: Knee. 2016 Aug;23(4):647-54. doi: 10.1016/j.knee.2015.08.013. Epub 2016 Jan 11.
Impact factor:
Publication type: Paper in international publication
Authors: Codinach, Margarita; Coll, Ruth; Garcia-Lopez, Joan; Huguet, Marina; Lopez, Ramon; Munar, Ana; Orozco, Lluis; Soler, Robert; Vives, Joaquim et al.
DOI: 10.1016/j.knee.2015.08.013

Increased infection risk after hip hemiarthroplasty in institutionalized patients with proximal femur fracture.

PMID: 26857632
Journal: INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
Year: 2016
Reference: Injury. 2016 Apr;47(4):872-6. doi: 10.1016/j.injury.2015.12.032. Epub 2016 Jan 7.
Impact factor: 1.91
Publication type: Paper in international publication
Authors: Gallardo-Calero, Irene, Larrainzar-Coghen, Thais, Rodriguez-Pardo, Dolors, Pigrau, Carles, Sanchez-Raya, Judith, Amat, Carles, Lung, Maily, Carrera, Luis, Corona, Pablo S et al.
DOI: 10.1016/j.injury.2015.12.032

Effect of Previous Irradiation on Vascular Thrombosis of Microsurgical Anastomosis: A Preclinical Study in Rats.

PMID: 27975009
Journal: Plastic and reconstructive surgery. Global open
Year: 2016
Reference: Plast Reconstr Surg Glob Open. 2016 Nov 23;4(11):e1073. eCollection 2016 Nov.
Impact factor: 0
Publication type: Paper in international publication
Authors: Verges, Ramona, Barrera-Ochoa, Sergi, Gallardo-Calero, Irene, Lopez-Fernandez, Alba, Romagosa, Cleofe, Velez, Roberto, Soldado, Francisco, Aguirre-Canyadell, Marius et al.
DOI: 10.1097/GOX.0000000000001073

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