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Nephrology and kidney transplantation

Our research group is accredited by the Agency for Management of University and Research Grants (AGAUR) in Catalonia, and focuses on two main areas of interest which are related to Solid Organ Transplantation and especially Kidney, and in clinical Nephrology. We tackle these areas from an innovative perspective, both basic-experimental and mechanistic, always with a translational goal. On the one hand, we investigate, develop, and use novel diagnostic and therapeutic technologies to decipher and target main molecular and immune mechanisms of transplant rejection as well as the immune susceptibility to opportunistic infections and malignancies. Also, a main task force of the group is devoted to better understand the main mechanisms involved in certain autoimmune glomerular diseases and idiopathic nephrotic syndrome as well as in diabetic kidney disease, having a specific interest in the role of the renin-angiotensin system. Our ultimate goal is to improve the management and care of patients suffering from kidney diseases as well as their quality of life, reducing associated morbidity and mortality.

Team

Nuria Bolaños Peruga

Nuria Bolaños Peruga

Research technician
Nephrology and kidney transplantation
Read more
Nuria Bolaños Peruga

Nuria Bolaños Peruga

Research technician
Nephrology and kidney transplantation
Read more

Projects

VALIDATE: Validation of a Trustworthy AI-based Clinical Decision Support System for Improving Patient Outcome in Acute Stroke Treatment

IP: Marta Aurora Rubiera Del Fueyo
Collaborators: Maria Victoria Sala Sanz de Madrid, Cristina Guirao Martinez, Claudia Meza Burgos, Federica Rizzo, Ester Sanchez Gavilan, David Rodriguez Luna, Renato Simonetti
Funding agency: EUROPEAN COMMISSION
Funding: 567950
Reference: VALIDATE_HE-HLTH-DISEASE21
Duration: 01/05/2022 - 30/04/2026

AGORA - Algoritmo de evolución del injerto en trasplante renal

IP: Oriol Bestard Matamoros
Collaborators: Emma Pardo De los Santos, Elena Isabel Crespo Gimeno, Maria Antonia Emilia Meneghini
Funding agency: Instituto de Salud Carlos III
Funding: 154033
Reference: AC21_2/00050
Duration: 01/01/2022 - 31/12/2024

Publications

Donor-Derived Cell-Free DNA: Attractive Biomarker Seeks a Context of Use.

PMID: 38106814
Journal: TRANSPLANT INTERNATIONAL
Year: 2023
Reference: Transpl Int. 2023 Dec 1;36:12406. doi: 10.3389/ti.2023.12406. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Bestard, Oriol; Naesens, Maarten; Pagliazzi, Angelica et al.
DOI: 10.3389/ti.2023.12406

Isatuximab Monotherapy for Desensitization in Highly Sensitized Patients Awaiting Kidney Transplant.

PMID: 38147137
Journal: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Year: 2023
Reference: J Am Soc Nephrol. 2023 Dec 26. doi: 10.1681/ASN.0000000000000287.
Impact factor:
Publication type: Paper in international publication
Authors: Abbadessa, Giovanni; Ali, Nicole; Bestard, Oriol; Brar, Amarpali; Cruzado, Josep M; Dudek, Markus; Gaber, A Osama; Lee, Helen; Lepine, Lucie; Montgomery, Robert A et al.
DOI: 10.1681/ASN.0000000000000287

Prospective observational study to validate a next-generation sequencing blood RNA signature to predict early kidney transplant rejection.

PMID: 38152017
Journal: AMERICAN JOURNAL OF TRANSPLANTATION
Year: 2023
Reference: Am J Transplant. 2023 Nov 29:S1600-6135(23)00723-2. doi: 10.1016/j.ajt.2023.09.021.
Impact factor:
Publication type: Paper in international publication
Authors: Alberici, Federico; Ansari, Mohammed Javeed; Augustine, Joshua; Benken, Scott; Bestard, Oriol; Bhati, Chandra; Chang, Anthony; Concepcion, Beatrice P; Donovan, Michael J; Gallon, Lorenzo et al.
DOI: 10.1016/j.ajt.2023.09.021

Breakthrough Infections Following mRNA SARS-CoV-2 Vaccination in Kidney Transplant Recipients.

PMID: 35384924
Journal: TRANSPLANTATION
Year: 2022
Reference: Transplantation. 2022 Jul 1;106(7):1430-1439. doi: 10.1097/TP.0000000000004119. Epub 2022 Apr 1.
Impact factor: 4.939
Publication type: Paper in international publication
Authors: Mazuecos, Auxiliadora, Villanego, Florentino, Zarraga, Sofia, Lopez, Veronica, Oppenheimer, Federico, Llinas-Mallol, Laura, Moina, Inigo, Alcalde, Guillermo, Sanchez-Alvarez, Emilio, Pascual, Julio et al.
DOI: 10.1097/TP.0000000000004119

High intrapatient variability of tacrolimus exposure associated with poorer outcomes in liver transplantation.

PMID: 35373449
Journal: CTS-Clinical and Translational Science
Year: 2022
Reference: Clin Transl Sci. 2022 Jun;15(6):1544-1555. doi: 10.1111/cts.13276. Epub 2022 Apr 19.
Impact factor: 4.689
Publication type: Paper in international publication
Authors: Charco, Ramon, Dopazo, Cristina, Bilbao, Itxarone, Garcia, Sonia, Gomez-Gavara, Concepcion, Caralt, Mireia, Campos-Varela, Isabel, Castells, Lluis, Hidalgo, Ernest, Moreso, Francisco et al.
DOI: 10.1111/cts.13276

COVID-19 in Patients with Glomerular Disease: Follow-Up Results from the IRoc-GN International Registry.

PMID: 35373130
Journal: Kidney360
Year: 2022
Reference: Kidney360. 2021 Dec 3;3(2):293-306. doi: 10.34067/KID.0006612021. eCollection 2022 Feb 24.
Impact factor: 0
Publication type: Paper in international publication
Authors: Avello, Alejandro, Lightstone, Liz, Turner-Stokes, Tabitha, Griffith, Megan, Torras, Joan, Martinez Valenzuela, Laura, Bestard, Oriol, Geddes, Colin, Flossmann, Oliver, Budge, Kelly L et al.
DOI: 10.34067/KID.0006612021

Clinical, Functional, and Mental Health Outcomes in Kidney Transplant Recipients 3 Mo After a Diagnosis of COVID-19.

PMID: 35320154
Journal: TRANSPLANTATION
Year: 2022
Reference: Transplantation. 2022 May 1;106(5):1012-1023. doi: 10.1097/TP.0000000000004075. Epub 2022 Apr 26.
Impact factor: 4.939
Publication type: Paper in international publication
Authors: Bemelman, Frederike J, du Buf-Vereijken, Peggy W G, van Ginneken, Betty, Maas, Nanda, Vogt, Liffert, van Jaarsveld, Brigit C, Klingenberg-Salahova, Farah, Verhofstede, Sabine, Vervloet, Marc G, Nurmohamed, Azam et al.
DOI: 10.1097/TP.0000000000004075

Long-term Effects of COVID-19 in Solid Organ Transplantation Recipients.

PMID: 34174006
Journal: Transplant Infectious Disease
Year: 2021
Reference: Transpl Infect Dis. 2021 Aug;23(4):e13677. doi: 10.1111/tid.13677. Epub 2021 Jul 12.
Impact factor: 2.228
Publication type: Letter or abstract
Authors: Garcia-Garcia, Sonia, Los-Arcos, Ibai, Moreso, Francesc, Berastegui, Cristina, Castells, Lluis, Gorgas Torner, Maria Q, Miarons, Marta, Larrosa-Garcia, Maria et al.
DOI: 10.1111/tid.13677

A multi-center study on safety and efficacy of immune checkpoint inhibitors in cancer patients with kidney transplant.

PMID: 33359528
Journal: KIDNEY INTERNATIONAL
Year: 2021
Reference: Kidney Int. 2021 Jul;100(1):196-205. doi: 10.1016/j.kint.2020.12.015. Epub 2020 Dec 24.
Impact factor: 10.612
Publication type: Paper in international publication
Authors: Blosser, Christopher, Zuniga, Sandra Carias, Soler, Maria Jose, Moreso, Francesc, Mithani, Zain, Ortiz-Melo, David, Jaimes, Edgar A, Gutgarts, Victoria, Lum, Erik, Danovitch, Gabriel M et al.
DOI: 10.1016/j.kint.2020.12.015

Renin-Angiotensin System Blockers and the Risk of COVID-19-Related Mortality in Patients with Kidney Failure.

PMID: 34088718
Journal: Clinical Journal of the American Society of Nephrology
Year: 2021
Reference: Clin J Am Soc Nephrol. 2021 Jul;16(7):1061-1072. doi: 10.2215/CJN.18961220. Epub 2021 Jun 4.
Impact factor: 8.237
Publication type: Paper in international publication
Authors: Soler, Maria Jose, Noordzij, Marlies, Abramowicz, Daniel, de Arriba, Gabriel, Basile, Carlo, van Buren, Marjolijn, Covic, Adrian, Crespo, Marta, Duivenvoorden, Raphael, Massy, Ziad et al.
DOI: 10.2215/CJN.18961220

COVID-19 in CKD Patients: Lessons from 553 CKD Patients with Biopsy-Proven Kidney Disease.

PMID: 34098555
Journal: KIDNEY & BLOOD PRESSURE RESEARCH
Year: 2021
Reference: Kidney Blood Press Res. 2021;46(4):452-459. doi: 10.1159/000515714. Epub 2021 Jun 7.
Impact factor: 2.687
Publication type: Paper in international publication
Authors: Agraz, Irene, Roman, Juan Leon, Garcia-Carro, Clara, Gabaldon, Alejandra, Torres, Irina, Bury, Roxana, Baldallo, Cinthia, Seron, Daniel, Soler, Maria Jose, Vergara, Ander et al.
DOI: 10.1159/000515714

The nephrology crystal ball: the medium-term future.

PMID: 31598700
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2020
Reference: Nephrol Dial Transplant. 2020 Feb 1;35(2):222-226. doi: 10.1093/ndt/gfz199.
Impact factor: 4.531
Publication type: Paper in international publication
Authors: Rychlik, Ivan, Soler, Maria J, Stevens, Kate, Spasovski, Goce, Wanner, Christoph, Massy, Ziad, Goumenos, Dimitrios, Fliser, Danilo, Zoccali, Carmine, Blankestijn, Peter J et al.
DOI: 10.1093/ndt/gfz199

Prevalence and Risk Factors for Major Infections In Patients with Anca-associated Vasculitis. Influence on The Disease Outcome.

PMID: 31203229
Journal: JOURNAL OF RHEUMATOLOGY
Year: 2020
Reference: J Rheumatol. 2020 Mar;47(3):407-414. doi: 10.3899/jrheum.190065. Epub 2019 Jun 15.
Impact factor: 3.35
Publication type: Paper in international publication
Authors: Garcia-Vives, Eloi, Segarra-Medrano, Alfons, Martinez-Valle, Ferran, Agraz, Irene, Solans-Laque, Roser et al.
DOI: 10.3899/jrheum.190065

Mild cognitive impairment and kidney disease: clinical aspects.

PMID: 31071220
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2020
Reference: Nephrol Dial Transplant. 2020 Jan 1;35(1):10-17. doi: 10.1093/ndt/gfz051.
Impact factor: 4.531
Publication type: Editorail in international publication
Authors: Wanner, Christoph, Wiecek, Andrzej, Zoccali, Carmine, Unwin, Robert, Capasso, Giovambattista, Trepiccione, Francesco, Stevens, Kathryn I, Soler, Maria Jose, Viggiano, Davide, Wagner, Carsten A et al.
DOI: 10.1093/ndt/gfz051

The Urinary Exosomal miRNA Expression Profile is Predictive of Clinical Response in Lupus Nephritis.

PMID: 32085620
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2020
Reference: Int J Mol Sci. 2020 Feb 18;21(4). pii: ijms21041372. doi: 10.3390/ijms21041372.
Impact factor: 4.556
Publication type: Paper in international publication
Authors: Garcia-Vives, Eloi, Sole, Cristina, Moline, Teresa, Vidal, Marta, Agraz, Irene, Ordi-Ros, Josep, Cortes-Hernandez, Josefina et al.
DOI: 10.3390/ijms21041372

Blog

News

An international study involving the Hospital del Mar Research Institute and VHIR shows that there are substantial differences between men and women in the energy metabolism of of renal tubular cells.

Dr. Conxita Jacobs' research has been awarded in the clinical project category, while Dr. Anna Meseguer's research has been recognised in the basic research category.

This initiative of the ”la Caixa” Foundation offers the selected entrepreneurial scientists financial support and support through individual mentoring and training.

Job offers

Predoctoral Student - Nephrology Research Group
Start date:
09/02/2022
End date:
23/02/2022
Document: Download
Predoctoral Nephrology Research Group
Start date:
18/01/2022
End date:
08/02/2022
Document: Download
LABORATORY TECHNICIAN - Translational Nephrology and Transplantation Research Grup.
Start date:
22/11/2021
End date:
06/12/2021
Document: Download