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Neurodegenerative Diseases

The research conducted in our group is geared toward elucidating the cause and molecular mechanisms of neurodegeneration in Parkinson's disease (PD), a disabling, currently incurable common neurodegenerative disorder. To this end, we perform clinical and pre-clinical translational research in both PD patients and in human-relevant experimental in vitro and in vivo PD-related models. 

Elucidating the molecular mechanisms underlying neurodegeneration in PD should allow to: 

  • Identify biomarkers for PD diagnosis, early detection, patient stratification, disease progression, prognosis or response to treatment. This is the objective of the VHIP Project that the team is carrying out.
  • Identify new molecular targets for potential therapeutic intervention and prevention.
  • Develop novel therapeutic strategies with disease-modifying potential.
  • Unravel molecular pathways common to other neurodegenerative diseases and, in a broader sense, brain aging.
     

Team

Silvia Enriquez Calzada

Silvia Enriquez Calzada

Predoctoral researcher
Neurodegenerative Diseases
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Gerard Roch Alba

Gerard Roch Alba

Predoctoral researcher
Neurodegenerative Diseases
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Javier Hoyo Pérez

Javier Hoyo Pérez

Administration and Management
Neurodegenerative Diseases
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Jorge Hernández Vara

Jorge Hernández Vara

Main researcher
Neurodegenerative Diseases
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Marta González Sepúlveda

Marta González Sepúlveda

Postdoctoral researcher
Neurodegenerative Diseases
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Pau Sarle Valles

Pau Sarle Valles

Predoctoral researcher
Neurodegenerative Diseases
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Silvia Enriquez Calzada

Silvia Enriquez Calzada

Predoctoral researcher
Neurodegenerative Diseases
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Gerard Roch Alba

Gerard Roch Alba

Predoctoral researcher
Neurodegenerative Diseases
Read more
Javier Hoyo Pérez

Javier Hoyo Pérez

Administration and Management
Neurodegenerative Diseases
Read more
Jorge Hernández Vara

Jorge Hernández Vara

Main researcher
Neurodegenerative Diseases
Read more
Marta González Sepúlveda

Marta González Sepúlveda

Postdoctoral researcher
Neurodegenerative Diseases
Read more
Pau Sarle Valles

Pau Sarle Valles

Predoctoral researcher
Neurodegenerative Diseases
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Projects

DECISION ON OPTIMAL COMBINATORIAL THERAPIES IN IMIDS USING SYSTEMS APPROACHES (DOCTIS)

IP: Sara Marsal Barril
Collaborators: Antonio Julia Cano, Javier Hoyo Pérez, DECISION ON OPTIMAL COMBINATORIAL THERAPIES IN IMIDS USING SYSTEMS APPROACHES (DOCTIS), DECISION ON OPTIMAL COMBINATORIAL THERAPIES IN IMIDS USING SYSTEMS APPROACHES (DOCTIS), Montse Sender Beleta, Nuria Palau Balaña, Edgar Nuñez Gallardo, Raul Tortosa Mendez, María Alba Erra Duran
Funding agency: EUROPEAN COMMISSION
Funding: 1079085
Reference: DOCTIS_H2020_SC1-BHC2019
Duration: 01/01/2020 - 31/12/2025

The Vall d’Hebron Iniciative for Parkinson associated to GBA (VHIP-GBA): from biospecimen collection to translational studies and therapies.

IP: Marta Martínez Vicente
Collaborators: José Antonio Arranz Amo, Jorge Hernández Vara, Eddie Pradas Gracia, Guillem Pintos Morell, Clara Carnicer Cáceres, Carles Lorenzo Bosquet, David Moreno Martinez, Daniela Samaniego Toro, Laura Castillo Ribelles, The Vall d’Hebron Iniciative for Parkinson associated to GBA (VHIP-GBA): from biospecimen collection to translational studies an
Funding agency: Instituto de Salud Carlos III
Funding: 245932.5
Reference: PI20/00728
Duration: 01/01/2021 - 30/06/2025

Sex-based modulation of neuromelanin-linked Parkinson’s disease pathology

IP: Miquel Vila Bover
Collaborators: -
Funding agency: Michael J. Fox Foundation
Funding: 163538.22
Reference: SEX_NEUROMELANINE_MJFF2020
Duration: 01/02/2021 - 31/12/2024

NIPARK Neuromelamina como diana terapéutica en la enfermedad de Parkinson y envejecimiento cerebral: abordaje por neuroimagen y estimulación cerebral

IP: Miquel Vila Bover
Collaborators: Marta González Sepúlveda
Funding agency: Instituto de Salud Carlos III
Funding: 249984.79
Reference: AC20/00121
Duration: 01/01/2021 - 31/12/2024

Blog

News

The event focused on advances in disease-modifying therapies and on the value of alliances between patients and professionals to promote more participatory care and research.

This VHIR initiative promotes well-being, empathy and community participation in Barcelona neighbourhoods through an intergenerational model

PAIR is an intergenerational initiative with people affected by Parkinson's disease and adolescents.

Coneix i participa al projecte VHIP

Vall d'Hebron Iniciativa per al Parkinson (VHIP) is a research project aimed at the development of biochemical markers for the early detection of Parkinson's disease. This study is carried out in people at high risk of having this disease, because they carry genetic mutations that predispose to the development of Parkinson's or because they present non-motor symptoms that manifest themselves years before motor symptoms.

Access the project and study