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Neuroradiology

The main characteristic of our group is its multidisciplinary nature, as it is comprised of neuroradiologists, technologists, and a physicist, engineer, and biochemist.

The main objectives of our projects are to gain knowledge about the pathophysiologic mechanisms implicated in several neurological diseases and to evaluate new biomarkers and therapies through the use of qualitative and quantitative magnetic resonance (MR) and computed tomography (CT) techniques, and by applying artificial intelligence tools to create prognostic models. Our focus is on the study of diseases such as multiple sclerosis, epilepsy, neuro-oncology, and stroke.

In addition, because of the experience we have acquired along the years in performing MR studies, we act as a platform for designing MR-based projects, processing images, and conducting quantitative data analysis.

Publications

Disentangling Neurodegeneration From Aging in Multiple Sclerosis Using Deep Learning: The Brain-Predicted Disease Duration Gap.

PMID: 39496109
Journal: NEUROLOGY
Year: 2024
Reference: Neurology. 2024 Nov 26;103(10):e209976. doi: 10.1212/WNL.0000000000209976. Epub 2024 Nov 4.
Impact factor:
Publication type: Paper in international publication
Authors: Abdel-Mannan, Omar; Al-Araji, Sarmad; Barkhof, Frederik; Bellenberg, Barbara; Bianchi, Alessia; Bisecco, Alvino; Brownlee, Wallace J; Brunetti, Arturo; Cagol, Alessandro; Calabrese, Massimiliano et al.
DOI: 10.1212/WNL.0000000000209976

Towards a Unified Set of Diagnostic Criteria for Multiple Sclerosis.

PMID: 39605172
Journal: ANNALS OF NEUROLOGY
Year: 2024
Reference: Ann Neurol. 2024 Nov 28. doi: 10.1002/ana.27145.
Impact factor:
Publication type: Paper in international publication
Authors: Azzimonti, Matteo; Barkhof, Frederik; Bodini, Benedetta; Bollo, Luca; Brownlee, Wallace J; Ciccarelli, Olga; Esposito, Federica; Filippi, Massimo; Killestein, Joep; Lazzarotto, Andrea et al.
DOI: 10.1002/ana.27145

ESR Essentials: gadolinium-wise MRI-practice recommendations by the European Society for Magnetic Resonance in Medicine and Biology.

PMID: 39702634
Journal: EUROPEAN RADIOLOGY
Year: 2024
Reference: Eur Radiol. 2024 Dec 19. doi: 10.1007/s00330-024-11214-4.
Impact factor:
Publication type: Paper in international publication
Authors: Mallio, Carlo A; Quattrocchi, Carlo C; Rovira, Alex; van der Molen, Aart J et al.
DOI: 10.1007/s00330-024-11214-4

Conservation of structural brain connectivity in people with multiple sclerosis.

PMID: 39735510
Journal: Network Neuroscience
Year: 2024
Reference: Netw Neurosci. 2024 Dec 10;8(4):1545-1562. doi: 10.1162/netn_a_00404. eCollection 2024.
Impact factor:
Publication type: Paper in international publication
Authors: Collorone, Sara; Deco, Gustavo; Filippi, Massimo; Foster, Michael A; Gonzalez-Escamilla, Gabriel; Groppa, Sergiu; Harbo, Hanne F; Hogestol, Einar A; Llufriu, Sara; Marti-Juan, Gerard et al.
DOI: 10.1162/netn_a_00404

MRI as a biomarker of the smouldering component of multiple sclerosis: time to wake up.

PMID: 37973633
Journal: EUROPEAN RADIOLOGY
Year: 2023
Reference: Eur Radiol. 2023 Nov 16. doi: 10.1007/s00330-023-10416-6.
Impact factor:
Publication type: Editorail in international publication
Authors: Arntzen, Ellen Christin; Coote, Susan; Jonsdottir, Johanna; Kalron, Alon; Kos, Daphne; Learmonth, Yvonne C; Moumdjian, Lousin; Nedeljkovic, Una; Novotna, Klara; Pareto, Deborah et al.
DOI: 10.1007/s00330-023-10416-6

Indirect Treatment Comparisons of Mosunetuzumab With Third- and Later-Line Treatments for Relapsed/Refractory Follicular Lymphoma.

PMID: 37981564
Journal: Clinical lymphoma, myeloma & leukemia
Year: 2023
Reference: Clin Lymphoma Myeloma Leuk. 2023 Sep 28:S2152-2650(23)02129-8. doi: 10.1016/j.clml.2023.09.007.
Impact factor:
Publication type: Paper in international publication
Authors: Bosch, Francesc; Kuruvilla, John; Maio, Danilo Di; Nastoupil, Loretta J; Pareto, Deborah; Rovira, Alex; Vassilakopoulos, Theodoros P; Wei, Michael C; Zumofen, Marie-Helene Blanchet et al.
DOI: 10.1016/j.clml.2023.09.007

Complex Chronic Portal Vein Recanalization Using an Electrified Guidewire as an Alternative to a Radiofrequency Guidewire.

PMID: 37989787
Journal: CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
Year: 2023
Reference: Cardiovasc Intervent Radiol. 2023 Nov 21. doi: 10.1007/s00270-023-03612-w.
Impact factor:
Publication type: Other (letters to the editor, abstracts, corrigendum, etc.)
Authors: Barnes-Navarro, Daniel; Bosch, Francesc; Camacho-Oviedo, John A; Diez-Miranda, Iratxe; Dyer-Hartnett, Shelagh C; Gonzalez-Junyent, Carla; Kuruvilla, John; Maio, Danilo Di; Nastoupil, Loretta J; Perez-Lafuente, Mercedes et al.
DOI: 10.1007/s00270-023-03612-w

Massive perivillous fibrin deposition: Diagnosis, obstetrical features, and treatment.

PMID: 37995528
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology
Year: 2023
Reference: Eur J Obstet Gynecol Reprod Biol. 2023 Nov 19;292:125-132. doi: 10.1016/j.ejogrb.2023.11.024.
Impact factor:
Publication type: Paper in international publication
Authors: Abisror, Noemie; Alijotas-Reig, Jaume; Barnes-Navarro, Daniel; Barnes-Navarro, Daniel; Camacho-Oviedo, John A; Camacho-Oviedo, John A; Cheloufi, Meryam; Coulomb, Aurore; Diez-Miranda, Iratxe; Diez-Miranda, Iratxe et al.
DOI: 10.1016/j.ejogrb.2023.11.024

SWI as an Alternative to Contrast-Enhanced Imaging to Detect Acute MS Lesions.

PMID: 35332015
Journal: AMERICAN JOURNAL OF NEURORADIOLOGY
Year: 2022
Reference: AJNR Am J Neuroradiol. 2022 Apr;43(4):534-539. doi: 10.3174/ajnr.A7474. Epub 2022 Mar 24.
Impact factor:
Publication type: Paper in international publication
Authors: Auger, C; Calderon, W; Caruana, G; de Barros, A; Montalban, X; Pessini, L M; Rovira, A; Salerno, A; Sastre-Garriga, J et al.
DOI: 10.3174/ajnr.A7474

Percutaneous angiographic arterial embolization of a vascular lesion in the colon of a patient on anticoagulant therapy.

PMID: 33248176
Journal: Gastroenterologia y Hepatologia
Year: 2022
Reference: Gastroenterol Hepatol. 2022 Apr;45(4):282-283. doi: 10.1016/j.gastrohep.2020.11.011. Epub 2020 Nov 25.
Impact factor:
Publication type: Paper in national publication
Authors: Alonso-Cotoner, Carmen; Gonzalez-Junyent, Carla; Serra-Ruiz, Xavier; Tasayco, Stephanie et al.
DOI: 10.1016/j.gastrohep.2020.11.011

Menopause does not modify disability trajectories in a longitudinal cohort of women with CIS and MS followed from disease onset.

PMID: 33609298
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2022
Reference: Eur J Neurol. 2022 Apr;29(4):1075-1081. doi: 10.1111/ene.14782. Epub 2021 Mar 17.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Auger, Cristina; Carbonell-Mirabent, Pere; Castillo, Joaquin; Comabella Lopez, Manuel; Galan, Ingrid; Midaglia, Luciana; Montalban, Xavier; Mulero, Patricia; Nos, Carlos et al.
DOI: 10.1111/ene.14782

MAGNIMS recommendations for harmonization of MRI data in MS multicenter studies.

PMID: 35245791
Journal: NeuroImage-Clinical
Year: 2022
Reference: Neuroimage Clin. 2022;34:102972. doi: 10.1016/j.nicl.2022.102972. Epub 2022 Feb 25.
Impact factor:
Publication type: Paper in international publication
Authors: Barkhof, Frederik; Battaglini, Marco; Cortese, Rosa; De Stefano, Nicola; Filippi, Massimo; Gandini Wheeler-Kingshott, Claudia A M; Oesingmann, Niels; Pareto, Deborah; Prados, Ferran; Rocca, Maria A et al.
DOI: 10.1016/j.nicl.2022.102972

Identification of patients with relapsing multiple sclerosis eligible for high-efficacy therapies.

PMID: 33966475
Journal: Neurodegenerative disease management
Year: 2021
Reference: Neurodegener Dis Manag. 2021 Jun;11(3):251-261. doi: 10.2217/nmt-2020-0049. Epub 2021 May 10.
Impact factor:
Publication type: Paper in international publication
Authors: Aguera, Eduardo; Brieva, Luis; Costa, Lucienne; Eichau, Sara; Garcia-Merino, Juan Antonio; Martinez-Yelamos, Sergio; Meca-Lallana, Jose; Rovira, Alex; Vidal-Jordana, Angela; Zarranz, Alfredo Rodriguez-Antiguedad et al.
DOI: 10.2217/nmt-2020-0049

The role of pontine lesion location in differentiating multiple sclerosis from vascular risk factor-related small vessel disease.

PMID: 32757905
Journal: Multiple Sclerosis Journal
Year: 2021
Reference: Mult Scler. 2021 May;27(6):968-972. doi: 10.1177/1352458520943777. Epub 2020 Aug 6.
Impact factor:
Publication type: Paper in international publication
Authors: Auger, Cristina; Barkhof, Frederik; Chard, Declan; Chung, Karen; DeLuca, Gabriele; Dos Passos, Giordani Rodrigues; Enzinger, Christian; Gasperini, Claudio; Geraldes, Ruth; Hagens, Marloes et al.
DOI: 10.1177/1352458520943777

MRI findings in cervical spondylotic myelopathy with gadolinium enhancement: Review of seven cases.

PMID: 33841903
Journal: BJR case reports
Year: 2021
Reference: BJR Case Rep. 2021 Jan 5;7(2):20200133. doi: 10.1259/bjrcr.20200133. eCollection 2021 Apr 1.
Impact factor:
Publication type: Letter or abstract
Authors: Auger, Cristina; de Barros, Andrea; Gonzalez Chinchon, Gonzalo; Herrera, Isabel; Kortazar Zubizarreta, Izaro; Pessini Ferreira, Lucas Maria; Pla, Albert; Rovira, Alex; Tortajada, Carlos et al.
DOI: 10.1259/bjrcr.20200133

Circulating AQP4 Levels in Patients with Cerebral Amyloid Angiopathy-Associated Intracerebral Hemorrhage.

PMID: 33801197
Journal: Journal of Clinical Medicine
Year: 2021
Reference: J Clin Med. 2021 Mar 2;10(5). pii: jcm10050989. doi: 10.3390/jcm10050989.
Impact factor:
Publication type: Paper in international publication
Authors: Arenillas, Juan F; Bonaterra-Pastra, Anna; Cardona Portela, Pere; Delgado, Pilar; Faura, Julia; Freijo, M Mar; Hernandez-Guillamon, Mar; Lebrato-Hernandez, Lucia; Marazuela, Paula; Martinez-Zabaleta, Maite et al.
DOI: 10.3390/jcm10050989

A validation study of manual atrophy measures in patients with Multiple Sclerosis.

PMID: 32246177
Journal: NEURORADIOLOGY
Year: 2020
Reference: Neuroradiology. 2020 Aug;62(8):955-964. doi: 10.1007/s00234-020-02401-3. Epub 2020 Apr 3.
Impact factor:
Publication type: Paper in international publication
Authors: Alberich, Manel; Alyafeai, Rumaiza; Auger, Cristina; Cappelle, Sarah; Montalban, Xavier; Pareto, Deborah; Rovira, Alex; Sastre-Garriga, Jaume; Tintore, Mar; Vidal-Jordana, Angela et al.
DOI: 10.1007/s00234-020-02401-3

Ammonium tetrathiomolybdate in the decoppering phase treatment of Wilson's disease with neurological symptoms: A case series.

PMID: 32202078
Journal: Brain and Behavior
Year: 2020
Reference: Brain Behav. 2020 May;10(5):e01596. doi: 10.1002/brb3.1596. Epub 2020 Mar 22.
Impact factor:
Publication type: Paper in international publication
Authors: Auger, Cristina; Cardona, Ignasi; De Fabregues, Oriol; Palasi, Antoni; Quintana, Manuel; Vargas, Victor; Vinas, Jaume et al.
DOI: 10.1002/brb3.1596

Testing the Food Experience in Healthy Human Volunteers: a Proof-of-Concept Study.

PMID: 32176761
Journal: Journal of Gastrointestinal and Liver Diseases
Year: 2020
Reference: J Gastrointestin Liver Dis. 2020 Mar 13;29(1):65-68. doi: 10.15403/jgld-806.
Impact factor:
Publication type: Paper in international publication
Authors: Accarino, Anna; Azpiroz, Fernando; Livovsky, Dan M; Lopez, Quiro; Lucas, Eduardo; Pareto, Deborah; Pribic, Teodora; Rovira, Alex et al.
DOI: 10.15403/jgld-806

Ratio of T1-Weighted to T2-Weighted Signal Intensity as a Measure of Tissue Integrity: Comparison with Magnetization Transfer Ratio in Patients with Multiple Sclerosis.

PMID: 32139431
Journal: AMERICAN JOURNAL OF NEURORADIOLOGY
Year: 2020
Reference: AJNR Am J Neuroradiol. 2020 Mar;41(3):461-463. doi: 10.3174/ajnr.A6481. Epub 2020 Mar 5.
Impact factor:
Publication type: Paper in international publication
Authors: Alberich, M; Auger, C; Garcia-Vidal, A; Montalban, X; Pareto, D; Rovira, A; Sastre-Garriga, J; Tintore, M et al.
DOI: 10.3174/ajnr.A6481

Spinal cord involvement in multiple sclerosis and neuromyelitis optica spectrum disorders.

PMID: 30663608
Journal: LANCET NEUROLOGY
Year: 2019
Reference: Lancet Neurol. 2019 Feb;18(2):185-197. doi: 10.1016/S1474-4422(18)30460-5.
Impact factor:
Publication type: Review in international publication
Authors: Amato, Maria Pia; Banwell, Brenda; Barkhof, Frederik; Bebo, Bruce; Becher, Burkhard; Bethoux, Francois; Brandt, Alexander; Brownlee, Wallace; Calabresi, Peter; Chatway, Jeremy et al.
DOI: 10.1016/S1474-4422(18)30460-5

Association between pathological and MRI findings in multiple sclerosis.

PMID: 30663609
Journal: LANCET NEUROLOGY
Year: 2019
Reference: Lancet Neurol. 2019 Feb;18(2):198-210. doi: 10.1016/S1474-4422(18)30451-4.
Impact factor:
Publication type: Review in international publication
Authors: Bruck, Wolfgang; Chard, Declan; Enzinger, Christian; Fazekas, Franz; Filippi, Massimo; Geurts, Jeroen J G; Hametner, Simon; Kuhlmann, Tanja; Preziosa, Paolo; Rocca, Maria A et al.
DOI: 10.1016/S1474-4422(18)30451-4

Lesion filling effect in regional brain volume estimations: a study in multiple sclerosis patients with low lesion load.

PMID: 26847633
Journal: NEURORADIOLOGY
Year: 2016
Reference: Neuroradiology. 2016 May;58(5):467-74. doi: 10.1007/s00234-016-1654-5. Epub 2016 Feb 4.
Impact factor:
Publication type: Paper in international publication
Authors: Auger, C; Aymerich, F X; Montalban, X; Pareto, D; Rovira, A; Sastre-Garriga, J; Tintore, M et al.
DOI: 10.1007/s00234-016-1654-5

Delineation of microhemorrhage in acute hepatic encephalopathy using susceptibility-weighted imaging.

PMID: 26860677
Journal: EUROPEAN JOURNAL OF RADIOLOGY
Year: 2016
Reference: Eur J Radiol. 2016 Mar;85(3):629-34. doi: 10.1016/j.ejrad.2015.12.025. Epub 2015 Dec 31.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Juli; Benson, John C; McKinney, Alexander M; Ott, Frederick; Payabvash, Seyedmehdi; Rykken, Jeffrey; Thalken, Gregory L et al.
DOI: 10.1016/j.ejrad.2015.12.025

Treating relapsing-remitting multiple sclerosis: therapy effects on brain atrophy.

PMID: 26041617
Journal: J NEUROL
Year: 2015
Reference: J Neurol. 2015 Dec;262(12):2617-26. doi: 10.1007/s00415-015-7798-0. Epub 2015 Jun 5.
Impact factor:
Publication type: Paper in international publication
Authors: Montalban, Xavier; Rovira, Alex; Sastre-Garriga, Jaume; Vidal-Jordana, Angela et al.
DOI: 10.1007/s00415-015-7798-0

Defining high, medium and low impact prognostic factors for developing multiple sclerosis.

PMID: 25902415
Journal: BRAIN
Year: 2015
Reference: Brain. 2015 Jul;138(Pt 7):1863-74. doi: 10.1093/brain/awv105. Epub 2015 Apr 21.
Impact factor:
Publication type: Paper in international publication
Authors: Arevalo, Maria Jesus; Arrambide, Georgina; Auger, Cristina; Castillo, Joaquin; Comabella, Manuel; Galan, Ingrid; Mitjana, Raquel; Montalban, Xavier; Negrotto, Laura; Nos, Carlos et al.
DOI: 10.1093/brain/awv105

Predictive value of early brain atrophy on response in patients treated with interferon beta.

PMID: 26185778
Journal: Neurology(R) neuroimmunology & neuroinflammation
Year: 2015
Reference: Neurol Neuroimmunol Neuroinflamm. 2015 Jul 2;2(4):e132. doi: 10.1212/NXI.0000000000000132. eCollection 2015 Aug.
Impact factor:
Publication type: Letter or abstract
Authors: Auger, Cristina; Montalban, Xavier; Pareto, Deborah; Perez-Miralles, Francisco Carlos; Rio, Jordi; Rovira, Alex; Sastre-Garriga, Jaume; Tintore, Mar; Vidal-Jordana, Angela et al.
DOI: 10.1212/NXI.0000000000000132

Effects of diazoxide in multiple sclerosis: A randomized, double-blind phase 2 clinical trial.

PMID: 26405686
Journal: NEUROL RES
Year: 2015
Reference: Neurol Neuroimmunol Neuroinflamm. 2015 Sep 10;2(5):e147. doi: 10.1212/NXI.0000000000000147. eCollection 2015 Oct.
Impact factor:
Publication type: Clinical Trials
Authors: Arroyo, Rafael; Campas, Clara; Casanova, Bonaventura; Fernandez, Oscar; Garcia-Merino, Antonio; Lensch, Eckart; Martinez-Rodriguez, Jose Enrique; Meca-Lallana, Virginia; Meuth, Sven G; Montalban, Xavier et al.
DOI: 10.1212/NXI.0000000000000147

Cerebral amyloid angiopathy-related inflammation: imaging findings and clinical outcome.

PMID: 24493378
Journal: NEURORADIOLOGY
Year: 2014
Reference: Neuroradiology. 2014 Apr;56(4):283-9. doi: 10.1007/s00234-014-1330-6. Epub 2014 Feb 4.
Impact factor:
Publication type: Paper in international publication
Authors: Auger, Cristina; Coscojuela, Pilar; Martucci, Matia; Rovira, Alex; Sarria, Silvana; Siurana, Sahyly; Toledo, Manuel; Vert, Carla et al.
DOI: 10.1007/s00234-014-1330-6

Diagnostic value of brain chronic black holes on T1-weighted MR images in clinically isolated syndromes.

PMID: 24576831
Journal: Multiple Sclerosis Journal
Year: 2014
Reference: Mult Scler. 2014 Oct;20(11):1471-7. doi: 10.1177/1352458514526083. Epub 2014 Feb 27.
Impact factor:
Publication type: Paper in international publication
Authors: Auger, Cristina; Barkhof, Frederik; Fazekas, Franz; Filippi, Massimo; Huerga, Elena; Mitjana, Raquel; Montalban, Xavier; Polman, Chris; Rocca, Maria A; Rovira, Alex et al.
DOI: 10.1177/1352458514526083

Evaluating the response to glatiramer acetate in relapsing-remitting multiple sclerosis (RRMS) patients.

PMID: 24622350
Journal: Multiple Sclerosis Journal
Year: 2014
Reference: Mult Scler. 2014 Oct;20(12):1602-8. doi: 10.1177/1352458514527863. Epub 2014 Mar 12.
Impact factor:
Publication type: Paper in international publication
Authors: Auger, Cristina; Castillo, Joaquin; Comabella, Manuel; Montalban, Xavier; Nos, Carlos; Rio, Jordi; Rovira, Alex; Sastre-Garriga, Jaume; Tintore, Mar; Tur, Carmen et al.
DOI: 10.1177/1352458514527863

Radiologically isolated syndrome: 5-year risk for an initial clinical event.

PMID: 24598783
Journal: PLoS One
Year: 2014
Reference: PLoS One. 2014 Mar 5;9(3):e90509. doi: 10.1371/journal.pone.0090509. eCollection 2014.
Impact factor:
Publication type: Paper in international publication
Authors: Amato, Maria Pia; Brassat, David; Brochet, Bruno; de Seze, Jerome; De Stefano, Nicola; Donlon, Stacy; Hua, Le H; Inglese, Matilde; Kantarci, Orhun; Katz, Ilana et al.
DOI: 10.1371/journal.pone.0090509

Location of brain lesions predicts conversion of clinically isolated syndromes to multiple sclerosis.

PMID: 23223533
Journal: NEUROLOGY
Year: 2013
Reference: Neurology. 2013 Jan 15;80(3):234-241. Epub 2012 Dec 5.
Impact factor:
Publication type: Paper in international publication
Authors: Absinta, Martina; Barkhof, Frederik; Battaglini, Marco; Chard, Declan; Ciccarelli, Olga; De Leucio, Alessandro; De Stefano, Nicola; Enzinger, Christian; Filippi, Massimo; Frederiksen, Jette et al.
DOI: 10.1212/WNL.0b013e31827debeb

Implication of breast cancer phenotype for patients with leptomeningeal carcinomatosis.

PMID: 23137566
Journal: BREAST
Year: 2013
Reference: Breast. 2013 Feb;22(1):19-23. doi: 10.1016/j.breast.2012.10.009. Epub 2012 Nov 6.
Impact factor:
Publication type: Letter whit IF
Authors: Bellet, Meritxell; Cortes, Javier; Di Cosimo, Serena; Gomez, Patricia; Oliveira, Mafalda; Peg, Vicente; Rovira, Alex; Sanchez-Olle, Gessami; Saura, Cristina; Torrejon, Davis et al.
DOI: 10.1016/j.breast.2012.10.009

Perfusion MRI: the five most frequently asked technical questions.

PMID: 23255738
Journal: AMERICAN JOURNAL OF ROENTGENOLOGY
Year: 2013
Reference: AJR Am J Roentgenol. 2013 Jan;200(1):24-34. doi: 10.2214/AJR.12.9543.
Impact factor:
Publication type: Review in international publication
Authors: Anzalone, Nicoletta; Dorfler, Arnd; Enterline, David; Essig, Marco; Law, Meng; Nguyen, Thanh Binh; Provenzale, James M; Rovira, Alex; Saake, Marc; Shiroishi, Mark S et al.
DOI: 10.2214/AJR.12.9543

Blog

News

The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.

Els doctors Xavier Montalban, Àlex Rovira i Mar Tintoré han estat reconeguts en la categoria de Neurociències i Comportament, i el doctor Jordi Rello en la categoria Interdisciplinària.

The program, promoted by Biocat in collaboration with CIMIT (Boston), is aimed at entrepreneurs in the process of bringing their technology to market in the next few years.

Rates

Magnetic Resonance image analysis