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Neurotraumatology and Neurosurgery Research Unit (UNINN)

The Neurotraumatology and Neurosurgery Research Unit (UNINN) is a translational research group fully integrated into the European research community and accredited as a Consolidated Research Group since 2005.

The UNINN conduct both basic and clinical research, with the aim of transferring benchside discoveries to the bedside. We have robust intramural synergies, national collaborations with basic scientists, and international collaborations and alliances with researchers from multiple countries and institutions with whom we share common research goals.

Our research unit participates in multinational clinical trials funded by the pharmaceutical industry and the European Union (EU). Our research unit is highly focused on developing and using new technologies to improve the assessment of clinical outcomes, incorporating quality of life measures, and patient-reported outcomes. We also maintain an important collection of brain tissue samples, serum, LCR, and microdialysates from the cerebral extracellular space of neurocritical patients. 

Publications

[Evaluation of the effectiveness of the new perioperative model to recover surgical activity during the COVID-19 pandemic].

PMID: 35764494
Journal: Journal of healthcare quality research
Year: 2022
Reference: J Healthc Qual Res. 2022 Mar 7. pii: S2603-6479(22)00009-4. doi: 10.1016/j.jhqr.2022.02.003.
Impact factor: 0
Publication type: Paper in national publication
Authors: Loaiza-Aldean, Y; de Miguel, M; Morales-Ariza, V; Gonzalez-Tallada, A; Manrique, S; Dominguez Gonzalez, J M; de Nadal, M et al.
DOI: 10.1016/j.jhqr.2022.02.003

Neurosurgery in a patient with severe hemophilia B: an experience using eftrenonacog alfa as perioperative management.

PMID: 35620255
Journal: Clinical case reports
Year: 2022
Reference: Clin Case Rep. 2022 May 23;10(5):e05848. doi: 10.1002/ccr3.5848. eCollection 2022 May.
Impact factor: 0
Publication type: Letter or abstract
Authors: Benitez Hidalgo, Olga, Martinez Garcia, M Fernanda, Bescos Cabestre, Agustin, Juarez Gimenez, Juan Carlos, Gironella Mesa, Mercedes, Bosch Albareda, Francesc et al.
DOI: 10.1002/ccr3.5848

Neurodevelopmental profile in children with benign external hydrocephalus syndrome. A pilot cohort study.

PMID: 33973055
Journal: CHILDS NERVOUS SYSTEM
Year: 2021
Reference: Childs Nerv Syst. 2021 Sep;37(9):2799-2806. doi: 10.1007/s00381-021-05201-z. Epub 2021 May 10.
Impact factor: 1.475
Publication type: Paper in international publication
Authors: Maruccia, Federica, Gomariz, Laura, Rosas, Katiuska, Durduran, Turgut, Paredes-Carmona, Fernando, Sahuquillo, Juan, Poca, Maria A et al.
DOI: 10.1007/s00381-021-05201-z

Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease.

PMID: 33836684
Journal: BMC Neurology
Year: 2021
Reference: BMC Neurol. 2021 Apr 9;21(1):154. doi: 10.1186/s12883-021-02179-8.
Impact factor: 2.474
Publication type: Paper in international publication
Authors: Marti-Fabregas, Joan, Prats-Sanchez, Luis, Martinez-Domeno, Alejandro, Kasner, Scott E, Greenberg, Joel H, Zhou, Chao, Edlow, Brian L, Putt, Mary E, Detre, John A, Yodh, Arjun G et al.
DOI: 10.1186/s12883-021-02179-8

How to Choose a Shunt for Patients with Normal Pressure Hydrocephalus: A Short Guide to Selecting the Best Shunt Assembly.

PMID: 33803977
Journal: Journal of Clinical Medicine
Year: 2021
Reference: J Clin Med. 2021 Mar 15;10(6). pii: jcm10061210. doi: 10.3390/jcm10061210.
Impact factor: 4.242
Publication type: Review in international publication
Authors: Sahuquillo, Juan, Rosas, Katiuska, Calvo, Helena, Alcina, Aloma, Gandara, Dario, Lopez-Bermeo, Diego, Poca, Maria-Antonia et al.
DOI: 10.3390/jcm10061210

Considerations in the Use of Gravitational Valves in the Management of Hydrocephalus. Some Lessons Learned with the Dual-Switch Valve.

PMID: 33445418
Journal: Journal of Clinical Medicine
Year: 2021
Reference: J Clin Med. 2021 Jan 12;10(2). pii: jcm10020246. doi: 10.3390/jcm10020246.
Impact factor: 4.242
Publication type: Review in international publication
Authors: Poca, Maria A, Gandara, Dario F, Rosas, Katiuska, Alcina, Aloma, Lopez-Bermeo, Diego, Sahuquillo, Juan et al.
DOI: 10.3390/jcm10020246

Early experience with a novel net temporary bridging device (Cascade) to assist endovascular coil embolization of intracranial aneurysms.

PMID: 31978881
Journal: JOURNAL OF NEUROSURGERY
Year: 2020
Reference: J Neurosurg. 2020 Jan 24:1-9. doi: 10.3171/2019.11.JNS192477.
Impact factor:
Publication type: Paper in international publication
Authors: Aixut, Sonia; Arikan, Fuat; Barranco Pons, Roger; Dinia, Lavinia; Gramegna, Laura Ludovica; Hernandez, David; Jansen, Olav; Lopez-Rueda, Antonio; Parra-Farinas, Carmen; Pinana, Carlos et al.
DOI: 10.3171/2019.11.JNS192477

A management algorithm for adult patients with both brain oxygen and intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC).

PMID: 31965267
Journal: INTENSIVE CARE MEDICINE
Year: 2020
Reference: Intensive Care Med. 2020 May;46(5):919-929. doi: 10.1007/s00134-019-05900-x. Epub 2020 Jan 21.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilera, Sergio; Arrastia, Ramon Diaz; Buki, Andras; Bulger, Eileen; Chesnut, Randall; Citerio, Giuseppe; Cooper, D Jamie; Diringer, Michael; Figaji, Anthony; Gao, Guoyi et al.
DOI: 10.1007/s00134-019-05900-x

Efficacy of Ronopterin (VAS203) in Patients with Moderate and Severe Traumatic Brain Injury (NOSTRA phase III trial): study protocol of a confirmatory, placebo-controlled, randomised, double blind, multi-centre study.

PMID: 31937347
Journal: Trials
Year: 2020
Reference: Trials. 2020 Jan 14;21(1):80. doi: 10.1186/s13063-019-3965-4.
Impact factor:
Publication type: Paper in international publication
Authors: Andrews, Peter; Beer, Ronny; Belli, Antonio; Bulters, Diederik; Fluhe, Charlotte; Ibanez, Javier; Lagares, Alfonso; LeFrant, Jean-Yves; Mokry, Michael; Sahuquillo, Joan et al.
DOI: 10.1186/s13063-019-3965-4

Role of Sulfonylurea Receptor 1 and Glibenclamide in Traumatic Brain Injury: A Review of the Evidence.

PMID: 31936452
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2020
Reference: Int J Mol Sci. 2020 Jan 9;21(2). pii: ijms21020409. doi: 10.3390/ijms21020409.
Impact factor:
Publication type: Review in international publication
Authors: Bell, Josh; Citerio, Giuseppe; Hemphill, J Claude; Jha, Ruchira M; Kimberly, W Taylor; Narayan, Raj K; Sahuquillo, Juan; Sheth, Kevin N; Simard, J Marc et al.
DOI: 10.3390/ijms21020409

Kir6.2, the Pore-Forming Subunit of ATP-Sensitive K+ Channels, Is Overexpressed in Human Posttraumatic Brain Contusions

PMID: 29737232
Journal: JOURNAL OF NEUROTRAUMA
Year: 2019
Reference: Journal of Neurotrauma. 2019 Jan;36(1):165-75. doi: 10.1089/neu.2017.5619
Impact factor: 3.754
Publication type: Paper in international publication
Authors: , , Poca, Maria-Antonia, Castro González, Lidia, Montoya Clemente, Noelia, Vidal Jorge, Marian, Sanchez Ortiz, David, Gandara, Dario, Martinez-Saez, Elena, Cicuendez, Marta et al.
DOI: 10.1089/neu.2017.5619

What s new in intraabdominal candidiasis in critically ill patients, a review.

PMID: 31585520
Journal: Hospital practice (1995)
Year: 2019
Reference: Hosp Pract (1995). 2019 Oct;47(4):171-176. doi: 10.1080/21548331.2019.1677032. Epub 2019 Oct 24.
Impact factor: 0
Publication type: Paper in international publication
Authors: Lagunes, L, Rey-Perez, A et al.
DOI: 10.1080/21548331.2019.1677032

A rare case of an intramedullary metastasis of a myxopapillary ependymoma.

PMID: 31528421
Journal: Surgical neurology international
Year: 2019
Reference: Surg Neurol Int. 2019 May 10;10:83. doi: 10.25259/SNI-96-2019. eCollection 2019.
Impact factor: 0
Publication type: Paper in international publication
Authors: Fonseca, Lino, Cicuendez, Marta, Martinez-Ricarte, Francisco, Martinez-Saez, Elena, Cordero, Esteban, Bescos, Agustin et al.
DOI: 10.25259/SNI-96-2019

Microvascular cerebral blood flow fluctuations in association with apneas and hypopneas in acute ischemic stroke.

PMID: 31037244
Journal: Neurophotonics
Year: 2019
Reference: Neurophotonics. 2019 Apr;6(2):025004. doi: 10.1117/1.NPh.6.2.025004. Epub 2019 Apr 23.
Impact factor: 3.581
Publication type: Paper in international publication
Authors: Gregori-Pla, Clara, Delgado-Mederos, Raquel, Cotta, Gianluca, Giacalone, Giacomo, Maruccia, Federica, Avtzi, Stella, Prats-Sanchez, Luis, Martinez-Domeno, Alejandro, Camps-Renom, Pol, Marti-Fabregas, Joan et al.
DOI: 10.1117/1.NPh.6.2.025004

Blog

News

The goal is to test a low-cost, easy-to-use and non-invasive monitor, which will serve to control intracranial pressure (PICO) values, which will help to control and treat different acute brain pathologies.

The new tool will improve patient care and allow early detection of complications, as the hospital previously did not have a specific form.

Entre els projectes es troben 12 investigacions on participen investigadors i investigadores de Vall d’Hebron.

Rates

Check the current rates for the LUMINEX MAGPIX service offered by the Neurotraumatology and Neurosurgery Research Unit (UNINN).