Neurotraumatology and Neurosurgery Research Unit (UNINN)

The Neurotraumatology and Neurosurgery Research Unit (UNINN) is a translational research group fully integrated into the European research community and accredited as a Consolidated Research Group since 2005.

The UNINN conduct both basic and clinical research, with the aim of transferring benchside discoveries to the bedside. We have robust intramural synergies, national collaborations with basic scientists, and international collaborations and alliances with researchers from multiple countries and institutions with whom we share common research goals.

Our research unit participates in multinational clinical trials funded by the pharmaceutical industry and the European Union (EU). Our research unit is highly focused on developing and using new technologies to improve the assessment of clinical outcomes, incorporating quality of life measures, and patient-reported outcomes. We also maintain an important collection of brain tissue samples, serum, LCR, and microdialysates from the cerebral extracellular space of neurocritical patients.

Projects

Aquest any no hi ha projectes actius.

Publications

Effect of different types of supervised exercise programs on cardiorespiratory and muscular fitness, pain, fatigue, mental health and inflammatory and oxidative stress biomarkers in older patients with post-COVID-19 sequelae "EJerSA-COVID-19": a randomized controlled trial.

PMID: 38102536
Journal: BMC Geriatrics
Year: 2023
Reference: BMC Geriatr. 2023 Dec 15;23(1):865. doi: 10.1186/s12877-023-04544-3.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez, Ignacio Delgado; Benet, Marta; Carbonell, Teresa; Del Carmen, Amin; Durduran, Turgut; Farres, Montserrat Girabent; Fischer, Jonas B; Garnacho-Castano, Manuel V; Garrido, Ainoa Biurrun; Jerez-Molina, Carmen et al.
DOI: 10.1186/s12877-023-04544-3

Modeling Brain-Heart Crosstalk Information in Patients with Traumatic Brain Injury.

PMID: 34642842
Journal: Neurocritical Care
Year: 2022
Reference: Neurocrit Care. 2022 Jun;36(3):738-750. doi: 10.1007/s12028-021-01353-7. Epub 2021 Oct 12.
Impact factor:
Publication type: Paper in international publication
Authors: Anke, Audny; Beer, Ronny; Bellander, Bo-Michael; Beqiri, Erta; Beqiri, Erta; Buki, Andras; Cabeleira, Manuel; Carbonara, Marco; Chieregato, Arturo; Citerio, Giuseppe et al.
DOI: 10.1007/s12028-021-01353-7

Extended Coagulation Profiling in Isolated Traumatic Brain Injury: A CENTER-TBI Analysis.

PMID: 34918214
Journal: Neurocritical Care
Year: 2022
Reference: Neurocrit Care. 2022 Jun;36(3):927-941. doi: 10.1007/s12028-021-01400-3. Epub 2021 Dec 16.
Impact factor:
Publication type: Paper in international publication
Authors: Akerlund, Cecilia; Amrein, Krisztina; Andelic, Nada; Andreassen, Lasse; Anke, Audny; Antoni, Anna; Ao, Braden Te; Audibert, Gerard; Azouvi, Philippe; Azzolini, Maria Luisa et al.
DOI: 10.1007/s12028-021-01400-3

Can We Cluster ICU Treatment Strategies for Traumatic Brain Injury by Hospital Treatment Preferences?

PMID: 34873673
Journal: Neurocritical Care
Year: 2022
Reference: Neurocrit Care. 2022 Jun;36(3):846-856. doi: 10.1007/s12028-021-01386-y. Epub 2021 Dec 6.
Impact factor:
Publication type: Paper in international publication
Authors: Akerlund, Cecilia; Amrein, Krisztina; Andelic, Nada; Andreassen, Lasse; Anke, Audny; Antoni, Anna; Ao, Braden Te; Audibert, Gerard; Azouvi, Philippe; Azzolini, Maria Luisa et al.
DOI: 10.1007/s12028-021-01386-y

Noise Levels and Sleep in a Surgical ICU.

PMID: 35566455
Journal: Journal of Clinical Medicine
Year: 2022
Reference: J Clin Med. 2022 Apr 22;11(9). pii: jcm11092328. doi: 10.3390/jcm11092328.
Impact factor:
Publication type: Paper in international publication
Authors: de Nadal, Miriam; Guisasola-Rabes, Maria; Sola-Enriquez, Berta; Velez-Pereira, Andres M et al.
DOI: 10.3390/jcm11092328

Neurodevelopmental profile in children with benign external hydrocephalus syndrome. A pilot cohort study.

PMID: 33973055
Journal: CHILDS NERVOUS SYSTEM
Year: 2021
Reference: Childs Nerv Syst. 2021 Sep;37(9):2799-2806. doi: 10.1007/s00381-021-05201-z. Epub 2021 May 10.
Impact factor:
Publication type: Paper in international publication
Authors: Durduran, Turgut; Gomariz, Laura; Maruccia, Federica; Paredes-Carmona, Fernando; Poca, Maria A; Rosas, Katiuska; Sahuquillo, Juan et al.
DOI: 10.1007/s00381-021-05201-z

Outcome Prediction after Moderate and Severe Traumatic Brain Injury: External Validation of Two Established Prognostic Models in 1742 European Patients.

PMID: 33161840
Journal: JOURNAL OF NEUROTRAUMA
Year: 2021
Reference: J Neurotrauma. 2021 May 15;38(10):1377-1388. doi: 10.1089/neu.2020.7300. Epub 2020 Dec 14.
Impact factor:
Publication type: Paper in international publication
Authors: Akerlund, Cecilia; Amrein, Krisztina; Andelic, Nada; Andreassen, Lasse; Anke, Audny; Antoni, Anna; Ao, Braden Te; Audibert, Gerard; Azouvi, Philippe; Azzolini, Maria Luisa et al.
DOI: 10.1089/neu.2020.7300

Rare functional genetic variants in COL7A1, COL6A5, COL1A2 and COL5A2 frequently occur in Chiari Malformation Type 1.

PMID: 33974636
Journal: PLoS One
Year: 2021
Reference: PLoS One. 2021 May 11;16(5):e0251289. doi: 10.1371/journal.pone.0251289. eCollection 2021.
Impact factor:
Publication type: Paper in international publication
Authors: Ashley-Koch, Allison; Drechsel, Oliver; Garrett, Melanie E; Labuda, Rick; Loth, Dorothy; Loth, Francis; Macaya, Alfons; Marce-Grau, Anna; Mestres I Soler, Olga; Ossowski, Stephan et al.
DOI: 10.1371/journal.pone.0251289

Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage.

PMID: 33891558
Journal: Science Immunology
Year: 2021
Reference: Sci Immunol. 2021 Feb 19;6(56). pii: 6/56/eabd6279. doi: 10.1126/sciimmunol.abd6279. Epub 2021 Feb 19.
Impact factor:
Publication type: Paper in international publication
Authors: Abdul-Rahim, Azmil; Abou-Hamden, Amal; Abraham, Michael; Abraham, Michael; Ahmed, Azam; Alba, Carlos Alarcon; Alchbli, Amal; Aldrich, E Francois; Ali, Hasan; Altschul, David et al.
DOI: 10.1126/sciimmunol.abd6279

Recommendations for specialized nutritional-metabolic management of the critical patient: Special situations, polytraumatisms and critical burn patients. Metabolism and Nutrition Working Group of the Spanish Society of Intensive and Critical Care Medicine and Coronary Units (SEMICYUC).

PMID: 32532416
Journal: Medicina Intensiva
Year: 2020
Reference: Med Intensiva. 2020 Jun;44 Suppl 1:73-76. doi: 10.1016/j.medin.2020.01.001.
Impact factor:
Publication type: Paper in national publication
Authors: Blesa-Malpica, A; Martin-Luengo, A; Robles-Gonzalez, A et al.
DOI: 10.1016/j.medin.2020.01.001

Brain Tissue Oxygen and Cerebrovascular Reactivity in Traumatic Brain Injury: A Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Exploratory Analysis of Insult Burden.

PMID: 32253987
Journal: JOURNAL OF NEUROTRAUMA
Year: 2020
Reference: J Neurotrauma. 2020 Sep 1;37(17):1854-1863. doi: 10.1089/neu.2020.7024. Epub 2020 May 4.
Impact factor:
Publication type: Paper in international publication
Authors: Anke, Audny; Beer, Ronny; Bellander, Bo-Michael; Beqiri, Erta; Beqiri, Erta; Buki, Andras; Cabeleira, Manuel; Cabeleira, Manuel; Carbonara, Marco; Chieregato, Arturo et al.
DOI: 10.1089/neu.2020.7024

Impact of Antithrombotic Agents on Radiological Lesion Progression in Acute Traumatic Brain Injury: A CENTER-TBI Propensity-Matched Cohort Analysis.

PMID: 32312149
Journal: JOURNAL OF NEUROTRAUMA
Year: 2020
Reference: J Neurotrauma. 2020 Oct 1;37(19):2069-2080. doi: 10.1089/neu.2019.6911. Epub 2020 Jun 3.
Impact factor:
Publication type: Paper in international publication
Authors: Akerlund, Cecilia; Amrein, Krisztina; Andelic, Nada; Andreassen, Lasse; Anke, Audny; Antoni, Anna; Audibert, Gerard; Azouvi, Philippe; Bartels, Ronald; Barzo, Pal et al.
DOI: 10.1089/neu.2019.6911

Informed consent procedures in patients with an acute inability to provide informed consent: Policy and practice in the CENTER-TBI study.

PMID: 32485440
Journal: JOURNAL OF CRITICAL CARE
Year: 2020
Reference: J Crit Care. 2020 Oct;59:6-15. doi: 10.1016/j.jcrc.2020.05.004. Epub 2020 May 25.
Impact factor:
Publication type: Paper in international publication
Authors: Akerlund, Cecilia; Amrein, Krisztina; Andelic, Nada; Andreassen, Lasse; Anke, Audny; Antoni, Anna; Ao, Braden Te; Audibert, Gerard; Azouvi, Philippe; Azzolini, Maria Luisa et al.
DOI: 10.1016/j.jcrc.2020.05.004

A rare case of an intramedullary metastasis of a myxopapillary ependymoma.

PMID: 31528421
Journal: Surgical neurology international
Year: 2019
Reference: Surg Neurol Int. 2019 May 10;10:83. doi: 10.25259/SNI-96-2019. eCollection 2019.
Impact factor:
Publication type: Paper in international publication
Authors: Bescos, Agustin; Cicuendez, Marta; Cordero, Esteban; Fonseca, Lino; Martinez-Ricarte, Francisco; Martinez-Saez, Elena et al.
DOI: 10.25259/SNI-96-2019

Cerebrovascular reactivity is not associated with therapeutic intensity in adult traumatic brain injury: a CENTER-TBI analysis.

PMID: 31240583
Journal: ACTA NEUROCHIRURGICA
Year: 2019
Reference: Acta Neurochir (Wien). 2019 Sep;161(9):1955-1964. doi: 10.1007/s00701-019-03980-8. Epub 2019 Jun 25.
Impact factor:
Publication type: Paper in international publication
Authors: Anke, Audny; Aries, Marcel; Beer, Ronny; Bellander, Bo-Michael; Beqiri, Erta; Buki, Andras; Cabeleira, Manuel; Carbonara, Marco; Chevallard, Giorgio; Chieregato, Arturo et al.
DOI: 10.1007/s00701-019-03980-8

Peri-ictal magnetic resonance imaging in status epilepticus: Temporal relationship and prognostic value in 60 patients.

PMID: 31499473
Journal: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
Year: 2019
Reference: Seizure. 2019 Oct;71:289-294. doi: 10.1016/j.seizure.2019.08.013. Epub 2019 Aug 31.
Impact factor:
Publication type: Paper in international publication
Authors: Quintana, Manuel; Requena, Manuel; Rovira, Alex; Santamarina, Estevo; Sarria-Estrada, Silvana; Sueiras, Maria; Toledo, Manuel et al.
DOI: 10.1016/j.seizure.2019.08.013

Myocardial Injury After Noncardiac Surgery. Could Dabigatran Be a First Step in Its Management?

PMID: 31401086
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2019
Reference: Rev Esp Cardiol (Engl Ed). 2019 Oct;72(10):803-805. doi: 10.1016/j.rec.2019.03.018. Epub 2019 Aug 7.
Impact factor:
Publication type: Editorial in national publication
Authors: Alvarez-Garcia, Jesus; de Nadal, Miriam; Popova, Ekaterina et al.
DOI: 10.1016/j.rec.2019.03.018

Outcome of cancer-related seizures in patients treated with lacosamide.

PMID: 28832891
Journal: ACTA NEUROLOGICA SCANDINAVICA
Year: 2018
Reference: Acta Neurol Scand. 2018 Jan;137(1):67-75. doi: 10.1111/ane.12809. Epub 2017 Aug 22.
Impact factor:
Publication type: Paper in international publication
Authors: Martinez-Ricarte, F; Martinez-Saez, E; Molins, A; Quintana, M; Salas-Puig, J; Santamarina, E; Toledo, M et al.
DOI: 10.1111/ane.12809

Neuropsychological alterations and neuroradiological findings in patients with post-traumatic concussion: Results of a pilot study.

PMID: 28007313
Journal: NEUROLOGIA
Year: 2018
Reference: Neurologia. 2018 Sep;33(7):427-437. doi: 10.1016/j.nrl.2016.10.003. Epub 2016 Dec 20.
Impact factor: 1.938
Publication type: Paper in national publication
Authors: Radoi, A, Poca, M A, Canas, V, Cevallos, J M, Membrado, L, Saavedra, M C, Vidal, M, Martinez-Ricarte, F, Sahuquillo, J et al.
DOI: 10.1016/j.nrl.2016.10.003

Revascularization experience and results in ischaemic cerebrovascular disease: Moyamoya disease and carotid occlusion.

PMID: 29550248
Journal: NEUROCIRUGIA
Year: 2018
Reference: Neurocirugia (Astur). 2018 Jul - Aug;29(4):170-186. doi: 10.1016/j.neucir.2018.01.006. Epub 2018 Mar 14.
Impact factor: 0.31
Publication type: Paper in national publication
Authors: Arikan, Fuat, Rubiera, Marta, Serena, Joaquin, Rodriguez-Hernandez, Ana, Gandara, Dario, Lorenzo-Bosquet, Carles, Tomasello, Alejandro, Chocron, Ivette, Quintana-Corvalan, Maximiliano, Sahuquillo, Juan et al.
DOI: 10.1016/j.neucir.2018.01.006

Anatomical Variations of Brain Venous Sinuses in Patients with Arteriovenous Malformations: Incidental Finding or Causative Factor?

PMID: 29462735
Journal: World Neurosurgery
Year: 2018
Reference: World Neurosurg. 2018 May;113:e465-e470. doi: 10.1016/j.wneu.2018.02.057. Epub 2018 Feb 17.
Impact factor: 1.924
Publication type: Paper in international publication
Authors: Rodriguez-Hernandez, Ana, Torne, Ramon, Reyes, Luis, Ensenat, Joaquim, Sanroman, Luis, Urra, Xabier et al.
DOI: 10.1016/j.wneu.2018.02.057

Influence of early neurological complications on clinical outcome following lung transplant.

PMID: 28301586
Journal: PLoS One
Year: 2017
Reference: PLoS One. 2017 Mar 16;12(3):e0174092. doi: 10.1371/journal.pone.0174092. eCollection 2017.
Impact factor:
Publication type: Paper in international publication
Authors: Canela, Merce; Carmona, Francesc; Deu, Maria; Gamez, Josep; Laborda, Cesar; Martinez-de La Ossa, Alejandro; Nadal, Miriam; Raguer, Nuria; Rochera, Isabel; Roman, Antonio et al.
DOI: 10.1371/journal.pone.0174092

Malignant infarction of the middle cerebral artery in a porcine model. A pilot study.

PMID: 28235044
Journal: PLoS One
Year: 2017
Reference: PLoS One. 2017 Feb 24;12(2):e0172637. doi: 10.1371/journal.pone.0172637. eCollection 2017.
Impact factor:
Publication type: Paper in international publication
Authors: Arikan, Fuat; Campos, Mireia; Castro, Lidia; Dalmau, Antoni; Esteves, Marielle; Gandara, Dario; Martinez-Valverde, Tamara; Sahuquillo, Juan; Sanchez-Guerrero, Angela; Tibau, Joan et al.
DOI: 10.1371/journal.pone.0172637

Adaptive Servoventilation Device Software in the Assessment of Residual Respiratory Events in Patients With Central or Complex Apnoeas.

PMID: 28209445
Journal: ARCHIVOS DE BRONCONEUMOLOGIA
Year: 2017
Reference: Arch Bronconeumol. 2017 Aug;53(8):455-457. doi: 10.1016/j.arbres.2016.11.026. Epub 2017 Feb 13.
Impact factor:
Publication type: Paper in national publication
Authors: Cambrodi, Roser; Ferre, Alex; Lloberes, Patricia; Sampol, Gabriel; Silveira, Maria-Guadalupe et al.
DOI: 10.1016/j.arbres.2016.11.026

[Classification of idiopathic generalised epilepsies in patients over 16 years of age].

PMID: 28074997
Journal: REVISTA DE NEUROLOGIA
Year: 2017
Reference: Rev Neurol. 2017 Jan 16;64(2):49-54.
Impact factor:
Publication type: Paper in national publication
Authors: Gonzalez-Cuevas, M; Quintana, M; Raspall-Chaure, M; Sala-Padro, J; Salas-Puig, J; Santamarina, E; Sueiras-Gil, M; Toledo, M et al.
DOI: 10.33588/rn.6402.2016219

Consensus statement from the 2014 International Microdialysis Forum.

PMID: 26194024
Journal: INTENS CARE MED
Year: 2015
Reference: Intensive Care Med. 2015 Sep;41(9):1517-28. doi: 10.1007/s00134-015-3930-y.
Impact factor:
Publication type: Paper in international publication
Authors: Bellander, Bo-Michael; Belli, Antonio; Boutelle, Martyn G; Carpenter, Keri L H; Carpenter, T Adrian; Chen, Jeff W; Claassen, Jan; Coles, Jonathan P; Czosnyka, Marek; Dahyot-Fizelier, Claire et al.
DOI: 10.1007/s00134-015-3930-y

Interside Latency Differences in Brainstem Auditory and Somatosensory Evoked Potentials. Defining Upper Limits to Determine Asymmetry.

PMID: 26061480
Journal: J CLIN NEUROPHYSIOL
Year: 2015
Reference: J Clin Neurophysiol. 2015 Oct;32(5):424-7. doi: 10.1097/WNP.0000000000000201.
Impact factor:
Publication type: Paper in international publication
Authors: Ferre, Alejandro; Minoves, Teresa; Moncho, Dulce; Poca, Maria A; Sahuquillo, Juan et al.
DOI: 10.1097/WNP.0000000000000201

Sulfonylurea Receptor 1 in Humans with Post-Traumatic Brain Contusions.

PMID: 26398596
Journal: J NEUROTRAUM
Year: 2015
Reference: J Neurotrauma. 2015 Oct 1;32(19):1478-87. doi: 10.1089/neu.2014.3706. Epub 2015 Jun 3.
Impact factor:
Publication type: Paper in international publication
Authors: Arikan, Fuat; Castro, Lidia; Cordero, Esteban; Martinez-Saez, Elena; Martinez-Valverde, Tamara; Poca, Maria-Antonia; Radoi, Andreea; Sahuquillo, Juan; Simard, J Marc; Vidal-Jorge, Marian et al.
DOI: 10.1089/neu.2014.3706

Use of perampanel in one case of super-refractory hypoxic myoclonic status: Case report.

PMID: 26286206
Journal: EPILEPSY BEHAV
Year: 2015
Reference: Epilepsy Behav Case Rep. 2015 Aug 8;4:56-9. doi: 10.1016/j.ebcr.2015.06.007. eCollection 2015.
Impact factor:
Publication type: Paper in international publication
Authors: Baneras, Jordi; Gonzalez, Montserrat; Guzman, Lorena; Lidon, Rosa M; Salas-Puig, Xavier; Santamarina, Estevo; Sueiras, Maria; Toledo, Manuel et al.
DOI: 10.1016/j.ebcr.2015.06.007

[Malformations of cortical development in adult patients with epilepsy: a series of 79 cases].

PMID: 24504876
Journal: REVISTA DE NEUROLOGIA
Year: 2014
Reference: Rev Neurol. 2014 Feb 16;58(4):147-51.
Impact factor:
Publication type: Paper in national publication
Authors: Alvarez-Sabin, Jose; Cambrodi-Masip, Roser; Gonzalez-Cuevas, Montserrat; Quintana, Manuel; Salas-Puig, Javier; Santamarina, Esteban; Sarria, Silvana; Sueiras-Gil, Maria; Toledo, Manuel et al.
DOI: 10.33588/rn.5804.2013524

Intraoperative Monitoring of Brain Tissue Oxygenation During Arteriovenous Malformation Resection.

PMID: 24492516
Journal: JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
Year: 2014
Reference: J Neurosurg Anesthesiol. 2014 Oct;26(4):328-41. doi: 10.1097/ANA.0000000000000033.
Impact factor:
Publication type: Paper in international publication
Authors: Arikan, Fuat; Noguer, Montserrat; Olive, Montserrat; Sahuquillo, Juan; Vidal-Jorge, Marian; Vilalta, Jordi et al.
DOI: 10.1097/ANA.0000000000000033

Lactate and the lactate-to-pyruvate molar ratio cannot be used as independent biomarkers for monitoring brain energetic metabolism: a microdialysis study in patients with traumatic brain injuries.

PMID: 25025772
Journal: PLOS ONE
Year: 2014
Reference: PLoS One. 2014 Jul 15;9(7):e102540. doi: 10.1371/journal.pone.0102540. eCollection 2014.
Impact factor: 3.534
Publication type: Paper in international publication
Authors: Sahuquillo, Juan, Merino, Maria-Angels, Sanchez-Guerrero, Angela, Arikan, Fuat, Vidal-Jorge, Marian, Martinez-Valverde, Tamara, Rey, Anna, Riveiro, Marilyn, Poca, Maria-Antonia et al.
DOI: 10.1371/journal.pone.0102540

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SafeICP to create a smart monitor to non-invasively measure intracranial pressure

The goal is to test a low-cost, easy-to-use and non-invasive monitor, which will serve to control intracranial pressure (PICO) values, which will help to control and treat different acute brain pathologies.