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Neurotraumatology and Neurosurgery Research Unit (UNINN)

The Neurotraumatology and Neurosurgery Research Unit (UNINN) is a translational research group fully integrated into the European research community and accredited as a Consolidated Research Group since 2005.

The UNINN conduct both basic and clinical research, with the aim of transferring benchside discoveries to the bedside. We have robust intramural synergies, national collaborations with basic scientists, and international collaborations and alliances with researchers from multiple countries and institutions with whom we share common research goals.

Our research unit participates in multinational clinical trials funded by the pharmaceutical industry and the European Union (EU). Our research unit is highly focused on developing and using new technologies to improve the assessment of clinical outcomes, incorporating quality of life measures, and patient-reported outcomes. We also maintain an important collection of brain tissue samples, serum, LCR, and microdialysates from the cerebral extracellular space of neurocritical patients. 

Publications

Serum metabolome associated with severity of acute traumatic brain injury.

PMID: 35538079
Journal: Nature Communications
Year: 2022
Reference: Nat Commun. 2022 May 10;13(1):2545. doi: 10.1038/s41467-022-30227-5.
Impact factor:
Publication type: Paper in international publication
Authors: Akerlund, Cecilia; Amrein, Krisztina; Andelic, Nada; Andreassen, Lasse; Anke, Audny; Antoni, Anna; Audibert, Gerard; Azouvi, Philippe; Azzolini, Maria Luisa; Bartels, Ronald et al.
DOI: 10.1038/s41467-022-30227-5

Discrepancy between disability and reported well-being after traumatic brain injury.

PMID: 35537823
Journal: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Year: 2022
Reference: J Neurol Neurosurg Psychiatry. 2022 May 10;93(7):785-96. doi: 10.1136/jnnp-2021-326615.
Impact factor:
Publication type: Paper in international publication
Authors: Akerlund, Cecilia; Amrein, Krisztina; Andelic, Nada; Andelic, Nada; Andreassen, Lasse; Anke, Audny; Antoni, Anna; Ao, Braden Te; Audibert, Gerard; Azouvi, Philippe et al.
DOI: 10.1136/jnnp-2021-326615

Surgery versus conservative treatment for traumatic acute subdural haematoma: a prospective, multicentre, observational, comparative effectiveness study.

PMID: 35526554
Journal: LANCET NEUROLOGY
Year: 2022
Reference: Lancet Neurol. 2022 Jul;21(7):620-631. doi: 10.1016/S1474-4422(22)00166-1. Epub 2022 May 5.
Impact factor:
Publication type: Paper in international publication
Authors: Akerlund, Cecilia; Amrein, Krisztina; Andelic, Nada; Andreassen, Lasse; Anke, Audny; Antoni, Anna; Audibert, Gerard; Azouvi, Philippe; Azzolini, Maria Luisa; Bartels, Ronald et al.
DOI: 10.1016/S1474-4422(22)00166-1

A genome-wide association study of outcome from traumatic brain injury.

PMID: 35301180
Journal: EBioMedicine
Year: 2022
Reference: EBioMedicine. 2022 Mar;77:103933. doi: 10.1016/j.ebiom.2022.103933. Epub 2022 Mar 14.
Impact factor:
Publication type: Paper in international publication
Authors: Adeoye, Opeolu; Akerlund, Cecilia; Amrein, Krisztina; Andelic, Nada; Anderson, Christopher D; Andreassen, Lasse; Anke, Audny; Antoni, Anna; Ao, Braden Te; Audibert, Gerard et al.
DOI: 10.1016/j.ebiom.2022.103933

ctDNA-Based Liquid Biopsy of Cerebrospinal Fluid in Brain Cancer.

PMID: 33919036
Journal: Cancers
Year: 2021
Reference: Cancers (Basel). 2021 Apr 21;13(9). pii: cancers13091989. doi: 10.3390/cancers13091989.
Impact factor:
Publication type: Review in international publication
Authors: Escudero, Laura; Martinez-Ricarte, Francisco; Seoane, Joan et al.
DOI: 10.3390/cancers13091989

Implications of initiating antiseizure drugs prior to the performance of EEG in first epileptic seizures.

PMID: 33875301
Journal: NEUROLOGIA
Year: 2021
Reference: Neurologia (Engl Ed). 2021 Apr 16:S0213-4853(21)00053-0. doi: 10.1016/j.nrl.2021.02.014.
Impact factor:
Publication type: Paper in national publication
Authors: Abraira, L; Ballve, A; Campos, D; Fonseca, E; Llaurado, A; Olive, M; Quintana, M; Requena, M; Santamarina, E; Sueiras, M et al.
DOI: 10.1016/j.nrl.2021.02.014

COVID-19 Infection in Critically Ill Patients Carries a High Risk of Venous Thrombo-embolism.

PMID: 33583710
Journal: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
Year: 2021
Reference: Eur J Vasc Endovasc Surg. 2021 Apr;61(4):628-634. doi: 10.1016/j.ejvs.2020.12.015. Epub 2020 Dec 23.
Impact factor:
Publication type: Paper in international publication
Authors: Bellmunt-Montoya, Sergi; de Nadal, Miriam; Ferrer, Ricard; Garcia-Reyes, Marvin; Gil, Daniel; Gil, Miquel; Llagostera, Secundino; Marrero, Carlos; Martinez-Carnovale, Lucia; Monreal, Manel et al.
DOI: 10.1016/j.ejvs.2020.12.015

Systemic Markers of Injury and Injury Response Are Not Associated with Impaired Cerebrovascular Reactivity in Adult Traumatic Brain Injury: A Collaborative European Neurotrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Study.

PMID: 33096953
Journal: JOURNAL OF NEUROTRAUMA
Year: 2021
Reference: J Neurotrauma. 2021 Apr 1;38(7):870-878. doi: 10.1089/neu.2020.7304. Epub 2020 Dec 14.
Impact factor:
Publication type: Paper in international publication
Authors: Anke, Audny; Beer, Ronny; Bellander, Bo-Michael; Beqiri, Erta; Buki, Andras; Cabeleira, Manuel; Cabeleira, Manuel; Carbonara, Marco; Chieregato, Arturo; Citerio, Giuseppe et al.
DOI: 10.1089/neu.2020.7304

Non-invasive estimation of intracranial pressure by diffuse optics - a proof-of-concept study.

PMID: 32460617
Journal: JOURNAL OF NEUROTRAUMA
Year: 2020
Reference: J Neurotrauma. 2020 Dec 1;37(23):2569-2579. doi: 10.1089/neu.2019.6965. Epub 2020 Jul 7.
Impact factor:
Publication type: Paper in international publication
Authors: Baguena, Marcelino; Cano, Paola; Durduran, Turgut; Fischer, Jonas Benedikt; Ghouse, Ameer; Maruccia, Federica; Poca, Maria A Dr; Rey-Perez, Anna; Sahuquillo, Juan; Tagliabue, Susanna et al.
DOI: 10.1089/neu.2019.6965

Low-resolution pressure reactivity index and its derived optimal cerebral perfusion pressure in adult traumatic brain injury: a CENTER-TBI study.

PMID: 32456684
Journal: CRITICAL CARE
Year: 2020
Reference: Crit Care. 2020 May 26;24(1):266. doi: 10.1186/s13054-020-02974-8.
Impact factor:
Publication type: Paper in international publication
Authors: Anke, Audny; Beer, Ronny; Bellander, Bo-Michael; Beqiri, Erta; Buki, Andras; Chevallard, Giorgio; Chieregato, Arturo; Citerio, Giuseppe; Czeiter, Endre; Czosnyka, Marek et al.
DOI: 10.1186/s13054-020-02974-8

How do 66 European institutional review boards approve one protocol for an international prospective observational study on traumatic brain injury? Experiences from the CENTER-TBI study.

PMID: 32398066
Journal: BMC Medical Ethics
Year: 2020
Reference: BMC Med Ethics. 2020 May 12;21(1):36. doi: 10.1186/s12910-020-00480-8.
Impact factor:
Publication type: Paper in international publication
Authors: Akerlund, Cecilia; Amrein, Krisztina; Andelic, Nada; Andreassen, Lasse; Anke, Audny; Antoni, Anna; Ao, Braden Te; Audibert, Gerard; Azouvi, Philippe; Azzolini, Maria Luisa et al.
DOI: 10.1186/s12910-020-00480-8

Association between Cerebrovascular Reactivity Monitoring and Mortality Is Preserved When Adjusting for Baseline Admission Characteristics in Adult Traumatic Brain Injury: A CENTER-TBI Study.

PMID: 31760893
Journal: JOURNAL OF NEUROTRAUMA
Year: 2020
Reference: J Neurotrauma. 2020 May 15;37(10):1233-1241. doi: 10.1089/neu.2019.6808. Epub 2019 Dec 30.
Impact factor:
Publication type: Paper in international publication
Authors: Anke, Audny; Beer, Ronny; Bellander, Bo-Michael; Beqiri, Erta; Buki, Andras; Cabeleira, Manuel; Chevallard, Giorgio; Chieregato, Arturo; Citerio, Giuseppe; Czeiter, Endre et al.
DOI: 10.1089/neu.2019.6808

[Hubris syndrome in neurosurgery].

PMID: 31364152
Journal: REVISTA DE NEUROLOGIA
Year: 2019
Reference: Rev Neurol. 2019 Sep 1;69(5):222. doi: 10.33588/rn.6905.2019245.
Impact factor:
Publication type: Letter or abstract
Authors: Vilalta, J et al.
DOI: 10.33588/rn.6905.2019245

Intravenous immunoglobulin to prevent myasthenic crisis after thymectomy and other procedures can be omitted in patients with well-controlled myasthenia gravis.

PMID: 31360225
Journal: Therapeutic Advances in Neurological Disorders
Year: 2019
Reference: Ther Adv Neurol Disord. 2019 Jul 17;12:1756286419864497. doi: 10.1177/1756286419864497. eCollection 2019.
Impact factor:
Publication type: Paper in international publication
Authors: Carmona, Francesc; de Nadal, Miriam; Deu, Maria; Gamez, Josep; Jauregui, Alberto; Martinez, Olga; Perez, Javier; Romero, Laura; Ruiz, Daniel; Salvado, Maria et al.
DOI: 10.1177/1756286419864497

Acromegaly remission, SIADH and pituitary function recovery after macroadenoma apoplexy

PMID: 31310082
Journal: Endocrinology, diabetes & metabolism case repo
Year: 2019
Reference: Endocrinol Diabetes Metab Case Rep. 2019 Jul 15;2019(1). doi: 10.1530/EDM-19-0057.
Impact factor:
Publication type: Paper in international publication
Authors: Arikan, F; Biagetti, B; Sanz-Sapera, E; Sarria-Estrada, S et al.
DOI: 10.1530/EDM-19-0057

Extensively drug-resistant Pseudomonas Aeruginosa outbreak in a burn unit: management and solutions.

PMID: 31285735
Journal: Annals of burns and fire disasters
Year: 2019
Reference: Ann Burns Fire Disasters. 2019 Mar 31;32(1):47-55.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilera-Saez, J; Andreu-Sola, V; Armadans Gil, L; Baena Caparros, J; Barret, J P; Campins, M; Larrosa Escartin, N; Rodriguez Garrido, V; Sanchez Garcia, J M et al.
DOI:

Cephalometric oropharynx and oral cavity analysis in Chiari malformation Type I: a retrospective case-control study.

PMID: 27153161
Journal: JOURNAL OF NEUROSURGERY
Year: 2017
Reference: J Neurosurg. 2017 Feb;126(2):626-633. doi: 10.3171/2016.1.JNS151590. Epub 2016 May 6.
Impact factor:
Publication type: Paper in international publication
Authors: Ferre, Alex; Macaya, Alfons; Martin, Bryn A; Poca, Maria-Antonia; Rovira, Alex; Sahuquillo, Juan; Urbizu, Aintzane et al.
DOI: 10.3171/2016.1.JNS151590

Effect of adjunctive perampanel on the quality of sleep and daytime somnolence in patients with epilepsy.

PMID: 28066710
Journal: Epilepsy & behavior case reports
Year: 2017
Reference: Epilepsy Behav Case Rep. 2016 Oct 21;7:13-15. doi: 10.1016/j.ebcr.2016.10.002. eCollection 2017.
Impact factor:
Publication type: Paper in international publication
Authors: Cambrodi, Roser; Ferrer, Alex; Gonzalez-Cuevas, Montserrat; Jurado, Maria Jose; Quintana, Manuel; Romero, Odile; Salas-Puig, Xavier; Santamarina, Estevo; Toledo, Manuel et al.
DOI: 10.1016/j.ebcr.2016.10.002

Association between source control and mortality in 258 patients with intra-abdominal candidiasis: a retrospective multi-centric analysis comparing intensive care versus surgical wards in Spain.

PMID: 27649699
Journal: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
Year: 2017
Reference: Eur J Clin Microbiol Infect Dis. 2017 Jan;36(1):95-104. doi: 10.1007/s10096-016-2775-9. Epub 2016 Sep 21.
Impact factor: 2.727
Publication type: Paper in international publication
Authors: Lagunes, L, Rey-Perez, A, Martin-Gomez, M T, Vena, A, de Egea, V, Munoz, P, Bouza, E, Diaz-Martin, A, Palacios-Garcia, I, Garnacho-Montero, J et al.
DOI: 10.1007/s10096-016-2775-9

Intracranial Arterial Dissection Mimicking a Saccular Aneurysm: Clinical Image.

PMID: 27923760
Journal: World Neurosurgery
Year: 2017
Reference: World Neurosurg. 2017 Feb;98:867.e5-867.e7. doi: 10.1016/j.wneu.2016.11.145. Epub 2016 Dec 5.
Impact factor: 2.685
Publication type: Paper in international publication
Authors: Rodriguez-Hernandez, Ana, Torne, Ramon, Arikan, Fuat et al.
DOI: 10.1016/j.wneu.2016.11.145

Brain Microdialysis as a Tool To Explore the Ionic Profile of the Brain Extracellular Space in Neurocritical Patients: A Methodological Approach and Feasibility Study.

PMID: 25019674
Journal: J NEUROTRAUM
Year: 2015
Reference: J Neurotrauma. 2015 Jan 1;32(1):7-16. doi: 10.1089/neu.2014.3473.
Impact factor:
Publication type: Paper in international publication
Authors: Manrique, Susana; Martinez-Valverde, Tamara; Montoya, Noelia; Munar, Francisca; Pellegri, Maria-Dolors; Poca, Maria-Antonia; Sahuquillo, Juan; Sanchez-Guerrero, Angela; Vidal-Jorge, Marian et al.
DOI: 10.1089/neu.2014.3473

Subarachnoid hemorrhage in systemic lupus erythematosus: Systematic review and report of three cases.

PMID: 25462090
Journal: CLINICAL NEUROLOGY AND NEUROSURGERY
Year: 2015
Reference: Clin Neurol Neurosurg. 2015 Jan;128:17-24. doi: 10.1016/j.clineuro.2014.10.018. Epub 2014 Nov 4.
Impact factor: 1.248
Publication type: Review in international publication
Authors: Sahuquillo, Juan, Torne, Ramon, Rodriguez-Hernandez, Ana, Bernard, Teuddis, Arikan Abello, Fuat, Vilalta Castan, Jordi et al.
DOI: 10.1016/j.clineuro.2014.10.018

Posterior fossa arteriovenous malformations: Significance of higher incidence of bleeding and hydrocephalus.

PMID: 25938563
Journal: CLINICAL NEUROLOGY AND NEUROSURGERY
Year: 2015
Reference: Clin Neurol Neurosurg. 2015 Jul;134:37-43. doi: 10.1016/j.clineuro.2015.04.003. Epub 2015 Apr 17.
Impact factor: 1.127
Publication type: Paper in international publication
Authors: Sahuquillo, Juan, Vilalta, Jordi, Cicuendez, Marta, Romero-Chala, Fabian, Torne, Ramon, Rodriguez-Hernandez, Ana, Arikan, Fuat et al.
DOI: 10.1016/j.clineuro.2015.04.003

Blog

News

The goal is to test a low-cost, easy-to-use and non-invasive monitor, which will serve to control intracranial pressure (PICO) values, which will help to control and treat different acute brain pathologies.

The new tool will improve patient care and allow early detection of complications, as the hospital previously did not have a specific form.

Entre els projectes es troben 12 investigacions on participen investigadors i investigadores de Vall d’Hebron.

Rates

Check the current rates for the LUMINEX MAGPIX service offered by the Neurotraumatology and Neurosurgery Research Unit (UNINN).