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Neurovascular Diseases

Stroke is a medical emergency and one of the leading causes of death and disability worldwide. In this context, the Neurovascular Diseases Group was established in 2001, focusing on biomedical research into both ischemic and hemorrhagic stroke from a basic and translational perspective. Our work in this research field has covered the entire disease spectrum, from prevention and treatment to recovery. In 2017, we expanded our research interests to include vascular dementia and Alzheimer’s disease, related to the β-amyloid protein. Our ultimate goal as a research team is to help answer critical questions that will improve the clinical management of stroke and dementia, conditions with significant health impacts due to their high prevalence and associated disability. We are also committed to promoting scientific education among researchers and the society, and to fostering public engagement in these areas.

Since 2001, dozens of researchers have carried out their work in this laboratory, and as a team we have leaded translational and clinical projects through both preclinical studies with experimental models, as well as cohort studies in patients. The laboratory stands out for its extensive national and international collaborations, working closely with other research groups and the biomedical industry.

Publications

Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer's Disease.

PMID: 33445800
Journal: Biomedicines
Year: 2021
Reference: Biomedicines. 2021 Jan 12;9(1). pii: biomedicines9010072. doi: 10.3390/biomedicines9010072.
Impact factor: 6.081
Publication type: Paper in international publication
Authors: Vera, Rocio, Lebrato-Hernandez, Lucia, Arenillas, Juan F, Perez-Sanchez, Soledad, Montaner, Joan, Sanchez-Quesada, Jose Luis, Hernandez-Guillamon, Mar, Cardona Portela, Pere, Martinez-Zabaleta, Maite, Tur, Silvia et al.
DOI: 10.3390/biomedicines9010072

Role of Blood-Based Biomarkers in Ischemic Stroke Prognosis: A Systematic Review.

PMID: 33430636
Journal: STROKE
Year: 2021
Reference: Stroke. 2021 Jan;52(2):543-551. doi: 10.1161/STROKEAHA.120.029232. Epub 2021 Jan 12.
Impact factor: 7.914
Publication type: Review in international publication
Authors: Montellano, Felipe A, Ungethum, Kathrin, Ramiro, Laura, Nacu, Aliona, Hellwig, Simon, Fluri, Felix, Whiteley, William N, Bustamante, Alejandro, Montaner, Joan, Heuschmann, Peter U et al.
DOI: 10.1161/STROKEAHA.120.029232

Defining a Target Population to Effectively Test a Neuroprotective Drug.

PMID: 33423513
Journal: STROKE
Year: 2021
Reference: Stroke. 2021 Jan;52(2):505-510. doi: 10.1161/STROKEAHA.120.032025. Epub 2021 Jan 11.
Impact factor: 7.914
Publication type: Paper in international publication
Authors: Garcia-Tornel, Alvaro, Deck, Matias, Muchada, Marian, Boned, Sandra, Rodriguez, Noelia, Juega, Jesus, Rodriguez-Luna, David, Pagola, Jorge, Rubiera, Marta, Hernandez-Jimenez, Macarena et al.
DOI: 10.1161/STROKEAHA.120.032025

Vascular risk factors as independent predictors of neurocognitive impairments in patients with late-onset epilepsy who have small-vessel disease.

PMID: 31399342
Journal: EPILEPSY & BEHAVIOR
Year: 2020
Reference: Epilepsy Behav. 2020 Mar;104(Pt B):106443. doi: 10.1016/j.yebeh.2019.106443. Epub 2019 Aug 6.
Impact factor: 2.508
Publication type: Paper in international publication
Authors: Turon, Marc, Abraira, Laura, Cazorla, Sonia, Fonseca, Elena, Quintana, Manuel, Toledo, Manuel, Salas-Puig, Xavier, Santamarina, Estevo et al.
DOI: 10.1016/j.yebeh.2019.106443

Corrigendum to "Correlation of blood biomarkers with early-onset seizures after an acute stroke event" [Epilepsy Behav 104(Pt B) (2020 Mar)].

PMID: 32248061
Journal: EPILEPSY & BEHAVIOR
Year: 2020
Reference: Epilepsy Behav. 2020 May;106:107045. doi: 10.1016/j.yebeh.2020.107045. Epub 2020 Apr 2.
Impact factor: 2.508
Publication type: Letter or abstract
Authors: Montaner, Joan, Alvarez-Sabin, Jose, Davalos, Antoni, Castellanos, Mar, Ustrell, Xavier, Abraira, Laura, Giannini, Nicola, Santamarina, Estevo, Cazorla, Sonia, Bustamante, Alejandro et al.
DOI: 10.1016/j.yebeh.2020.107045

Proteasomal-mediated degradation of AKAP150 accompanies AMPAR endocytosis during cLTD.

PMID: 32205379
Journal: eNeuro
Year: 2020
Reference: eNeuro. 2020 Apr 16;7(2). pii: ENEURO.0218-19.2020. doi: 10.1523/ENEURO.0218-19.2020. Print 2020 Mar/Apr.
Impact factor: 3.544
Publication type: Paper in international publication
Authors: Cheng, Wenwen, Siedlecki-Wullich, Dolores, Catala-Solsona, Judit, Fabregas, Cristina, Fado, Rut, Sole, Montse, Unzeta, Mercedes, Saura, Carlos A, Rodriguez-Alvarez, Jose, Minano-Molina, Alfredo J et al.
DOI: 10.1523/ENEURO.0218-19.2020

Correlation of blood biomarkers with early-onset seizures after an acute stroke event.

PMID: 31677998
Journal: EPILEPSY & BEHAVIOR
Year: 2020
Reference: Epilepsy Behav. 2020 Mar;104(Pt B):106549. doi: 10.1016/j.yebeh.2019.106549. Epub 2019 Oct 31.
Impact factor: 2.508
Publication type: Paper in international publication
Authors: Grau-Lopez, Laia, Jimenez, Marta, Ciurans, Jordi, Becerra, Juan Luis, Millan, Monica, Cardona, Pere, Terceno, Mikel, Zaragoza, Josep, Canovas, David, Gasull, Teresa et al.
DOI: 10.1016/j.yebeh.2019.106549

Blog

News

For three days, the III Stroke Congress of the national RICORS-ICTUS network and a symposium focused on cerebral haemorrhage were held.

The TOUCH MSCA-COFUND doctoral training programme, led by UAB and focusing on the field of mental health, has opened its first call for applications, offering 13 doctoral positions.

The Cardiovascular Diseases and Neurovascular Diseases groups at VHIR will investigate new therapeutic strategies for heart failure, nanomedicine in stroke and the prevention of cardiovascular toxicity in the case of oncological treatments.