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Neurovascular Diseases

Stroke is a medical emergency and a leading cause of death and disability worldwide affecting millions of subjects. In this context the Neurovascular Research Laboratory was created in 2001 focused in stroke research from a basic and translational perspective, covering all stages of the disease: from prevention and treatment, to recovery.

Nowadays our team is composed by a highly motivated group of researchers including clinical and basic scientists, with group leaders involved in National and International projects with public or private research funding on biomarkers for clinical decision making in stroke, the presence of silent infarctions, the assessment of cognition and cognitive decline, developing experimental models of cerebral ischemia testing new treatments complementary to reperfusion, and developing studies on cerebral amyloid angiopathy, tissue neurorepair or post-stroke rehabilitation.

Complementary studies on vascular dementia and Alzheimer disease related to amyloid-beta protein have also been encompassed as part of our research in the last years.

Team

Elena Lopez Cancio Martínez

Elena Lopez Cancio Martínez

Postdoctoral researcher
Neurovascular Diseases
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Elisa Carenza

Elisa Carenza

Predoctoral researcher
Neurovascular Diseases
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Iratxe Ugarriza Serrano

Iratxe Ugarriza Serrano

Neurovascular Diseases
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Kerrie Adrián Campbell

Kerrie Adrián Campbell

Research technician
Neurovascular Diseases
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Marcel Lamana Vallverdu

Marcel Lamana Vallverdu

Research technician
Neurovascular Diseases
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Maria Pilar Delgado Martínez

Maria Pilar Delgado Martínez

Main researcher
Neurovascular Diseases
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Elena Lopez Cancio Martínez

Elena Lopez Cancio Martínez

Postdoctoral researcher
Neurovascular Diseases
Read more
Elisa Carenza

Elisa Carenza

Predoctoral researcher
Neurovascular Diseases
Read more
Iratxe Ugarriza Serrano

Iratxe Ugarriza Serrano

Neurovascular Diseases
Read more
Kerrie Adrián Campbell

Kerrie Adrián Campbell

Research technician
Neurovascular Diseases
Read more
Marcel Lamana Vallverdu

Marcel Lamana Vallverdu

Research technician
Neurovascular Diseases
Read more
Maria Pilar Delgado Martínez

Maria Pilar Delgado Martínez

Main researcher
Neurovascular Diseases
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Projects

RICORS-ICTUS

IP: Anna Rosell Novel
Collaborators: Marcel Lamana Vallverdu, Anna Penalba Morenilla, Maria Mar Hernandez Guillamon, Olga Maisterra Santos, Maria Pilar Delgado Martínez, Jesús Pizarro Gonzálvez
Funding agency: Instituto de Salud Carlos III
Funding: 250214.8
Reference: RD21/0006/0007
Duration: 01/01/2022 - 31/12/2024

PRESTIGE-AF: PREvention of STroke in Intracerebral hemorrhaGE survivors with Atrial Fibrillation

IP: Joan Montaner Villalonga
Collaborators: Anna Penalba Morenilla, Tamara Del Rio Higueras, Ariadna Martín Balcells, Olalla Pancorbo Rosal, Olga Sánchez- Maroto Carrizo, Amaia Latasa Arrazubi, Daisy Guamán Pilco, Marcel Lamana Vallverdu
Funding agency: EUROPEAN COMMISSION
Funding: 481723
Reference: PRESTIGE-AF_H2020SC12017
Duration: 01/12/2017 - 30/11/2024

DIGITAL, RISK-BASED SCREENING FOR ATRIAL FIBRILLATION IN THE EUROPEAN COMMUNITY

IP: Joan Montaner Villalonga
Collaborators: Marcel Lamana Vallverdu
Funding agency: EUROPEAN COMMISSION
Funding: 91282.5
Reference: AFFECT-EU_H2020_SC1BHC2019
Duration: 01/01/2020 - 31/03/2024

Demencia mixta por Alzheimer y enfermedad cerebrovascular: un estudio clínico y experimental.

IP: Maria Pilar Delgado Martínez
Collaborators: Francesc Pujadas Navinés, Olga Maisterra Santos, Laura Castillo Ribelles, Carles Lorenzo Bosquet, Antonio Palasi Franco, Maria Belén Gutiérrez Iglesias, Jesús Pizarro Gonzálvez, Diana Liebana Gutierrez
Funding agency: Instituto de Salud Carlos III
Funding: 134310
Reference: PI19/00217
Duration: 01/01/2020 - 30/06/2024

Publications

A multi-trait genetic Study of Hemostatic factors and Hemorrhagic transformation after stroke treatment.

PMID: 38103737
Journal: Journal of thrombosis and haemostasis : JTH
Year: 2023
Reference: J Thromb Haemost. 2023 Dec 14:S1538-7836(23)00870-X. doi: 10.1016/j.jtha.2023.11.027.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Sabin, Jose; Arenillas, Juan F; Carcel-Marquez, Jara; Castellanos, Maria Del Mar; Castillo, Jose; Cullell, Natalia; de Vries, Paul S; Fernandez-Cadenas, Israel; Freijo-Guerrero, Marimar; Gallego-Fabrega, Cristina et al.
DOI: 10.1016/j.jtha.2023.11.027

The CHIVA strategy applied to large-diameter saphenous veins.

PMID: 35373939
Journal: INTERNATIONAL ANGIOLOGY
Year: 2022
Reference: Int Angiol. 2022 Apr 4. pii: S0392-9590.22.04831-3. doi: 10.23736/S0392-9590.22.04831-3.
Impact factor: 2.789
Publication type: Paper in international publication
Authors: Tenezaca-Sari, Xavier, Garcia-Reyes, Marvin, Escribano-Ferrer, Jose Maria, Marrero, Carlos, Bellmunt-Montoya, Sergi et al.
DOI: 10.23736/S0392-9590.22.04831-3

Evolution of quality indicators in acute stroke during the RACECAT Trial: impact in the general population.

PMID: 35373657
Journal: International Journal of Stroke
Year: 2022
Reference: Int J Stroke. 2022 May 4:17474930221093523. doi: 10.1177/17474930221093523.
Impact factor: 5.266
Publication type: Paper in international publication
Authors: Olive-Gadea, Marta, Perez de la Ossa, Natalia, Jovin, Tudor G, Abilleira, Sonia, Jimenez-Fabrega, Xavier, Cardona, Pere, Chamorro, Angel, Flores, Alan, Silva, Yolanda, Purroy, Francisco et al.
DOI: 10.1177/17474930221093523

[Prognostic and monitoring biomarkers in chronic inflammatory demyelinating polyneuropathy].

PMID: 35332927
Journal: REVISTA DE NEUROLOGIA
Year: 2022
Reference: Rev Neurol. 2022 Apr 1;74(7):232-241. doi: 10.33588/rn.7407.2021495.
Impact factor: 0.87
Publication type: Review in national publication
Authors: Llaurado, A, Sanchez-Tejerina, D, Vidal-Taboada, J M, Salvado, M, Sotoca, J, Juntas-Morales, R et al.
DOI: 10.33588/rn.7407.2021495

Magnetic Mesoporous Silica Nanorods Loaded with Ceria and Functionalized with Fluorophores for Multimodal Imaging.

PMID: 35252779
Journal: ACS Applied Nano Materials
Year: 2022
Reference: ACS Appl Nano Mater. 2022 Feb 25;5(2):2113-2125. doi: 10.1021/acsanm.1c03837. Epub 2022 Feb 10.
Impact factor: 5.097
Publication type: Paper in international publication
Authors: Grzelak, Jan, Gazquez, Jaume, Grayston, Alba, Teles, Mariana, Herranz, Fernando, Roher, Nerea, Rosell, Anna, Roig, Anna, Gich, Marti et al.
DOI: 10.1021/acsanm.1c03837

Thumb-up sign: Characterization of an undescribed seizure semiologic sign.

PMID: 34015572
Journal: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
Year: 2021
Reference: Seizure. 2021 Jul;89:62-64. doi: 10.1016/j.seizure.2021.04.029. Epub 2021 May 11.
Impact factor: 3.184
Publication type: Letter whit IF
Authors: Vilaseca, Andreu, Fonseca, Elena, Anciones Martin, Carla, Seijo-Raposo, Ivan, Abraira, Laura, Santamarina, Estevo, Quintana, Manuel, Alvarez-Sabin, Jose, Gil-Nagel, Antonio, Toledo, Manuel et al.
DOI: 10.1016/j.seizure.2021.04.029

Status epilepticus without impairment of consciousness: Long-term outcomes according to duration.

PMID: 33992961
Journal: EPILEPSY & BEHAVIOR
Year: 2021
Reference: Epilepsy Behav. 2021 Jul;120:108007. doi: 10.1016/j.yebeh.2021.108007. Epub 2021 May 13.
Impact factor: 2.937
Publication type: Paper in international publication
Authors: Santamarina, E, Parejo-Carbonell, B, Abraira, L, Gutierrez-Viedma, A, Fonseca, E, Seijo, I, Abarrategui, B, Salas-Puig, X, Quintana, M, Toledo, M et al.
DOI: 10.1016/j.yebeh.2021.108007

Implications of initiating antiseizure drugs prior to the performance of EEG in first epileptic seizures.

PMID: 33875301
Journal: NEUROLOGIA
Year: 2021
Reference: Neurologia (Engl Ed). 2021 Apr 16. pii: S0213-4853(21)00053-0. doi: 10.1016/j.nrl.2021.02.014.
Impact factor: 3.109
Publication type: Paper in national publication
Authors: Llaurado, A, Quintana, M, Fonseca, E, Abraira, L, Toledo, M, Requena, M, Olive, M, Ballve, A, Campos, D, Sueiras, M et al.
DOI: 10.1016/j.nrl.2021.02.014

COVID-19 Infection in Critically Ill Patients Carries a High Risk of Venous Thrombo-embolism.

PMID: 33583710
Journal: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
Year: 2021
Reference: Eur J Vasc Endovasc Surg. 2021 Apr;61(4):628-634. doi: 10.1016/j.ejvs.2020.12.015. Epub 2020 Dec 23.
Impact factor: 7.069
Publication type: Paper in international publication
Authors: Ferrer, Ricard, de Nadal, Miriam, Monreal, Manel, Llagostera, Secundino, Ruiz-Rodriguez, Juan Carlos, Gil, Miquel, Martinez-Carnovale, Lucia, Bellmunt-Montoya, Sergi, Riera, Claudia, Gil, Daniel et al.
DOI: 10.1016/j.ejvs.2020.12.015

Epilepsy in time of COVID-19. a survey-based study.

PMID: 32799337
Journal: ACTA NEUROLOGICA SCANDINAVICA
Year: 2020
Reference: Acta Neurol Scand. 2020 Dec;142(6):545-554. doi: 10.1111/ane.13335. Epub 2020 Sep 6.
Impact factor: 2.684
Publication type: Paper in international publication
Authors: Fonseca, Elena, Quintana, Manuel, Lallana, Sofia, Restrepo, Juan Luis, Abraira, Laura, Santamarina, Estevo, Seijo-Raposo, Ivan, Toledo, Manuel et al.
DOI: 10.1111/ane.13335

Blood biomarkers for the diagnosis and differentiation of stroke: A systematic review and meta-analysis.

PMID: 32746751
Journal: International Journal of Stroke
Year: 2020
Reference: Int J Stroke. 2020 Oct;15(7):704-721. doi: 10.1177/1747493020946157. Epub 2020 Aug 3.
Impact factor: 4.882
Publication type: Review in international publication
Authors: Mohania, Dheeraj, Prasad, Kameshwar, Vibha, Deepti, Pandit, Awadh K, Kumar, Pradeep, Kumar, Amit, Nath, Manabesh, Misra, Shubham, Montaner, Joan, Ramiro, Laura et al.
DOI: 10.1177/1747493020946157

How soon should urgent EEG be performed following a first epileptic seizure?

PMID: 32694039
Journal: EPILEPSY & BEHAVIOR
Year: 2020
Reference: Epilepsy Behav. 2020 Oct;111:107315. doi: 10.1016/j.yebeh.2020.107315. Epub 2020 Jul 18.
Impact factor: 2.508
Publication type: Paper in international publication
Authors: Toledo, M, Quintana, M, Abraira, L, Llaurado, A, Santamarina, E, Fonseca, E, Olive, M, Requena, M, Sueiras, M, Guzman, L et al.
DOI: 10.1016/j.yebeh.2020.107315

Tumor-associated status epilepticus: A prospective cohort in a tertiary hospital.

PMID: 32702656
Journal: EPILEPSY & BEHAVIOR
Year: 2020
Reference: Epilepsy Behav. 2020 Oct;111:107291. doi: 10.1016/j.yebeh.2020.107291. Epub 2020 Jul 20.
Impact factor: 2.508
Publication type: Paper in international publication
Authors: Abraira, Laura, Quintana, Manuel, Sueiras, Maria, Thonon, Vanessa, Toledo, Manuel, Salas-Puig, Javier, Fonseca, Elena, Cordero, Esteban, Martinez-Ricarte, Francisco, Santamarina, Estevo et al.
DOI: 10.1016/j.yebeh.2020.107291

When to Stop.

PMID: 31177974
Journal: STROKE
Year: 2019
Reference: Stroke. 2019 Jul;50(7):1781-1788. doi: 10.1161/STROKEAHA.119.025088. Epub 2019 Jun 10.
Impact factor: 6.046
Publication type: Paper in international publication
Authors: Olive-Gadea, Marta, Garcia-Tornel, Alvaro, Requena, Manuel, Rubiera, Marta, Muchada, Marian, Pagola, Jorge, Rodriguez-Luna, David, Deck, Matias, Juega, Jesus, Rodriguez-Villatoro, Noelia et al.
DOI: 10.1161/STROKEAHA.119.025088

Matrix metalloproteinases and ADAMs in stroke.

PMID: 31165904
Journal: CELLULAR AND MOLECULAR LIFE SCIENCES
Year: 2019
Reference: Cell Mol Life Sci. 2019 Aug;76(16):3117-3140. doi: 10.1007/s00018-019-03175-5. Epub 2019 Jun 5.
Impact factor: 7.014
Publication type: Review in international publication
Authors: Montaner, Joan, Ramiro, Laura, Simats, Alba, Hernandez-Guillamon, Mar, Delgado, Pilar, Bustamante, Alejandro, Rosell, Anna et al.
DOI: 10.1007/s00018-019-03175-5

Effect of brivaracetam on the anger levels of epilepsy patients. A prospective open-labelled controlled study.

PMID: 31079028
Journal: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
Year: 2019
Reference: Seizure. 2019 Jul;69:198-203. doi: 10.1016/j.seizure.2019.04.021. Epub 2019 May 1.
Impact factor: 2.765
Publication type: Paper in international publication
Authors: Toledo, Manuel, Abraira, Laura, Mazuela, Gonzalo, Quintana, Manuel, Cazorla, Sonia, Santamarina, Estevo et al.
DOI: 10.1016/j.seizure.2019.04.021

Peripheral administration of human recombinant ApoJ/clusterin modulates brain beta-amyloid levels in APP23 mice.

PMID: 31077261
Journal: Alzheimers Research & Therapy
Year: 2019
Reference: Alzheimers Res Ther. 2019 May 10;11(1):42. doi: 10.1186/s13195-019-0498-8.
Impact factor: 6.142
Publication type: Paper in international publication
Authors: Bonaterra, Anna, Sanchez-Quesada, Jose Luis, Montaner, Joan, Maspoch, Daniel, Cano-Sarabia, Mary, Hernandez-Guillamon, Mar, Colell, Guillem, Sole, Montse, Marazuela, Paula, de Retana, Sofia Fernandez et al.
DOI: 10.1186/s13195-019-0498-8

Arterial Stiffness Is Associated With Basal Ganglia Enlarged Perivascular Spaces and Cerebral Small Vessel Disease Load.

PMID: 29669870
Journal: STROKE
Year: 2018
Reference: Stroke. 2018 May;49(5):1279-1281. doi: 10.1161/STROKEAHA.118.020163. Epub 2018 Apr 18.
Impact factor: 6.239
Publication type: Paper in international publication
Authors: Riba-Llena, Iolanda, Jimenez-Balado, Joan, Castane, Xavier, Girona, Anna, Lopez-Rueda, Antonio, Mundet, Xavier, Jarca, Carmen I, Alvarez-Sabin, Jose, Montaner, Joan, Delgado, Pilar et al.
DOI: 10.1161/STROKEAHA.118.020163

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

PMID: 29531354
Journal: NATURE GENETICS
Year: 2018
Reference: Nat Genet. 2018 Apr;50(4):524-537. doi: 10.1038/s41588-018-0058-3. Epub 2018 Mar 12.
Impact factor: 27.125
Publication type: Paper in international publication
Authors: Haessler, Jeffrey, Brown, Robert D Jr, Butterworth, Adam S, Carrera, Caty, Carty, Cara L, Chasman, Daniel I, Chen, Wei-Min, Cole, John W, Correa, Adolfo, Cotlarciuc, Ioana et al.
DOI: 10.1038/s41588-018-0058-3

Obstructive sleep apnea and silent cerebral infarction in hypertensive individuals.

PMID: 28631309
Journal: JOURNAL OF SLEEP RESEARCH
Year: 2018
Reference: J Sleep Res. 2018 Apr;27(2):232-239. doi: 10.1111/jsr.12571. Epub 2017 Jun 20.
Impact factor: 3.433
Publication type: Paper in international publication
Authors: Montaner, Joan, Alvarez-Sabin, Jose, Romero, Odile, Delgado, Pilar, Quintana, Manuel, Santamarina, Estevo, Ferre, Alex, Maisterra, Olga, Riba-Llena, Iolanda, Sampol, Gabriel et al.
DOI: 10.1111/jsr.12571

CCL23: A new CC chemokine involved in human brain damage.

PMID: 29415332
Journal: JOURNAL OF INTERNAL MEDICINE
Year: 2018
Reference: J Intern Med. 2018 May;283(5):461-475. doi: 10.1111/joim.12738. Epub 2018 Mar 5.
Impact factor: 6.754
Publication type: Paper in international publication
Authors: Simats, Alba, Garcia-Berrocoso, Teresa, Penalba, Anna, Giralt, Dolors, Llovera, Gemma, Jiang, Yinghua, Ramiro, Laura, Bustamante, Alejandro, Martinez-Saez, Elena, Canals, Francesc et al.
DOI: 10.1111/joim.12738

Blog

News

For three days, the III Stroke Congress of the national RICORS-ICTUS network and a symposium focused on cerebral haemorrhage were held.

The TOUCH MSCA-COFUND doctoral training programme, led by UAB and focusing on the field of mental health, has opened its first call for applications, offering 13 doctoral positions.

The Cardiovascular Diseases and Neurovascular Diseases groups at VHIR will investigate new therapeutic strategies for heart failure, nanomedicine in stroke and the prevention of cardiovascular toxicity in the case of oncological treatments.